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Volumn 20, Issue 6, 2012, Pages 481-501

Strategies for non-invasive delivery of biologics

Author keywords

Biologic; Drug delivery; Macromolecule; Nasal; Oral; Pulmonary

Indexed keywords

CALCITONIN; CARRIER PROTEIN; CHITOSAN; DESLORELIN; ENOXAPARIN; HUMAN GROWTH HORMONE; INSULIN; LIPOSOME; LOW MOLECULAR WEIGHT HEPARIN; PENETRATION ENHANCING AGENT; POLYACRYLIC ACID; PROTEINASE INHIBITOR; PROTIRELIN; RECOMBINANT HUMAN INSULIN; TESTOSTERONE; TRANSFERRIN;

EID: 84861805671     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2012.693499     Document Type: Review
Times cited : (48)

References (262)
  • 1
    • 0033047323 scopus 로고    scopus 로고
    • Stability and surface activity of lactate dehydrogenase in spray-dried trehalose
    • Adler M, Lee G. (1999). Stability and surface activity of lactate dehydrogenase in spray-dried trehalose. J Pharm Sci, 88, 199-208.
    • (1999) J Pharm Sci , vol.88 , pp. 199-208
    • Adler, M.1    Lee, G.2
  • 2
    • 0029102179 scopus 로고
    • Passive difusion of weak organic electrolytes across Caco-2 cell monolayers: Uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers
    • Adson A, Burton PS, Raub TJ, Barsuhn CL, Audus KL, Ho NF. (1995). Passive difusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers. J Pharm Sci, 84, 1197-1204.
    • (1995) J Pharm Sci , vol.84 , pp. 1197-1204
    • Adson, A.1    Burton, P.S.2    Raub, T.J.3    Barsuhn, C.L.4    Audus, K.L.5    Ho, N.F.6
  • 3
    • 84857357652 scopus 로고    scopus 로고
    • Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations
    • Al-Qadi S, Grenha A, Carrión-Recio D, Seijo B, Remuñán-López C. (2012). Microencapsulated chitosan nanoparticles for pulmonary protein delivery: in vivo evaluation of insulin-loaded formulations. J Control Release, 157, 383-390.
    • (2012) J Control Release , vol.157 , pp. 383-390
    • Al-Qadi, S.1    Grenha, A.2    Carrión-Recio, D.3    Seijo, B.4    Remuñán-López, C.5
  • 5
    • 72149095736 scopus 로고    scopus 로고
    • Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats
    • Amet N, Wang W, Shen WC. (2010). Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats. J Control Release, 141, 177-182.
    • (2010) J Control Release , vol.141 , pp. 177-182
    • Amet, N.1    Wang, W.2    Shen, W.C.3
  • 7
    • 0031784906 scopus 로고    scopus 로고
    • Nasal insulin delivery in rabbits using soybean-derived sterylglucoside and sterol mixtures as novel enhancers in suspension dosage forms
    • Ando T, Maitani Y, Yamamoto T, Takayama K, Nagai T. (1998). Nasal insulin delivery in rabbits using soybean-derived sterylglucoside and sterol mixtures as novel enhancers in suspension dosage forms. Biol Pharm Bull, 21, 862-865.
    • (1998) Biol Pharm Bull , vol.21 , pp. 862-865
    • Ando, T.1    Maitani, Y.2    Yamamoto, T.3    Takayama, K.4    Nagai, T.5
  • 8
    • 0033840471 scopus 로고    scopus 로고
    • Predicting human oral bioavailability of a compound: Development of a novel quantitative structure-bioavailability relationship
    • Andrews CW, Bennett L, Yu LX. (2000). Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship. Pharm Res, 17, 639-644.
    • (2000) Pharm Res , vol.17 , pp. 639-644
    • Andrews, C.W.1    Bennett, L.2    Yu, L.X.3
  • 10
    • 0030791920 scopus 로고    scopus 로고
    • The efect of chronic nasal application of chitosan solutions on cilia beat frequency in guinea pigs
    • Aspden T, Illum L, Skaugrud O. (1997a). The efect of chronic nasal application of chitosan solutions on cilia beat frequency in guinea pigs. Int J Pharm, 153:137-146.
    • (1997) Int J Pharm , vol.153 , pp. 137-146
    • Aspden, T.1    Illum, L.2    Skaugrud, O.3
  • 11
    • 0031004232 scopus 로고    scopus 로고
    • Chitosan as a nasal delivery system: The efect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers
    • Aspden TJ, Mason JD, Jones NS, Lowe J, Skaugrud O, Illum L. (1997b). Chitosan as a nasal delivery system: the efect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers. J Pharm Sci, 86, 509-513.
    • (1997) J Pharm Sci , vol.86 , pp. 509-513
    • Aspden, T.J.1    Mason, J.D.2    Jones, N.S.3    Lowe, J.4    Skaugrud, O.5    Illum, L.6
  • 12
    • 0033816196 scopus 로고    scopus 로고
    • Intestinal permeation enhancers
    • Aungst BJ. (2000). Intestinal permeation enhancers. J Pharm Sci, 89, 429-442.
    • (2000) J Pharm Sci , vol.89 , pp. 429-442
    • Aungst, B.J.1
  • 13
    • 42649137232 scopus 로고    scopus 로고
    • Targeted delivery of nanoparticles for the treatment of lung diseases
    • Azarmi S, Roa WH, Löbenberg R. (2008). Targeted delivery of nanoparticles for the treatment of lung diseases. Adv Drug Deliv Rev, 60, 863-875.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 863-875
    • Azarmi, S.1    Roa, W.H.2    Löbenberg, R.3
  • 14
    • 60049089372 scopus 로고    scopus 로고
    • Synthesis and evaluation of pegylated dendrimeric nanocarrier for pulmonary delivery of low molecular weight heparin
    • Bai S, Ahsan F. (2009). Synthesis and evaluation of pegylated dendrimeric nanocarrier for pulmonary delivery of low molecular weight heparin. Pharm Res, 26, 539-548.
    • (2009) Pharm Res , vol.26 , pp. 539-548
    • Bai, S.1    Ahsan, F.2
  • 15
    • 77951135527 scopus 로고    scopus 로고
    • Inhalable lactose-based dry powder formulations of low molecular weight heparin
    • Bai S, Gupta V, Ahsan F. (2010). Inhalable lactose-based dry powder formulations of low molecular weight heparin. J Aerosol Med Pulm Drug Deliv, 23, 97-104.
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , pp. 97-104
    • Bai, S.1    Gupta, V.2    Ahsan, F.3
  • 16
    • 34548026026 scopus 로고    scopus 로고
    • Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin
    • Bai S, Tomas C, Ahsan F. (2007). Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin. J Pharm Sci, 96, 2090-2106.
    • (2007) J Pharm Sci , vol.96 , pp. 2090-2106
    • Bai, S.1    Tomas, C.2    Ahsan, F.3
  • 17
    • 62649101845 scopus 로고    scopus 로고
    • Pure insulin nanoparticle agglomerates for pulmonary delivery
    • Bailey MM, Gorman EM, Munson EJ, Berkland C. (2008). Pure insulin nanoparticle agglomerates for pulmonary delivery. Langmuir, 24, 13614-13620.
    • (2008) Langmuir , vol.24 , pp. 13614-13620
    • Bailey, M.M.1    Gorman, E.M.2    Munson, E.J.3    Berkland, C.4
  • 18
    • 0038001512 scopus 로고    scopus 로고
    • Biotin uptake by human intestinal and liver epithelial cells: Role of the SMVT system
    • Balamurugan K, Ortiz A, Said HM. (2003). Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. Am J Physiol Gastrointest Liver Physiol, 285, G73-G77.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Balamurugan, K.1    Ortiz, A.2    Said, H.M.3
  • 19
    • 0022545796 scopus 로고
    • Transferrin receptors in the human gastrointestinal tract. Relationship to body iron stores
    • Banerjee D, Flanagan PR, Cluett J, Valberg LS. (1986). Transferrin receptors in the human gastrointestinal tract. Relationship to body iron stores. Gastroenterology, 91, 861-869.
    • (1986) Gastroenterology , vol.91 , pp. 861-869
    • Banerjee, D.1    Flanagan, P.R.2    Cluett, J.3    Valberg, L.S.4
  • 20
    • 67650033008 scopus 로고    scopus 로고
    • Characteristics of compounds that cross the blood-brain barrier
    • Banks WA. (2009). Characteristics of compounds that cross the blood-brain barrier. BMC Neurol, 9 Suppl 1, S3.
    • (2009) BMC Neurol , vol.9 , Issue.SUPPL. 1
    • Banks, W.A.1
  • 21
    • 26644452975 scopus 로고    scopus 로고
    • Tiomers: A new generation of mucoadhesive polymers
    • Bernkop-Schnürch A. (2005). Tiomers: a new generation of mucoadhesive polymers. Adv Drug Deliv Rev, 57, 1569-1582.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1569-1582
    • Bernkop-Schnürch, A.1
  • 23
    • 0035813815 scopus 로고    scopus 로고
    • Chemically modifed chitosans as enzyme inhibitors
    • Bernkop-Schnürch A, Kast CE. (2001). Chemically modifed chitosans as enzyme inhibitors. Adv Drug Deliv Rev, 52, 127-137.
