-
1
-
-
0003893137
-
-
New York: Cold Spring Harbor Laboratory Press
-
Blackburn E, Greider C (eds). Telomers. New York: Cold Spring Harbor Laboratory Press, 1995.
-
(1995)
Telomers
-
-
Blackburn, E.1
Greider, C.2
-
2
-
-
0025787643
-
Telomere loss: Mitotic clock or genetic time bomb?
-
Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat Res 1991; 256: 271-282.
-
(1991)
Mutat Res.
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
3
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92: 401-413.
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
van Steensel, B.1
Smogorzewska, A.2
de Lange, T.3
-
4
-
-
0033529563
-
For better or worse? Telomerase inhibition and cancer
-
de Lange T, Jacks T. For better or worse? Telomerase inhibition and cancer. Cell 1999; 98: 273-275.
-
(1999)
Cell
, vol.98
, pp. 273-275
-
-
de Lange, T.1
Jacks, T.2
-
5
-
-
0028077099
-
Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
-
Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994; 91: 9857-9860.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9857-9860
-
-
Vaziri, H.1
Dragowska, W.2
Allsopp, R.C.3
Thomas, T.E.4
Harley, C.B.5
Lansdorp, P.M.6
-
6
-
-
0029748585
-
Telomeres and telomerase in human leukemias
-
Shay JW, Werbin H, Wright WE. Telomeres and telomerase in human leukemias. Leukemia 1996; 10: 1255-1261.
-
(1996)
Leukemia
, vol.10
, pp. 1255-1261
-
-
Shay, J.W.1
Werbin, H.2
Wright, W.E.3
-
7
-
-
0030920228
-
Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells
-
Engelhardt M, Kumar R, Albanell J, Pettengell R, Han R, Moore MAS. Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 1997; 90: 182-193.
-
(1997)
Blood
, vol.90
, pp. 182-193
-
-
Engelhardt, M.1
Kumar, R.2
Albanell, J.3
Pettengell, R.4
Han, R.5
Moore, M.A.S.6
-
8
-
-
0030964322
-
Clinical implications of telomerase activity levels in acute leukemia
-
Ohyashiki JH, Ohyashiki K, Iwama H, Hayashi S, Toyama K, Shay JW. Clinical implications of telomerase activity levels in acute leukemia. Clin Cancer Res 1997; 3: 619-625.
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 619-625
-
-
Ohyashiki, J.H.1
Ohyashiki, K.2
Iwama, H.3
Hayashi, S.4
Toyama, K.5
Shay, J.W.6
-
9
-
-
0033973802
-
Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture
-
Engelhardt M, Mackenzie K, Drullinsky P, Silver RT, Moore MA. Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture. Cancer Res 2000; 60: 610-617.
-
(2000)
Cancer Res.
, vol.60
, pp. 610-617
-
-
Engelhardt, M.1
Mackenzie, K.2
Drullinsky, P.3
Silver, R.T.4
Moore, M.A.5
-
10
-
-
0343750701
-
Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry
-
Brummendorf TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ et al. Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 2000; 95: 1883-1890.
-
(2000)
Blood
, vol.95
, pp. 1883-1890
-
-
Brummendorf, T.H.1
Holyoake, T.L.2
Rufer, N.3
Barnett, M.J.4
Schulzer, M.5
Eaves, C.J.6
-
11
-
-
0032729434
-
Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit
-
Hu BT, Insel RA. Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit. Eur J Immunol 1999; 29: 3745-3753.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 3745-3753
-
-
Hu, B.T.1
Insel, R.A.2
-
12
-
-
0035337499
-
Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: Comparisons with tumor mast-cell lines
-
Chaves-Dias C, Hundley TR, Gilfillan AM, Kirshenbaum AS, Cunha-Melo JR, Metcalfe DD et al. Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines. J Immunol 2001; 166: 6647-6656.
