Synthesis and human telomerase inhibition of a series of regioisomeric disubstituted amidoanthraquinones

Chemical and Pharmaceutical Bulletin

Volumn 55, Issue 2, 2007, Pages 284-292

  Huang, Hsu Shan ^a   Chen, In Been ^a   Huang, Kuo Feng ^b   Lu, Wei Chih ^c   Shieh, Fu Ying ^d   Huang, Yi Yuan ^d   Huang, Fong Chun ^d   Lin, Jing Jer ^d  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c CHENG HSIN REHABILITATION MEDICAL CENTER   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Anthraquinone; Cytotoxicity; G quadruplex; Human telomerase reverse transcriptase (hTERT); Secreted alkaline phosphatase (SEAP) assay; Telomerase assay; Telomerase inhibition; TRAP assay

Indexed keywords

1,5 DIAMIDOANTHRAQUINONE; 1,5 DIAMINOANTHRAQUINONE; 2,6 BIS(2 BUTYLACETAMIDO)ANTHRAQUINONE; 2,6 BIS(2 CHLOROACETAMIDO)ANTHRAQUINONE; 2,6 BIS(2 CHLOROBENZAMIDO)ANTHRAQUINONE; 2,6 BIS(2 CHLOROPROPIONAMIDO)ANTHRAQUINONE; 2,6 BIS(2 ETHYLAMINOACETAMIDO)ANTHRAQUINONE; 2,6 BIS(2 ETHYLAMINOPROPIONAMIDO)ANTHRAQUINONE; 2,6 BIS(2 HEXYLACETAMIDO)ANTHRAQUINONE; 2,6 BIS(2 PENTYLAMINOACETAMIDO)ANTHRAQUINONE; 2,6 BIS(2 PROPYLAMINOETHANAMIDO)ANTHRAQUINONE; 2,6 BIS(BENZAMIDO)ANTHRAQUINONE; 2,6 DIAMIDOANTHRAQUINONE; AMETANTRONE; ANTHRAQUINONE; ANTHRAQUINONE DERIVATIVE; ANTIINFECTIVE AGENT; CYTOTOXIC AGENT; MITOXANTRONE; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CYTOTOXICITY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IC 50; MINIMUM INHIBITORY CONCENTRATION; PHARMACOPHORE; PROTEIN EXPRESSION; SOMATIC CELL; SUBSTITUTION REACTION; TELOMERE;

AMIDES; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL PROLIFERATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOMERISM; MOLECULAR STRUCTURE; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 33846954426     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.284     Document Type: Article

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