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Volumn , Issue , 2011, Pages 206-257

G-Quadruplex DNA and its Ligands in Anticancer Therapy

Author keywords

DNA quadruplex research; G quadruplex DNA; G quadruplex ligands

Indexed keywords


EID: 84879686399     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118092804.ch5     Document Type: Chapter
Times cited : (3)

References (271)
  • 1
    • 0036519363 scopus 로고    scopus 로고
    • DNA and its associated processes as targets for cancer therapy
    • Hurley, L. H. (2002). DNA and its associated processes as targets for cancer therapy. Nature Reviews Cancer, 2 , 188-200.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 188-200
    • Hurley, L.H.1
  • 2
    • 0036562687 scopus 로고    scopus 로고
    • Telomere maintenance as a target for anticancer drug discovery
    • Neidle, S., Parkinson, G. (2002). Telomere maintenance as a target for anticancer drug discovery. Nature Reviews Drug Discovery, 1 , 383-393.
    • (2002) Nature Reviews Drug Discovery , vol.1 , pp. 383-393
    • Neidle, S.1    Parkinson, G.2
  • 3
    • 16844375686 scopus 로고    scopus 로고
    • Chemical approaches to the discovery and development of cancer therapies
    • Neidle, S., Thurston, D. E. (2005). Chemical approaches to the discovery and development of cancer therapies. Nature Reviews Cancer, 5 , 285-296.
    • (2005) Nature Reviews Cancer , vol.5 , pp. 285-296
    • Neidle, S.1    Thurston, D.E.2
  • 5
    • 35748937058 scopus 로고    scopus 로고
    • Quartets in G-major The first international meeting on quadruplex DNA
    • Bates, P., Mergny, J.-L., Yang, D. (2007). Quartets in G-major. The first international meeting on quadruplex DNA. EMBO Reports, 8 , 1003-1010.
    • (2007) EMBO Reports , vol.8 , pp. 1003-1010
    • Bates, P.1    Mergny, J.-L.2    Yang, D.3
  • 6
    • 35648953239 scopus 로고    scopus 로고
    • First international meeting on quadruplex
    • Wilson, W. D., Sugiyama, H. (2007). First international meeting on quadruplex. ACS Chemical Biology, 2 , 589-594.
    • (2007) ACS Chemical Biology , vol.2 , pp. 589-594
    • Wilson, W.D.1    Sugiyama, H.2
  • 7
    • 67849101508 scopus 로고    scopus 로고
    • Meeting report: second international meeting on quadruplex DNA
    • Herbert, B.-S., Huppert, J. L., Johnson, F. B., Lane, A. N., Phan, A. T. (2009). Meeting report: second international meeting on quadruplex DNA. Biochimie, 91 , 1059-1065.
    • (2009) Biochimie , vol.91 , pp. 1059-1065
    • Herbert, B.-S.1    Huppert, J.L.2    Johnson, F.B.3    Lane, A.N.4    Phan, A.T.5
  • 12
    • 0024787884 scopus 로고
    • Monovalent cationinduced structure of telomeric DNA: the G-quartet model
    • Williamson, J. R., Raghuraman, M. K., Cech, T. R. (1989). Monovalent cationinduced structure of telomeric DNA: the G-quartet model. Cell , 59 , 871-880.
    • (1989) Cell , vol.59 , pp. 871-880
    • Williamson, J.R.1    Raghuraman, M.K.2    Cech, T.R.3
  • 14
    • 1042268168 scopus 로고    scopus 로고
    • G-quartets 40 years later: from 5-GMP to molecular biology and supramolecular chemistry
    • Davis, J. T. (2004). G-quartets 40 years later: from 5-GMP to molecular biology and supramolecular chemistry. Angewandte Chemie, International Edition, 43 , 668-698.
    • (2004) Angewandte Chemie, International Edition , vol.43 , pp. 668-698
    • Davis, J.T.1
  • 15
    • 0035018021 scopus 로고    scopus 로고
    • G-quadruplex DNA structures-variations on a theme
    • Simonsson, T. (2001). G-quadruplex DNA structures-variations on a theme. Biological Chemistry, 382 , 621-628.
    • (2001) Biological Chemistry , vol.382 , pp. 621-628
    • Simonsson, T.1
  • 17
    • 47249089630 scopus 로고    scopus 로고
    • Polymorphism of human telomeric quadruplex structures
    • Dai, J., Carver, M., Yang, D. (2008). Polymorphism of human telomeric quadruplex structures. Biochimie, 90 , 1172-1183.
    • (2008) Biochimie , vol.90 , pp. 1172-1183
    • Dai, J.1    Carver, M.2    Yang, D.3
  • 18
    • 77952870567 scopus 로고    scopus 로고
    • Monomorphic RNA G-quadruplex and polymorphic DNA G-quadruplex structures responding to cellular environmental factors
    • Zhang, D.-H., Fujimoto, T., Saxena, S., Yu, H.-Q., Miyoshi, D., Sugimoto, N. (2010). Monomorphic RNA G-quadruplex and polymorphic DNA G-quadruplex structures responding to cellular environmental factors. Biochemistry, 49 , 4554-4563.
    • (2010) Biochemistry , vol.49 , pp. 4554-4563
    • Zhang, D.-H.1    Fujimoto, T.2    Saxena, S.3    Yu, H.-Q.4    Miyoshi, D.5    Sugimoto, N.6
  • 19
    • 45749103733 scopus 로고    scopus 로고
    • Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
    • Huppert, J. L. (2008). Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes. Chemical Society Reviews, 37 , 1375-1384.
    • (2008) Chemical Society Reviews , vol.37 , pp. 1375-1384
    • Huppert, J.L.1
  • 20
    • 76349097100 scopus 로고    scopus 로고
    • Human telomeric G-quadruplex: structures of DNA and RNA sequences
    • Phan, A. T. (2010). Human telomeric G-quadruplex: structures of DNA and RNA sequences. FEBS Journal, 277 , 1107-1117.
    • (2010) FEBS Journal , vol.277 , pp. 1107-1117
    • Phan, A.T.1
  • 21
    • 0028166475 scopus 로고
    • Conformational polymorphism in telomeric structures: loop orientation and interloop pairing in d(G4TnG4)
    • Mohanty, D., Bansal, M. (1994). Conformational polymorphism in telomeric structures: loop orientation and interloop pairing in d(G4TnG4). Biopolymers, 34 , 1187-1211.
    • (1994) Biopolymers , vol.34 , pp. 1187-1211
    • Mohanty, D.1    Bansal, M.2
  • 22
    • 0035979714 scopus 로고    scopus 로고
    • V-shaped scaffold: a new architectural motif identified in an A·(G·G·G·G) pentad-containing dimeric DNA quadruplex involving stacked G(anti)·G(anti)·G(anti)·G(syn) Tetrads
    • Zhang, N., Gorin, A., Majumdar, A., Kettani, A., Chernichenko, N., Skripkin, E., et al . (2001). V-shaped scaffold: a new architectural motif identified in an A·(G·G·G·G) pentad-containing dimeric DNA quadruplex involving stacked G(anti)·G(anti)·G(anti)·G(syn) Tetrads. Journal of Molecular Biology, 311 , 1063-1079.
    • (2001) Journal of Molecular Biology , vol.311 , pp. 1063-1079
    • Zhang, N.1    Gorin, A.2    Majumdar, A.3    Kettani, A.4    Chernichenko, N.5    Skripkin, E.6
  • 23
    • 3042671689 scopus 로고    scopus 로고
    • Influence of loop size on the stability of intramolecular DNA quadruplexes
    • Risitano, A., Fox Keith, R. (2004). Influence of loop size on the stability of intramolecular DNA quadruplexes. Nucleic Acids Research, 32 , 2598-2606.
    • (2004) Nucleic Acids Research , vol.32 , pp. 2598-2606
    • Risitano, A.1    Fox Keith, R.2
  • 25
    • 27944459311 scopus 로고    scopus 로고
    • Role of loop residues and cations on the formation and stability of dimeric DNA G-quadruplexes
    • Cevec, M., Plavec, J. (2005). Role of loop residues and cations on the formation and stability of dimeric DNA G-quadruplexes. Biochemistry, 44 , 15238-15246.
    • (2005) Biochemistry , vol.44 , pp. 15238-15246
    • Cevec, M.1    Plavec, J.2
  • 26
    • 34047190331 scopus 로고    scopus 로고
    • Sequence effects of single base loops in intramolecular quadruplex DNA
    • Rachwal, P. A., Brown, T., Fox, K. R. (2007). Sequence effects of single base loops in intramolecular quadruplex DNA. FEBS Letters, 581 , 1657-1660.
    • (2007) FEBS Letters , vol.581 , pp. 1657-1660
    • Rachwal, P.A.1    Brown, T.2    Fox, K.R.3
  • 27
    • 34547646128 scopus 로고    scopus 로고
    • Intramolecular DNA quadruplexes with different arrangements of short and long loops
    • Rachwal, P. A., Findlow, I. S., Werner, J. M., Brown, T., Fox, K. R. (2007). Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Research, 35 , 4214-4222.
    • (2007) Nucleic Acids Research , vol.35 , pp. 4214-4222
    • Rachwal, P.A.1    Findlow, I.S.2    Werner, J.M.3    Brown, T.4    Fox, K.R.5
  • 28
    • 0027191126 scopus 로고
    • Conformational polymorphism in G-tetraplex structures: strand reversal by base flipover or sugar flipover
    • Mohanty, D., Bansal, M. (1993). Conformational polymorphism in G-tetraplex structures: strand reversal by base flipover or sugar flipover. Nucleic Acids Research, 21 , 1767-1774.
    • (1993) Nucleic Acids Research , vol.21 , pp. 1767-1774
    • Mohanty, D.1    Bansal, M.2
  • 29
    • 0037133510 scopus 로고    scopus 로고
    • Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications
    • Dapic, V., Bates, P. J., Trent, J. O., Rodger, A., Thomas, S. D., Miller, D. M. (2002). Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications. Biochemistry, 41 , 3676-3685.
    • (2002) Biochemistry , vol.41 , pp. 3676-3685
    • Dapic, V.1    Bates, P.J.2    Trent, J.O.3    Rodger, A.4    Thomas, S.D.5    Miller, D.M.6
  • 30
    • 0027240171 scopus 로고
    • Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution
    • Smith, F. W., Feigon, J. (1993). Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution. Biochemistry, 32 , 8682-8692.
    • (1993) Biochemistry , vol.32 , pp. 8682-8692
    • Smith, F.W.1    Feigon, J.2
  • 31
    • 35448930321 scopus 로고    scopus 로고
    • Crystallographic studies of quadruplex nucleic acids
    • Campbell, N. H., Parkinson, G. N. (2007). Crystallographic studies of quadruplex nucleic acids. Methods, 43 , 252-263.
    • (2007) Methods , vol.43 , pp. 252-263
    • Campbell, N.H.1    Parkinson, G.N.2
  • 32
    • 0025079955 scopus 로고
    • Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein
    • Raghuraman, M. K., Cech, T. R. (1990). Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein. Nucleic Acids Research, 18 , 4543-4552.
