9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7582-7591

  Ma, Yan ^a   Ou, Tian Miao ^a   Hou, Jin Qiang ^a   Lu, Yu Jing ^a   Tan, Jia Heng ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

9 N Substituted berberine derivatives; c myc G quadruplex; Down regulation of transcription; Synthesis

Indexed keywords

9 N 2' (1 PIPERIDINE)ETHYLBERBERINE; 9 N 2' (2 HYDROXYL)ETHYLBERBERINE; 9 N 2' (4 MORPHILINE)ETHYLBERBERINE; 9 N 2' (N',N' DIMETHYLAMINO)ETHYLBERBERINE; 9 N 2' (PHENYL)ETHYLBERBERINE; 9 N 3' (1 PIPERIDINE)PROPYLBERBERINE; 9 N 3' (1 PYRROLE)PROPYLBERBERINE; 9 N 3' (4 MORPHILINE)PROPYLBERBERINE; 9 N 3' (N',N' DIMETHYLAMINO)PROPYLBERBERINE; 9 N 6' AMINO HEXYLBERBERINE; BERBERINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA STRUCTURE; DOSE RESPONSE; DOWN REGULATION; DRUG SCREENING; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LYMPHOMA; ONCOGENE C MYC; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; THERMODYNAMICS;

BASE SEQUENCE; BERBERINE; CELL GROWTH PROCESSES; CIRCULAR DICHROISM; DNA; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEXES; GENES, MYC; HL-60 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 49149099403     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.029     Document Type: Article

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