    • (2001) Adv Drug Deliv Rev , vol.52 , pp. 127-137
    • Bernkop-Schnürch, A.1    Kast, C.E.2
  • 24
    • 0141551200 scopus 로고    scopus 로고
    • Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: Thiomer/GSH systems
    • Bernkop-Schnürch A, Kast CE, Guggi D. (2003). Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release, 93, 95-103.
    • (2003) J Control Release , vol.93 , pp. 95-103
    • Bernkop-Schnürch, A.1    Kast, C.E.2    Guggi, D.3
  • 25
    • 55849123635 scopus 로고    scopus 로고
    • Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery
    • Bi R, Shao W, Wang Q, Zhang N. (2008). Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery. J Drug Target, 16, 639-648.
    • (2008) J Drug Target , vol.16 , pp. 639-648
    • Bi, R.1    Shao, W.2    Wang, Q.3    Zhang, N.4
  • 26
    • 67649764422 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as insulin inhalation carriers for enhanced pulmonary delivery
    • Bi R, Shao W, Wang Q, Zhang N. (2009). Solid lipid nanoparticles as insulin inhalation carriers for enhanced pulmonary delivery. J Biomed Nanotechnol, 5, 84-92.
    • (2009) J Biomed Nanotechnol , vol.5 , pp. 84-92
    • Bi, R.1    Shao, W.2    Wang, Q.3    Zhang, N.4
  • 27
    • 1142309558 scopus 로고    scopus 로고
    • Lectin-mediated drug targeting: History and applications
    • Bies C, Lehr CM, Woodley JF. (2004). Lectin-mediated drug targeting: history and applications. Adv Drug Deliv Rev, 56, 425-435.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 425-435
    • Bies, C.1    Lehr, C.M.2    Woodley, J.F.3
  • 28
    • 14844317382 scopus 로고    scopus 로고
    • Strategic approaches for overcoming peptide and protein instability within biodegradable nano-and microparticles
    • Bilati U, Allémann E, Doelker E. (2005). Strategic approaches for overcoming peptide and protein instability within biodegradable nano-and microparticles. Eur J Pharm Biopharm, 59, 375-388.
    • (2005) Eur J Pharm Biopharm , vol.59 , pp. 375-388
    • Bilati, U.1    Allémann, E.2    Doelker, E.3
  • 29
    • 34547681735 scopus 로고    scopus 로고
    • Chitosan and trimethyl chitosan chloride (TMC) as adjuvants for inducing immune responses to ovalbumin in mice following nasal administration
    • Boonyo W, Junginger HE, Waranuch N, Polnok A, Pitaksuteepong T. (2007). Chitosan and trimethyl chitosan chloride (TMC) as adjuvants for inducing immune responses to ovalbumin in mice following nasal administration. J Control Release, 121, 168-175.
    • (2007) J Control Release , vol.121 , pp. 168-175
    • Boonyo, W.1    Junginger, H.E.2    Waranuch, N.3    Polnok, A.4    Pitaksuteepong, T.5
  • 30
    • 0035936969 scopus 로고    scopus 로고
    • Infuence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance
    • Bosquillon C, Lombry C, Préat V, Vanbever R. (2001). Infuence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J Control Release, 70, 329-339.
    • (2001) J Control Release , vol.70 , pp. 329-339
    • Bosquillon, C.1    Lombry, C.2    Préat, V.3    Vanbever, R.4
  • 31
    • 33846799473 scopus 로고    scopus 로고
    • Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles
    • Bravo-Osuna I, Vauthier C, Farabollini A, Palmieri GF, Ponchel G. (2007). Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles. Biomaterials, 28, 2233-2243.
    • (2007) Biomaterials , vol.28 , pp. 2233-2243
    • Bravo-Osuna, I.1    Vauthier, C.2    Farabollini, A.3    Palmieri, G.F.4    Ponchel, G.5
  • 32
    • 13844256698 scopus 로고    scopus 로고
    • Tat peptide-mediated cellular delivery: Back to basics
    • Brooks H, Lebleu B, Vivès E. (2005). Tat peptide-mediated cellular delivery: back to basics. Adv Drug Deliv Rev, 57, 559-577.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 559-577
    • Brooks, H.1    Lebleu, B.2    Vivès, E.3
  • 33
    • 79955840998 scopus 로고    scopus 로고
    • Human growth hormone: New delivery systems, alternative routes of administration, and their pharmacological relevance
    • Cázares-Delgadillo J, Ganem-Rondero A, Kalia YN. (2011). Human growth hormone: new delivery systems, alternative routes of administration, and their pharmacological relevance. Eur J Pharm Biopharm, 78, 278-288.
    • (2011) Eur J Pharm Biopharm , vol.78 , pp. 278-288
    • Cázares-Delgadillo, J.1    Ganem-Rondero, A.2    Kalia, Y.N.3
  • 34
    • 11844288271 scopus 로고    scopus 로고
    • Infuence of molecular weight on oral absorption of water soluble chitosans
    • Chae SY, Jang MK, Nah JW. (2005). Infuence of molecular weight on oral absorption of water soluble chitosans. J Control Release, 102, 383-394.
    • (2005) J Control Release , vol.102 , pp. 383-394
    • Chae, S.Y.1    Jang, M.K.2    Nah, J.W.3
  • 35
    • 38949154100 scopus 로고    scopus 로고
    • Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery
    • Chae SY, Jin CH, Shin HJ, Youn YS, Lee S, Lee KC. (2008). Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery. Bioconjug Chem, 19, 334-341.
    • (2008) Bioconjug Chem , vol.19 , pp. 334-341
    • Chae, S.Y.1    Jin, C.H.2    Shin, H.J.3    Youn, Y.S.4    Lee, S.5    Lee, K.C.6
  • 36
    • 34447577190 scopus 로고    scopus 로고
    • Efective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
    • Chalasani KB, Russell-Jones GJ, Jain AK, Diwan P V, Jain SK. (2007). Efective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release, 122, 141-150.
    • (2007) J Control Release , vol.122 , pp. 141-150
    • Chalasani, K.B.1    Russell-Jones, G.J.2    Jain, A.K.3    Diwan, P.V.4    Jain, S.K.5
  • 37
    • 0027496885 scopus 로고
    • Chitosan matrix for oral sustained delivery of ampicillin
    • Chandy T, Sharma C P. (1993). Chitosan matrix for oral sustained delivery of ampicillin. Biomaterials, 14, 939-944.
    • (1993) Biomaterials , vol.14 , pp. 939-944
    • Chandy, T.1    Sharma, C.P.2
  • 39
    • 70349784917 scopus 로고    scopus 로고
    • The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin
    • Chen MC, Wong HS, Lin KJ, Chen HL, Wey SP, Sonaje K, Lin YH, Chu CY, Sung HW. (2009). The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials, 30, 6629-6637.
    • (2009) Biomaterials , vol.30 , pp. 6629-6637
    • Chen, M.C.1    Wong, H.S.2    Lin, K.J.3    Chen, H.L.4    Wey, S.P.5    Sonaje, K.6    Lin, Y.H.7    Chu, C.Y.8    Sung, H.W.9
  • 40
    • 77957018121 scopus 로고    scopus 로고
    • In vitro and in vivo characterisation of a novel peptide delivery system: Amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes
    • Cheng WP, Tompson C, Ryan SM, Aguirre T, Tetley L, Brayden DJ. (2010). In vitro and in vivo characterisation of a novel peptide delivery system: amphiphilic polyelectrolyte-salmon calcitonin nanocomplexes. J Control Release, 147, 289-297.
    • (2010) J Control Release , vol.147 , pp. 289-297
    • Cheng, W.P.1    Tompson, C.2    Ryan, S.M.3    Aguirre, T.4    Tetley, L.5    Brayden, D.J.6
  • 41
    • 59949091288 scopus 로고    scopus 로고
    • Evaluation of aerosol delivery of nanosuspension for pre-clinical pulmonary drug delivery
    • Chiang PC, Alsup JW, Lai Y, Hu Y, Heyde BR, Tung D. (2009). Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery. Nanoscale Res Lett, 4, 254-261.
    • (2009) Nanoscale Res Lett , vol.4 , pp. 254-261
    • Chiang, P.C.1    Alsup, J.W.2    Lai, Y.3    Hu, Y.4    Heyde, B.R.5    Tung, D.6
  • 42
    • 67349152120 scopus 로고    scopus 로고
    • Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery
    • Chono S, Fukuchi R, Seki T, Morimoto K. (2009). Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery. J Control Release, 137, 104-109.
    • (2009) J Control Release , vol.137 , pp. 104-109
    • Chono, S.1    Fukuchi, R.2    Seki, T.3    Morimoto, K.4
  • 43
    • 33750118934 scopus 로고    scopus 로고
    • Infuence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofoxacin incorporated into liposomes
    • Chono S, Tanino T, Seki T, Morimoto K. (2006). Infuence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofoxacin incorporated into liposomes. J Drug Target, 14, 557-566.
