Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

Journal of Molecular Biology

Volumn 334, Issue 1, 2003, Pages 25-36

  Gavathiotis, Evripidis ^a,b   Heald, Robert A ^a   Stevens, Malcolm F G ^a   Searle, Mark S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Molecular dynamics; NMR spectroscopy; Quadruplex DNA; Quinoacridinium cation; Telomerase inhibition

Indexed keywords

3,11 DIFLUORO 6,8,13 TRIMETHYL 8H QUINO[4,3,2 KL]ACRIDINIUM METHYLSULFATE; ACRIDINE DERIVATIVE; POTASSIUM ION; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DENSITY; DNA STRAND; ENZYME INHIBITION; FLUORINATION; HUMAN; INTERCALATION COMPLEX; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

EID: 0142195770     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.09.018     Document Type: Article

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