The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: Implications for drug targeting and control of gene expression

Journal of Medicinal Chemistry

Volumn 52, Issue 9, 2009, Pages 2863-2874

  Sun, Daekyu ^a,b,c   Hurley, Laurence H ^a,b,c  

^a UNIVERSITY OF ARIZONA   (United States)

^b BIO5 Institute   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMINE; DEOXYRIBONUCLEASE I; DIMETHYL SULFOXIDE; FAR UPSTREAM ELEMENT; GUANINE QUADRUPLEX; NUCLEASE HYPERSENSITIVE ELEMENT III1; NUCLEASE S1; PERMANGANATE POTASSIUM; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; DNA FLANKING REGION; DNA FOOTPRINTING; DNA HELIX; DNA SEQUENCE; DNA STRUCTURE; DNA SUPERCOILING; DRUG TARGETING; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; ONCOGENE C MYC; PLASMID; PROMOTER REGION; TRANSCRIPTION REGULATION;

BASE COMPOSITION; BASE SEQUENCE; BROMINE; DEOXYRIBONUCLEASE I; DNA, SINGLE-STRANDED; DNA, SUPERHELICAL; DRUG DESIGN; G-QUADRUPLEXES; GENE EXPRESSION REGULATION; GENES, MYC; HUMANS; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; POTASSIUM CHLORIDE; POTASSIUM PERMANGANATE; PROMOTER REGIONS, GENETIC; SINGLE-STRAND SPECIFIC DNA AND RNA ENDONUCLEASES; SPHINGOSINE; TRANSCRIPTION, GENETIC;

EID: 65649089445     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900055s     Document Type: Article

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