    • (2006) J Drug Target , vol.14 , pp. 557-566
    • Chono, S.1    Tanino, T.2    Seki, T.3    Morimoto, K.4
  • 44
    • 33846395107 scopus 로고    scopus 로고
    • Uptake characteristics of liposomes by rat alveolar macrophages: Infuence of particle size and surface mannose modifcation
    • Chono S, Tanino T, Seki T, Morimoto K. (2007). Uptake characteristics of liposomes by rat alveolar macrophages: infuence of particle size and surface mannose modifcation. J Pharm Pharmacol, 59, 75-80.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 75-80
    • Chono, S.1    Tanino, T.2    Seki, T.3    Morimoto, K.4
  • 45
    • 1842706398 scopus 로고    scopus 로고
    • Impact of formulation and methods of pulmonary delivery on absorption of parathyroid hormone (1-34) from rat lungs
    • Codrons V, Vanderbist F, Ucakar B, Préat V, Vanbever R. (2004). Impact of formulation and methods of pulmonary delivery on absorption of parathyroid hormone (1-34) from rat lungs. J Pharm Sci, 93, 1241-1252.
    • (2004) J Pharm Sci , vol.93 , pp. 1241-1252
    • Codrons, V.1    Vanderbist, F.2    Ucakar, B.3    Préat, V.4    Vanbever, R.5
  • 46
    • 0035815518 scopus 로고    scopus 로고
    • Oral immunisation with peptide and protein antigens by formulation in lipid vesicles incorporating bile salts (bilosomes)
    • Conacher M, Alexander J, Brewer JM. (2001). Oral immunisation with peptide and protein antigens by formulation in lipid vesicles incorporating bile salts (bilosomes). Vaccine, 19, 2965-2974.
    • (2001) Vaccine , vol.19 , pp. 2965-2974
    • Conacher, M.1    Alexander, J.2    Brewer, J.M.3
  • 47
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone RA. (2009). Barrier properties of mucus. Adv Drug Deliv Rev, 61, 75-85.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 75-85
    • Cone, R.A.1
  • 48
    • 0242288486 scopus 로고    scopus 로고
    • Absorption enhancers for nasal drug delivery
    • Davis SS, Illum L. (2003). Absorption enhancers for nasal drug delivery. Clin Pharmacokinet, 42, 1107-1128.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 1107-1128
    • Davis, S.S.1    Illum, L.2
  • 49
    • 5344233384 scopus 로고    scopus 로고
    • The efect of various liposome formulations on insulin penetration across Caco-2 cell monolayer
    • Degim Z, Unal N, Essiz D, Abbasoglu U. (2004). The efect of various liposome formulations on insulin penetration across Caco-2 cell monolayer. Life Sci, 75, 2819-2827.
    • (2004) Life Sci , vol.75 , pp. 2819-2827
    • Degim, Z.1    Unal, N.2    Essiz, D.3    Abbasoglu, U.4
  • 50
    • 0028239908 scopus 로고
    • The third helix of the Antennapedia homeodomain translocates through biological membranes
    • Derossi D, Joliot AH, Chassaing G, Prochiantz A. (1994). The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem, 269, 10444-10450.
    • (1994) J Biol Chem , vol.269 , pp. 10444-10450
    • Derossi, D.1    Joliot, A.H.2    Chassaing, G.3    Prochiantz, A.4
  • 51
    • 77949833508 scopus 로고    scopus 로고
    • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
    • Dhuria SV, Hanson LR, Frey WH 2nd. (2010). Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci, 99, 1654-1673.
    • (2010) J Pharm Sci , vol.99 , pp. 1654-1673
    • Dhuria, S.V.1    Hanson, L.R.2    Frey II, W.H.3
  • 52
    • 8644259904 scopus 로고    scopus 로고
    • Efects of diferent N-trimethyl chitosans on in vitro/in vivo ofoxacin transcorneal permeation
    • Di Colo G, Burgalassi S, Zambito Y, Monti D, Chetoni P. (2004). Efects of diferent N-trimethyl chitosans on in vitro/in vivo ofoxacin transcorneal permeation. J Pharm Sci, 93, 2851-2862.
    • (2004) J Pharm Sci , vol.93 , pp. 2851-2862
    • Di Colo, G.1    Burgalassi, S.2    Zambito, Y.3    Monti, D.4    Chetoni, P.5
  • 53
    • 48549107174 scopus 로고    scopus 로고
    • Polymeric enhancers of mucosal epithelia permeability: Syn
    • thesis, transepithelial penetration-enhancing properties, mechanism of action, safety issues
    • Di Colo G, Zambito Y, Zaino C. (2008). Polymeric enhancers of mucosal epithelia permeability: synthesis, transepithelial penetration-enhancing properties, mechanism of action, safety issues. J Pharm Sci, 97, 1652-1680.
    • (2008) J Pharm Sci , vol.97 , pp. 1652-1680
    • Di Colo, G.1    Zambito, Y.2    Zaino, C.3
  • 54
    • 51649104303 scopus 로고    scopus 로고
    • Towards quantitative prediction of oral drug absorption
    • Dressman JB, Telen K, Jantratid E. (2008). Towards quantitative prediction of oral drug absorption. Clin Pharmacokinet, 47, 655-667.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 655-667
    • Dressman, J.B.1    Telen, K.2    Jantratid, E.3
  • 55
    • 77954247722 scopus 로고    scopus 로고
    • Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride
    • du Plessis LH, Kotzé AF, Junginger HE. (2010a). Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride. Drug Deliv, 17, 399-407.
    • (2010) Drug Deliv , vol.17 , pp. 399-407
    • Du Plessis, L.H.1    Kotzé, A.F.2    Junginger, H.E.3
  • 56
    • 72149107329 scopus 로고    scopus 로고
    • Enhancement of nasal and intestinal calcitonin delivery by the novel Pheroid fatty acid based delivery system, and by N-trimethyl chitosan chloride
    • du Plessis LH, Lubbe J, Strauss T, Kotzé AF. (2010b). Enhancement of nasal and intestinal calcitonin delivery by the novel Pheroid fatty acid based delivery system, and by N-trimethyl chitosan chloride. Int J Pharm, 385, 181-186.
    • (2010) Int J Pharm , vol.385 , pp. 181-186
    • Du Plessis, L.H.1    Lubbe, J.2    Strauss, T.3    Kotzé, A.F.4
  • 58
    • 0031904113 scopus 로고    scopus 로고
    • Recent advances in pulmonary drug delivery using large, porous inhaled particles
    • Edwards DA, Ben-Jebria A, Langer R. (1998). Recent advances in pulmonary drug delivery using large, porous inhaled particles. J Appl Physiol, 85, 379-385.
    • (1998) J Appl Physiol , vol.85 , pp. 379-385
    • Edwards, D.A.1    Ben-Jebria, A.2    Langer, R.3
  • 60
    • 0023772572 scopus 로고
    • Alternative delivery systems for peptides and proteins as drugs
    • Eppstein DA, Longenecker JP. (1988). Alternative delivery systems for peptides and proteins as drugs. Crit Rev Ter Drug Carrier Syst, 5, 99-139.
    • (1988) Crit Rev ter Drug Carrier Syst , vol.5 , pp. 99-139
    • Eppstein, D.A.1    Longenecker, J.P.2
  • 61
    • 0023693299 scopus 로고
    • Measurement of gastrointestinal pH profles in normal ambulant human subjects
    • Evans DF, Pye G, Bramley R, Clark AG, Dyson TJ, Hardcastle JD. (1988). Measurement of gastrointestinal pH profles in normal ambulant human subjects. Gut, 29, 1035-1041.
    • (1988) Gut , vol.29 , pp. 1035-1041
    • Evans, D.F.1    Pye, G.2    Bramley, R.3    Clark, A.G.4    Dyson, T.J.5    Hardcastle, J.D.6
  • 62
    • 29244456136 scopus 로고    scopus 로고
    • Enhancement of bronchial octreotide absorption by chitosan and N-trimethyl chitosan shows linear in vitro/in vivo correlation
    • Florea BI, Tanou M, Junginger HE, Borchard G. (2006). Enhancement of bronchial octreotide absorption by chitosan and N-trimethyl chitosan shows linear in vitro/in vivo correlation. J Control Release, 110, 353-361
    • (2006) J Control Release , vol.110 , pp. 353-361
    • Florea, B.I.1    Tanou, M.2    Junginger, H.E.3    Borchard, G.4
  • 63
    • 33646159752 scopus 로고    scopus 로고
    • In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan
    • Föger F, Schmitz T, Bernkop-Schnürch A. (2006). In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials, 27, 4250-4255.
    • (2006) Biomaterials , vol.27 , pp. 4250-4255
    • Föger, F.1    Schmitz, T.2    Bernkop-Schnürch, A.3
  • 65
    • 18244365849 scopus 로고    scopus 로고
    • Protein drug stability: A formulation challenge
    • Frokjaer S, Otzen DE. (2005). Protein drug stability: a formulation challenge. Nat Rev Drug Discov, 4, 298-306.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 298-306
    • Frokjaer, S.1    Otzen, D.E.2
  • 66
    • 0035937124 scopus 로고    scopus 로고
    • Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery
    • Futaki S, Suzuki T, Ohashi W, Yagami T, Tanaka S, Ueda K, Sugiura Y. (2001). Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem, 276, 5836-5840.
