Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation

Journal of Medicinal Chemistry

Volumn 49, Issue 2, 2006, Pages 582-599

  Moore, Michael J B ^a   Schultes, Christoph M ^a,c   Cuesta, Javier ^a,d   Cuenca, Francisco ^a   Gunaratnam, Mekala ^a   Tanious, Farial A ^b   Wilson, W David ^b   Neidle, Stephen ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b GEORGIA STATE UNIVERSITY   (United States)

^c University of Göttingen   (Germany)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3,6 [4 (PYRROLIDIN 1 YL)BUTANAMIDO] 9 [4' (N,N DIMETHYLAMINO)ANILINO]ACRIDINE; 3,6 BIS[3 (PYRROLIDIN 1 YL)PROPIONAMIDO] 9 [4' [2'' (PYRROLIDIN 1YL)ACETAMIDO]ANILINO]ACRIDINE; 3,6 BIS[3 (PYRROLIDIN 1 YL)PROPIONAMIDO] 9 [4' [3'' (PYRROLIDIN 1 YL)BUTANAMIDO]ANILINO]ACRIDINE; 3,6 BIS[3 (PYRROLIDIN 1 YL)PROPIONAMIDO] 9 [4' [3'' (PYRROLIDIN 1 YL)PROPANAMIDO]ANILINO]ACRIDINE; 3,6 BIS[4 (PYRROLIDIN 1 YL)BUTANAMIDO] 9 [4' [3'' (PYRROLIDIN 1 YL)PROPANAMIDO]ANILINO]ACRIDINE; 3,6 BIS[4 (PYRROLIDIN 1 YL)HEXANAMIDO] 9 [4' [3'' (PYRROLIDIN 1YL)PROPANAMIDO]ANILINO]ACRIDINE; 3,6 BIS[5 (PYRROLIDIN 1 YL)HEXANAMIDO] 9 [4' (N,N DIMETHYLAMINO)ANILINO]ACRIDINE; 3,6 BIS[5 (PYRROLIDIN 1 YL)PENTANAMIDO] 9 [4' (N,N DIMETHYLAMINO)ANILINO]ACRIDINE; 3,6 BIS[5 (PYRROLIDIN 1 YL)PENTANAMIDO] 9 [4' [3'' (PYRROLIDIN 1 YL)PROPANAMIDO]ANILINO]ACRIDINE; ACRIDINE DERIVATIVE; G QUADRUPLEX TELOMERE TARGETING AGENT; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; MOLECULAR DYNAMICS; MOLECULAR MODEL; QUALITATIVE ANALYSIS; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; TELOMERE;

ACRIDINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; LIGANDS; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUANTUM THEORY; SURFACE PLASMON RESONANCE; TELOMERASE; TELOMERE;

EID: 31544446381     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050555a     Document Type: Article

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