Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: The importance of G-quadruplex binding

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 23, 2004, Pages 5845-5849

  Harrison, R John ^a   Reszka, Anthony P ^a   Haider, Shozeb M ^a   Romagnoli, Barbara ^a   Morrell, James ^a   Read, Martin A ^a   Gowan, Sharon M ^b   Incles, Christopher M ^a   Kelland, Lloyd R ^c   Neidle, Stephen ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Acridone; Quadruplex DNA; Telomerase

Indexed keywords

ACRIDINE; ACRIDONE DERIVATIVE; ANTINEOPLASTIC AGENT; BRACO 19; DNA; ETHIDIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALCULATION; CELL LINE; CELL PROLIFERATION; COMPARATIVE STUDY; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MELTING POINT; SUBSTITUTION REACTION;

ACRIDINES; CELL LINE, TUMOR; DNA; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; TELOMERASE;

EID: 7044249456     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.037     Document Type: Article

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