-
(2001)
J. Immunol.
, vol.166
, pp. 6647-6656
-
-
Chaves-Dias, C.1
Hundley, T.R.2
Gilfillan, A.M.3
Kirshenbaum, A.S.4
Cunha-Melo, J.R.5
Metcalfe, D.D.6
-
13
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
-
14
-
-
0032487675
-
Both Rb/pl6INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. Both Rb/pl6INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998; 396: 84-88.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
15
-
-
0032923742
-
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
-
Jiang XR, Jimenetz G, Chang E. Frolkis M, Kusler B, Sage M et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genet 1999; 21: 111-114.
-
(1999)
Nature Genet.
, vol.21
, pp. 111-114
-
-
Jiang, X.R.1
Jimenetz, G.2
Chang, E.3
Frolkis, M.4
Kusler, B.5
Sage, M.6
-
16
-
-
0032924343
-
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
-
Morales CP, Holt SE, Ouellette M, Kaur KJ, Van Y, Wilson KS et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 1999; 21: 115-118.
-
(1999)
Nat. Genet.
, vol.21
, pp. 115-118
-
-
Morales, C.P.1
Holt, S.E.2
Ouellette, M.3
Kaur, K.J.4
Van, Y.5
Wilson, K.S.6
-
17
-
-
0033614998
-
Creation of human tumor cells with defined genetic elements
-
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumor cells with defined genetic elements. Nature 1999; 400: 464-468.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
18
-
-
0034660513
-
Risky immortalization by telomerase
-
Wang J, Hannon GJ, Beach DH. Risky immortalization by telomerase. Nature 2000; 405: 755-756.
-
(2000)
Nature
, vol.405
, pp. 755-756
-
-
Wang, J.1
Hannon, G.J.2
Beach, D.H.3
-
19
-
-
0033614980
-
Rebuilding the road to cancer
-
Weitzman JB, Yaniv M. Rebuilding the road to cancer. Nature 1999; 400: 401-402.
-
(1999)
Nature
, vol.400
, pp. 401-402
-
-
Weitzman, J.B.1
Yaniv, M.2
-
20
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
Hahn CW, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999; 5: 1164-1170.
-
(1999)
Nat. Med.
, vol.5
, pp. 1164-1170
-
-
Hahn, C.W.1
Stewart, S.A.2
Brooks, M.W.3
York, S.G.4
Eaton, E.5
Kurachi, A.6
-
21
-
-
0033568462
-
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
-
Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 1999; 13: 2388-2399.
-
(1999)
Genes Dev.
, vol.13
, pp. 2388-2399
-
-
Zhang, X.1
Mar, V.2
Zhou, W.3
Harrington, L.4
Robinson, M.O.5
-
22
-
-
0025817238
-
Establishment of a novel heterotransplantable acute lymphoblastic leukemia cell line with a t(17;19) chromosomal translocation the growth of which is inhibited by interleukin-3
-
Ohyashiki K, Fujieda H, Miyauchi J, Ohyashiki JH, Tauchi T, Saito M et al. Establishment of a novel heterotransplantable acute lymphoblastic leukemia cell line with a t(17;19) chromosomal translocation the growth of which is inhibited by interleukin-3. Leukemia 1991; 5: 322-331.
-
(1991)
Leukemia
, vol.5
, pp. 322-331
-
-
Ohyashiki, K.1
Fujieda, H.2
Miyauchi, J.3
Ohyashiki, J.H.4
Tauchi, T.5
Saito, M.6
-
23
-
-
0035108553
-
CIS1, a cytokine-inducible SH2 protein, suppresses BCR-ABL-mediated transformation: Involvement of the ubiquitin proteasome pathway
-
Tauchi T, Yoshimura A, Ohyashiki K. CIS1, a cytokine-inducible SH2 protein, suppresses BCR-ABL-mediated transformation: involvement of the ubiquitin proteasome pathway. Exp Hematol 2001; 29: 356-361.
-
(2001)
Exp. Hematol.