    • (1990) Nucleic Acids Research , vol.18 , pp. 4543-4552
    • Raghuraman, M.K.1    Cech, T.R.2
  • 33
    • 0033534681 scopus 로고    scopus 로고
    • Binding sites and dynamics of ammonium ions in a telomere repeat DNA quadruplex
    • Hud, N. V., Schultze, P., Sklenar, V., Feigon, J. (1999). Binding sites and dynamics of ammonium ions in a telomere repeat DNA quadruplex. Journal of Molecular Biology, 285 , 233-243.
    • (1999) Journal of Molecular Biology , vol.285 , pp. 233-243
    • Hud, N.V.1    Schultze, P.2    Sklenar, V.3    Feigon, J.4
  • 36
    • 28444473880 scopus 로고    scopus 로고
    • 205Tl NMR methods for the characterization of monovalent cation binding to nucleic acids
    • Gill, M. L., Strobel, S. A., Loria, J. P. (2005). 205Tl NMR methods for the characterization of monovalent cation binding to nucleic acids. Journal of the American Chemical Society, 127 , 16723-16732.
    • (2005) Journal of the American Chemical Society , vol.127 , pp. 16723-16732
    • Gill, M.L.1    Strobel, S.A.2    Loria, J.P.3
  • 38
    • 0037142071 scopus 로고    scopus 로고
    • Crystal structure of parallel quadruplexes from human telomeric DNA
    • Parkinson, G. N., Lee, M. P. H., Neidle, S. (2002). Crystal structure of parallel quadruplexes from human telomeric DNA. Nature, 417 , 876-880.
    • (2002) Nature , vol.417 , pp. 876-880
    • Parkinson, G.N.1    Lee, M.P.H.2    Neidle, S.3
  • 39
    • 26844479560 scopus 로고    scopus 로고
    • Characterization of the monovalent ion position and hydrogen-bond network in guanine quartets by DFT calculations of NMR parameters
    • van Mourik, T., Dingley, A. J. (2005). Characterization of the monovalent ion position and hydrogen-bond network in guanine quartets by DFT calculations of NMR parameters. Chemistry-A European Journal, 11 , 6064-6079.
    • (2005) Chemistry-A European Journal , vol.11 , pp. 6064-6079
    • van Mourik, T.1    Dingley, A.J.2
  • 41
    • 33847644454 scopus 로고    scopus 로고
    • Probing hydrogen bonding and ion-carbonyl interactions by solid-state 17O NMR spectroscopy: G-ribbon and G-quartet
    • Kwan, I. C. M., Mo, X., Wu, G. (2007). Probing hydrogen bonding and ion-carbonyl interactions by solid-state 17O NMR spectroscopy: G-ribbon and G-quartet. Journal of the American Chemical Society, 129 , 2398-2407.
    • (2007) Journal of the American Chemical Society , vol.129 , pp. 2398-2407
    • Kwan, I.C.M.1    Mo, X.2    Wu, G.3
  • 42
    • 0027918585 scopus 로고
    • Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex
    • Wang, Y., Patel, D. J. (1993). Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex. Structure, 1 , 263-282.
    • (1993) Structure , vol.1 , pp. 263-282
    • Wang, Y.1    Patel, D.J.2
  • 43
    • 0037443979 scopus 로고    scopus 로고
    • Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions
    • Redon, S., Bombard, S., Elizondo-Riojas, M. A., Chottard, J. C. (2003). Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions. Nucleic Acids Research, 31 , 1605-1613.
    • (2003) Nucleic Acids Research , vol.31 , pp. 1605-1613
    • Redon, S.1    Bombard, S.2    Elizondo-Riojas, M.A.3    Chottard, J.C.4
  • 44
    • 6044261572 scopus 로고    scopus 로고
    • Intramolecular quadruplex conformation of human telomeric DNA assessed with 125I-radioprobing
    • He, Y., Neumann, R. D., Panyutin, I. G. (2004). Intramolecular quadruplex conformation of human telomeric DNA assessed with 125I-radioprobing. Nucleic Acids Research, 32 , 5359-5367.
    • (2004) Nucleic Acids Research , vol.32 , pp. 5359-5367
    • He, Y.1    Neumann, R.D.2    Panyutin, I.G.3
  • 46
  • 47
    • 33646943863 scopus 로고    scopus 로고
    • Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
    • Ambrus, A., Chen, D., Dai, J., Bialis, T., Jones, R. A., Yang, D. (2006). Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution. Nucleic Acids Research, 34 , 2723-2735.
    • (2006) Nucleic Acids Research , vol.34 , pp. 2723-2735
    • Ambrus, A.1    Chen, D.2    Dai, J.3    Bialis, T.4    Jones, R.A.5    Yang, D.6
  • 48
    • 34249846802 scopus 로고    scopus 로고
    • Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation
    • Dai, J., Punchihewa, C., Ambrus, A., Chen, D., Jones, R. A., Yang, D. (2007). Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation. Nucleic Acids Research, 35 , 2440-2450.
    • (2007) Nucleic Acids Research , vol.35 , pp. 2440-2450
    • Dai, J.1    Punchihewa, C.2    Ambrus, A.3    Chen, D.4    Jones, R.A.5    Yang, D.6
  • 49
    • 34447344080 scopus 로고    scopus 로고
    • Structure of a human telomeric DNA sequence stabilized by 8-bromoguanosine substitutions, as determined by NMR in a K+ solution
    • Matsugami, A., Xu, Y., Noguchi, Y., Sugiyama, H., Katahira, M. (2007). Structure of a human telomeric DNA sequence stabilized by 8-bromoguanosine substitutions, as determined by NMR in a K+ solution. FEBS Journal, 274 , 3545-3556.
    • (2007) FEBS Journal , vol.274 , pp. 3545-3556
    • Matsugami, A.1    Xu, Y.2    Noguchi, Y.3    Sugiyama, H.4    Katahira, M.5
  • 50
    • 20144364292 scopus 로고    scopus 로고
    • Prevalence of quadruplexes in the human genome
    • Huppert, J. L., Balasubramanian, S. (2005). Prevalence of quadruplexes in the human genome. Nucleic Acids Research, 33 , 2908-2916.
    • (2005) Nucleic Acids Research , vol.33 , pp. 2908-2916
    • Huppert, J.L.1    Balasubramanian, S.2
  • 51
    • 33846928449 scopus 로고    scopus 로고
    • G-quadruplexes in promoters throughout the human genome
    • Huppert, J. L., Balasubramanian, S. (2007). G-quadruplexes in promoters throughout the human genome. Nucleic Acids Research, 35 , 406-413.
    • (2007) Nucleic Acids Research , vol.35 , pp. 406-413
    • Huppert, J.L.1    Balasubramanian, S.2
  • 52
    • 73349110442 scopus 로고    scopus 로고
    • Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
    • Fernando, H., Sewitz, S., Darot, J., Tavare, S., Huppert, J. L., Balasubramanian, S. (2009). Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression. Nucleic Acids Research, 37 , 6716-6722.
    • (2009) Nucleic Acids Research , vol.37 , pp. 6716-6722
    • Fernando, H.1    Sewitz, S.2    Darot, J.3    Tavare, S.4    Huppert, J.L.5    Balasubramanian, S.6
  • 53
    • 73349127073 scopus 로고    scopus 로고
    • Genome-wide colonization of gene regulatory elements by G4 DNA motifs
    • Du, Z., Zhao, Y., Li, N. (2009). Genome-wide colonization of gene regulatory elements by G4 DNA motifs. Nucleic Acids Research, 37 , 6784-6798.
    • (2009) Nucleic Acids Research , vol.37 , pp. 6784-6798
    • Du, Z.1    Zhao, Y.2    Li, N.3
  • 54
    • 68549136741 scopus 로고    scopus 로고
    • G-quadruplex structures: in vivo evidence and function
    • Lipps, H. J., Rhodes, D. (2009). G-quadruplex structures: in vivo evidence and function. Trends in Cell Biology, 19 , 414-422.
    • (2009) Trends in Cell Biology , vol.19 , pp. 414-422
    • Lipps, H.J.1    Rhodes, D.2
  • 56
    • 44849095213 scopus 로고    scopus 로고
    • Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates
    • Paeschke, K., Juranek, S., Simonsson, T., Hempel, A., Rhodes, D., Lipps, H. J. (2008). Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates. Nature Structural & Molecular Biology, 15 , 598-604.
    • (2008) Nature Structural & Molecular Biology , vol.15 , pp. 598-604
    • Paeschke, K.1    Juranek, S.2    Simonsson, T.3    Hempel, A.4    Rhodes, D.5    Lipps, H.J.6
  • 57
    • 33745121203 scopus 로고    scopus 로고
    • Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation
    • Rawal, P., Kummarasetti, V. B. R., Ravindran, J., Kumar, N., Halder, K., Sharma, R., et al . (2006). Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation. Genome Research, 16 , 644-655.
    • (2006) Genome Research , vol.16 , pp. 644-655
    • Rawal, P.1    Kummarasetti, V.B.R.2    Ravindran, J.3    Kumar, N.4    Halder, K.5    Sharma, R.6
  • 58
    • 67249138595 scopus 로고    scopus 로고
    • Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells
    • Verma, A., Yadav, V. K., Basundra, R., Kumar, A., Chowdhury, S. (2009). Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells. Nucleic Acids Research, 37 , 4194-4204.
    • (2009) Nucleic Acids Research , vol.37 , pp. 4194-4204
    • Verma, A.1    Yadav, V.K.2    Basundra, R.3    Kumar, A.4    Chowdhury, S.5
  • 59
    • 70549099970 scopus 로고    scopus 로고
    • The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
    • Brooks, T. A., Hurley, L. H. (2009). The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics. Nature Reviews Cancer, 9 , 849-861.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 849-861
    • Brooks, T.A.1    Hurley, L.H.2
  • 62
    • 0029004009 scopus 로고
    • PuF/NM23-H2/NDPK-B transactivates a human c-myc promoter-CAT gene via a functional nuclease hypersensitive element
    • Berberich, S. J., Postel, E. H. (1995). PuF/NM23-H2/NDPK-B transactivates a human c-myc promoter-CAT gene via a functional nuclease hypersensitive element. Oncogene, 10 , 2343-2347.
    • (1995) Oncogene , vol.10 , pp. 2343-2347
    • Berberich, S.J.1    Postel, E.H.2
  • 63
    • 0032030327 scopus 로고    scopus 로고
    • DNA tetraplex formation in the control region of c-myc
    • Simonsson, T., Pecinka, P., Kubista, M. (1998). DNA tetraplex formation in the control region of c-myc. Nucleic Acids Research, 26 , 1167-1172.
    • (1998) Nucleic Acids Research , vol.26 , pp. 1167-1172
    • Simonsson, T.1    Pecinka, P.2    Kubista, M.3
  • 64
    • 3242666778 scopus 로고    scopus 로고
    • Propeller-type parallel-stranded Gquadruplexes in the human c-myc promoter
    • Phan, A. T., Modi, Y. S., Patel, D. J. (2004). Propeller-type parallel-stranded Gquadruplexes in the human c-myc promoter. Journal of the American Chemical Society, 126 , 8710-8716.
