Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3414-3417

  Ma, Yan ^a   Ou, Tian Miao ^a   Tan, Jia Heng ^a   Hou, Jin Qiang ^a   Huang, Shi Liang ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Berberine derivatives; G Quadruplex; Selectivity; Telomerase inhibitors

Indexed keywords

BERBERINE DERIVATIVE; UNCLASSIFIED DRUG; ZH 4D;

ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE SPECTROSCOPY; HUMAN; IC 50; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE; TELOMERE;

AZA COMPOUNDS; BERBERINE; CELL LINE, TUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEXES; HUMANS; LIGANDS; REVERSE TRANSCRIPTASE INHIBITORS; TELOMERASE; TELOMERE;

EID: 66349113993     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.030     Document Type: Article

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