Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

Autophagy

Volumn 9, Issue 9, 2013, Pages 1308-1320

  Castillo, Karen ^a,b   Nassif, Melissa ^a,b   Valenzuela, Vicente ^a,b   Rojas, Fabiola ^c   Matus, Soledad ^d   Mercado, Gabriela ^a,b   Court, Felipe A ^d,e   Van Zundert, Brigitte ^c   Hetz, Claudio ^a,b,d,f  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSIDAD ANDRÉS BELLO   (Chile)

^d Santiago   (Chile)

^e PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Amyotrophic lateral sclerosis; Autophagy; Copper zinc superoxide dismutase 1; Protein aggregation; Trehalose

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; TRANSCRIPTION FACTOR FKHR; TREHALOSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOPHAGY; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; DRUG POTENCY; LIFESPAN; MOTONEURON; MOUSE; NEUROPROTECTION; NONHUMAN; RECEPTOR UPREGULATION;

MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; AUTOPHAGY; COPPER-ZINC SUPEROXIDE DISMUTASE 1; PROTEIN AGGREGATION; TREHALOSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; CELL SURVIVAL; CYTOPROTECTION; DISEASE PROGRESSION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; LONGEVITY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NEUROGLIA; PROTEIN STRUCTURE, QUATERNARY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUPEROXIDE DISMUTASE; TRANSCRIPTION, GENETIC; TREHALOSE;

EID: 84884294596     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.25188     Document Type: Article

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