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Volumn 10, Issue 1, 2013, Pages

Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders

Author keywords

[No Author keywords available]

Indexed keywords

2',5' DIDEOXYADENOSINE; ALPHA SYNUCLEIN; AMIODARONE; ATAXIN 3; CALPASTATIN; CALPEPTIN; CARBAMAZEPINE; CENTRAL NERVOUS SYSTEM AGENTS; CLONIDINE; COPPER ZINC SUPEROXIDE DISMUTASE; FLUSPIRILENE; HUNTINGTIN; L 690330; LITHIUM; LOPERAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MINOXIDIL; N(G) NITROARGININE METHYL ESTER; NF 449; NIMODIPINE; NITRENDIPINE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; POLYGLUTAMINE; RAPAMYCIN; RILMENIDINE; TEMSIROLIMUS; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL;

EID: 84875753542     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2012.09.010     Document Type: Review
Times cited : (36)

References (40)
  • 1
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • N. Mizushima Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1
  • 2
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • Z. Xie, and D.J. Klionsky Autophagosome formation: core machinery and adaptations Nat. Cell Biol. 9 2007 1102 1109
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 3
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • D.C. Rubinsztein The roles of intracellular protein-degradation pathways in neurodegeneration Nature 443 2006 780 786
    • (2006) Nature , vol.443 , pp. 780-786
    • Rubinsztein, D.C.1
  • 4
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • M. Komatsu Loss of autophagy in the central nervous system causes neurodegeneration in mice Nature 441 2006 880 884
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1
  • 5
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • T. Hara Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Nature 441 2006 885 889
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1
  • 6
    • 57649227693 scopus 로고    scopus 로고
    • Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
    • S. Sarkar Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies Cell Death Differ. 16 2009 46 56
    • (2009) Cell Death Differ. , vol.16 , pp. 46-56
    • Sarkar, S.1
  • 7
    • 79954425069 scopus 로고    scopus 로고
    • Protein misfolding disorders and macroautophagy
    • F.M. Menzies Protein misfolding disorders and macroautophagy Curr. Opin. Cell Biol. 23 2011 190 197
    • (2011) Curr. Opin. Cell Biol. , vol.23 , pp. 190-197
    • Menzies, F.M.1
  • 8
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • B. Ravikumar Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease Nat. Genet. 36 2004 585 595
    • (2004) Nat. Genet. , vol.36 , pp. 585-595
    • Ravikumar, B.1
  • 9
    • 78149475088 scopus 로고    scopus 로고
    • Regulation of mammalian autophagy in physiology and pathophysiology
    • B. Ravikumar Regulation of mammalian autophagy in physiology and pathophysiology Physiol. Rev. 90 2010 1383 1435
    • (2010) Physiol. Rev. , vol.90 , pp. 1383-1435
    • Ravikumar, B.1
  • 10
    • 59649114573 scopus 로고    scopus 로고
    • Autophagic clearance of aggregate-prone proteins associated with neurodegeneration
    • S. Sarkar Autophagic clearance of aggregate-prone proteins associated with neurodegeneration Methods Enzymol. 453C 2009 83 110
    • (2009) Methods Enzymol. , vol.453 C , pp. 83-110
    • Sarkar, S.1
  • 11
    • 0041589248 scopus 로고    scopus 로고
    • Alpha-Synuclein is degraded by both autophagy and the proteasome
    • J.L. Webb Alpha-Synuclein is degraded by both autophagy and the proteasome J. Biol. Chem. 278 2003 25009 25013
    • (2003) J. Biol. Chem. , vol.278 , pp. 25009-25013
    • Webb, J.L.1
  • 12
    • 0035880474 scopus 로고    scopus 로고
    • Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease
    • A. Wyttenbach Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease Hum. Mol. Genet. 10 2001 1829 1845
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1829-1845
    • Wyttenbach, A.1
  • 13
    • 25444483066 scopus 로고    scopus 로고
    • Lithium induces autophagy by inhibiting inositol monophosphatase
    • S. Sarkar Lithium induces autophagy by inhibiting inositol monophosphatase J. Cell Biol. 170 2005 1101 1111
    • (2005) J. Cell Biol. , vol.170 , pp. 1101-1111
    • Sarkar, S.1
  • 14
    • 42249106042 scopus 로고    scopus 로고
    • Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
    • A. Williams Novel targets for Huntington's disease in an mTOR-independent autophagy pathway Nat. Chem. Biol. 4 2008 295 305
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 295-305
    • Williams, A.1
  • 15
    • 34248994604 scopus 로고    scopus 로고
    • Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
    • S. Sarkar Small molecules enhance autophagy and reduce toxicity in Huntington's disease models Nat. Chem. Biol. 3 2007 331 338
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 331-338
    • Sarkar, S.1
  • 16
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • S. Sarkar Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein J. Biol. Chem. 282 2007 5641 5652
    • (2007) J. Biol. Chem. , vol.282 , pp. 5641-5652
    • Sarkar, S.1
  • 17
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Y. Kabeya LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J. 19 2000 5720 5728
    • (2000) EMBO J. , vol.19 , pp. 5720-5728
    • Kabeya, Y.1
  • 18
    • 37649024076 scopus 로고    scopus 로고
    • Small molecule regulators of autophagy identified by an image-based high-throughput screen
    • L. Zhang Small molecule regulators of autophagy identified by an image-based high-throughput screen Proc. Natl. Acad. Sci. U. S. A. 104 2007 19023 19028
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 19023-19028
    • Zhang, L.1
  • 19
    • 70349616273 scopus 로고    scopus 로고
    • Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
    • A.D. Balgi Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling PLoS One 4 2009 e7124
    • (2009) PLoS One , vol.4 , pp. 7124
    • Balgi, A.D.1