    • (2001) J Biol Chem , vol.276 , pp. 5836-5840
    • Futaki, S.1    Suzuki, T.2    Ohashi, W.3    Yagami, T.4    Tanaka, S.5    Ueda, K.6    Sugiura, Y.7
  • 67
    • 0037177459 scopus 로고    scopus 로고
    • Lectin-mediated drug delivery: Binding and uptake of BSA-WGA conjugates using the Caco-2 model
    • Gabor F, Schwarzbauer A, Wirth M. (2002). Lectin-mediated drug delivery: binding and uptake of BSA-WGA conjugates using the Caco-2 model. Int J Pharm, 237, 227-239.
    • (2002) Int J Pharm , vol.237 , pp. 227-239
    • Gabor, F.1    Schwarzbauer, A.2    Wirth, M.3
  • 69
    • 40849086344 scopus 로고    scopus 로고
    • Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: Intestinal mucosal toxicity and absorption-enhancing mechanism of spermine
    • Gao Y, He L, Katsumi H, Sakane T, Fujita T, Yamamoto A. (2008). Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: intestinal mucosal toxicity and absorption-enhancing mechanism of spermine. Int J Pharm, 354, 126-134.
    • (2008) Int J Pharm , vol.354 , pp. 126-134
    • Gao, Y.1    He, L.2    Katsumi, H.3    Sakane, T.4    Fujita, T.5    Yamamoto, A.6
  • 70
    • 0027327379 scopus 로고
    • The efect of trypsin inhibitor on the pancreas and small intestine of mice
    • Ge YC, Morgan RG. (1993). The efect of trypsin inhibitor on the pancreas and small intestine of mice. Br J Nutr, 70, 333-345.
    • (1993) Br J Nutr , vol.70 , pp. 333-345
    • Ge, Y.C.1    Morgan, R.G.2
  • 71
    • 33746474818 scopus 로고    scopus 로고
    • Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan-a review
    • George M, Abraham TE. (2006). Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review. J Control Release, 114, 1-14.
    • (2006) J Control Release , vol.114 , pp. 1-14
    • George, M.1    Abraham, T.E.2
  • 72
    • 0037393955 scopus 로고    scopus 로고
    • Challenges for the oral delivery of macromolecules
    • Goldberg M, Gomez-Orellana I. (2003). Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov, 2, 289-295.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 289-295
    • Goldberg, M.1    Gomez-Orellana, I.2
  • 73
    • 32644440948 scopus 로고    scopus 로고
    • Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats
    • Goto T, Morishita M, Kavimandan NJ, Takayama K, Peppas NA. (2006). Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats. J Pharm Sci, 95, 462-469.
    • (2006) J Pharm Sci , vol.95 , pp. 462-469
    • Goto, T.1    Morishita, M.2    Kavimandan, N.J.3    Takayama, K.4    Peppas, N.A.5
  • 75
    • 20744434748 scopus 로고    scopus 로고
    • Microencapsulated chitosan nanoparticles for lung protein delivery
    • Grenha A, Seijo B, Remuñán-López C. (2005). Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci, 25, 427-437.
    • (2005) Eur J Pharm Sci , vol.25 , pp. 427-437
    • Grenha, A.1    Seijo, B.2    Remuñán-López, C.3
  • 76
    • 22244488749 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs: Barriers and developments
    • Hamman JH, Enslin GM, Kotzé AF. (2005). Oral delivery of peptide drugs: barriers and developments. BioDrugs, 19, 165-177.
    • (2005) BioDrugs , vol.19 , pp. 165-177
    • Hamman, J.H.1    Enslin, G.M.2    Kotzé, A.F.3
  • 77
    • 0037203655 scopus 로고    scopus 로고
    • Efect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: In vivo evaluation in rat nasal epithelia
    • Hamman JH, Stander M, Kotzé AF. (2002). Efect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia. Int J Pharm, 232, 235-242.
    • (2002) Int J Pharm , vol.232 , pp. 235-242
    • Hamman, J.H.1    Stander, M.2    Kotzé, A.F.3
  • 78
    • 33744536662 scopus 로고    scopus 로고
    • Pulmonary delivery of insulin by liposomal carriers
    • Huang YY, Wang CH. (2006). Pulmonary delivery of insulin by liposomal carriers. J Control Release, 113, 9-14.
    • (2006) J Control Release , vol.113 , pp. 9-14
    • Huang, Y.Y.1    Wang, C.H.2
  • 79
    • 32244439546 scopus 로고    scopus 로고
    • Inhaled insulin is better absorbed when administered as a dry powder compared to solution in the presence or absence of alkylglycosides
    • Hussain A, Majumder QH, Ahsan F. (2006). Inhaled insulin is better absorbed when administered as a dry powder compared to solution in the presence or absence of alkylglycosides. Pharm Res, 23, 138-147.
    • (2006) Pharm Res , vol.23 , pp. 138-147
    • Hussain, A.1    Majumder, Q.H.2    Ahsan, F.3
  • 80
    • 0031783879 scopus 로고    scopus 로고
    • Chitosan and its use as a pharmaceutical excipient
    • Illum L. (1998). Chitosan and its use as a pharmaceutical excipient. Pharm Res, 15, 1326-1331.
    • (1998) Pharm Res , vol.15 , pp. 1326-1331
    • Illum, L.1
  • 81
    • 0037459005 scopus 로고    scopus 로고
    • Nasal drug delivery-possibilities, problems and solutions
    • Illum L. (2003). Nasal drug delivery-possibilities, problems and solutions. J Control Release, 87, 187-198.
    • (2003) J Control Release , vol.87 , pp. 187-198
    • Illum, L.1
  • 82
    • 1042269557 scopus 로고    scopus 로고
    • Is nose-to-brain transport of drugs in man a reality?
    • Illum L. (2004). Is nose-to-brain transport of drugs in man a reality? J Pharm Pharmacol, 56, 3-17.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 3-17
    • Illum, L.1
  • 83
    • 33947529032 scopus 로고    scopus 로고
    • Nanoparticulate systems for nasal delivery of drugs: A real improvement over simple systems?
    • Illum L. (2007). Nanoparticulate systems for nasal delivery of drugs: a real improvement over simple systems? J Pharm Sci, 96, 473-483.
    • (2007) J Pharm Sci , vol.96 , pp. 473-483
    • Illum, L.1
  • 84
    • 0028124642 scopus 로고
    • Chitosan as a novel nasal delivery system for peptide drugs
    • Illum L, Farraj NF, Davis SS. (1994). Chitosan as a novel nasal delivery system for peptide drugs. Pharm Res, 11, 1186-1189.
    • (1994) Pharm Res , vol.11 , pp. 1186-1189
    • Illum, L.1    Farraj, N.F.2    Davis, S.S.3
  • 85
    • 43249125970 scopus 로고    scopus 로고
    • Efective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier
    • Jain AK, Khar RK, Ahmed FJ, Diwan PV. (2008). Efective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier. Eur J Pharm Biopharm, 69, 426-435.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 426-435
    • Jain, A.K.1    Khar, R.K.2    Ahmed, F.J.3    Diwan, P.V.4
  • 86
    • 39549088108 scopus 로고    scopus 로고
    • Characterization and aerodynamic evaluation of spray dried recombinant human growth hormone using protein stabilizing agents
    • Jalalipour M, Gilani K, Tajerzadeh H, Najafabadi AR, Barghi M. (2008a). Characterization and aerodynamic evaluation of spray dried recombinant human growth hormone using protein stabilizing agents. Int J Pharm, 352, 209-216.
    • (2008) Int J Pharm , vol.352 , pp. 209-216
    • Jalalipour, M.1    Gilani, K.2    Tajerzadeh, H.3    Najafabadi, A.R.4    Barghi, M.5
  • 87
    • 57349198332 scopus 로고    scopus 로고
    • Efect of dimethyl-beta-cyclodextrin concentrations on the pulmonary delivery of recombinant human growth hormone dry powder in rats
    • Jalalipour M, Najafabadi AR, Gilani K, Esmaily H, Tajerzadeh H. (2008b). Efect of dimethyl-beta-cyclodextrin concentrations on the pulmonary delivery of recombinant human growth hormone dry powder in rats. J Pharm Sci, 97, 5176-5185.
    • (2008) J Pharm Sci , vol.97 , pp. 5176-5185
    • Jalalipour, M.1    Najafabadi, A.R.2    Gilani, K.3    Esmaily, H.4    Tajerzadeh, H.5
  • 89
    • 83355173904 scopus 로고    scopus 로고
    • Goblet cell-targeting nanoparticles for oral insulin delivery and the infuence of mucus on insulin transport
    • Jin Y, Song Y, Zhu X, Zhou D, Chen C, Zhang Z, Huang Y. (2012). Goblet cell-targeting nanoparticles for oral insulin delivery and the infuence of mucus on insulin transport. Biomaterials, 33, 1573-1582.
    • (2012) Biomaterials , vol.33 , pp. 1573-1582
    • Jin, Y.1    Song, Y.2    Zhu, X.3    Zhou, D.4    Chen, C.5    Zhang, Z.6    Huang, Y.7
  • 90
    • 84940489319 scopus 로고    scopus 로고
    • Nasal absorption and local tissue reaction of insulin nanocomplexes of trimethyl chitosan derivatives in rats
    • Jintapattanakit A, Peungvicha P, Sailasuta A, Kissel T, Junyaprasert VB. (2010). Nasal absorption and local tissue reaction of insulin nanocomplexes of trimethyl chitosan derivatives in rats. J Pharm Pharmacol, 62, 583-591.
