-
2
-
-
0018963044
-
Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge
-
Yeh, L. A., Lee, K. H. & Kim, K. H. Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge. J. Biol. Chem. 255, 2308-2314 (1980).
-
(1980)
J. Biol. Chem
, vol.255
, pp. 2308-2314
-
-
Yeh, L.A.1
Lee, K.H.2
Kim, K.H.3
-
3
-
-
0024546378
-
The AMP-activated protein kinase - a multisubstrate regulator of lipid metabolism
-
Hardie, D. G., Carling, D. & Sim, A. T. R. The AMP-activated protein kinase - a multisubstrate regulator of lipid metabolism. Trends Biochem. Sci. 14, 20-23 (1989).
-
(1989)
Trends Biochem. Sci
, vol.14
, pp. 20-23
-
-
Hardie, D.G.1
Carling, D.2
Sim, A.T.R.3
-
4
-
-
0022534202
-
A yeast gene that is essential for release from glucose repression encodes a protein kinase
-
Celenza, J. L. & Carlson, M. A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science 233, 1175-1180 (1986).
-
(1986)
Science
, vol.233
, pp. 1175-1180
-
-
Celenza, J.L.1
Carlson, M.2
-
5
-
-
0027932717
-
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
-
Mitchelhill, K. I. et al. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J. Biol. Chem. 269, 2361-2364 (1994).
-
(1994)
J. Biol. Chem
, vol.269
, pp. 2361-2364
-
-
Mitchelhill, K.I.1
-
6
-
-
0028070457
-
-
Woods, A. et al. Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J. Biol. Chem. 269, 19509-19515 (1994). Cloning of cDNA and sequencing of the first catalytic subunit of mammalian AMPK, demonstrating similarity with the catalytic subunit of the yeast SNF1 complex.
-
Woods, A. et al. Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J. Biol. Chem. 269, 19509-19515 (1994). Cloning of cDNA and sequencing of the first catalytic subunit of mammalian AMPK, demonstrating similarity with the catalytic subunit of the yeast SNF1 complex.
-
-
-
-
7
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn, B. B., Alquier, T., Carling, D. & Hardie, D. G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25 (2005).
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
8
-
-
33845514595
-
Interleukin-6 regulation of AMP-activated protein kinase: Potential role in the systemic response to exercise and prevention of the metabolic syndrome
-
Ruderman, N. B. et al. Interleukin-6 regulation of AMP-activated protein kinase: potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes 55 (Suppl. 2), S48-S54 (2006).
-
(2006)
Diabetes
, vol.55
, Issue.SUPPL. 2
-
-
Ruderman, N.B.1
-
9
-
-
33646570554
-
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
-
Watt, M. J. et al. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Med. 12, 541-548 (2006).
-
(2006)
Nature Med
, vol.12
, pp. 541-548
-
-
Watt, M.J.1
-
10
-
-
0034773404
-
-
Zhou, G. et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167-1174 (2001). Revealed that AMPK was likely to be the target for the drug metformin, currently prescribed to >120 million people with type 2 diabetes worldwide.
-
Zhou, G. et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167-1174 (2001). Revealed that AMPK was likely to be the target for the drug metformin, currently prescribed to >120 million people with type 2 diabetes worldwide.
-
-
-
-
11
-
-
0037067666
-
The antidiabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways
-
Fryer, L. G., Parbu-Patel, A. & Carling, D. The antidiabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways. J. Biol. Chem. 277, 25226-25232 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 25226-25232
-
-
Fryer, L.G.1
Parbu-Patel, A.2
Carling, D.3
-
12
-
-
33749336146
-
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
-
Lee, Y. S. et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55, 2256-2264 (2006).
-
(2006)
Diabetes
, vol.55
, pp. 2256-2264
-
-
Lee, Y.S.1
-
13
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J. A. et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342 (2006).
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
-
14
-
-
33845789994
-
Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway
-
Hwang, J. T. et al. Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett. 247, 115-121 (2007).
