Antitumor polycyclic acridines. 8. Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts

Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2002, Pages 590-597

  Heald, Robert A ^a   Modi, Chetna ^a   Cookson, Jenny C ^a   Hutchinson, Ian ^a   Laughton, Charles A ^a   Gowan, Sharon M ^b   Kelland, Lloyd R ^b   Stevens, Malcolm F G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,11 DIFLUORO 6,8,13 TRIMETHYL 8H QUINO[4,3,2 KL]ACRIDINIUM METHOSULFATE; 3,6,8,11,13 PENTAMETHYL 8H QUINO[4,3,2 KL]ACRIDINIUM METHOSULFATE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA; NSC 714186; NSC 714187; POLYCYCLIC AROMATIC COMPOUND; TAQ POLYMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA STRUCTURE; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; METHYLATION; PH; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; TUMOR CELL LINE;

ACRIDINES; CELL NUCLEUS; CRYSTALLOGRAPHY, X-RAY; DNA; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 0037203972     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011015q     Document Type: Article

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