Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 3880-3888

  Laronze Cochard, Marie ^a   Kim, Young Min ^a   Brassart, Bertrand ^a   Riou, Jean François ^b   Laronze, Jean Yves ^a   Sapi, Janos ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b CNRS   (France)

Author keywords

4,5 Disubstituted acridine; G quadruplex ligand; Telomere

Indexed keywords

3,6 BIS(AMINOALKYL)ACRIDINE DERIVATIVE; 4,5 BIS[3 (N,N DIMETHYLAMINO)PROPYLAMINOMETHYL]ACRIDINE; ACRIDINE DERIVATIVE; BRACO 19; GUANINE QUADRUPLEX; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; MELTING POINT; TELOMERE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

ACRIDINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEXES; HUMANS; LIGANDS; MOLECULAR STRUCTURE; NUCLEIC ACID DENATURATION; TELOMERASE; TELOMERE;

EID: 67749103504     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.021     Document Type: Article

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