Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties

ChemMedChem

Volumn 5, Issue 4, 2010, Pages 575-583

  Alcaro, Stefano ^a   Artese, Anna ^a   Iley, James N ^b   Missailidis, Sotiris ^b   Ortuso, Francesco ^a   Parrotta, Lucia ^a   Pasceri, Raffaele ^a   Paduano, Francesco ^a   Sissi, Claudia ^c   Trapasso, Rancesco ^a   Vigorita, Maria Gabriella ^d  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b OPEN UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF PADOVA   (Italy)

^d UNIVERSITY OF MESSINA   (Italy)

Author keywords

Docking; Fluorenones; G quadruplex binders; Morpholine; Telomeres

Indexed keywords

4 METHYL [ 4 [2 [(9 OXO 9H 2 FLUORENYL)CARBONYL]AMINO]ETHYL] 1,4 OXAZINAN 4 IUM IODIDE; 4 METHYL [ 4 [3 [(9 OXO 9H 4 FLUORENYL)CARBONYL]AMINO]PROPYL] 1,4 OXAZINAN 4 IUM IODIDE; 4 METHYL [4 [2 [(9 OXO 9H 4 FLUORENYL)CARBONYL]AMINO]ETHYL) 1,4 OXAZINAN 4 IUM IODIDE; 4 METHYL [4 [3 [(9 OXO 9H 2 FLUORENYL)CARBONYL]AMINO]ETHYL] 1,4 OXAZINAN 4 IUM IODIDE; AMIDE; CATION; FLUORENONE DERIVATIVE; GUANINE QUADRUPLEX; N [2 (4 MORPHOLINYL)ETHYL] 9 OXO 9H FLUORENE 2 CARBOXAMIDE; N [2 (4 MORPHOLINYL)ETHYL] 9 OXO 9H FLUORENE 4 CARBOXAMIDE; N [3 (4 MORPHOLINYL)PROPYL] 9 OXO 9H FLUORENE 2 CARBOXAMIDE; N [3 (4 MORPHOLINYL)PROPYL] 9 OXO 9H FLUORENE 4 CARBOXAMIDE; N MORPHOLINYL 9 OXO 9H FLUORENE 2 CARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; DNA BINDING; DNA SEQUENCE; DRUG BINDING; DRUG DESIGN; DRUG DNA BINDING; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DATABASES, PROTEIN; DNA; DRUG DESIGN; FLUORENES; G-QUADRUPLEXES; HUMANS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERE;

EID: 77950638598     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900541     Document Type: Article

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