    • (2004) Journal of the American Chemical Society , vol.126 , pp. 8710-8716
    • Phan, A.T.1    Modi, Y.S.2    Patel, D.J.3
  • 67
    • 34147100699 scopus 로고    scopus 로고
    • Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives
    • Ou, T.-M., Lu, Y.-J., Zhang, C., Huang, Z.-S., Wang, X.-D., Tan, J.-H., et al . (2007). Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives. Journal of Medicinal Chemistry, 50 , 1465-1474.
    • (2007) Journal of Medicinal Chemistry , vol.50 , pp. 1465-1474
    • Ou, T.-M.1    Lu, Y.-J.2    Zhang, C.3    Huang, Z.-S.4    Wang, X.-D.5    Tan, J.-H.6
  • 68
    • 65649089445 scopus 로고    scopus 로고
    • The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-myc promoter: implications for drug targeting and control of gene expression
    • Sun, D., Hurley, L. H. (2009). The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-myc promoter: implications for drug targeting and control of gene expression. Journal of Medicinal Chemistry, 52 , 2863-2874.
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 2863-2874
    • Sun, D.1    Hurley, L.H.2
  • 69
    • 3042785608 scopus 로고    scopus 로고
    • Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
    • Duquette, M. L., Handa, P., Vincent, J. A., Taylor, A. F., Maizels, N. (2004). Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes & Development, 18 , 1618-1629.
    • (2004) Genes & Development , vol.18 , pp. 1618-1629
    • Duquette, M.L.1    Handa, P.2    Vincent, J.A.3    Taylor, A.F.4    Maizels, N.5
  • 70
    • 47849105417 scopus 로고    scopus 로고
    • Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions
    • Qin, Y., Hurley, L. H. (2008). Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions. Biochimie, 90 , 1149-1171.
    • (2008) Biochimie , vol.90 , pp. 1149-1171
    • Qin, Y.1    Hurley, L.H.2
  • 71
    • 34347273762 scopus 로고    scopus 로고
    • Tetraplex DNA and its interacting proteins
    • Fry, M. (2007). Tetraplex DNA and its interacting proteins. Frontiers in Bioscience, 12 , 4336-4351.
    • (2007) Frontiers in Bioscience , vol.12 , pp. 4336-4351
    • Fry, M.1
  • 72
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn, E. H. (2001). Switching and signaling at the telomere. Cell , 106 , 661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 74
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov, V. L., Hirose, Y., Langmore, J. P. (1997). Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell , 88 , 657-666.
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 75
    • 0030982721 scopus 로고    scopus 로고
    • The terminal DNA structure of mammalian chromosomes
    • McElligott, R., Wellinger, R. J. (1997). The terminal DNA structure of mammalian chromosomes. EMBO Journal, 16 , 3705-3714.
    • (1997) EMBO Journal , vol.16 , pp. 3705-3714
    • McElligott, R.1    Wellinger, R.J.2
  • 76
  • 77
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., Futcher, A. B., Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature, 345 , 458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 79
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C. W., Blackburn, E. H. (1985). Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell , 43 , 405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 80
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin, G. B. (1989). The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell , 59 , 521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 82
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J. W., Bacchetti, S. (1997). A survey of telomerase activity in human cancer. European Journal of Cancer, 33 , 787-791.
    • (1997) European Journal of Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 83
    • 0033152429 scopus 로고    scopus 로고
    • Telomerase and the maintenance of chromosome ends
    • Bryan, T. M., Cech, T. R. (1999). Telomerase and the maintenance of chromosome ends. Current Opinion in Cell Biology, 11 , 318-324.
    • (1999) Current Opinion in Cell Biology , vol.11 , pp. 318-324
    • Bryan, T.M.1    Cech, T.R.2
  • 84
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi, K., Yu, E. Y., Khurts, S., Ben-Porath, I., Currier, J. L., Metz, G. B., et al . (2003). Telomerase maintains telomere structure in normal human cells. Cell , 114 , 241-253.
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1    Yu, E.Y.2    Khurts, S.3    Ben-Porath, I.4    Currier, J.L.5    Metz, G.B.6
  • 87
    • 55249100310 scopus 로고    scopus 로고
    • Design of selective G-quadruplex ligands as potential anticancer agents
    • Tan, J.-H., Gu, L.-Q., Wu, J.-Y. (2008). Design of selective G-quadruplex ligands as potential anticancer agents. Mini-Reviews in Medicinal Chemistry, 8 , 1163-1178.
    • (2008) Mini-Reviews in Medicinal Chemistry , vol.8 , pp. 1163-1178
    • Tan, J.-H.1    Gu, L.-Q.2    Wu, J.-Y.3
  • 89
    • 76349122184 scopus 로고    scopus 로고
    • Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer
    • Neidle, S. (2010). Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS Journal, 277 , 1118-1125.
    • (2010) FEBS Journal , vol.277 , pp. 1118-1125
    • Neidle, S.1
  • 90
    • 0141988720 scopus 로고    scopus 로고
    • Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase
    • Gomez, D., Aouali, N., Renaud, A., Douarre, C., Shin-ya, K., Tazi, J., et al . (2003). Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase. Cancer Research, 63 , 6149-6153.
    • (2003) Cancer Research , vol.63 , pp. 6149-6153
    • Gomez, D.1    Aouali, N.2    Renaud, A.3    Douarre, C.4    Shin-ya, K.5    Tazi, J.6
  • 92
    • 28244437839 scopus 로고    scopus 로고
    • Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells
    • Binz, N., Shalaby, T., Rivera, P., Shin-ya, K., Grotzer, M. A. (2005). Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells. European Journal of Cancer, 41 , 2873-2881.
    • (2005) European Journal of Cancer , vol.41 , pp. 2873-2881
    • Binz, N.1    Shalaby, T.2    Rivera, P.3    Shin-ya, K.4    Grotzer, M.A.5
  • 93
    • 31544441946 scopus 로고    scopus 로고
    • Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines
    • Zhou, J. M., Zhu, X. F., Lu, Y. J., Deng, R., Huang, Z. S., Mei, Y. P., et al . (2006). Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 25 , 503-511.
    • (2006) Oncogene , vol.25 , pp. 503-511
    • Zhou, J.M.1    Zhu, X.F.2    Lu, Y.J.3    Deng, R.4    Huang, Z.S.5    Mei, Y.P.6
  • 94
    • 6944239985 scopus 로고    scopus 로고
    • Biological activity of the G-quadruplex ligand RHPS4 (3,11difluoro-6,8,13- trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration
    • Leonetti, C., Amodei, S., D'Angelo, C., Rizzo, A., Benassi, B., Antonelli, A., et al . (2004). Biological activity of the G-quadruplex ligand RHPS4 (3,11difluoro-6,8,13- trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration. Molecular Pharmacology, 66 , 1138-1146.
    • (2004) Molecular Pharmacology , vol.66 , pp. 1138-1146
    • Leonetti, C.1    Amodei, S.2    D'Angelo, C.3    Rizzo, A.4    Benassi, B.5    Antonelli, A.6
  • 95
    • 20944447769 scopus 로고    scopus 로고
    • Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands
    • Pennarun, G., Granotier, C., Gauthier, L. R., Gomez, D., Hoffschir, F., Mandine, E., et al . (2005). Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene, 24 , 2917-2928.
    • (2005) Oncogene , vol.24 , pp. 2917-2928
    • Pennarun, G.1    Granotier, C.2    Gauthier, L.R.3    Gomez, D.4    Hoffschir, F.5    Mandine, E.6
  • 96
    • 34247208639 scopus 로고    scopus 로고
    • Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
    • Phatak, P., Cookson, J. C., Dai, F., Smith, V., Gartenhaus, R. B., Stevens, M. F. G., et al . (2007). Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. British Journal of Cancer, 96 , 1223-1233.
    • (2007) British Journal of Cancer , vol.96 , pp. 1223-1233
    • Phatak, P.1    Cookson, J.C.2    Dai, F.3    Smith, V.4    Gartenhaus, R.B.5    Stevens, M.F.G.6
  • 97
    • 33746916385 scopus 로고    scopus 로고
    • The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells
    • Gomez, D., O'Donohue, M.-F., Wenner, T., Douarre, C., Macadre, J., Koebel, P., et al . (2006). The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Research, 66 , 6908-6912.
    • (2006) Cancer Research , vol.66 , pp. 6908-6912
    • Gomez, D.1    O'Donohue, M.-F.2    Wenner, T.3    Douarre, C.4    Macadre, J.5    Koebel, P.6
  • 98
    • 33845994055 scopus 로고    scopus 로고
    • Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells
    • Gomez, D., Wenner, T., Brassart, B., Douarre, C., O'Donohue, M.-F., El Khoury, V., et al . (2006). Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells. Journal of Biological Chemistry, 281 , 38721-38729.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 38721-38729
    • Gomez, D.1    Wenner, T.2    Brassart, B.3    Douarre, C.4    O'Donohue, M.-F.5    El Khoury, V.6
  • 100
    • 70449725230 scopus 로고    scopus 로고
    • Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
    • Rizzo, A., Salvati, E., Porru, M., D'Angelo, C., Stevens, M. F., D'Incalci, M., et al . (2009). Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway. Nucleic Acids Research, 37 , 5353-5364.
    • (2009) Nucleic Acids Research , vol.37 , pp. 5353-5364
    • Rizzo, A.1    Salvati, E.2    Porru, M.3    D'Angelo, C.4    Stevens, M.F.5    D'Incalci, M.6
  • 103
    • 0028905957 scopus 로고
    • Heterogeneous nuclear ribonucleoprotein K is a DNA-binding transactivator
    • Tomonaga, T., Levens, D. (1995). Heterogeneous nuclear ribonucleoprotein K is a DNA-binding transactivator. Journal of Biological Chemistry, 270 , 4875-4881.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 4875-4881
    • Tomonaga, T.1    Levens, D.2
  • 104
    • 0028909518 scopus 로고
    • Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene
    • Michelotti, E. F., Tomonaga, T., Krutzsch, H., Levens, D. (1995). Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene. Journal of Biological Chemistry, 270 , 9494-9499.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 9494-9499
    • Michelotti, E.F.1    Tomonaga, T.2    Krutzsch, H.3    Levens, D.4
  • 105
    • 0029002696 scopus 로고
    • Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins
    • Majello, B., De Luca, P., Suske, G., Lania, L. (1995). Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins. Oncogene, 10 , 1841-1848.
    • (1995) Oncogene , vol.10 , pp. 1841-1848
    • Majello, B.1    De Luca, P.2    Suske, G.3    Lania, L.4
  • 107
    • 33646462913 scopus 로고    scopus 로고
    • Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2P1 promoter
    • Dexheimer, T. S., Sun, D., Hurley, L. H. (2006). Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2P1 promoter. Journal of the American Chemical Society, 128 , 5404-5415.
    • (2006) Journal of the American Chemical Society , vol.128 , pp. 5404-5415
    • Dexheimer, T.S.1    Sun, D.2    Hurley, L.H.3
  • 108
    • 77953211752 scopus 로고    scopus 로고
    • Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives
    • Wang, X.-D., Ou, T.-M., Lu, Y.-J., Li, Z., Xu, Z., Xi, C., et al . (2010). Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. Journal of Medicinal Chemistry, 53 , 4390-4398.
