Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity

Journal of Medicinal Chemistry

Volumn 48, Issue 23, 2005, Pages 7198-7207

  Cookson, Jennifer C ^a   Heald, Robert A ^a   Stevens, Malcolm F G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 METHYLQUINO[4,3,2, KL]ACRIDINE DERIVATIVE; 8,13 DIMETHYLQUINO[4,3,2 KL]ACRIDINIUM IODIDE DERIVATIVE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; PALLADIUM; POLYCYCLIC HYDROCARBON; PROPANE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL NUCLEUS; CELL STRAIN MCF 7; CELLULAR DISTRIBUTION; CULTURE MEDIUM; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROMETRY; LIVER MICROSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS; TELOMERE; TISSUE CULTURE;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; FLOW CYTOMETRY; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MICROSCOPY, CONFOCAL; MICROSOMES, LIVER; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 27844466279     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm058031y     Document Type: Article

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