Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes

Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2003, Pages 571-583

  Kim, Mu Yong ^a,b   Duan, Wenhu ^a,e   Gleason Guzman, Mary ^a   Hurley, Laurence H ^a,c,d  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d University of Arizona   (United States)

^e SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; OXAZINE DERIVATIVE; QUINOLONE DERIVATIVE; TELOMERASE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA CLEAVAGE; DRUG DESIGN; DRUG EFFICACY; DRUG INTERACTION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TELOMERE;

ANTINEOPLASTIC AGENTS; CELL DIVISION; DNA; DNA TOPOISOMERASES, TYPE II; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FLUOROQUINOLONES; HUMANS; OXAZINES; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERE; TUMOR CELLS, CULTURED;

EID: 0037434540     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0203377     Document Type: Article

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