    • (2010) Journal of Medicinal Chemistry , vol.53 , pp. 4390-4398
    • Wang, X.-D.1    Ou, T.-M.2    Lu, Y.-J.3    Li, Z.4    Xu, Z.5    Xi, C.6
  • 109
    • 60549101098 scopus 로고    scopus 로고
    • Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells
    • Cogoi, S., Paramasivam, M., Filichev, V., Geci, I., Pedersen, E. B., Xodo, L. E. (2009). Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells. Journal of Medicinal Chemistry, 52 , 564-568.
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 564-568
    • Cogoi, S.1    Paramasivam, M.2    Filichev, V.3    Geci, I.4    Pedersen, E.B.5    Xodo, L.E.6
  • 110
    • 66249142691 scopus 로고    scopus 로고
    • Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription
    • Paramasivam, M., Membrino, A., Cogoi, S., Fukuda, H., Nakagama, H., Xodo, L. E. (2009). Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription. Nucleic Acids Research, 37 , 2841-2853.
    • (2009) Nucleic Acids Research , vol.37 , pp. 2841-2853
    • Paramasivam, M.1    Membrino, A.2    Cogoi, S.3    Fukuda, H.4    Nakagama, H.5    Xodo, L.E.6
  • 111
    • 68249156463 scopus 로고    scopus 로고
    • Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands
    • Palumbo, S. M. L., Ebbinghaus, S. W., Hurley, L. H. (2009). Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands. Journal of the American Chemical Society, 131 , 10878-10891.
    • (2009) Journal of the American Chemical Society , vol.131 , pp. 10878-10891
    • Palumbo, S.M.L.1    Ebbinghaus, S.W.2    Hurley, L.H.3
  • 112
    • 0032618597 scopus 로고    scopus 로고
    • Regulation of mammalian ribosomal gene transcription by RNA polymerase I
    • Grummt, I. (1999). Regulation of mammalian ribosomal gene transcription by RNA polymerase I. Progress in Nucleic Acid Research and Molecular Biology, 62 , 109-154.
    • (1999) Progress in Nucleic Acid Research and Molecular Biology , vol.62 , pp. 109-154
    • Grummt, I.1
  • 113
    • 0033034413 scopus 로고    scopus 로고
    • High affinity interactions of nucleolin with G-G-paired rDNA
    • Hanakahi, L. A., Sun, H., Maizels, N. (1999). High affinity interactions of nucleolin with G-G-paired rDNA. Journal of Biological Chemistry, 274 , 15908-15912.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 15908-15912
    • Hanakahi, L.A.1    Sun, H.2    Maizels, N.3
  • 115
    • 0032754311 scopus 로고    scopus 로고
    • Molecular dissection of nucleolin's role in growth and cell proliferation: new insights
    • Srivastava, M., Pollard, H. B. (1999). Molecular dissection of nucleolin's role in growth and cell proliferation: new insights. The FASEB Journal, 13 , 1911-1922.
    • (1999) The FASEB Journal , vol.13 , pp. 1911-1922
    • Srivastava, M.1    Pollard, H.B.2
  • 117
    • 60049088906 scopus 로고    scopus 로고
    • Conditional knockout of nucleolin in DT40 cells reveals the functional redundancy of its RNA-binding domains
    • Storck, S., Thiry, M., Bouvet, P. (2009). Conditional knockout of nucleolin in DT40 cells reveals the functional redundancy of its RNA-binding domains. Biology of the Cell , 101 , 153-167.
    • (2009) Biology of the Cell , vol.101 , pp. 153-167
    • Storck, S.1    Thiry, M.2    Bouvet, P.3
  • 119
    • 56649105133 scopus 로고    scopus 로고
    • RNA polymerases I and III, non-coding RNAs and cancer
    • White, R. J. (2008). RNA polymerases I and III, non-coding RNAs and cancer. Trends in Genetics, 24 , 622-629.
    • (2008) Trends in Genetics , vol.24 , pp. 622-629
    • White, R.J.1
  • 120
    • 38349095525 scopus 로고    scopus 로고
    • Genomic distribution and functional analyses of potential G-quadruplexforming sequences in Saccharomyces cerevisiae
    • Hershman, S. G., Chen, Q., Lee, J. Y., Kozak, M. L., Yue, P., Wang, L.-S., et al . (2008). Genomic distribution and functional analyses of potential G-quadruplexforming sequences in Saccharomyces cerevisiae. Nucleic Acids Research, 36 , 144-156.
    • (2008) Nucleic Acids Research , vol.36 , pp. 144-156
    • Hershman, S.G.1    Chen, Q.2    Lee, J.Y.3    Kozak, M.L.4    Yue, P.5    Wang, L.-S.6
  • 125
    • 0142195770 scopus 로고    scopus 로고
    • Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat
    • Gavathiotis, E., Heald, R. A., Stevens, M. F. G., Searle, M. S. (2003). Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat. Journal of Molecular Biology, 334 , 25-36.
    • (2003) Journal of Molecular Biology , vol.334 , pp. 25-36
    • Gavathiotis, E.1    Heald, R.A.2    Stevens, M.F.G.3    Searle, M.S.4
  • 126
    • 33644833219 scopus 로고    scopus 로고
    • Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    • Phan, A. T., Kuryavyi, V., Gaw, H. Y., Patel, D. J. (2005). Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nature Chemical Biology, 1 , 167-173.
    • (2005) Nature Chemical Biology , vol.1 , pp. 167-173
    • Phan, A.T.1    Kuryavyi, V.2    Gaw, H.Y.3    Patel, D.J.4
  • 127
    • 33847675742 scopus 로고    scopus 로고
    • Structural basis for binding of porphyrin to human telomeres
    • Parkinson, G. N., Ghosh, R., Neidle, S. (2007). Structural basis for binding of porphyrin to human telomeres. Biochemistry, 46 , 2390-2397.
    • (2007) Biochemistry , vol.46 , pp. 2390-2397
    • Parkinson, G.N.1    Ghosh, R.2    Neidle, S.3
  • 128
    • 48749109524 scopus 로고    scopus 로고
    • Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
    • Parkinson, G. N., Cuenca, F., Neidle, S. (2008). Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. Journal of Molecular Biology, 381 , 1145-1156.
    • (2008) Journal of Molecular Biology , vol.381 , pp. 1145-1156
    • Parkinson, G.N.1    Cuenca, F.2    Neidle, S.3
  • 130
    • 37549029243 scopus 로고    scopus 로고
    • Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4
    • Martino, L., Virno, A., Pagano, B., Virgilio, A., Di Micco, S., Galeone, A., et al . (2007). Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4. Journal of the American Chemical Society, 129 , 16048-16056.
    • (2007) Journal of the American Chemical Society , vol.129 , pp. 16048-16056
    • Martino, L.1    Virno, A.2    Pagano, B.3    Virgilio, A.4    Di Micco, S.5    Galeone, A.6
  • 133
  • 135
  • 136
    • 47549098577 scopus 로고    scopus 로고
    • Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives
    • Huang, H.-S., Huang, K.-F., Li, C.-L., Huang, Y.-Y., Chiang, Y.-H., Huang, F.-C., et al . (2008). Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorganic & Medicinal Chemistry, 16 , 6976-6986.
    • (2008) Bioorganic & Medicinal Chemistry , vol.16 , pp. 6976-6986
    • Huang, H.-S.1    Huang, K.-F.2    Li, C.-L.3    Huang, Y.-Y.4    Chiang, Y.-H.5    Huang, F.-C.6
  • 137
    • 52449117457 scopus 로고    scopus 로고
    • Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation
    • Zagotto, G., Sissi, C., Lucatello, L., Pivetta, C., Cadamuro, S. A., Fox, K. R., et al . (2008). Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. Journal of Medicinal Chemistry, 51 , 5566-5574.
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 5566-5574
    • Zagotto, G.1    Sissi, C.2    Lucatello, L.3    Pivetta, C.4    Cadamuro, S.A.5    Fox, K.R.6
  • 138
    • 0035352382 scopus 로고    scopus 로고
    • DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition
    • Perry, P. J., Jenkins, T. C. (2001). DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition. Mini-Reviews in Medicinal Chemistry, 1 , 31-41.
    • (2001) Mini-Reviews in Medicinal Chemistry , vol.1 , pp. 31-41
    • Perry, P.J.1    Jenkins, T.C.2
  • 139
    • 0034578478 scopus 로고    scopus 로고
    • G-quadruplexes as therapeutic targets
    • Neidle, S., Read, M. A. (2000). G-quadruplexes as therapeutic targets. Biopolymers, 56 , 195-208.
    • (2000) Biopolymers , vol.56 , pp. 195-208
    • Neidle, S.1    Read, M.A.2
  • 140
    • 38049007426 scopus 로고    scopus 로고
    • Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives
    • Zagotto, G., Sissi, C., Moro, S., Dal Ben, D., Parkinson, G. N., Fox, K. R., et al . (2008). Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorganic & Medicinal Chemistry, 16 , 354-361.
    • (2008) Bioorganic & Medicinal Chemistry , vol.16 , pp. 354-361
    • Zagotto, G.1    Sissi, C.2    Moro, S.3    Dal Ben, D.4    Parkinson, G.N.5    Fox, K.R.6
  • 142
    • 0033524027 scopus 로고    scopus 로고
    • Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships
    • Read, M. A.,Wood, A. A., Harrison, J. R., Gowan, S. M., Kelland, L. R., Dosanjh, H. S., et al . (1999). Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships. Journal of Medicinal Chemistry, 42 , 4538-4546.
    • (1999) Journal of Medicinal Chemistry , vol.42 , pp. 4538-4546
    • Read, M.A.1    Wood, A.A.2    Harrison, J.R.3    Gowan, S.M.4    Kelland, L.R.5    Dosanjh, H.S.6
  • 143
    • 67749103504 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)- substituted acridines as potent telomeric G-quadruplex ligands
    • Laronze-Cochard, M., Kim, Y.-M., Brassart, B., Riou, J.-F., Laronze, J.-Y., Sapi, J. (2009). Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)- substituted acridines as potent telomeric G-quadruplex ligands. European Journal of Medicinal Chemistry, 44 , 3880-3888.
    • (2009) European Journal of Medicinal Chemistry , vol.44 , pp. 3880-3888
    • Laronze-Cochard, M.1    Kim, Y.-M.2    Brassart, B.3    Riou, J.-F.4    Laronze, J.-Y.5    Sapi, J.6
  • 144
  • 147
    • 31544446381 scopus 로고    scopus 로고
    • Trisubstituted acridines as G-quadruplex telomere targeting agents Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation
    • Moore, M. J. B., Schultes, C. M., Cuesta, J., Cuenca, F., Gunaratnam, M., Tanious, F. A., et al . (2006). Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. Journal of Medicinal Chemistry, 49 , 582-599.
    • (2006) Journal of Medicinal Chemistry , vol.49 , pp. 582-599
    • Moore, M.J.B.1    Schultes, C.M.2    Cuesta, J.3    Cuenca, F.4    Gunaratnam, M.5    Tanious, F.A.6
  • 148
    • 3142748255 scopus 로고    scopus 로고
    • Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors
    • Schultes, C. M., Guyen, B., Cuesta, J., Neidle, S. (2004). Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors. Bioorganic & Medicinal Chemistry Letters, 14 , 4347-4351.
