Anticancer activity of CX-3543: A direct inhibitor of rRNA biogenesis

Cancer Research

Volumn 69, Issue 19, 2009, Pages 7653-7661

  Drygin, Denis ^a   Siddiqui Jain, Adam ^a   O'Brien, Sean ^a   Schwaebe, Michael ^a   Lin, Amy ^a   Bliesath, Josh ^a   Ho, Caroline B ^a   Proffitt, Chris ^a   Trent, Katy ^a   Whitten, Jeffrey P ^a   Lim, John K C ^a   Von Hoff, Daniel ^b   Anderes, Kenna ^a   Rice, William G ^a  

^a Cylene Pharmaceuticals   (United States)

^b TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CX 3543; DNA DIRECTED RNA POLYMERASE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GUANINE QUADRUPLEX; NUCLEIC ACID SYNTHESIS INHIBITOR; NUCLEOLIN; QUARFLOXIN; RIBOSOME DNA; RIBOSOME RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG SELECTIVITY; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOLUS; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; RNA SYNTHESIS; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; BENZOXAZINES; CELL LINE, TUMOR; CELL NUCLEOLUS; DNA POLYMERASE I; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; FEMALE; G-QUADRUPLEXES; HL-60 CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICE, SCID; NEOPLASMS; PHOSPHOPROTEINS; QUINOLONES; RNA, RIBOSOMAL; RNA-BINDING PROTEINS; TELOMERE; TRANSCRIPTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 70350220557     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1304     Document Type: Article

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