Crystal structure of parallel quadruplexes from human telomeric DNA

Nature

Volumn 417, Issue 6891, 2002, Pages 876-880

  Parkinson, Gary N ^a   Lee, Michael P H ^a   Neidle, Stephen ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CRYSTAL STRUCTURE; POTASSIUM; PROTEINS;

PARALLEL QUADRUPLEXES;

DNA;

TELOMERASE; TRINUCLEOTIDE;

DNA;

ARTICLE; CELL DEATH; CHROMOSOME STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DEGRADATION; DNA HELIX; DNA RECOMBINATION; DNA SEQUENCE; DNA STRAND; DNA STRUCTURE; HUMAN; HUMAN CELL; HYDROGEN BOND; INTERCALATION COMPLEX; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; PROTEIN FOLDING; SOMATIC CELL; TELOMERE;

BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; POTASSIUM; REPETITIVE SEQUENCES, NUCLEIC ACID; SODIUM; TELOMERE;

EID: 0037142071     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature755     Document Type: Article

References (29)

1. Telomere dysfunction increases mutation rate and genomic instability
2. Quadruplex structure of oxytricha telomeric DNA oligonucleotides
3. 4) form parallel-stranded potassium cation stabilized G-quadruplexes with anti glycosidic torsion angles in solution
4. DNA G-quartets in a 1.86 Å resolution structure of an Oxytricha nova telomeric protein-DNA complex
5. In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
6. 3] G-tetraplex
7. Normal human chromosomes have long G-rich telomeric overhangs at one end
8. G-quadruplex DNA structures-variations on a theme
9. The crystal structure of a parallel-stranded guanine tetraplex at 0.95 Å resolution
10. Hélène a target for drug design
11. Telomere maintenance mechanisms as a target for drug development
12. A G-Quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
13. Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
14. A human nuclease specific for G4 DNA
15. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
16. Solution structures of unimolecular quadruplexes formed by oligonucleotides containing Oxytricha telomere repeats
17. Structure and stability of human telomeric sequence
18. Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: Structure-activity relationships
19. Human telomerase inhibition by substituted acridine derivatives
20. Selective interactions of cationic porphyrins with G-quadruplex structures
21. Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
22. Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes
23. NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA
24. Structural characterization of a guanine-quadruplex ligand complex
25. Accelerated assembly of G-quadruplex structures by a small molecule
26. Processing of X-ray diffraction data collected in oscillation mode
27. Crystallography & NMR system: A new software suite for macromolecular structure determination
28. SHELX-97: High-resolution refinement
29. Horjales A FRODO subpackage for protein-ligand fitting with interactive energy minimisation