    • (2004) Bioorganic & Medicinal Chemistry Letters , vol.14 , pp. 4347-4351
    • Schultes, C.M.1    Guyen, B.2    Cuesta, J.3    Neidle, S.4
  • 149
    • 0036241599 scopus 로고    scopus 로고
    • A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
    • Gowan, S. M., Harrison, J. R., Patterson, L., Valenti, M., Read, M. A., Neidle, S., et al . (2002). A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Molecular Pharmacology, 61 , 1154-1162.
    • (2002) Molecular Pharmacology , vol.61 , pp. 1154-1162
    • Gowan, S.M.1    Harrison, J.R.2    Patterson, L.3    Valenti, M.4    Read, M.A.5    Neidle, S.6
  • 151
    • 7444237059 scopus 로고    scopus 로고
    • A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells
    • Incles, C. M., Schultes, C. M., Kempski, H., Koehler, H., Kelland, L. R., Neidle, S. (2004). A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Molecular Cancer Therapeutics, 3 , 1201-1206.
    • (2004) Molecular Cancer Therapeutics , vol.3 , pp. 1201-1206
    • Incles, C.M.1    Schultes, C.M.2    Kempski, H.3    Koehler, H.4    Kelland, L.R.5    Neidle, S.6
  • 152
    • 13944272246 scopus 로고    scopus 로고
    • The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
    • Burger, A. M., Dai, F., Schultes, C. M., Reszka, A. P., Moore, M. J., Double, J. A., et al . (2005). The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Research, 65 , 1489-1496.
    • (2005) Cancer Research , vol.65 , pp. 1489-1496
    • Burger, A.M.1    Dai, F.2    Schultes, C.M.3    Reszka, A.P.4    Moore, M.J.5    Double, J.A.6
  • 153
    • 18044391665 scopus 로고    scopus 로고
    • Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-current status and future prospects
    • Kelland, L. R. (2005). Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-current status and future prospects. European Journal of Cancer, 41 , 971-979.
    • (2005) European Journal of Cancer , vol.41 , pp. 971-979
    • Kelland, L.R.1
  • 154
    • 0142148097 scopus 로고    scopus 로고
    • Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation Sensitivity of resistant cells to combination treatment with a telomerase inhibitor
    • Incles, C. M., Schultes, C. M., Kelland, L. R., Neidle, S. (2003). Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor. Molecular Pharmacology, 64 , 1101-1108.
    • (2003) Molecular Pharmacology , vol.64 , pp. 1101-1108
    • Incles, C.M.1    Schultes, C.M.2    Kelland, L.R.3    Neidle, S.4
  • 156
    • 42749095866 scopus 로고    scopus 로고
    • Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential
    • Taetz, S., Muerdter, T. E., Zapp, J., Boettcher, S., Baldes, C., Kleideiter, E., et al . (2008). Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential. International Journal of Pharmaceutics, 357 , 6-14.
    • (2008) International Journal of Pharmaceutics , vol.357 , pp. 6-14
    • Taetz, S.1    Muerdter, T.E.2    Zapp, J.3    Boettcher, S.4    Baldes, C.5    Kleideiter, E.6
  • 157
    • 0029138009 scopus 로고
    • RNA aptamers that bind flavin and nicotinamide redox cofactors
    • Lauhon, C. T., Szostak, J. W. (1995). RNA aptamers that bind flavin and nicotinamide redox cofactors. Journal of the American Chemical Society, 117 , 1246-1257.
    • (1995) Journal of the American Chemical Society , vol.117 , pp. 1246-1257
    • Lauhon, C.T.1    Szostak, J.W.2
  • 158
    • 35848942604 scopus 로고    scopus 로고
    • Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression
    • Bejugam, M., Sewitz, S., Shirude, P. S., Rodriguez, R., Shahid, R., Balasubramanian, S. (2007). Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression. Journal of the American Chemical Society, 129 , 12926-12927.
    • (2007) Journal of the American Chemical Society , vol.129 , pp. 12926-12927
    • Bejugam, M.1    Sewitz, S.2    Shirude, P.S.3    Rodriguez, R.4    Shahid, R.5    Balasubramanian, S.6
  • 161
    • 77950638598 scopus 로고    scopus 로고
    • Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties
    • Alcaro, S., Artese, A., Iley, J. N., Missailidis, S., Ortuso, F., Parrotta, L., et al . (2010). Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties. ChemMedChem, 5 , 575-583.
    • (2010) ChemMedChem , vol.5 , pp. 575-583
    • Alcaro, S.1    Artese, A.2    Iley, J.N.3    Missailidis, S.4    Ortuso, F.5    Parrotta, L.6
  • 163
    • 71849100513 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands
    • Nielsen, M. C., Borch, J., Ulven, T. (2009). Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands. Bioorganic & Medicinal Chemistry, 17 , 8241-8246.
    • (2009) Bioorganic & Medicinal Chemistry , vol.17 , pp. 8241-8246
    • Nielsen, M.C.1    Borch, J.2    Ulven, T.3
  • 164
    • 0035282707 scopus 로고    scopus 로고
    • Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes
    • Koeppel, F., Riou, J.-F., Laoui, A., Mailliet, P., Arimondo, P. B., Labit, D., et al . (2001). Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes. Nucleic Acids Research, 29 , 1087-1096.
    • (2001) Nucleic Acids Research , vol.29 , pp. 1087-1096
    • Koeppel, F.1    Riou, J.-F.2    Laoui, A.3    Mailliet, P.4    Arimondo, P.B.5    Labit, D.6
  • 166
    • 2342568938 scopus 로고    scopus 로고
    • Synthesis and evaluation of analogs of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilizing ligands and potential inhibitors of the enzyme telomerase
    • Guyen, B., Schultes, C. M., Hazel, P., Mann, J., Neidle, S. (2004). Synthesis and evaluation of analogs of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilizing ligands and potential inhibitors of the enzyme telomerase. Organic & Biomolecular Chemistry, 2 , 981-988.
    • (2004) Organic & Biomolecular Chemistry , vol.2 , pp. 981-988
    • Guyen, B.1    Schultes, C.M.2    Hazel, P.3    Mann, J.4    Neidle, S.5
  • 167
    • 28544447925 scopus 로고    scopus 로고
    • Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase
    • Zhou, J.-L., Lu, Y.-J., Ou, T.-M., Zhou, J.-M., Huang, Z.-S., Zhu, X.-F., et al . (2005). Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase. Journal of Medicinal Chemistry, 48 , 7315-7321.
    • (2005) Journal of Medicinal Chemistry , vol.48 , pp. 7315-7321
    • Zhou, J.-L.1    Lu, Y.-J.2    Ou, T.-M.3    Zhou, J.-M.4    Huang, Z.-S.5    Zhu, X.-F.6
  • 168
    • 54549117013 scopus 로고    scopus 로고
    • 5- N-methylated quindoline derivatives as telomeric G-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation
    • Lu, Y.-J., Ou, T.-M., Tan, J.-H., Hou, J.-Q., Shao, W.-Y., Peng, D., et al . (2008). 5- N-methylated quindoline derivatives as telomeric G-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation. Journal of Medicinal Chemistry, 51 , 6381-6392.
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 6381-6392
    • Lu, Y.-J.1    Ou, T.-M.2    Tan, J.-H.3    Hou, J.-Q.4    Shao, W.-Y.5    Peng, D.6
  • 169
    • 34249746928 scopus 로고    scopus 로고
    • Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells
    • Liu, J. N., Deng, R., Guo, J. F., Zhou, J. M., Feng, G. K., Huang, Z. S., et al . (2007). Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells. Leukemia, 21 , 1300-1302.
    • (2007) Leukemia , vol.21 , pp. 1300-1302
    • Liu, J.N.1    Deng, R.2    Guo, J.F.3    Zhou, J.M.4    Feng, G.K.5    Huang, Z.S.6
  • 170
    • 73149108422 scopus 로고    scopus 로고
    • G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells
    • Zhou, W.-J., Deng, R., Zhang, X.-Y., Feng, G.-K., Gu, L.-Q., Zhu, X.-F. (2009). G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells. Molecular Cancer Therapeutics, 8 , 3203-3213.
    • (2009) Molecular Cancer Therapeutics , vol.8 , pp. 3203-3213
    • Zhou, W.-J.1    Deng, R.2    Zhang, X.-Y.3    Feng, G.-K.4    Gu, L.-Q.5    Zhu, X.-F.6
  • 171
    • 32044449998 scopus 로고    scopus 로고
    • Synthesis and testing of a triaza-cyclopenta[b]phenanthrene scaffold as a DNA binding agent
    • Hooda, J., Bednarski, D., Irish, L., Firestine, S. M. (2006). Synthesis and testing of a triaza-cyclopenta[b]phenanthrene scaffold as a DNA binding agent. Bioorganic & Medicinal Chemistry, 14 , 1902-1909.
    • (2006) Bioorganic & Medicinal Chemistry , vol.14 , pp. 1902-1909
    • Hooda, J.1    Bednarski, D.2    Irish, L.3    Firestine, S.M.4
  • 172
    • 0037203972 scopus 로고    scopus 로고
    • Antitumor polycyclic acridines 8. Synthesis and telomeraseinhibitory activity of methylated pentacyclic acridinium salts
    • Heald, R. A., Modi, C., Cookson, J. C., Hutchinson, I., Laughton, C. A., Gowan, S. M., et al . (2002). Antitumor polycyclic acridines. 8. Synthesis and telomeraseinhibitory activity of methylated pentacyclic acridinium salts. Journal of Medicinal Chemistry, 45 , 590-597.
    • (2002) Journal of Medicinal Chemistry , vol.45 , pp. 590-597
    • Heald, R.A.1    Modi, C.2    Cookson, J.C.3    Hutchinson, I.4    Laughton, C.A.5    Gowan, S.M.6
  • 174
    • 0034760505 scopus 로고    scopus 로고
    • Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
    • Gowan, S. M., Heald, R., Stevens, M. F. G., Kelland, L. R. (2001). Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes. Molecular Pharmacology, 60 , 981-988.
    • (2001) Molecular Pharmacology , vol.60 , pp. 981-988
    • Gowan, S.M.1    Heald, R.2    Stevens, M.F.G.3    Kelland, L.R.4
  • 175
    • 27844521369 scopus 로고    scopus 로고
    • Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents
    • Cookson, J. C., Dai, F., Smith, V., Heald, R. A., Laughton, C. A., Stevens, M. F. G., et al . (2005). Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents. Molecular Pharmacology, 68 , 1551-1558.
    • (2005) Molecular Pharmacology , vol.68 , pp. 1551-1558
    • Cookson, J.C.1    Dai, F.2    Smith, V.3    Heald, R.A.4    Laughton, C.A.5    Stevens, M.F.G.6
  • 177
    • 58149359322 scopus 로고    scopus 로고
    • G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors
    • Leonetti, C., Scarsella, M., Riggio, G., Rizzo, A., Salvati, E., D'Incalci, M., et al . (2008). G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors. Clinical Cancer Research, 14 , 7284-7291.
    • (2008) Clinical Cancer Research , vol.14 , pp. 7284-7291
    • Leonetti, C.1    Scarsella, M.2    Riggio, G.3    Rizzo, A.4    Salvati, E.5    D'Incalci, M.6
  • 178
    • 27844466279 scopus 로고    scopus 로고
    • Antitumor polycyclic acridines 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity
    • Cookson, J. C., Heald, R. A., Stevens, M. F. G. (2005). Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity. Journal of Medicinal Chemistry, 48 , 7198-7207.