    • (2010) J Pharm Pharmacol , vol.62 , pp. 583-591
    • Jintapattanakit, A.1    Peungvicha, P.2    Sailasuta, A.3    Kissel, T.4    Junyaprasert, V.B.5
  • 91
    • 0031560925 scopus 로고    scopus 로고
    • Preparation of peptide and protein powders for inhalation
    • Johnson KA. (1997). Preparation of peptide and protein powders for inhalation. Adv Drug Deliv Rev, 26, 3-15.
    • (1997) Adv Drug Deliv Rev , vol.26 , pp. 3-15
    • Johnson, K.A.1
  • 93
    • 54849439914 scopus 로고    scopus 로고
    • Usefulness of cell-penetrating peptides to improve intestinal insulin absorption
    • Kamei N, Morishita M, Eda Y, Ida N, Nishio R, Takayama K. (2008). Usefulness of cell-penetrating peptides to improve intestinal insulin absorption. J Control Release, 132, 21-25.
    • (2008) J Control Release , vol.132 , pp. 21-25
    • Kamei, N.1    Morishita, M.2    Eda, Y.3    Ida, N.4    Nishio, R.5    Takayama, K.6
  • 94
    • 67349268446 scopus 로고    scopus 로고
    • Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides
    • Kamei N, Morishita M, Takayama K. (2009b). Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides. J Control Release, 136, 179-186.
    • (2009) J Control Release , vol.136 , pp. 179-186
    • Kamei, N.1    Morishita, M.2    Takayama, K.3
  • 95
    • 44149098811 scopus 로고    scopus 로고
    • Identifcation of a peptide sequence that improves transport of macromolecules across the intestinal mucosal barrier targeting goblet cells
    • Kang SK, Woo JH, Kim MK, Woo SS, Choi JH, Lee HG, Lee NK, Choi YJ. (2008). Identifcation of a peptide sequence that improves transport of macromolecules across the intestinal mucosal barrier targeting goblet cells. J Biotechnol, 135, 210-216.
    • (2008) J Biotechnol , vol.135 , pp. 210-216
    • Kang, S.K.1    Woo, J.H.2    Kim, M.K.3    Woo, S.S.4    Choi, J.H.5    Lee, H.G.6    Lee, N.K.7    Choi, Y.J.8
  • 96
    • 33645974002 scopus 로고    scopus 로고
    • Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates
    • Kavimandan NJ, Losi E, Peppas NA. (2006). Novel delivery system based on complexation hydrogels as delivery vehicles for insulin-transferrin conjugates. Biomaterials, 27, 3846-3854.
    • (2006) Biomaterials , vol.27 , pp. 3846-3854
    • Kavimandan, N.J.1    Losi, E.2    Peppas, N.A.3
  • 97
    • 75149147526 scopus 로고    scopus 로고
    • Biodegradation, biodistribution and toxicity of chitosan
    • Kean T, Tanou M. (2010). Biodegradation, biodistribution and toxicity of chitosan. Adv Drug Deliv Rev, 62, 3-11
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 3-11
    • Kean, T.1    Tanou, M.2
  • 98
    • 57349182296 scopus 로고    scopus 로고
    • Efect of cell-penetrating peptides on the nasal absorption of insulin
    • Khafagy el-S, Morishita M, Isowa K, Imai J, Takayama K. (2009a). Efect of cell-penetrating peptides on the nasal absorption of insulin. J Control Release, 133, 103-108
    • (2009) J Control Release , vol.133 , pp. 103-108
    • El-S, K.1    Morishita, M.2    Isowa, K.3    Imai, J.4    Takayama, K.5
  • 99
    • 70349198899 scopus 로고    scopus 로고
    • Efciency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins
    • Khafagy el-S, Morishita M, Kamei N, Eda Y, Ikeno Y, Takayama K. (2009b). Efciency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins. Int J Pharm, 381, 49-55
    • (2009) Int J Pharm , vol.381 , pp. 49-55
    • El-S, K.1    Morishita, M.2    Kamei, N.3    Eda, Y.4    Ikeno, Y.5    Takayama, K.6
  • 100
    • 36248965689 scopus 로고    scopus 로고
    • Current challenges in non-invasive insulin delivery systems: A comparative review
    • Khafagy el-S, Morishita M, Onuki Y, Takayama K. (2007). Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev, 59, 1521-1546.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 1521-1546
    • El-S, K.1    Morishita, M.2    Onuki, Y.3    Takayama, K.4
  • 101
    • 84859720244 scopus 로고    scopus 로고
    • Oral biodrug delivery using cell-penetrating peptide
    • Khafagy el-S, Morishita M. (2012). Oral biodrug delivery using cell-penetrating peptide. Adv Drug Deliv Rev, 64, 531-539.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 531-539
    • El-S, K.1    Morishita, M.2
  • 102
    • 79958174556 scopus 로고    scopus 로고
    • Advances in mucoadhesion and mucoadhesive polymers
    • Khutoryanskiy VV. (2011). Advances in mucoadhesion and mucoadhesive polymers. Macromol Biosci, 11, 748-764.
    • (2011) Macromol Biosci , vol.11 , pp. 748-764
    • Khutoryanskiy, V.V.1
  • 103
    • 35649003327 scopus 로고    scopus 로고
    • Toxicity screening after repeated dose of a newly developed oral heparin derivative in male cynomolgus monkeys
    • Kim CY, Kim J, Han K, Kim S, Park K, Byun Y. (2007). Toxicity screening after repeated dose of a newly developed oral heparin derivative in male cynomolgus monkeys. J Toxicol Sci, 32, 411-420.
    • (2007) J Toxicol Sci , vol.32 , pp. 411-420
    • Kim, C.Y.1    Kim, J.2    Han, K.3    Kim, S.4    Park, K.5    Byun, Y.6
  • 104
    • 26644447763 scopus 로고    scopus 로고
    • Evaluation of absorption of heparin-DOCA conjugates on the intestinal wall using a surface plasmon resonance
    • Kim SK, Kim K, Lee S, Park K, Park JH, Kwon IC, Choi K, Kim CY, Byun Y. (2005). Evaluation of absorption of heparin-DOCA conjugates on the intestinal wall using a surface plasmon resonance. J Pharm Biomed Anal, 39, 861-870.
    • (2005) J Pharm Biomed Anal , vol.39 , pp. 861-870
    • Kim, S.K.1    Kim, K.2    Lee, S.3    Park, K.4    Park, J.H.5    Kwon, I.C.6    Choi, K.7    Kim, C.Y.8    Byun, Y.9
  • 105
    • 35248870571 scopus 로고    scopus 로고
    • A newly developed oral heparin derivative for deep vein thrombosis: Non-human primate study
    • Kim SK, Lee DY, Kim CY, Nam JH, Moon HT, Byun Y. (2007a). A newly developed oral heparin derivative for deep vein thrombosis: non-human primate study. J Control Release, 123, 155-163.
    • (2007) J Control Release , vol.123 , pp. 155-163
    • Kim, S.K.1    Lee, D.Y.2    Kim, C.Y.3    Nam, J.H.4    Moon, H.T.5    Byun, Y.6
  • 106
    • 34249914210 scopus 로고    scopus 로고
    • Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anti-coagulant
    • Kim SK, Lee DY, Lee E, Lee YK, Kim CY, Moon HT, Byun Y. (2007b). Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anti-coagulant. J Control Release, 120, 4-10.
    • (2007) J Control Release , vol.120 , pp. 4-10
    • Kim, S.K.1    Lee, D.Y.2    Lee, E.3    Lee, Y.K.4    Kim, C.Y.5    Moon, H.T.6    Byun, Y.7
  • 107
    • 28444435477 scopus 로고    scopus 로고
    • Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI
    • Kleemann E, Neu M, Jekel N, Fink L, Schmehl T, Gessler T, Seeger W, Kissel T. (2005). Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J Control Release, 109, 299-316.
    • (2005) J Control Release , vol.109 , pp. 299-316
    • Kleemann, E.1    Neu, M.2    Jekel, N.3    Fink, L.4    Schmehl, T.5    Gessler, T.6    Seeger, W.7    Kissel, T.8
  • 108
    • 43449134352 scopus 로고    scopus 로고
    • Inhaled insulin's last gasp?
    • Jun
    • Kling J. (2008). Inhaled insulin's last gasp? Nat Biotechnol, Jun, p. 5.
    • (2008) Nat Biotechnol , pp. 5
    • Kling, J.1
  • 109
    • 67649664257 scopus 로고    scopus 로고
    • Insulin-micro-and nanoparticles for pulmonary delivery
    • Klingler C, Müller BW, Steckel H. (2009). Insulin-micro-and nanoparticles for pulmonary delivery. Int J Pharm, 377, 173-179.
    • (2009) Int J Pharm , vol.377 , pp. 173-179
    • Klingler, C.1    Müller, B.W.2    Steckel, H.3
  • 110
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • Knowles MR, Boucher RC. (2002). Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest, 109, 571-577.