, vol.29
, pp. 356-361
-
-
Tauchi, T.1
Yoshimura, A.2
Ohyashiki, K.3
-
24
-
-
0029790435
-
A nonradioactive. fluorescence-based telomeric repeat amplification protocol to detect and quantitate telomerase activity
-
Ohyashiki JH, Ohyashiki K, Toyama K, Shay JW. A nonradioactive. fluorescence-based telomeric repeat amplification protocol to detect and quantitate telomerase activity. Trends Genet 1996; 12: 395-396.
-
(1996)
Trends Genet.
, vol.12
, pp. 395-396
-
-
Ohyashiki, J.H.1
Ohyashiki, K.2
Toyama, K.3
Shay, J.W.4
-
25
-
-
0032490118
-
Telomerase activity in lung cancer cells obtained from bronchial washings
-
Yahata N, Ohyashiki K, Ohyashiki JH, Iwama H, Hayashi S, Ando K et al. Telomerase activity in lung cancer cells obtained from bronchial washings. J Natl Cancer Inst 1998; 90: 684-690.
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 684-690
-
-
Yahata, N.1
Ohyashiki, K.2
Ohyashiki, J.H.3
Iwama, H.4
Hayashi, S.5
Ando, K.6
-
26
-
-
0031922795
-
Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals
-
Iwama H, Ohyashiki K, Ohyashiki JH, Hayashi S, Yahata N, Ando K et al. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum Genet 1998; 102: 397-402.
-
(1998)
Hum. Genet.
, vol.102
, pp. 397-402
-
-
Iwama, H.1
Ohyashiki, K.2
Ohyashiki, J.H.3
Hayashi, S.4
Yahata, N.5
Ando, K.6
-
27
-
-
0034988035
-
ABL-specific tyrosine kinase inhibitor, STI571 in vitro, affects Ph-positive acute lymphoblastic leukemia and chronic myelogenous leukemia in blastic crisis
-
Nakajima A, Tauchi T, Ohyashiki K. ABL-specific tyrosine kinase inhibitor, STI571 in vitro, affects Ph-positive acute lymphoblastic leukemia and chronic myelogenous leukemia in blastic crisis. Leukemia 2001; 15: 989-990.
-
(2001)
Leukemia
, vol.15
, pp. 989-990
-
-
Nakajima, A.1
Tauchi, T.2
Ohyashiki, K.3
-
28
-
-
0345643319
-
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
-
Rufer N, Brummendorf TH, Kolvraa S, Bischoff C, Christensen K, Wadsworth L et al. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 1999; 190: 157-167.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 157-167
-
-
Rufer, N.1
Brummendorf, T.H.2
Kolvraa, S.3
Bischoff, C.4
Christensen, K.5
Wadsworth, L.6
-
29
-
-
0035857396
-
Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus
-
Shin-ya K, Wierzba K, Matsuo K, Ohtani T, Yamada Y, Furihata K et al. Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am ChemSoc 2001; 123: 1262-1263.
-
(2001)
J. Am. ChemSoc.
, vol.123
, pp. 1262-1263
-
-
Shin-ya, K.1
Wierzba, K.2
Matsuo, K.3
Ohtani, T.4
Yamada, Y.5
Furihata, K.6
-
30
-
-
0037070575
-
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
-
Kim MY, Vankayalapati H, Shin-ya K, Wierzba K, Hurley LH. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex. J Am Chem Soc 2002; 124: 2098-2099.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 2098-2099
-
-
Kim, M.Y.1
Vankayalapati, H.2
Shin-ya, K.3
Wierzba, K.4
Hurley, L.H.5
-
31
-
-
0030681073
-
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
-
Kilian A, Bowtell DD, Abud HE, Hime GR, Venter DJ, Keese PK et al. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet 1997; 6: 2011-2019.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 2011-2019
-
-
Kilian, A.1
Bowtell, D.D.2
Abud, H.E.3
Hime, G.R.4
Venter, D.J.5
Keese, P.K.6
-
32
-
-
0032530136
-
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
-
Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res 1998; 58: 4168-172.
-
(1998)
Cancer Res.