    • (2005) Journal of Medicinal Chemistry , vol.48 , pp. 7198-7207
    • Cookson, J.C.1    Heald, R.A.2    Stevens, M.F.G.3
  • 179
    • 39749123789 scopus 로고    scopus 로고
    • Antitumor polycyclic acridines 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents
    • Cheng, M.-K., Modi, C., Cookson, J. C., Hutchinson, I., Heald, R. A., McCarroll, A. J., et al . (2008). Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents. Journal of Medicinal Chemistry, 51 , 963-975.
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 963-975
    • Cheng, M.-K.1    Modi, C.2    Cookson, J.C.3    Hutchinson, I.4    Heald, R.A.5    McCarroll, A.J.6
  • 181
    • 34547562328 scopus 로고    scopus 로고
    • G-quadruplex recognition by quinacridines: a SAR, NMR, and biological study
    • Hounsou, C., Guittat, L., Monchaud, D., Jourdan, M., Saettel, N., Mergny, J.-L., et al. (2007). G-quadruplex recognition by quinacridines: a SAR, NMR, and biological study. ChemMedChem, 2 , 655-666.
    • (2007) ChemMedChem , vol.2 , pp. 655-666
    • Hounsou, C.1    Guittat, L.2    Monchaud, D.3    Jourdan, M.4    Saettel, N.5    Mergny, J.-L.6
  • 182
    • 72549085730 scopus 로고    scopus 로고
    • Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19
    • Debray, J., Zeghida, W., Jourdan, M., Monchaud, D., Dheu-Andries, M.-L., Dumy, P., et al . (2009). Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19. Organic & Biomolecular Chemistry, 7 , 5219-5228.
    • (2009) Organic & Biomolecular Chemistry , vol.7 , pp. 5219-5228
    • Debray, J.1    Zeghida, W.2    Jourdan, M.3    Monchaud, D.4    Dheu-Andries, M.-L.5    Dumy, P.6
  • 184
    • 54349093794 scopus 로고    scopus 로고
    • Submicromolar, selective g-quadruplex ligands from one pot: thermodynamic and structural studies of human telomeric DNA binding by azacyanines
    • Cetinkol Ozgul, P., Engelhart Aaron, E., Nanjunda Rupesh, K., Wilson, W. D., Hud Nicholas, V. (2008). Submicromolar, selective g-quadruplex ligands from one pot: thermodynamic and structural studies of human telomeric DNA binding by azacyanines. Chembiochem, 9 , 1889-1892.
    • (2008) Chembiochem , vol.9 , pp. 1889-1892
    • Cetinkol Ozgul, P.1    Engelhart Aaron, E.2    Nanjunda Rupesh, K.3    Wilson, W.D.4    Hud Nicholas, V.5
  • 185
    • 0030668587 scopus 로고    scopus 로고
    • New quinolones, ofloxacin and levofloxacin, inhibit telomerase activity in transitional cell carcinoma cell lines
    • Yamakuchi,M., Nakata, M., Kawahara, K.-i., Kitajima, I., Maruyama, I. (1997). New quinolones, ofloxacin and levofloxacin, inhibit telomerase activity in transitional cell carcinoma cell lines. Cancer Letters, 119 , 213-219.
    • (1997) Cancer Letters , vol.119 , pp. 213-219
    • Yamakuchi, M.1    Nakata, M.2    Kawahara, K.-i.3    Kitajima, I.4    Maruyama, I.5
  • 186
    • 0035553175 scopus 로고    scopus 로고
    • Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects
    • Duan, W., Rangan, A., Vankayalapati, H., Kim, M.-Y., Zeng, Q., Sun, D., et al . (2001). Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects. Molecular Cancer Therapeutics, 1 , 103-120.
    • (2001) Molecular Cancer Therapeutics , vol.1 , pp. 103-120
    • Duan, W.1    Rangan, A.2    Vankayalapati, H.3    Kim, M.-Y.4    Zeng, Q.5    Sun, D.6
  • 187
    • 0037434540 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes
    • Kim, M.-Y., Duan, W., Gleason-Guzman, M., Hurley, L. H. (2003). Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes. Journal of Medicinal Chemistry, 46 , 571-583.
    • (2003) Journal of Medicinal Chemistry , vol.46 , pp. 571-583
    • Kim, M.-Y.1    Duan, W.2    Gleason-Guzman, M.3    Hurley, L.H.4
  • 188
    • 0037167611 scopus 로고    scopus 로고
    • The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10- perylenetetracarboxylic acid diimides
    • Kern, J. T., Wang, T. P., Kerwin, S. M. (2002). The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10- perylenetetracarboxylic acid diimides. Biochemistry, 41 , 11379-11389.
    • (2002) Biochemistry , vol.41 , pp. 11379-11389
    • Kern, J.T.1    Wang, T.P.2    Kerwin, S.M.3
  • 189
    • 0037060042 scopus 로고    scopus 로고
    • Perylene diimide Gquadruplex DNA binding selectivity is mediated by ligand aggregation
    • Kerwin, S. M., Chen, G., Kern, J. T., Thomas, P. W. (2002). Perylene diimide Gquadruplex DNA binding selectivity is mediated by ligand aggregation. Bioorganic & Medicinal Chemistry Letters, 12 , 447-450.
    • (2002) Bioorganic & Medicinal Chemistry Letters , vol.12 , pp. 447-450
    • Kerwin, S.M.1    Chen, G.2    Kern, J.T.3    Thomas, P.W.4
  • 190
    • 33750952242 scopus 로고    scopus 로고
    • Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition
    • Sissi, C., Lucatello, L., Paul Krapcho, A., Maloney, D. J., Boxer, M. B., Camarasa, M. V., et al . (2007). Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition. Bioorganic & Medicinal Chemistry, 15 , 555-562.
    • (2007) Bioorganic & Medicinal Chemistry , vol.15 , pp. 555-562
    • Sissi, C.1    Lucatello, L.2    Paul Krapcho, A.3    Maloney, D.J.4    Boxer, M.B.5    Camarasa, M.V.6
  • 191
    • 0034819870 scopus 로고    scopus 로고
    • Design and synthesis of the G-quadruplex-specific cleaving reagent perylene-EDTA·iron(II)
    • Tuntiwechapikul, W., Lee, J. T., Salazar, M. (2001). Design and synthesis of the G-quadruplex-specific cleaving reagent perylene-EDTA·iron(II). Journal of the American Chemical Society, 123 , 5606-5607.
    • (2001) Journal of the American Chemical Society , vol.123 , pp. 5606-5607
    • Tuntiwechapikul, W.1    Lee, J.T.2    Salazar, M.3
  • 192
    • 33750958882 scopus 로고    scopus 로고
    • Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA
    • Samudrala, R., Zhang, X., Wadkins, R. M., Mattern, D. L. (2007). Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA. Bioorganic & Medicinal Chemistry, 15 , 186-193.
    • (2007) Bioorganic & Medicinal Chemistry , vol.15 , pp. 186-193
    • Samudrala, R.1    Zhang, X.2    Wadkins, R.M.3    Mattern, D.L.4
  • 193
    • 0036888355 scopus 로고    scopus 로고
    • The aggregation and G-quadruplex DNA selectivity of charged 3,4,9,10-perylenetetracarboxylic acid diimides
    • Kern, J. T., Kerwin, S. M. (2002). The aggregation and G-quadruplex DNA selectivity of charged 3,4,9,10-perylenetetracarboxylic acid diimides. Bioorganic & Medicinal Chemistry Letters, 12 , 3395-3398.
    • (2002) Bioorganic & Medicinal Chemistry Letters , vol.12 , pp. 3395-3398
    • Kern, J.T.1    Kerwin, S.M.2
  • 194
    • 33847785752 scopus 로고    scopus 로고
    • Specific interactions with intra- and intermolecular G-quadruplex DNA structures by hydrosoluble coronene derivatives: a new class of telomerase inhibitors
    • Franceschin, M., Alvino, A., Casagrande, V., Mauriello, C., Pascucci, E., Savino, M., et al . (2007). Specific interactions with intra- and intermolecular G-quadruplex DNA structures by hydrosoluble coronene derivatives: a new class of telomerase inhibitors. Bioorganic & Medicinal Chemistry, 15 , 1848-1858.
    • (2007) Bioorganic & Medicinal Chemistry , vol.15 , pp. 1848-1858
    • Franceschin, M.1    Alvino, A.2    Casagrande, V.3    Mauriello, C.4    Pascucci, E.5    Savino, M.6
  • 197
    • 0032495774 scopus 로고    scopus 로고
    • Cationic porphyrins as telomerase inhibitors: the interaction of tetra(N-methyl-4- pyridyl)porphine with quadruplex DNA
    • Wheelhouse, R. T., Sun, D., Han, H., Han, F. X., Hurley, L. H. (1998). Cationic porphyrins as telomerase inhibitors: the interaction of tetra(N-methyl-4- pyridyl)porphine with quadruplex DNA. Journal of the American Chemical Society, 120 , 3261-3262.
    • (1998) Journal of the American Chemical Society , vol.120 , pp. 3261-3262
    • Wheelhouse, R.T.1    Sun, D.2    Han, H.3    Han, F.X.4    Hurley, L.H.5
  • 200
    • 0033534146 scopus 로고    scopus 로고
    • Sequence and structural selectivity of nucleic acid binding ligands
    • Ren, J., Chaires, J. B. (1999). Sequence and structural selectivity of nucleic acid binding ligands. Biochemistry, 38 , 16067-16075.
    • (1999) Biochemistry , vol.38 , pp. 16067-16075
    • Ren, J.1    Chaires, J.B.2
  • 201
    • 0033083378 scopus 로고    scopus 로고
    • Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells
    • Izbicka, E., Wheelhouse, R. T., Raymond, E., Davidson, K. K., Lawrence, R. A., Sun, D., et al . (1999). Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Research, 59 , 639-644.
    • (1999) Cancer Research , vol.59 , pp. 639-644
    • Izbicka, E.1    Wheelhouse, R.T.2    Raymond, E.3    Davidson, K.K.4    Lawrence, R.A.5    Sun, D.6
  • 202
    • 0037731436 scopus 로고    scopus 로고
    • The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures
    • Kim, M.-Y., Gleason-Guzman, M., Izbicka, E., Nishioka, D., Hurley, L. H. (2003). The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. Cancer Research, 63 , 3247-3256.
    • (2003) Cancer Research , vol.63 , pp. 3247-3256
    • Kim, M.-Y.1    Gleason-Guzman, M.2    Izbicka, E.3    Nishioka, D.4    Hurley, L.H.5
  • 203
    • 0036597090 scopus 로고    scopus 로고
    • The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo
    • Grand, C. L., Han, H., Munoz, R. M., Weitman, S., Von Hoff, D. D., Hurley, L. H., et al . (2002). The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo. Molecular Cancer Therapeutics, 1 , 565-573.
    • (2002) Molecular Cancer Therapeutics , vol.1 , pp. 565-573
    • Grand, C.L.1    Han, H.2    Munoz, R.M.3    Weitman, S.4    Von Hoff, D.D.5    Hurley, L.H.6
  • 204
    • 27244435211 scopus 로고    scopus 로고
    • Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents
    • Sun, D., Guo, K., Rusche, J. J., Hurley, L. H. (2005). Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Research, 33 , 6070-6080.