    • (2002) J Clin Invest , vol.109 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 112
    • 0027965843 scopus 로고
    • Study on pulmonary delivery of salmon calcitonin in rats: Efects of protease inhibitors and absorption enhancers
    • Kobayashi S, Kondo S, Juni K. (1994). Study on pulmonary delivery of salmon calcitonin in rats: efects of protease inhibitors and absorption enhancers. Pharm Res, 11, 1239-1243.
    • (1994) Pharm Res , vol.11 , pp. 1239-1243
    • Kobayashi, S.1    Kondo, S.2    Juni, K.3
  • 113
    • 0029918843 scopus 로고    scopus 로고
    • Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats
    • Kobayashi S, Kondo S, Juni K. (1996). Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats. Pharm Res, 13, 80-83.
    • (1996) Pharm Res , vol.13 , pp. 80-83
    • Kobayashi, S.1    Kondo, S.2    Juni, K.3
  • 114
    • 0027999059 scopus 로고
    • Intratracheal delivery of peptide and protein agents: Absorption from solution and dry powder by rat lung
    • Komada F, Iwakawa S, Yamamoto N, Sakakibara H, Okumura K. (1994). Intratracheal delivery of peptide and protein agents: absorption from solution and dry powder by rat lung. J Pharm Sci, 83, 863-867.
    • (1994) J Pharm Sci , vol.83 , pp. 863-867
    • Komada, F.1    Iwakawa, S.2    Yamamoto, N.3    Sakakibara, H.4    Okumura, K.5
  • 115
    • 0033007333 scopus 로고    scopus 로고
    • Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: In vitro evaluation in intestinal epithelial cells (Caco-2)
    • Kotzé AF, Tanou MM, Luebetaen HL, de Boer AG, Verhoef JC, Junginger HE. (1999). Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2). J Pharm Sci, 88, 253-257.
    • (1999) J Pharm Sci , vol.88 , pp. 253-257
    • Kotzé, A.F.1    Tanou, M.M.2    Luebetaen, H.L.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 116
    • 3242669006 scopus 로고    scopus 로고
    • Pulmonary delivery of deslorelin: Large-porous PLGA particles and HPbetaCD complexes
    • Koushik K, Dhanda DS, Cheruvu NP, Kompella UB. (2004). Pulmonary delivery of deslorelin: large-porous PLGA particles and HPbetaCD complexes. Pharm Res, 21, 1119-1126.
    • (2004) Pharm Res , vol.21 , pp. 1119-1126
    • Koushik, K.1    Dhanda, D.S.2    Cheruvu, N.P.3    Kompella, U.B.4
  • 117
    • 1542511344 scopus 로고    scopus 로고
    • Preparation of large porous deslorelin-PLGA microparticles with reduced residual solvent and cellular uptake using a supercritical carbon dioxide process
    • Koushik K, Kompella UB. (2004). Preparation of large porous deslorelin-PLGA microparticles with reduced residual solvent and cellular uptake using a supercritical carbon dioxide process. Pharm Res, 21, 524-535.
    • (2004) Pharm Res , vol.21 , pp. 524-535
    • Koushik, K.1    Kompella, U.B.2
  • 118
    • 29244473159 scopus 로고    scopus 로고
    • Tiolated chitosan microparticles: A vehicle for nasal peptide drug delivery
    • Krauland AH, Guggi D, Bernkop-Schnürch A. (2006). Tiolated chitosan microparticles: a vehicle for nasal peptide drug delivery. Int J Pharm, 307, 270-277.
    • (2006) Int J Pharm , vol.307 , pp. 270-277
    • Krauland, A.H.1    Guggi, D.2    Bernkop-Schnürch, A.3
  • 119
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • Lai SK, Wang YY, Hanes J. (2009). Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev, 61, 158-171.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 158-171
    • Lai, S.K.1    Wang, Y.Y.2    Hanes, J.3
  • 120
  • 121
    • 37749004225 scopus 로고    scopus 로고
    • Protein therapeutics: A summary and pharmacological classifcation
    • Leader B, Baca QJ, Golan DE. (2008). Protein therapeutics: a summary and pharmacological classifcation. Nat Rev Drug Discov, 7, 21-39.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 21-39
    • Leader, B.1    Baca, Q.J.2    Golan, D.E.3
  • 122
    • 70350622459 scopus 로고    scopus 로고
    • In vivo antitumor efects of chitosan-conjugated docetaxel after oral administration
    • Lee E, Kim H, Lee IH, Jon S. (2009). In vivo antitumor efects of chitosan-conjugated docetaxel after oral administration. J Control Release, 140, 79-85.
    • (2009) J Control Release , vol.140 , pp. 79-85
    • Lee, E.1    Kim, H.2    Lee, I.H.3    Jon, S.4
  • 123
    • 77958191382 scopus 로고    scopus 로고
    • A novel approach to oral delivery of insulin by conjugating with low molecular weight chitosan
    • Lee E, Lee J, Jon S. (2010). A novel approach to oral delivery of insulin by conjugating with low molecular weight chitosan. Bioconjug Chem, 21, 1720-1723.
    • (2010) Bioconjug Chem , vol.21 , pp. 1720-1723
    • Lee, E.1    Lee, J.2    Jon, S.3
  • 124
    • 54549097056 scopus 로고    scopus 로고
    • Conjugated chitosan as a novel platform for oral delivery of paclitaxel
    • Lee E, Lee J, Lee IH, Yu M, Kim H, Chae SY, Jon S. (2008). Conjugated chitosan as a novel platform for oral delivery of paclitaxel. J Med Chem, 51, 6442-6449.
    • (2008) J Med Chem , vol.51 , pp. 6442-6449
    • Lee, E.1    Lee, J.2    Lee, I.H.3    Yu, M.4    Kim, H.5    Chae, S.Y.6    Jon, S.7
  • 125
    • 33744943511 scopus 로고    scopus 로고
    • PEGylated glucagon-like peptide-1 displays preserved efects on insulin release in isolated pancreatic islets and improved biological activity in db/db mice
    • Lee S, Youn YS, Lee SH, Byun Y, Lee KC. (2006a). PEGylated glucagon-like peptide-1 displays preserved efects on insulin release in isolated pancreatic islets and improved biological activity in db/db mice. Diabetologia, 49, 1608-1611.
    • (2006) Diabetologia , vol.49 , pp. 1608-1611
    • Lee, S.1    Youn, Y.S.2    Lee, S.H.3    Byun, Y.4    Lee, K.C.5
  • 126
    • 15244363744 scopus 로고    scopus 로고
    • Synthesis characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1
    • Lee SH, Lee S, Youn YS, Na DH, Chae SY, Byun Y, Lee KC. (2005). Synthesis, characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1. Bioconjug Chem, 16, 377-382.
    • (2005) Bioconjug Chem , vol.16 , pp. 377-382
    • Lee, S.H.1    Lee, S.2    Youn, Y.S.3    Na, D.H.4    Chae, S.Y.5    Byun, Y.6    Lee, K.C.7
  • 127
    • 0024836302 scopus 로고
    • Penetration and enzymatic barriers to peptide and protein absorption
    • Lee VHL, Yamamoto A. (1989). Penetration and enzymatic barriers to peptide and protein absorption. Adv Drug Deliv Rev, 4:171-207.
    • (1989) Adv Drug Deliv Rev , vol.4 , pp. 171-207
    • Lee, V.H.L.1    Yamamoto, A.2
  • 128
    • 0033638463 scopus 로고    scopus 로고
    • Oral delivery of new heparin derivatives in rats
    • Lee Y, Kim SH, Byun Y. (2000). Oral delivery of new heparin derivatives in rats. Pharm Res, 17, 1259-1264.
    • (2000) Pharm Res , vol.17 , pp. 1259-1264
    • Lee, Y.1    Kim, S.H.2    Byun, Y.3
  • 129
    • 33645227760 scopus 로고    scopus 로고
    • Efcacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys
    • Lee YK, Kim SK, Lee DY, Lee S, Kim CY, Shin HC, Moon HT, Byun Y. (2006b). Efcacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys. J Control Release, 111, 290-298.
    • (2006) J Control Release , vol.111 , pp. 290-298
    • Lee, Y.K.1    Kim, S.K.2    Lee, D.Y.3    Lee, S.4    Kim, C.Y.5    Shin, H.C.6    Moon, H.T.7    Byun, Y.8
  • 130
    • 0033996243 scopus 로고    scopus 로고
    • Lectin-mediated drug delivery: The second generation of bioadhesives
    • Lehr CM. (2000). Lectin-mediated drug delivery: the second generation of bioadhesives. J Control Release, 65, 19-29.
    • (2000) J Control Release , vol.65 , pp. 19-29
    • Lehr, C.M.1
  • 131
    • 84861814311 scopus 로고    scopus 로고
    • Inhaled insulin is approved in Europe and United States
    • Lenzer J. (2006). Inhaled insulin is approved in Europe and United States. BMJ (Clinical research ed), Mar 11, p. 7537.
