Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3802-3804

  Satyanarayana, Mavurapu ^a   Rzuczek, Suzanne G ^a   LaVoie, Edmond J ^a,c   Pilch, Daniel S ^b,c   Liu, Angela ^b,c   Liu, Leroy F ^b,c   Rice, Joseph E ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Cytotoxic; G quadruplex stabilizer; Hexaoxazole; Macrocycle; Ring closing metathesis; Selective; Synthesis

Indexed keywords

DNA; MACROCYCLIC COMPOUND; OXAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RING CLOSING METATHESIS;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DNA; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 44849098127     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.032     Document Type: Article

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