    • (2005) Nucleic Acids Research , vol.33 , pp. 6070-6080
    • Sun, D.1    Guo, K.2    Rusche, J.J.3    Hurley, L.H.4
  • 205
    • 42249101229 scopus 로고    scopus 로고
    • The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents
    • Sun, D., Liu,W.-J., Guo, K., Rusche, J. J., Ebbinghaus, S., Gokhale, V., et al . (2008). The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents. Molecular Cancer Therapeutics, 7 , 880-889.
    • (2008) Molecular Cancer Therapeutics , vol.7 , pp. 880-889
    • Sun, D.1    Liu, W.-J.2    Guo, K.3    Rusche, J.J.4    Ebbinghaus, S.5    Gokhale, V.6
  • 206
    • 34548183518 scopus 로고    scopus 로고
    • Formation of pseudosymmetrical G-quadruplex and i-Motif structures in the proximal promoter region of the RET oncogene
    • Guo, K., Pourpak, A., Beetz-Rogers, K., Gokhale, V., Sun, D., Hurley, L. H. (2007). Formation of pseudosymmetrical G-quadruplex and i-Motif structures in the proximal promoter region of the RET oncogene. Journal of the American Chemical Society, 129 , 10220-10228.
    • (2007) Journal of the American Chemical Society , vol.129 , pp. 10220-10228
    • Guo, K.1    Pourpak, A.2    Beetz-Rogers, K.3    Gokhale, V.4    Sun, D.5    Hurley, L.H.6
  • 207
    • 38049017592 scopus 로고    scopus 로고
    • Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4
    • Qin, Y., Rezler, E. M., Gokhale, V., Sun, D., Hurley, L. H. (2007). Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4. Nucleic Acids Research, 35 , 7698-7713.
    • (2007) Nucleic Acids Research , vol.35 , pp. 7698-7713
    • Qin, Y.1    Rezler, E.M.2    Gokhale, V.3    Sun, D.4    Hurley, L.H.5
  • 208
    • 39149144832 scopus 로고    scopus 로고
    • Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells
    • Mikami-Terao, Y., Akiyama, M., Yuza, Y., Yanagisawa, T., Yamada, O., Yamada, H. (2008). Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells. Cancer Letters, 261 , 226-234.
    • (2008) Cancer Letters , vol.261 , pp. 226-234
    • Mikami-Terao, Y.1    Akiyama, M.2    Yuza, Y.3    Yanagisawa, T.4    Yamada, O.5    Yamada, H.6
  • 209
    • 33747168762 scopus 로고    scopus 로고
    • A phenol quaternary ammonium porphyrin as a potent telomerase inhibitor by selective interaction with quadruplex DNA
    • Wang, P., Ren, L., He, H., Liang, F., Zhou, X., Tan, Z. (2006). A phenol quaternary ammonium porphyrin as a potent telomerase inhibitor by selective interaction with quadruplex DNA. ChemBioChem, 7 , 1155-1159.
    • (2006) ChemBioChem , vol.7 , pp. 1155-1159
    • Wang, P.1    Ren, L.2    He, H.3    Liang, F.4    Zhou, X.5    Tan, Z.6
  • 211
    • 33751089304 scopus 로고    scopus 로고
    • Tetramethylpyridiniumporphyrazines-a new class of G-quadruplex inducing and stabilizing ligands
    • Goncalves, D. P. N., Rodriguez, R., Balasubramanian, S., Sanders, J. K. M. (2006). Tetramethylpyridiniumporphyrazines-a new class of G-quadruplex inducing and stabilizing ligands. Chemical Communication, 4685-4687.
    • (2006) Chemical Communication , pp. 4685-4687
    • Goncalves, D.P.N.1    Rodriguez, R.2    Balasubramanian, S.3    Sanders, J.K.M.4
  • 212
    • 34250837616 scopus 로고    scopus 로고
    • Quaternary ammonium zinc phthalocyanine: inhibiting telomerase by stabilizing G quadruplexes and inducing G-quadruplex structure transition and formation
    • Ren, L., Zhang, A., Huang, J., Wang, P., Weng, X., Zhang, L., et al . (2007). Quaternary ammonium zinc phthalocyanine: inhibiting telomerase by stabilizing G quadruplexes and inducing G-quadruplex structure transition and formation. Chem- BioChem, 8 , 775-780.
    • (2007) Chem- BioChem , vol.8 , pp. 775-780
    • Ren, L.1    Zhang, A.2    Huang, J.3    Wang, P.4    Weng, X.5    Zhang, L.6
  • 213
    • 72949092489 scopus 로고    scopus 로고
    • Guanidiniummodified phthalocyanines as high-affinity G-quadruplex fluorescent probes and transcriptional regulators
    • International Edition S9362/9361-S9362/9316
    • Alzeer, J., Vummidi, B. R., Roth, P. J. C., Luedtke, N. W. (2009). Guanidiniummodified phthalocyanines as high-affinity G-quadruplex fluorescent probes and transcriptional regulators. Angewandte Chemie, International Edition, 48 , 9362-9365, S9362/9361-S9362/9316.
    • (2009) Angewandte Chemie , vol.48 , pp. 9362-9365
    • Alzeer, J.1    Vummidi, B.R.2    Roth, P.J.C.3    Luedtke, N.W.4
  • 214
    • 77955213299 scopus 로고    scopus 로고
    • Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes
    • Yaku, H., Murashima, T., Miyoshi, D., Sugimoto, N. (2010). Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes. Chemical Communication, 46 , 5740-5742.
    • (2010) Chemical Communication , vol.46 , pp. 5740-5742
    • Yaku, H.1    Murashima, T.2    Miyoshi, D.3    Sugimoto, N.4
  • 215
    • 34547607293 scopus 로고    scopus 로고
    • Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands
    • Fu, B., Huang, J., Ren, L., Weng, X., Zhou, Y., Du, Y., et al . (2007). Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands. Chemical Communications, 3264-3266.
    • (2007) Chemical Communications , pp. 3264-3266
    • Fu, B.1    Huang, J.2    Ren, L.3    Weng, X.4    Zhou, Y.5    Du, Y.6
  • 216
    • 73949088948 scopus 로고    scopus 로고
    • Pyridylsubstituted corrole isomers: synthesis and their regulation to G-quadruplex structures
    • Ma, H., Zhang, M., Zhang, D., Huang, R., Zhao, Y., Yang, H., et al . (2010). Pyridylsubstituted corrole isomers: synthesis and their regulation to G-quadruplex structures. Chem.-Asian J ., 5 , 114-122.
    • (2010) Chem.-Asian J . , vol.5 , pp. 114-122
    • Ma, H.1    Zhang, M.2    Zhang, D.3    Huang, R.4    Zhao, Y.5    Yang, H.6
  • 218
    • 0037070575 scopus 로고    scopus 로고
    • Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
    • Kim, M.-Y., Vankayalapati, H., Shin-ya, K., Wierzba, K., Hurley, L. H. (2002). Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex. Journal of the American Chemical Society, 124 , 2098-2099.
    • (2002) Journal of the American Chemical Society , vol.124 , pp. 2098-2099
    • Kim, M.-Y.1    Vankayalapati, H.2    Shin-ya, K.3    Wierzba, K.4    Hurley, L.H.5
  • 219
    • 0242609879 scopus 로고    scopus 로고
    • Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry
    • Rosu, F., Gabelica, V., Shin-ya, K., De Pauw, E. (2003). Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry. Chemical Communications, 2702-2703.
    • (2003) Chemical Communications , pp. 2702-2703
    • Rosu, F.1    Gabelica, V.2    Shin-ya, K.3    De Pauw, E.4
  • 221
    • 0842289983 scopus 로고    scopus 로고
    • Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma
    • Shammas, M. A., Reis, R. J. S., Li, C., Koley, H., Hurley, L. H., Anderson, K. C., et al . (2004). Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clinical Cancer Research, 10 , 770-776.
    • (2004) Clinical Cancer Research , vol.10 , pp. 770-776
    • Shammas, M.A.1    Reis, R.J.S.2    Li, C.3    Koley, H.4    Hurley, L.H.5    Anderson, K.C.6
  • 223
    • 33645280314 scopus 로고    scopus 로고
    • Gquadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3telomeric overhang in cancer cells
    • Tahara, H., Shin-Ya, K., Seimiya, H., Yamada, H., Tsuruo, T., Ide, T. (2006). Gquadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3telomeric overhang in cancer cells. Oncogene, 25 , 1955-1966.
    • (2006) Oncogene , vol.25 , pp. 1955-1966
    • Tahara, H.1    Shin-Ya, K.2    Seimiya, H.3    Yamada, H.4    Tsuruo, T.5    Ide, T.6
  • 224
    • 0041353443 scopus 로고    scopus 로고
    • Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways
    • Tauchi, T., Shin-ya, K., Sashida, G., Sumi, M., Nakajima, A., Shimamoto, T., et al . (2003). Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene, 22 , 5338-5347.
    • (2003) Oncogene , vol.22 , pp. 5338-5347
    • Tauchi, T.1    Shin-ya, K.2    Sashida, G.3    Sumi, M.4    Nakajima, A.5    Shimamoto, T.6
  • 225
    • 33748701981 scopus 로고    scopus 로고
    • Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia
    • Tauchi, T., Shin-ya, K., Sashida, G., Sumi, M., Okabe, S., Ohyashiki, J. H., et al . (2006). Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia. Oncogene, 25 , 5719-5725.
    • (2006) Oncogene , vol.25 , pp. 5719-5725
    • Tauchi, T.1    Shin-ya, K.2    Sashida, G.3    Sumi, M.4    Okabe, S.5    Ohyashiki, J.H.6
  • 226
    • 0037350830 scopus 로고    scopus 로고
    • Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy
    • Nakajima, A., Tauchi, T., Sashida, G., Sumi, M., Abe, K., Yamamoto, K., et al . (2003). Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy. Leukemia, 17 , 560-567.
    • (2003) Leukemia , vol.17 , pp. 560-567
    • Nakajima, A.1    Tauchi, T.2    Sashida, G.3    Sumi, M.4    Abe, K.5    Yamamoto, K.6
  • 227
    • 13944253127 scopus 로고    scopus 로고
    • A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia
    • Sumi, M., Tauchi, T., Sashida, G., Nakajima, A., Gotoh, A., Shin-Ya, K., et al . (2004). A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia. International Journal of Oncology, 24 , 1481-1487.
    • (2004) International Journal of Oncology , vol.24 , pp. 1481-1487
    • Sumi, M.1    Tauchi, T.2    Sashida, G.3    Nakajima, A.4    Gotoh, A.5    Shin-Ya, K.6
  • 229
    • 38749119006 scopus 로고    scopus 로고
    • Lysinyl macrocyclic hexaoxazoles: synthesis and selective G-quadruplex stabilizing properties
    • Rzuczek, S. G., Pilch, D. S., LaVoie, E. J., Rice, J. E. (2008). Lysinyl macrocyclic hexaoxazoles: synthesis and selective G-quadruplex stabilizing properties. Bioorganic & Medicinal Chemistry Letters, 18 , 913-917.