, vol.58
, pp. 4168-4172
-
-
Ulaner, G.A.1
Hu, J.F.2
Vu, T.H.3
Giudice, L.C.4
Hoffman, A.R.5
-
33
-
-
0033577876
-
Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
-
Wick M, Zubov D, Hagen G. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 1999; 232: 97-106.
-
(1999)
Gene
, vol.232
, pp. 97-106
-
-
Wick, M.1
Zubov, D.2
Hagen, G.3
-
34
-
-
0034352944
-
The hTERT alpha splice variant is a dominant negative inhibitor of telomerase activity
-
Colgin LM, Wilkinson C, Englezou A, Kilian A, Robinson MO, Reddel RR. The hTERT alpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia 2000; 2: 426-432.
-
(2000)
Neoplasia
, vol.2
, pp. 426-432
-
-
Colgin, L.M.1
Wilkinson, C.2
Englezou, A.3
Kilian, A.4
Robinson, M.O.5
Reddel, R.R.6
-
36
-
-
0030938901
-
Reverse transcriptase motifs in the catalytic subunit of telomerase
-
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 1997; 276: 561-567.
-
(1997)
Science
, vol.276
, pp. 561-567
-
-
Lingner, J.1
Hughes, T.R.2
Shevchenko, A.3
Mann, M.4
Lundblad, V.5
Cech, T.R.6
-
37
-
-
0035878750
-
Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells
-
Sachsinger J, Gonzalez-Suarez E, Samper E, Heicappell R, Muller M, Blasco MA. Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells. Cancer Res 2001; 61: 5580-5586.
-
(2001)
Cancer Res.
, vol.61
, pp. 5580-5586
-
-
Sachsinger, J.1
Gonzalez-Suarez, E.2
Samper, E.3
Heicappell, R.4
Muller, M.5
Blasco, M.A.6
-
38
-
-
0032765047
-
Studies of the molecular mechanisms in the regulation of telomerase activity
-
Liu JP. Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 1999; 13: 2091-2104.
-
(1999)
FASEB J.
, vol.13
, pp. 2091-2104
-
-
Liu, J.P.1
-
39
-
-
0029810884
-
Telomerase regulation during entry into the cell cycle in normal human T cells
-
Buchkovich KJ, Greider CW. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell 1996; 7: 1443-1454.
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 1443-1454
-
-
Buchkovich, K.J.1
Greider, C.W.2
-
40
-
-
0032566005
-
Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
-
Kondo S, Kondo Y, Li G, Silverman RH, Cowell JK. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene 1998; 16: 3323-3330.
-
(1998)
Oncogene
, vol.16
, pp. 3323-3330
-
-
Kondo, S.1
Kondo, Y.2
Li, G.3
Silverman, R.H.4
Cowell, J.K.5
-
42
-
-
4243937106
-
A highly selective telomerase inhibitor limiting human cancer cell proliferation
-
Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, Priepke H et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J 2001; 20: 6958-6968.
-
(2001)
EMBO J.
, vol.20
, pp. 6958-6968
-
-
Damm, K.1
Hemmann, U.2
Garin-Chesa, P.3
Hauel, N.4
Kauffmann, I.5
Priepke, H.6
-
44
-
-
0035853058
-
Telomere dysfunction alters the chemotherapeutic profile of transformed cells
-
Lee KH, Rudolph KL, Ju YJ, Greenberg RA, Cannizzaro L et al. Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc Natl Acad Sci USA 2001; 98: 3381-3386.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3381-3386
-
-
Lee, K.H.1
Rudolph, K.L.2
Ju, Y.J.3
Greenberg, R.A.4
Cannizzaro, L.5
-
46
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000; 406: 641-645.
-
(2000)
Nature
, vol.406
, pp. 641-645
-
-
Artandi, S.E.1
Chang, S.2
Lee, S.L.3
Alson, S.4
Gottlieb, G.J.5
Chin, L.6
-
47
-
-
0033834247
-
Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology
-
Wright WE, Shay JW. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 2000; 6: 849-851.
-
(2000)
Nat. Med.
, vol.6
, pp. 849-851
-
-
Wright, W.E.1
Shay, J.W.2
|