Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: Activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents

Molecular Pharmacology

Volumn 68, Issue 6, 2005, Pages 1551-1558

  Cookson, Jennifer C ^a   Dai, Fangping ^b   Smith, Victoria ^b   Heald, Robert A ^a   Laughton, Charles A ^a   Stevens, Malcolm F G ^a   Burger, Angelika M ^b,c  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Institute for Experimental Oncology   (Germany)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; 3,11 DIFLUORO 6,8,13 TRIMETHYL 8H QUINO[4,3,2 KL]ACRIDINIUM METHOSULFATE; CISPLATIN; DOXORUBICIN; GEMCITABINE; HEAT SHOCK PROTEIN; PACLITAXEL; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SENSITIVITY ANALYSIS; TELOMERE; TUMOR CELL; TUMOR XENOGRAFT;

ACRIDINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA-BINDING PROTEINS; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; PHARMACOKINETICS; TELOMERASE; TELOMERE;

EID: 27844521369     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.013300     Document Type: Article

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