Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6976-6986

  Huang, Hsu Shan ^a   Huang, Kuo Feng ^b   Li, Cho Lu ^a   Huang, Yi Yuan ^c   Chiang, Yi Hsuan ^c   Huang, Fong Chun ^c   Lin, Jing Jer ^c  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Anthraquinones; Cytotoxicity; G quadruplex; hTERT; SEAP assay; Telomerase assay; Telomerase inhibition; TRAP assay

Indexed keywords

2,7 BIS(ACETAMIDO)ANTHRAQUINONE; 2,7 BIS(CYCLOPROPANECARBONAMIDO)ANTHRAQUINONE; 2,7 BIS[2 (DIMETHYLAMINO)ACETAMIDO]ANTHRAQUINONE; 2,7 BIS[2 (ETHYLAMINO)ACETAMIDO]ANTHRAQUINONE; 2,7 BIS[2 (ISOPROPYLAMINO)ACETAMIDO]ANTHRAQUINONE; 2,7 BIS[2 (PYRROLIDINO)ACETAMIDO]ANTHRAQUINONE; 2,7 BIS[3 (DIETHYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; 2,7 BIS[3 (DIMETHYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; 2,7 BIS[3 (ETHYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; 2,7 BIS[3 (PIPERIDINO)PROPIONAMIDO]ANTHRAQUINONE; 2,7 BIS[3 (PROPYLAMINO)PROPIONAMIDO]ANTHRAQUINONE; 2,7 BIS[3 (PYRROLIDINO)PROPIONAMIDO]ANTHRAQUINONE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 47549098577     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.072     Document Type: Article

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