Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 24, 2009, Pages 8241-8246

  Nielsen, Mads Corvinius ^a   Borch, Jonas ^a   Ulven, Trond ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

DNA; G quadruplex; Phenanthrolines

Indexed keywords

1,10 [2,20 (1,10 PHENANTHROLINE 4,7 DIYL)BIS(AZANEDIYL)BIS (ETHANE 2,1 DIYL)]DIGUANIDINE; 1,10 [3,30 (1,10 PHENANTHROLINE 4,7 DIYL)BIS(AZANEDIYL)BIS(PROPANE 3,1 DIYL))DIGUANIDINE; 1,10 [4,40 (1,10 PHENANTHROLINE 4,7 DIYL)BIS(AZANEDIYL)BIS (BUTANE-4,1-DIYL)]DIGUANIDINE; 1,10 PHENANTHROLINE 4,7 DIAMINE; 4,7 DIAMINO 1,10 PHENANTHROLINE; ANTINEOPLASTIC AGENT; GUANINE QUADRUPLEX; N 1 , N 1' (1,10 PHENANTHROLINE 4,7 DIYL)BIS(N2,N2 DIMETHYLETHANE 1,2 DIAMINE); N 1 , N 1' (1,10 PHENANTHROLINE 4,7 DIYL)BIS(N3,N3 DIMETHYLPROPANE 1,3 DIAMINE); N 1 , N 1' (1,10 PHENANTHROLINE 4,7 DIYL)DIBUTANE 1,4 DIAMINE; N 1 ,N 1' (1,10 PHENANTHROLINE 4,7 DIYL)BIS(N 4 , N 4 DIMETHYLBUTANE 1,4 DIAMINE); UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CIRCULAR DICHROISM; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

BINDING SITES; CIRCULAR DICHROISM; DRUG DESIGN; G-QUADRUPLEXES; HYDROGEN BONDING; LIGANDS; METHYLATION; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; PHENANTHROLINES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TELOMERE;

EID: 71849100513     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.055     Document Type: Article

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