9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5493-5501

  Zhang, Wan Jin ^a   Ou, Tian Miao ^a   Lu, Yu Jing ^a   Huang, Ying Yu ^a   Wu, Wei Bin ^a   Huang, Zhi Shu ^a   Zhou, Jin Lin ^a   Wong, Kwok Yin ^b,c   Gu, Lian Quan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b State Key Laboratory of Chinese Medicine and Molecular Pharmacology   (China)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

9 Substituted berberine; Synthesis; Telomerase inhibitor; Telomeric G quadruplex DNA

Indexed keywords

9 O 2 (DIETHYLAMINO)ETHYLBERBERINE; 9 O 2 (DIISOPROPYLAMINO)ETHYLBERBERINE; 9 O 3 (1 PIPERAZINYL)PROPYLBERBERINE; 9 O 3 (1 PIPERIDIN)PROPYLBERBERINE; 9 O 3 (4 MORPHILIN)PROPYLBERBERINE; 9 O 3 (DIETHYLAMINO)PROPYLBERBERINE; 9 O 3 (DIMETHYLAMINO)PROPYLBERBERINE; AMINE; BERBERINE; BERBERINE DERIVATIVE; CARBENE; DNA; LIGAND; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; COMPARATIVE STUDY; CONTROLLED STUDY; DERIVATIZATION; DIALYSIS; DRUG DNA INTERACTION; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; HUMAN; PHARMACOLOGICAL BLOCKING; POLYMERASE CHAIN REACTION; SUBSTITUTION REACTION; TELOMERE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

BERBERINE; CATIONS; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; GENE AMPLIFICATION; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; METALS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE; TELOMERE;

EID: 34250782208     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.050     Document Type: Article

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