-
(2007)
Cancer Lett
, vol.247
, pp. 115-121
-
-
Hwang, J.T.1
-
15
-
-
33644943620
-
AMPK: A key sensor of fuel and energy status in skeletal muscle
-
Hardie, D. G. & Sakamoto, K. AMPK: a key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda) 21, 48-60 (2006).
-
(2006)
Physiology (Bethesda)
, vol.21
, pp. 48-60
-
-
Hardie, D.G.1
Sakamoto, K.2
-
16
-
-
33847080728
-
AMPK in metabolic control and insulin signalling
-
Towler, M. C. & Hardie, D. G. AMPK in metabolic control and insulin signalling. Circ. Res. 100, 328-341 (2007).
-
(2007)
Circ. Res
, vol.100
, pp. 328-341
-
-
Towler, M.C.1
Hardie, D.G.2
-
17
-
-
33847072201
-
AMP-activated protein kinase as a drug target
-
Hardie, D. G. AMP-activated protein kinase as a drug target. Annu. Rev. Pharmacol. Toxicol. 47, 185-210 (2007).
-
(2007)
Annu. Rev. Pharmacol. Toxicol
, vol.47
, pp. 185-210
-
-
Hardie, D.G.1
-
18
-
-
0029910018
-
Characterization of the AMP-activated protein kinase kinase from rat liver, and identification of threonine-172 as the major site at which it phosphorylates and activates AMP-activated protein kinase
-
Hawley, S. A. et al. Characterization of the AMP-activated protein kinase kinase from rat liver, and identification of threonine-172 as the major site at which it phosphorylates and activates AMP-activated protein kinase. J. Biol. Chem. 271, 27879-27887 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 27879-27887
-
-
Hawley, S.A.1
-
19
-
-
33845949733
-
Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
-
Suter, M. et al. Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J. Biol. Chem. 281, 32207-32216 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 32207-32216
-
-
Suter, M.1
-
20
-
-
0345107247
-
-
Hawley, S. A. et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2, 28 (2003). Along with reference 61, identified the complex between LKB1, STRAD and MO25 as the major upstream kinase for AMPK in mammalian cells, and suggested a novel link between AMPK and cancer.
-
Hawley, S. A. et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2, 28 (2003). Along with reference 61, identified the complex between LKB1, STRAD and MO25 as the major upstream kinase for AMPK in mammalian cells, and suggested a novel link between AMPK and cancer.
-
-
-
-
22
-
-
34147152841
-
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
-
Sanders, M. J., Grondin, P. O., Hegarty, B. D., Snowden, M. A. & Carling, D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem. J. 403, 139-148 (2007).
-
(2007)
Biochem. J
, vol.403
, pp. 139-148
-
-
Sanders, M.J.1
Grondin, P.O.2
Hegarty, B.D.3
Snowden, M.A.4
Carling, D.5
-
23
-
-
85047689953
-
-
Corton, J. M., Gillespie, J. G., Hawley, S. A. & Hardie, D. G. 5-aminoimidazole-4-carboxamide ribonucleoside: a specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229, 558-565 (1995). Defined the mechanism of action of 5-aminoimidazole-4-carboxamide ribonucleoside, which was subsequently widely used to define the downstream effects of AMPK.
-
Corton, J. M., Gillespie, J. G., Hawley, S. A. & Hardie, D. G. 5-aminoimidazole-4-carboxamide ribonucleoside: a specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229, 558-565 (1995). Defined the mechanism of action of 5-aminoimidazole-4-carboxamide ribonucleoside, which was subsequently widely used to define the downstream effects of AMPK.
-
-
-
-
24
-
-
33646374461
-
Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice
-
Hancock, C. R., Janssen, E. & Terjung, R. L. Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice. J. Appl. Physiol. 100, 406-413 (2006).
-
(2006)
J. Appl. Physiol
, vol.100
, pp. 406-413
-
-
Hancock, C.R.1
Janssen, E.2
Terjung, R.L.3
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