The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

Journal of Biological Chemistry

Volumn 276, Issue 38, 2001, Pages 35243-35246

  Arico, Sébastien ^a   Petiot, Anne ^a,c   Bauvy, Chantal ^a   Dubbelhuis, Peter F ^b   Meijer, Alfred J ^b   Codogno, Patrice ^a   Ogier Denis, Eric ^a  

^a INSERM   (France)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; HUMAN ENGINEERING; MUTAGENESIS; TUMORS;

MACROAUTOPHAGY;

ENZYMES;

INTERLEUKIN 13; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; AKT1 PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATASE; PRIMER DNA; PROTEIN SERINE THREONINE KINASE; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; HUMAN; HUMAN CELL; MACROAUTOPHAGY; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE; WILD TYPE; CELL DIVISION; CELL STRAIN HT29; DRUG ANTAGONISM; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AUTOPHAGY; BASE SEQUENCE; CELL DIVISION; DNA PRIMERS; ENZYME ACTIVATION; GENES, TUMOR SUPPRESSOR; HT29 CELLS; HUMANS; INTERLEUKIN-13; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 0035929650     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C100319200     Document Type: Article

References (43)

1. Dunn, Jr., W. A. (1994) Trends Cell Biol. 4, 139-143
2. Bohley, P., and Seglen, P. O. (1992) Experientia (Basel) 48, 151-157
3. Mortimore, G. E., and Kadowaki, M. (1994) in Cellular Proteolytic Systems (Ciechanover, A. J., and Schwartz, A. L., eds), pp. 65-87, Wiley-Liss, New York
4. Tanaka, Y., Guhde, G., Suter, A., Eskelinen, E. L., Hartmann, D., Lullmann-Rauch, R., Janssen, P. M. L., Blanz, J., von Figura, K., and Saftig, P. (2000) Nature 406, 902-906
5. Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., and Levine, B. (1999) Nature 402, 672-676
6. Klionsky, D. T., and Ohsumi, Y. (1999) Annu. Rev. Cell Dev. Biol. 15, 1-32
7. Ohsumi, Y. (2001) Nat. Rev. Mol. Cell. Biol. 2, 211-216
8. Blommaart, E. F. C., Luiken, J. J. F. P., and Meijer, A. J. (1997) Histochem. J. 20, 365-385
9. Codogno, P., Ogier-Denis, E., and Houri, J. J. (1997) Cell. Signal. 9, 125-130
10. Klionsky, D. J., and Emr, S. D. (2000) Science 290, 1717-1721
11. Seglen, P. O., and Gordon, P. B. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 1889-1892
12. Blommaart, E. F. C., Krause, U., Schellens, J. P. M., Vreeling-Sindelárová, H., and Meijer, A. J. (1997) Eur. J. Biochem. 243, 240-246
13. Petiot, A., Ogier-Denis, E., Blommaart, E. F. C., Meijer, A. J., and Codogno, P. (2000) J. Biol. Chem. 275, 992-998
14. Kihara, A., Noda, T., Ishihara, N., and Ohsumi, Y. (2001) J. Cell Biol. 152, 519-530
15. Di Cristofano, A., and Pandolfi, P. P. (2000) Cell 100, 387-390
16. Li, J., Yen, C., Liaw, D., Podsypania, K., Bose, S., Wag, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. (1997) Science 275, 1943-1947
17. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R., and Tonks, N. K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9052-9057
18. Maehama, T., and Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378
19. Wu, X. Y., Senechal, K., Neshat, M. S., Whang, Y. E., and Sawyers, C. L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15587-15591
20. Ogier-Denis, E., Couvineau, A., Maoret, J. J., Houri, J. J., Bauvy, C., Destefanis, D., Isidoro, C., Laburthe, M., and Codogno, P. (1995) J. Biol. Chem. 270, 13-16
21. Ogier-Denis, E., Houri, J. J., Bauvy, C., and Codogno, P. (1996) J. Biol. Chem. 271, 28593-28600
22. Weng, L. P., Smith, W. M., Dahia, P. L. M., Ziebold, U., Gil, E., Lees, J. A., and Eng, C. (1999) Cancer Res. 59, 5808-5814
23. Wright, K., Kolios, G., Westwick, J., and Waed, S. G. (1999) J. Biol. Chem. 274, 18515-18523
24. Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovic, M., and Hemmings, B. A. (1995) Nature 378, 785-789
25. Cantley, L. C., and Neel, B. G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4240-4245
26. Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N., and Parsons, R. (1998) Cancer Res. 58, 5667-5672
27. Wang, Z. J., Taylor, F., Churchman, M., Norbury, G., and Tomlinson, I. (1998) Am. J. Pathol. 153, 363-366
28. Guanti, G., Resta, N., Simone, C., Cariola, F., Demma, I., Fiorente, P., and Gentile, M. (2000) Hum. Mol. Genet. 9, 283-287
29. Kihara, A., Kabeya, Y., Ohsumi, Y., and Yoshimori, T. (2001) EMBO Rep. 2, 330-335
30. Vanhaesebroeck, B., and Alessi, D. R. (2000) Biochem. J. 346, 561-576
31. Wang, X., Gjörloff-Wingren, A., Saxena, M., Pathan, N., Reed, J. C., and Mustelin, T. (2000) J. Immunol. 164, 1934-1939
32. Zakeri, Z., Bursch, W., Tenniswood, M., and Lockshin, R. A. (1995) Cell Death Diff. 2, 83-92
33. Lemasters, J. J., Nieminen, A. L., Qian, T., Trost, L. C., Elmore, S. P., Nishimura, Y., Crowe, R. A., Cascio, W. E., Bradham, C. A., Brenner, D. A., and Herman, B. (1998) Biochim. Biophys. Acta 1366, 177-196
34. Di Cristofano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P. P. (1998) Nat. Genet. 19, 348-355
35. Gimm, O., Attie-Bitach, T., Lees, J. A., Vekemans, M., and Eng, C. (2000) Hum. Mol. Genet. 9, 1633-1639
36. Clarke, P. G. H. (1990) Anat. Embryol. 181, 195-213
37. Lee, C.-Y., and Baehrecke, E. H. (2001) Development (Camb.) 128, 1443-1455
38. Blommaart, E. F. C., Luiken, J. J. F. P., Blommaart, P. J. E., Vanwoerkom, G. M., and Meijer, A. J. (1995) J. Biol. Chem. 270, 2320-2326
39. Noda, T., and Ohsumi, Y. (1998) J. Biol. Chem. 273, 3963-3966
40. Rohde, J., Heitman, J., and Cardenas, M. E. (2001) J. Biol. Chem. 276, 9583-9586
41. van Sluijters, D. A., Dubbelhuis, P. F., Blommaart, E. F. C., and Meijer, A. J. (2000) Biochem. J. 351, 545-550
42. Hara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M. T., Belham, C., and Avruch, J. (1998) J. Biol. Chem. 273, 14484-14494
43. Kimball, S. R., Shantz, L. M., Horetsky, R. L., and Jefferson, L. S. (1999) J. Biol. Chem. 274, 11647-11652