A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

FASEB Journal

Volumn 25, Issue 6, 2011, Pages 1934-1942

  Tian, Yuan ^a   Bustos, Victor ^a   Flajolet, Marc ^a   Greengard, Paul ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Beclin1; SMER28; Ulk1

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN BETA C TERMINAL FRAGMENT; AUTOPHAGY PROTEIN 5; BECLIN 1; FLUSPIRILENE; GAMMA SECRETASE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PIMOZIDE; SMALL MOLECULE ENHANCER OF RAPAMYCIN 28; SPERMIDINE; TAU PROTEIN; ULK1 PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DRUG INHIBITION; EMBRYO; LIGHT CHAIN; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN PROCESSING;

ALLYL COMPOUNDS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AUTOPHAGY; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION REGULATION; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NEUROBLASTOMA; NEURONS; PEPTIDE FRAGMENTS; QUINAZOLINES; RATS;

EID: 79957917512     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-175158     Document Type: Article

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