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Volumn 64, Issue 6, 2009, Pages 807-827

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

Author keywords

HUMDISEASE; MOLNEURO; SYSNEURO

Indexed keywords

ALPHA SYNUCLEIN; LEUCINE RICH REPEAT TRANSMEMBRANE PROTEIN 2; MEMBRANE PROTEIN; MUTANT PROTEIN; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

EID: 72149087091     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2009.11.006     Document Type: Article
Times cited : (415)

References (53)
  • 1
    • 38349029763 scopus 로고    scopus 로고
    • Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum
    • Arlotta P., Molyneaux B.J., Jabaudon D., Yoshida Y., and Macklis J.D. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J. Neurosci. 28 (2008) 622-632
    • (2008) J. Neurosci. , vol.28 , pp. 622-632
    • Arlotta, P.1    Molyneaux, B.J.2    Jabaudon, D.3    Yoshida, Y.4    Macklis, J.D.5
  • 3
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
    • Conway K.A., Harper J.D., and Lansbury P.T. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat. Med. 4 (1998) 1318-1320
    • (1998) Nat. Med. , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 5
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo A.M., Stefanis L., Fredenburg R., Lansbury P.T., and Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305 (2004) 1292-1295
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 7
    • 45549085874 scopus 로고    scopus 로고
    • The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
    • Gandhi P.N., Wang X., Zhu X., Chen S.G., and Wilson-Delfosse A.L. The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J. Neurosci. Res. 86 (2008) 1711-1720
    • (2008) J. Neurosci. Res. , vol.86 , pp. 1711-1720
    • Gandhi, P.N.1    Wang, X.2    Zhu, X.3    Chen, S.G.4    Wilson-Delfosse, A.L.5
  • 9
    • 68949218403 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?
    • Gillardon F. Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?. J. Neurochem. 110 (2009) 1514-1522
    • (2009) J. Neurochem. , vol.110 , pp. 1514-1522
    • Gillardon, F.1
  • 11
    • 0037073748 scopus 로고    scopus 로고
    • Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion
    • Gosavi N., Lee H.J., Lee J.S., Patel S., and Lee S.J. Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. J. Biol. Chem. 277 (2002) 48984-48992
    • (2002) J. Biol. Chem. , vol.277 , pp. 48984-48992
    • Gosavi, N.1    Lee, H.J.2    Lee, J.S.3    Patel, S.4    Lee, S.J.5
  • 16
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • Imai Y., Gehrke S., Wang H.Q., Takahashi R., Hasegawa K., Oota E., and Lu B. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 27 (2008) 2432-2443
    • (2008) EMBO J. , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3    Takahashi, R.4    Hasegawa, K.5    Oota, E.6    Lu, B.7
  • 17
    • 0033230886 scopus 로고    scopus 로고
    • Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
    • Ishihara T., Hong M., Zhang B., Nakagawa Y., Lee M.K., Trojanowski J.Q., and Lee V.M. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24 (1999) 751-762
    • (1999) Neuron , vol.24 , pp. 751-762
    • Ishihara, T.1    Hong, M.2    Zhang, B.3    Nakagawa, Y.4    Lee, M.K.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 18
    • 34447118788 scopus 로고    scopus 로고
    • LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
    • Jaleel M., Nichols R.J., Deak M., Campbell D.G., Gillardon F., Knebel A., and Alessi D.R. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem. J. 405 (2007) 307-317
    • (2007) Biochem. J. , vol.405 , pp. 307-317
    • Jaleel, M.1    Nichols, R.J.2    Deak, M.3    Campbell, D.G.4    Gillardon, F.5    Knebel, A.6    Alessi, D.R.7
  • 20
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
    • Lee H.J., Patel S., and Lee S.J. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J. Neurosci. 25 (2005) 6016-6024
    • (2005) J. Neurosci. , vol.25 , pp. 6016-6024
    • Lee, H.J.1    Patel, S.2    Lee, S.J.3
  • 21
    • 33845656077 scopus 로고    scopus 로고
    • Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein
    • Lee H.J., Khoshaghideh F., Lee S., and Lee S.J. Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein. Eur. J. Neurosci. 24 (2006) 3153-3162
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 3153-3162
    • Lee, H.J.1    Khoshaghideh, F.2    Lee, S.3    Lee, S.J.4
  • 22
