Specific interactions with intra- and intermolecular G-quadruplex DNA structures by hydrosoluble coronene derivatives: A new class of telomerase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 4, 2007, Pages 1848-1858

  Franceschin, Marco ^a   Alvino, Antonello ^a   Casagrande, Valentina ^a   Mauriello, Clementina ^a   Pascucci, Emanuela ^a   Savino, Maria ^a   Ortaggi, Giancarlo ^a   Bianco, Armandodoriano ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

G quadruplex; Hydrosoluble coronene derivatives; Telomerase inhibitors

Indexed keywords

CORONENE DERIVATIVE; N,N' BIS[2 (1 PIPERIDINO)ETHYL] 5,11 BIS[2 (4 METHYL 1 PIPERAZINO)ETHYL]CORONENE 2,3:8,9 TETRACARBOXYLIC DIIMIDE; N,N' BIS[3 (DIMETHYLAMINO)PROPYL] 5,11 BIS[2 (1 PIPERIDINO)ETHYL]CORONENE 2,3:8,9 TETRACARBOXYLIC DIIMIDE; N,N' BIS[3 (DIMETHYLAMINO)PROPYL] 5,11 BIS[2 (4 METHYL 1 PIPERAZINO)ETHYL]CORONENE 2,3:8,9 TETRACARBOXYLIC DIIMIDE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL FREE SYSTEM; CHEMICAL STRUCTURE; CORRELATION ANALYSIS; DNA STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR MODEL; SYNTHESIS;

CELL-FREE SYSTEM; DNA; ELECTROSTATICS; HUMANS; HYDROPHOBICITY; MODELS, MOLECULAR; POLYCYCLIC COMPOUNDS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 33847785752     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.11.032     Document Type: Article

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