  • 20
    • 77954898129 scopus 로고    scopus 로고
    • A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
    • M.M. Lipinski A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions Dev. Cell 18 2010 1041 1052
    • (2010) Dev. Cell , vol.18 , pp. 1041-1052
    • Lipinski, M.M.1
  • 21
    • 84859901966 scopus 로고    scopus 로고
    • Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC
    • N.C. McKnight Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC EMBO J. 31 2012 1931 1946
    • (2012) EMBO J. , vol.31 , pp. 1931-1946
    • McKnight, N.C.1
  • 22
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • S. Kimura Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3 Autophagy 3 2007 452 460
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1
  • 23
    • 65249089754 scopus 로고    scopus 로고
    • Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates
    • S. Sarkar Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates Autophagy 5 2009 307 313
    • (2009) Autophagy , vol.5 , pp. 307-313
    • Sarkar, S.1
  • 24
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • G. Bjorkoy p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death J. Cell Biol. 171 2005 603 614
    • (2005) J. Cell Biol. , vol.171 , pp. 603-614
    • Bjorkoy, G.1
  • 25
    • 77955863456 scopus 로고    scopus 로고
    • A reporter cell system to monitor autophagy based on p62/SQSTM1
    • K.B. Larsen A reporter cell system to monitor autophagy based on p62/SQSTM1 Autophagy 6 2010 784 793
    • (2010) Autophagy , vol.6 , pp. 784-793
    • Larsen, K.B.1
  • 26
    • 0032168160 scopus 로고    scopus 로고
    • Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
    • G.R. Jackson Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons Neuron 21 1998 633 642
    • (1998) Neuron , vol.21 , pp. 633-642
    • Jackson, G.R.1
  • 27
    • 33749242234 scopus 로고    scopus 로고
    • Drosophila in the study of neurodegenerative disease
    • J.L. Marsh, and L.M. Thompson Drosophila in the study of neurodegenerative disease Neuron 52 2006 169 178
    • (2006) Neuron , vol.52 , pp. 169-178
    • Marsh, J.L.1    Thompson, L.M.2
  • 28
    • 31544454404 scopus 로고    scopus 로고
    • Rapamycin alleviates toxicity of different aggregate-prone proteins
    • Z. Berger Rapamycin alleviates toxicity of different aggregate-prone proteins Hum. Mol. Genet. 15 2006 433 442
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 433-442
    • Berger, Z.1
  • 29
    • 37849042536 scopus 로고    scopus 로고
    • A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
    • S. Sarkar A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin Hum. Mol. Genet. 17 2008 170 178
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 170-178
    • Sarkar, S.1
  • 30
    • 79959886743 scopus 로고    scopus 로고
    • Complex inhibitory effects of nitric oxide on autophagy
    • S. Sarkar Complex inhibitory effects of nitric oxide on autophagy Mol. Cell 43 2011 19 32
    • (2011) Mol. Cell , vol.43 , pp. 19-32
    • Sarkar, S.1
  • 31
    • 77955383021 scopus 로고    scopus 로고
    • Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease
    • B.R. Underwood Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease Hum. Mol. Genet. 19 2010 3413 3429
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3413-3429
    • Underwood, B.R.1
  • 32
    • 74249103961 scopus 로고    scopus 로고
    • Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3
    • F.M. Menzies Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3 Brain 133 Pt 1 2010 93 104
    • (2010) Brain , vol.133 , Issue.PART 1 , pp. 93-104
    • Menzies, F.M.1
  • 33
    • 77953486943 scopus 로고    scopus 로고
    • Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
    • C. Rose Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease Hum. Mol. Genet. 19 2010 2144 2153
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 2144-2153
    • Rose, C.1
  • 34
    • 84863210676 scopus 로고    scopus 로고
    • Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
    • V. Schaeffer Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy Brain 135 Pt 7 2012 2169 2177
    • (2012) Brain , vol.135 , Issue.PART 7 , pp. 2169-2177
    • Schaeffer, V.1
  • 35
    • 77954955573 scopus 로고    scopus 로고
    • Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
    • J.A. Rodriguez-Navarro Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation Neurobiol. Dis. 39 2010 423 438
    • (2010) Neurobiol. Dis. , vol.39 , pp. 423-438
    • Rodriguez-Navarro, J.A.1
  • 36
    • 41149124406 scopus 로고    scopus 로고
    • Lithium delays progression of amyotrophic lateral sclerosis
    • F. Fornai Lithium delays progression of amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U. S. A. 105 2008 2052 2057
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 2052-2057
    • Fornai, F.1
  • 37
    • 77649219699 scopus 로고    scopus 로고
    • Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice
    • S. Zheng Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice PLoS Genet. 6 2010 e1000838
    • (2010) PLoS Genet. , vol.6 , pp. 1000838
    • Zheng, S.1
  • 38
    • 70449529855 scopus 로고    scopus 로고
    • Induction of autophagy by spermidine promotes longevity
    • T. Eisenberg Induction of autophagy by spermidine promotes longevity Nat. Cell Biol. 11 2009 1305 1314
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1305-1314
    • Eisenberg, T.1
  • 39
    • 77954597127 scopus 로고    scopus 로고
    • An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis
    • T. Hidvegi An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis Science 329 2010 229 232
    • (2010) Science , vol.329 , pp. 229-232
    • Hidvegi, T.1
  • 40
    • 78149319082 scopus 로고    scopus 로고
    • Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration
    • P. Grumati Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration Nat. Med. 16 2010 1313 1320
    • (2010) Nat. Med. , vol.16 , pp. 1313-1320
    • Grumati, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.