    • (2006) BMJ (Clinical Research Ed), Mar 11 , pp. 7537
    • Lenzer, J.1
  • 132
    • 33751195735 scopus 로고    scopus 로고
    • Hydrogels in controlled release formulations: Network design and mathematical modeling
    • Lin CC, Metters AT. (2006). Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliv Rev, 58, 1379-1408.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1379-1408
    • Lin, C.C.1    Metters, A.T.2
  • 133
    • 56649089693 scopus 로고    scopus 로고
    • Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs
    • Lin YH, Sonaje K, Lin KM, Juang JH, Mi FL, Yang HW, Sung HW. (2008). Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J Control Release, 132, 141-149.
    • (2008) J Control Release , vol.132 , pp. 141-149
    • Lin, Y.H.1    Sonaje, K.2    Lin, K.M.3    Juang, J.H.4    Mi, F.L.5    Yang, H.W.6    Sung, H.W.7
  • 134
    • 0344876583 scopus 로고    scopus 로고
    • Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats
    • Liu H, Tang R, Pan WS, Zhang Y, Liu H. (2003). Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats. J Pharm Pharmacol, 55, 1523-1529.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 1523-1529
    • Liu, H.1    Tang, R.2    Pan, W.S.3    Zhang, Y.4    Liu, H.5
  • 135
    • 20444385828 scopus 로고    scopus 로고
    • Interaction of various pectin formulations with porcine colonic tissues
    • Liu L, Fishman ML, Hicks KB, Kende M. (2005). Interaction of various pectin formulations with porcine colonic tissues. Biomaterials, 26, 5907-5916.
    • (2005) Biomaterials , vol.26 , pp. 5907-5916
    • Liu, L.1    Fishman, M.L.2    Hicks, K.B.3    Kende, M.4
  • 136
    • 0032999379 scopus 로고    scopus 로고
    • Alginate-pectin-poly-L-lysine particulate as a potential controlled release formulation
    • Liu P, Krishnan TR. (1999). Alginate-pectin-poly-L-lysine particulate as a potential controlled release formulation. J Pharm Pharmacol, 51, 141-149.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 141-149
    • Liu, P.1    Krishnan, T.R.2
  • 137
    • 84860193946 scopus 로고    scopus 로고
    • Intranasal delivery of biologics to the central nervous system
    • Lochhead JJ, Torne RG. (2012). Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev, 64, 614-628.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 614-628
    • Lochhead, J.J.1    Torne, R.G.2
  • 138
    • 0030453145 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
    • Luessen HL, de Leeuw BJ, Langemeÿer MW, de Boer AB, Verhoef JC, Junginger HE. (1996). Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm Res, 13, 1668-1672.
    • (1996) Pharm Res , vol.13 , pp. 1668-1672
    • Luessen, H.L.1    De Leeuw, B.J.2    Langemeÿer, M.W.3    De Boer, A.B.4    Verhoef, J.C.5    Junginger, H.E.6
  • 139
    • 0031914743 scopus 로고    scopus 로고
    • Spray-drying of air-liquid interface sensitive recombinant human growth hormone
    • Maa YF, Nguyen PA, Hsu SW. (1998). Spray-drying of air-liquid interface sensitive recombinant human growth hormone. J Pharm Sci, 87, 152-159.
    • (1998) J Pharm Sci , vol.87 , pp. 152-159
    • Maa, Y.F.1    Nguyen, P.A.2    Hsu, S.W.3
  • 140
    • 0033043629 scopus 로고    scopus 로고
    • Protein inhalation powders: Spray drying vs spray freeze drying
    • Maa YF, Nguyen PA, Sweeney T, Shire SJ, Hsu CC. (1999). Protein inhalation powders: spray drying vs spray freeze drying. Pharm Res, 16, 249-254.
    • (1999) Pharm Res , vol.16 , pp. 249-254
    • Maa, Y.F.1    Nguyen, P.A.2    Sweeney, T.3    Shire, S.J.4    Hsu, C.C.5
  • 141
    • 0032782252 scopus 로고    scopus 로고
    • Complexation graft copolymer networks: Swelling properties, calcium binding and proteolytic enzyme inhibition
    • Madsen F, Peppas NA. (1999). Complexation graft copolymer networks: swelling properties, calcium binding and proteolytic enzyme inhibition. Biomaterials, 20, 1701-1708.
    • (1999) Biomaterials , vol.20 , pp. 1701-1708
    • Madsen, F.1    Peppas, N.A.2
  • 143
    • 79551528343 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of WGA-carbopol modifed liposomes as carriers for oral peptide delivery
    • Makhlof A, Fujimoto S, Tozuka Y, Takeuchi H. (2011a). In vitro and in vivo evaluation of WGA-carbopol modifed liposomes as carriers for oral peptide delivery. Eur J Pharm Biopharm, 77, 216-224.
    • (2011) Eur J Pharm Biopharm , vol.77 , pp. 216-224
    • Makhlof, A.1    Fujimoto, S.2    Tozuka, Y.3    Takeuchi, H.4
  • 144
    • 79954628593 scopus 로고    scopus 로고
    • Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery
    • Makhlof A, Tozuka Y, Takeuchi H. (2011b). Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur J Pharm Sci, 42, 445-451.
    • (2011) Eur J Pharm Sci , vol.42 , pp. 445-451
    • Makhlof, A.1    Tozuka, Y.2    Takeuchi, H.3
  • 145
    • 78651228118 scopus 로고    scopus 로고
    • A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa
    • Makhlof A, Werle M, Tozuka Y, Takeuchi H. (2011c). A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa. J Control Release, 149, 81-88.
    • (2011) J Control Release , vol.149 , pp. 81-88
    • Makhlof, A.1    Werle, M.2    Tozuka, Y.3    Takeuchi, H.4
  • 146
    • 77954887591 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of inhaled GLP-1 (MKC253): Proof-of-concept studies in healthy normal volunteers and in patients with type 2 diabetes
    • Marino MT, Costello D, Baughman R, Boss A, Cassidy J, Damico C, van Marle S, van Vliet A, Richardson PC. (2010). Pharmacokinetics and pharmacodynamics of inhaled GLP-1 (MKC253): proof-of-concept studies in healthy normal volunteers and in patients with type 2 diabetes. Clin Pharmacol Ter, 88, 243-250.
    • (2010) Clin Pharmacol ter , vol.88 , pp. 243-250
    • Marino, M.T.1    Costello, D.2    Baughman, R.3    Boss, A.4    Cassidy, J.5    Damico, C.6    Van Marle, S.7    Van Vliet, A.8    Richardson, P.C.9
  • 147
    • 0034468106 scopus 로고    scopus 로고
    • Design and in vivo evaluation of an oral delivery system for insulin
    • Marschütz MK, Caliceti P, Bernkop-Schnürch A. (2000). Design and in vivo evaluation of an oral delivery system for insulin. Pharm Res, 17, 1468-1474.
    • (2000) Pharm Res , vol.17 , pp. 1468-1474
    • Marschütz, M.K.1    Caliceti, P.2    Bernkop-Schnürch, A.3
  • 148
    • 0029149771 scopus 로고
    • Efects of absorption enhancers on rat nasal epithelium in vivo: Release of marker compounds in the nasal cavity
    • Marttin E, Verhoef JC, Romeijn SG, Merkus FW. (1995). Efects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity. Pharm Res, 12, 1151-1157.
    • (1995) Pharm Res , vol.12 , pp. 1151-1157
    • Marttin, E.1    Verhoef, J.C.2    Romeijn, S.G.3    Merkus, F.W.4
  • 149
    • 27744525788 scopus 로고    scopus 로고
    • Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    • Massodi I, Bidwell GL 3rd, Raucher D. (2005). Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery. J Control Release, 108, 396-408.
    • (2005) J Control Release , vol.108 , pp. 396-408
    • Massodi, I.1    Bidwell III, G.L.2    Raucher, D.3
  • 150
    • 33751233271 scopus 로고    scopus 로고
    • Clinical evaluation of inhaled insulin
    • Mastrandrea LD, Quattrin T. (2006). Clinical evaluation of inhaled insulin. Adv Drug Deliv Rev, 58, 1061-1075.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1061-1075
    • Mastrandrea, L.D.1    Quattrin, T.2
  • 151
    • 0017289856 scopus 로고
    • Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor
    • Melmed RN, El-Aaser AA, Holt SJ. (1976). Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor. Biochim Biophys Acta, 421, 280-288.
    • (1976) Biochim Biophys Acta , vol.421 , pp. 280-288
    • Melmed, R.N.1    El-Aaser, A.A.2    Holt, S.J.3
  • 153
    • 45749109076 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation
    • Mi FL, Wu YY, Lin YH, Sonaje K, Ho YC, Chen CT, Juang JH, Sung HW. (2008). Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation. Bioconjug Chem, 19, 1248-1255.
    • (2008) Bioconjug Chem , vol.19 , pp. 1248-1255
    • Mi, F.L.1    Wu, Y.Y.2    Lin, Y.H.3    Sonaje, K.4    Ho, Y.C.5    Chen, C.T.6    Juang, J.H.7    Sung, H.W.8
  • 154
    • 1142273203 scopus 로고    scopus 로고
    • Drug targeting to the colon with lectins and neoglycoconjugates
    • Minko T. (2004). Drug targeting to the colon with lectins and neoglycoconjugates. Adv Drug Deliv Rev, 56, 491-509.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 491-509
    • Minko, T.1
  • 155
    • 0033794501 scopus 로고    scopus 로고
    • Polyarginine enters cells more efciently than other polycationic homopolymers
    • Mitchell DJ, Kim DT, Steinman L, Fathman CG, Rothbard JB. (2000). Polyarginine enters cells more efciently than other polycationic homopolymers. J Pept Res, 56, 318-325.