    • (2008) Bioorganic & Medicinal Chemistry Letters , vol.18 , pp. 913-917
    • Rzuczek, S.G.1    Pilch, D.S.2    LaVoie, E.J.3    Rice, J.E.4
  • 230
    • 44849098127 scopus 로고    scopus 로고
    • Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency
    • Satyanarayana, M., Rzuczek, S. G., LaVoie, E. J., Pilch, D. S., Liu, A., Liu, L. F., et al . (2008). Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency. Bioorganic & Medicinal Chemistry Letters, 18 , 3802-3804.
    • (2008) Bioorganic & Medicinal Chemistry Letters , vol.18 , pp. 3802-3804
    • Satyanarayana, M.1    Rzuczek, S.G.2    LaVoie, E.J.3    Pilch, D.S.4    Liu, A.5    Liu, L.F.6
  • 232
    • 60349105930 scopus 로고    scopus 로고
    • Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole
    • Tera, M., Iida, K., Ishizuka, H., Takagi, M., Suganuma, M., Doi, T., et al . (2009). Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole. Chem- BioChem, 10 , 431-435.
    • (2009) Chem- BioChem , vol.10 , pp. 431-435
    • Tera, M.1    Iida, K.2    Ishizuka, H.3    Takagi, M.4    Suganuma, M.5    Doi, T.6
  • 233
    • 77952065213 scopus 로고    scopus 로고
    • Macrocyclic hexaoxazoles: influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity
    • Satyanarayana, M., Kim, Y.-A., Rzuczek, S. G., Pilch, D. S., Liu, A. A., Liu, L. F., et al . (2010). Macrocyclic hexaoxazoles: influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity. Bioorganic & Medicinal Chemistry Letters, 20 , 3150-3154.
    • (2010) Bioorganic & Medicinal Chemistry Letters , vol.20 , pp. 3150-3154
    • Satyanarayana, M.1    Kim, Y.-A.2    Rzuczek, S.G.3    Pilch, D.S.4    Liu, A.A.5    Liu, L.F.6
  • 234
    • 77952045784 scopus 로고    scopus 로고
    • Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents
    • Rzuczek, S. G., Pilch, D. S., Liu, A., Liu, L., La Voie, E. J., Rice, J. E. (2010). Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents. Journal of Medicinal Chemistry, 53 , 3632-3644.
    • (2010) Journal of Medicinal Chemistry , vol.53 , pp. 3632-3644
    • Rzuczek, S.G.1    Pilch, D.S.2    Liu, A.3    Liu, L.4    La Voie, E.J.5    Rice, J.E.6
  • 235
    • 34250878987 scopus 로고    scopus 로고
    • Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA
    • Barbieri, C. M., Srinivasan, A. R., Rzuczek, S. G., Rice, J. E., LaVoie, E. J., Pilch, D. S. (2007). Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA. Nucleic Acids Research, 35 , 3272-3286.
    • (2007) Nucleic Acids Research , vol.35 , pp. 3272-3286
    • Barbieri, C.M.1    Srinivasan, A.R.2    Rzuczek, S.G.3    Rice, J.E.4    LaVoie, E.J.5    Pilch, D.S.6
  • 236
    • 47649122998 scopus 로고    scopus 로고
    • Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds
    • Pilch, D. S., Barbieri, C. M., Rzuczek, S. G., LaVoie, E. J., Rice, J. E. (2008). Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds. Biochimie, 90 , 1233-1249.
    • (2008) Biochimie , vol.90 , pp. 1233-1249
    • Pilch, D.S.1    Barbieri, C.M.2    Rzuczek, S.G.3    LaVoie, E.J.4    Rice, J.E.5
  • 242
    • 77955423929 scopus 로고    scopus 로고
    • Furan based cyclic homo-oligopeptides bind G-quadruplex selectively and repress c-MYC transcription
    • Agarwal, T., Roy, S., Chakraborty, T. K., Maiti, S. (2010). Furan based cyclic homo-oligopeptides bind G-quadruplex selectively and repress c-MYC transcription. Bioorganic & Medicinal Chemistry Letters, 20 , 4346-4349.
    • (2010) Bioorganic & Medicinal Chemistry Letters , vol.20 , pp. 4346-4349
    • Agarwal, T.1    Roy, S.2    Chakraborty, T.K.3    Maiti, S.4
  • 245
    • 33846569026 scopus 로고    scopus 로고
    • Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge
    • White, E. W., Tanious, F., Ismail, M. A., Reszka, A. P., Neidle, S., Boykin, D. W., et al . (2007). Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophysical Chemistry, 126 , 140-153.
    • (2007) Biophysical Chemistry , vol.126 , pp. 140-153
    • White, E.W.1    Tanious, F.2    Ismail, M.A.3    Reszka, A.P.4    Neidle, S.5    Boykin, D.W.6
  • 246
    • 73649107875 scopus 로고    scopus 로고
    • Diverse modes of 5-[4- (aminoiminomethyl)phenyl]-[2,2-bifuran]-5-carboximidamide (DB832) interaction with multi-stranded DNA structures
    • Kaluzhny, D. N., Borisova, O. F., Shchyolkina, A. K. (2009). Diverse modes of 5-[4- (aminoiminomethyl)phenyl]-[2,2-bifuran]-5-carboximidamide (DB832) interaction with multi-stranded DNA structures. Biopolymers, 93 , 8-20.
    • (2009) Biopolymers , vol.93 , pp. 8-20
    • Kaluzhny, D.N.1    Borisova, O.F.2    Shchyolkina, A.K.3
  • 248
    • 0037096736 scopus 로고    scopus 로고
    • Detection of telomerase inhibitors based on G-quadruplex ligands by a modified telomeric repeat amplification protocol assay
    • Gomez, D., Mergny, J.-L., Riou, J.-F. (2002). Detection of telomerase inhibitors based on G-quadruplex ligands by a modified telomeric repeat amplification protocol assay. Cancer Research, 62 , 3365-3368.
    • (2002) Cancer Research , vol.62 , pp. 3365-3368
    • Gomez, D.1    Mergny, J.-L.2    Riou, J.-F.3
  • 249
    • 65749094668 scopus 로고    scopus 로고
    • G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo
    • Gunaratnam, M., Green, C., Moreira, J. B., Moorhouse, A. D., Kelland, L. R., Moses, J. E., et al . (2009). G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo. Biochemical Pharmacology, 78 , 115-122.
    • (2009) Biochemical Pharmacology , vol.78 , pp. 115-122
    • Gunaratnam, M.1    Green, C.2    Moreira, J.B.3    Moorhouse, A.D.4    Kelland, L.R.5    Moses, J.E.6
  • 250
    • 33747519108 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structures
    • Wheelhouse, R. T., Jennings, S. A., Phillips, V. A., Pletsas, D., Murphy, P. M., Garbett, N. C., et al . (2006). Design, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structures. Journal of Medicinal Chemistry, 49 , 5187-5198.
    • (2006) Journal of Medicinal Chemistry , vol.49 , pp. 5187-5198
    • Wheelhouse, R.T.1    Jennings, S.A.2    Phillips, V.A.3    Pletsas, D.4    Murphy, P.M.5    Garbett, N.C.6
  • 252
    • 52649094807 scopus 로고    scopus 로고
    • Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand
    • Li, G., Huang, J., Zhang, M., Zhou, Y., Zhang, D., Wu, Z., et al . (2008). Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand. Chemical Communications, 4564-4566.
    • (2008) Chemical Communications , pp. 4564-4566
    • Li, G.1    Huang, J.2    Zhang, M.3    Zhou, Y.4    Zhang, D.5    Wu, Z.6
  • 254
    • 56749154566 scopus 로고    scopus 로고
    • Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA Gquadruplexes
    • Dash, J., Shirude, P. S., Hsu, S.-T. D., Balasubramanian, S. (2008). Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA Gquadruplexes. Journal of the American Chemical Society, 130 , 15950-15956.
    • (2008) Journal of the American Chemical Society , vol.130 , pp. 15950-15956
    • Dash, J.1    Shirude, P.S.2    Hsu, S.-T.D.3    Balasubramanian, S.4
  • 261
    • 49149099403 scopus 로고    scopus 로고
    • 9- N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and downregulation of oncogene c-myc
    • Ma, Y., Ou, T.-M., Hou, J.-Q., Lu, Y.-J., Tan, J.-H., Gu, L.-Q., et al . (2008). 9- N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and downregulation of oncogene c-myc. Bioorganic & Medicinal Chemistry, 16 , 7582-7591.
    • (2008) Bioorganic & Medicinal Chemistry , vol.16 , pp. 7582-7591
    • Ma, Y.1    Ou, T.-M.2    Hou, J.-Q.3    Lu, Y.-J.4    Tan, J.-H.5    Gu, L.-Q.6
  • 262
    • 66349113993 scopus 로고    scopus 로고
    • Synthesis and evaluation of 9-O-substituted berberine derivatives containing azaaromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands
    • Ma, Y., Ou, T.-M., Tan, J.-H., Hou, J.-Q., Huang, S.-L., Gu, L.-Q., et al . (2009). Synthesis and evaluation of 9-O-substituted berberine derivatives containing azaaromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands. Bioorganic & Medicinal Chemistry Letters, 19 , 3414-3417.
    • (2009) Bioorganic & Medicinal Chemistry Letters , vol.19 , pp. 3414-3417
    • Ma, Y.1    Ou, T.-M.2    Tan, J.-H.3    Hou, J.-Q.4    Huang, S.-L.5    Gu, L.-Q.6
  • 263
    • 65649141960 scopus 로고    scopus 로고
    • Isaindigotone derivatives: a new class of highly selective ligands for telomeric Gquadruplex DNA
    • Tan, J.-H., Ou, T.-M., Hou, J.-Q., Lu, Y.-J., Huang, S.-L., Luo, H.-B., et al . (2009). Isaindigotone derivatives: a new class of highly selective ligands for telomeric Gquadruplex DNA. Journal of Medicinal Chemistry, 52 , 2825-2835.
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 2825-2835
    • Tan, J.-H.1    Ou, T.-M.2    Hou, J.-Q.3    Lu, Y.-J.4    Huang, S.-L.5    Luo, H.-B.6
  • 269
    • 61449108107 scopus 로고    scopus 로고
    • Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex
    • Huang, J., Li, G., Wu, Z., Song, Z., Zhou, Y., Shuai, L., et al . (2009). Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex. Chemical Communication, 902-904.
    • (2009) Chemical Communication , pp. 902-904
    • Huang, J.1    Li, G.2    Wu, Z.3    Song, Z.4    Zhou, Y.5    Shuai, L.6
  • 271
    • 34548304323 scopus 로고    scopus 로고
    • A new steroid derivative stabilizes G-quadruplexes and induces telomere uncapping in human tumor cells
    • Brassart, B., Gomez, D., De Cian, A., Paterski, R., Montagnac, A., Qui, K.-H., et al. (2007). A new steroid derivative stabilizes G-quadruplexes and induces telomere uncapping in human tumor cells. Molecular Pharmacology, 72 , 631-640.
    • (2007) Molecular Pharmacology , vol.72 , pp. 631-640
    • Brassart, B.1    Gomez, D.2    De Cian, A.3    Paterski, R.4    Montagnac, A.5    Qui, K.-H.6


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