Switching and signaling at the telomere

Cell

Volumn 106, Issue 6, 2001, Pages 661-673

  Blackburn, Elizabeth H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DOUBLE STRANDED DNA; SINGLE STRANDED DNA; TELOMERASE;

CHROMOSOME REARRANGEMENT; CHROMOSOME SIZE; CHROMOSOME STRUCTURE; DNA DAMAGE; DNA PROTEIN COMPLEX; DNA STRAND; DNA STRUCTURE; DNA SYNTHESIS; ENZYME SUBSTRATE COMPLEX; EUKARYOTE; GENE SWITCHING; HUMAN; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TELOMERE;

EID: 0035929353     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00492-5     Document Type: Review

References (110)

1. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
2. Protection of telomeres by the Ku protein in fission yeast
3. Pot1, the putative telomere end-binding protein in fission yeast and humans
4. Telomeres and double-strand breaks: Trying to make ends meet
5. TRF1 is a dimer and bends telomeric DNA
6. Telomerase RNA structure and function
7. Telomere states and cell fates
8. The end of the (DNA) line
9. Extension of life-span by introduction of telomerase into normal human cells
10. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
11. Telomere-led premeiotic chromosome movement in fission yeast
12. Two types of telomeric chromatin in Tetrahymena thermophila
13. RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
14. Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination
15. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
16. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
17. Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae
18. Telomere folding is required for the stable maintenance of telomere position effects in yeast
19. Telomere looping permits gene activation by a downstream UAS in yeast
20. Cytology of telomeres
21. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
22. Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans
23. Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process
24. Positive and negative regulation of telomerase access to the telomere
25. Telomeres and telomerase: At the end, it all comes together
26. Identification of Kluyveromyces lactis telomerase: Discontinuous synthesis along the 30-nucleotide-long templating domain
27. Nuclear pore complexes in the organization of silent telomeric chromatin
28. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
29. A sense of the end
30. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
31. Yeast Ku as a regulator of chromosomal DNA end structure
32. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
33. TRF1 promotes parallel pairing of telomeric tracts in vitro
34. Mammalian telomeres end in a large duplex loop
35. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
36. Telomere dysfunction increases mutation rate and genomic instability
37. Inhibition of telomerase limits the growth of human cancer cells
38. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
39. G-strand overhangs on telomeres in telomerase-deficient mouse cells
40. Immortalization of human CD8(+) T cell clones by ectopic expression of telomerase reverse transcriptase
41. Ku acts in a unique way at the mammalian telomere to prevent end joining
42. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
43. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
44. TIN2, a new regulator of telomere length in human cells
45. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
46. Block in anaphase chromosome separation caused by a telomerase template mutation
47. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
48. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
49. Rap1 protein regulates telomere turnover in yeast
50. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
51. Heterogeneity in telomere length of human chromosomes
52. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells
53. The dynamics of yeast telomeres and silencing proteins through the cell cycle
54. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
55. In vivo and in vitro studies of telomeres and telomerase
56. Viable deletions of a telomere from a Drosophila chromosome
57. Identification of human Rap1: Implications for telomere evolution
58. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
59. A protein-counting mechanism for telomere length regulation in yeast
60. Cell cycle restriction of telomere elongation
61. Runaway telomere elongation caused by telomerase RNA gene mutations
62. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
63. Short telomeres in yeast are highly recombinogenic
64. Telomere fusion caused by mutating the terminal region of telomeric DNA
65. Telomeres and their control
66. Silent information regulator protein complexes in Saccharomyces cerevisiae: A SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3
67. T-loops at trypanosome telomeres
68. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
69. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
70. Drosophila telomeres: Another way to end it all
71. Drosophila telomeres: Two transposable elements with important roles in chromosomes
72. Cdc13 delivers separate complexes to the telomere for end protection and replication
73. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
74. Functionally interacting telomerase RNAs in the yeast telomerase complex
75. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
76. Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
77. Chromosome ends: All the same under their caps
78. The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction
79. Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage
80. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
81. Specific telomerase RNA residues distant from the template are essential for telomerase function
82. Mammalian ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
83. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae
84. Analysis of telomere lengths in cloned sheep
85. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
86. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
87. Control of human telomere length by TRF1 and TRF2
88. The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena
89. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
90. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
91. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
92. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
93. TRF2 protects human telomeres from end-to-end fusions
94. Telomere processing in Euplotes
95. Asymmetric DNA bending induced by the yeast multifunctional factor TUF
96. Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?
97. Three telomerases with completely non-telomeric template replacements are catalytically active
98. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase
99. Tales of tails: Regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
100. Regulation of telomere length and telomerase in T and B cells: A mechanism for maintaining replicative potential
101. Human telomerase contains two cooperating telomerase RNA molecules
102. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
103. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase
104. Human endothelial cell life extension by telomerase expression
105. Developmentally programmed healing of chromosomes by telomerase in Tetrahymena
106. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
107. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
108. A biochemical function for the Sm complex
109. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
110. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres