Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4873-4884

  Perry, Philip J ^a   Reszka, Anthony P ^a   Wood, Alexis A ^a   Read, Martin A ^a   Gowan, Sharon M ^a   Dosanjh, Harvinder S ^a   Trent, John O ^a,b   Jenkins, Terence C ^a,c   Kelland, Lloyd R ^a   Neidle, Stephen ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b Center for Palliative Care   (United States)

^c UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDOANTHRACENE 9,10 DIONE; ANTHRACENE DERIVATIVE; DIAMIDOANTHRACENE 9,10 DIONE; DNA POLYMERASE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DNA BINDING; DRUG ANTAGONISM; ENTHALPY; ENZYME INHIBITION; LIGAND BINDING; MOLECULAR MODEL; PROTEIN FOLDING; STEREOCHEMISTRY; STEREOISOMERISM; STOICHIOMETRY; TELOMERE;

ANTHRACENES; ANTINEOPLASTIC AGENTS; CALORIMETRY; CELL DIVISION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; OVARIAN NEOPLASMS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TAQ POLYMERASE; TELOMERASE; TELOMERE; THERMODYNAMICS; TUMOR CELLS, CULTURED;

EID: 7844223625     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981067o     Document Type: Article

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