    • 34548621385 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
    • Li X., Tan Y.C., Poulose S., Olanow C.W., Huang X.Y., and Yue Z. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J. Neurochem. 103 (2007) 238-247
    • (2007) J. Neurochem. , vol.103 , pp. 238-247
    • Li, X.1    Tan, Y.C.2    Poulose, S.3    Olanow, C.W.4    Huang, X.Y.5    Yue, Z.6
  • 25
    • 0025943571 scopus 로고
    • The rat brain synucleins; family of proteins transiently associated with neuronal membrane
    • Maroteaux L., and Scheller R.H. The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res. Mol. Brain Res. 11 (1991) 335-343
    • (1991) Brain Res. Mol. Brain Res. , vol.11 , pp. 335-343
    • Maroteaux, L.1    Scheller, R.H.2
  • 26
    • 0023722437 scopus 로고
    • Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L., Campanelli J.T., and Scheller R.H. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8 (1988) 2804-2815
    • (1988) J. Neurosci. , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 28
    • 0029807527 scopus 로고    scopus 로고
    • Control of memory formation through regulated expression of a CaMKII transgene
    • Mayford M., Bach M.E., Huang Y.Y., Wang L., Hawkins R.D., and Kandel E.R. Control of memory formation through regulated expression of a CaMKII transgene. Science 274 (1996) 1678-1683
    • (1996) Science , vol.274 , pp. 1678-1683
    • Mayford, M.1    Bach, M.E.2    Huang, Y.Y.3    Wang, L.4    Hawkins, R.D.5    Kandel, E.R.6
  • 36
    • 45549099576 scopus 로고    scopus 로고
    • Cytoskeletal requirements in axonal transport of slow component-b
    • Roy S., Winton M.J., Black M.M., Trojanowski J.Q., and Lee V.M. Cytoskeletal requirements in axonal transport of slow component-b. J. Neurosci. 28 (2008) 5248-5256
    • (2008) J. Neurosci. , vol.28 , pp. 5248-5256
    • Roy, S.1    Winton, M.J.2    Black, M.M.3    Trojanowski, J.Q.4    Lee, V.M.5
  • 37
    • 33745847479 scopus 로고    scopus 로고
    • Diagnosis and treatment of Parkinson disease: molecules to medicine
    • Savitt J.M., Dawson V.L., and Dawson T.M. Diagnosis and treatment of Parkinson disease: molecules to medicine. J. Clin. Invest. 116 (2006) 1744-1754
    • (2006) J. Clin. Invest. , vol.116 , pp. 1744-1754
    • Savitt, J.M.1    Dawson, V.L.2    Dawson, T.M.3
  • 41
    • 33746445842 scopus 로고    scopus 로고
    • Activity-related redistribution of presynaptic proteins at the active zone
    • Tao-Cheng J.H. Activity-related redistribution of presynaptic proteins at the active zone. Neuroscience 141 (2006) 1217-1224
    • (2006) Neuroscience , vol.141 , pp. 1217-1224
    • Tao-Cheng, J.H.1
  • 42
    • 0033080404 scopus 로고    scopus 로고
    • Role of microtubules in the organization of the Golgi complex
    • Thyberg J., and Moskalewski S. Role of microtubules in the organization of the Golgi complex. Exp. Cell Res. 246 (1999) 263-279
    • (1999) Exp. Cell Res. , vol.246 , pp. 263-279
    • Thyberg, J.1    Moskalewski, S.2
  • 44
    • 0031762949 scopus 로고    scopus 로고
    • Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia
    • Trojanowski J.Q., Goedert M., Iwatsubo T., and Lee V.M. Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death Differ. 5 (1998) 832-837
    • (1998) Cell Death Differ. , vol.5 , pp. 832-837
    • Trojanowski, J.Q.1    Goedert, M.2    Iwatsubo, T.3    Lee, V.M.4
  • 46
    • 41549144503 scopus 로고    scopus 로고
    • The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
    • Wang L., Xie C., Greggio E., Parisiadou L., Shim H., Sun L., Chandran J., Lin X., Lai C., Yang W.J., et al. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J. Neurosci. 28 (2008) 3384-3391
    • (2008) J. Neurosci. , vol.28 , pp. 3384-3391
    • Wang, L.1    Xie, C.2    Greggio, E.3    Parisiadou, L.4    Shim, H.5    Sun, L.6    Chandran, J.7    Lin, X.8    Lai, C.9    Yang, W.J.10
  • 47
    • 0006327768 scopus 로고
    • Role of microtubules in the distribution of the Golgi apparatus: effect of taxol and microinjected anti-alpha-tubulin antibodies
    • Wehland J., Henkart M., Klausner R., and Sandoval I.V. Role of microtubules in the distribution of the Golgi apparatus: effect of taxol and microinjected anti-alpha-tubulin antibodies. Proc. Natl. Acad. Sci. USA 80 (1983) 4286-4290
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 4286-4290
    • Wehland, J.1    Henkart, M.2    Klausner, R.3    Sandoval, I.V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.