    • (2000) J Pept Res , vol.56 , pp. 318-325
    • Mitchell, D.J.1    Kim, D.T.2    Steinman, L.3    Fathman, C.G.4    Rothbard, J.B.5
  • 156
    • 33344468568 scopus 로고    scopus 로고
    • Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: Utilization of polyamines and bile acids
    • Miyake M, Minami T, Hirota M, Toguchi H, Odomi M, Ogawara K, Higaki K, Kimura T. (2006a). Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: utilization of polyamines and bile acids. J Control Release, 111, 27-34.
    • (2006) J Control Release , vol.111 , pp. 27-34
    • Miyake, M.1    Minami, T.2    Hirota, M.3    Toguchi, H.4    Odomi, M.5    Ogawara, K.6    Higaki, K.7    Kimura, T.8
  • 157
    • 33749548071 scopus 로고    scopus 로고
    • Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption
    • Miyake M, Minami T, Toguchi H, Odomi M, Ogawara K, Higaki K, Kimura T. (2006b). Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption. J Control Release, 115, 130-133.
    • (2006) J Control Release , vol.115 , pp. 130-133
    • Miyake, M.1    Minami, T.2    Toguchi, H.3    Odomi, M.4    Ogawara, K.5    Higaki, K.6    Kimura, T.7
  • 159
    • 33847281527 scopus 로고    scopus 로고
    • A novel approach using functional peptides for efcient intestinal absorption of insulin
    • Morishita M, Kamei N, Ehara J, Isowa K, Takayama K. (2007). A novel approach using functional peptides for efcient intestinal absorption of insulin. J Control Release, 118, 177-184.
    • (2007) J Control Release , vol.118 , pp. 177-184
    • Morishita, M.1    Kamei, N.2    Ehara, J.3    Isowa, K.4    Takayama, K.5
  • 160
    • 0037123696 scopus 로고    scopus 로고
    • Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers
    • Morishita M, Lowman AM, Takayama K, Nagai T, Peppas NA. (2002). Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers. J Control Release, 81, 25-32.
    • (2002) J Control Release , vol.81 , pp. 25-32
    • Morishita, M.1    Lowman, A.M.2    Takayama, K.3    Nagai, T.4    Peppas, N.A.5
  • 161
    • 38949188925 scopus 로고    scopus 로고
    • Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides
    • Nakase I, Takeuchi T, Tanaka G, Futaki S. (2008). Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides. Adv Drug Deliv Rev, 60, 598-607.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 598-607
    • Nakase, I.1    Takeuchi, T.2    Tanaka, G.3    Futaki, S.4
  • 163
    • 84862833264 scopus 로고    scopus 로고
    • Liposomes containing glycocholate as potential oral insulin delivery systems: Preparation, in vitro characterization, and improved protection against enzymatic degradation
    • Niu M, Lu Y, Hovgaard L, Wu W. (2011). Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation. Int J Nanomedicine, 6, 1155-1166.
    • (2011) Int J Nanomedicine , vol.6 , pp. 1155-1166
    • Niu, M.1    Lu, Y.2    Hovgaard, L.3    Wu, W.4
  • 164
    • 0028024296 scopus 로고
    • Pulmonary delivery of powders and solutions containing recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the rabbit
    • Niven RW, Lott FD, Ip AY, Cribbs JM. (1994). Pulmonary delivery of powders and solutions containing recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the rabbit. Pharm Res, 11, 1101-1109.
    • (1994) Pharm Res , vol.11 , pp. 1101-1109
    • Niven, R.W.1    Lott, F.D.2    Ip, A.Y.3    Cribbs, J.M.4
  • 166
    • 1542498664 scopus 로고    scopus 로고
    • Alternative routes of insulin delivery
    • Owens DR, Zinman B, Bolli G. (2003). Alternative routes of insulin delivery. Diabet Med, 20, 886-898.
    • (2003) Diabet Med , vol.20 , pp. 886-898
    • Owens, D.R.1    Zinman, B.2    Bolli, G.3
  • 167
    • 84655167657 scopus 로고    scopus 로고
    • Chitosan nanoconstructs for improved oral delivery of low molecular weight heparin: In vitro and in vivo evaluation
    • Paliwal R, Paliwal SR, Agrawal GP, Vyas SP. (2012). Chitosan nanoconstructs for improved oral delivery of low molecular weight heparin: In vitro and in vivo evaluation. Int J Pharm, 422, 179-184.
    • (2012) Int J Pharm , vol.422 , pp. 179-184
    • Paliwal, R.1    Paliwal, S.R.2    Agrawal, G.P.3    Vyas, S.P.4
  • 169
  • 170
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • Patton JS. (1996). Mechanisms of macromolecule absorption by the lungs. Adv Drug Deliv Rev, 19:3-36.
    • (1996) Adv Drug Deliv Rev , vol.19 , pp. 3-36
    • Patton, J.S.1
  • 171
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • Patton JS, Byron PR. (2007). Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov, 6, 67-74.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 172
    • 0027624286 scopus 로고
    • Preparation, structure and difusional behavior of hydrogels in controlled-release
    • Peppas NA, Khare AR. (1993). Preparation, Structure and Difusional Behavior of Hydrogels in Controlled-Release. Adv Drug Deliv Rev, 11:1-35.
    • (1993) Adv Drug Deliv Rev , vol.11 , pp. 1-35
    • Peppas, N.A.1    Khare, A.R.2
  • 173
    • 0037572320 scopus 로고    scopus 로고
    • Efect of salts on lysozyme stability at the water-oil interface and upon encapsulation in poly(lactic-co-glycolic) acid microspheres
    • Pérez C, Griebenow K. (2003). Efect of salts on lysozyme stability at the water-oil interface and upon encapsulation in poly(lactic-co-glycolic) acid microspheres. Biotechnol Bioeng, 82, 825-832.
    • (2003) Biotechnol Bioeng , vol.82 , pp. 825-832
    • Pérez, C.1    Griebenow, K.2
  • 175
    • 0037523228 scopus 로고    scopus 로고
    • Visualization of insulin-loaded nanocapsules: In vitro and in vivo studies after oral administration to rats
    • Pinto-Alphandary H, Aboubakar M, Jaillard D, Couvreur P, Vauthier C. (2003). Visualization of insulin-loaded nanocapsules: in vitro and in vivo studies after oral administration to rats. Pharm Res, 20, 1071-1084.
    • (2003) Pharm Res , vol.20 , pp. 1071-1084
    • Pinto-Alphandary, H.1    Aboubakar, M.2    Jaillard, D.3    Couvreur, P.4    Vauthier, C.5
  • 176
    • 0033919959 scopus 로고    scopus 로고
    • Efects of salt addition on the microencapsulation of proteins using W/O/W double emulsion technique
    • Pistel KF, Kissel T. (2000). Efects of salt addition on the microencapsulation of proteins using W/O/W double emulsion technique. J Microencapsul, 17, 467-483.
    • (2000) J Microencapsul , vol.17 , pp. 467-483
    • Pistel, K.F.1    Kissel, T.2
  • 178
    • 0034868135 scopus 로고    scopus 로고
    • Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide
    • Ramanathan S, Pooyan S, Stein S, Prasad PD, Wang J, Leibowitz MJ, Ganapathy V, Sinko PJ. (2001). Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide. Pharm Res, 18, 950-956.
    • (2001) Pharm Res , vol.18 , pp. 950-956
    • Ramanathan, S.1    Pooyan, S.2    Stein, S.3    Prasad, P.D.4    Wang, J.5    Leibowitz, M.J.6    Ganapathy, V.7    Sinko, P.J.8
  • 179
    • 44649138531 scopus 로고    scopus 로고
    • Inhalable large porous microspheres of low molecular weight heparin: In vitro and in vivo evaluation
    • Rawat A, Majumder QH, Ahsan F. (2008). Inhalable large porous microspheres of low molecular weight heparin: in vitro and in vivo evaluation. J Control Release, 128, 224-232.
    • (2008) J Control Release , vol.128 , pp. 224-232
    • Rawat, A.1    Majumder, Q.H.2    Ahsan, F.3
  • 180
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • Reese TS, Karnovsky MJ. (1967). Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol, 34, 207-217.
    • (1967) J Cell Biol , vol.34 , pp. 207-217
    • Reese, T.S.1    Karnovsky, M.J.2
  • 181
    • 62849083225 scopus 로고    scopus 로고
    • Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption
    • Rekha MR, Sharma CP. (2009). Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. J Control Release, 135, 144-151.
    • (2009) J Control Release , vol.135 , pp. 144-151
    • Rekha, M.R.1    Sharma, C.P.2
  • 182
    • 1342264314 scopus 로고    scopus 로고
    • Mysteries of the transferrin-transferrin receptor 1 interaction uncovered
    • Richardson DR. (2004). Mysteries of the transferrin-transferrin receptor 1 interaction uncovered. Cell, 116, 483-485.
    • (2004) Cell , vol.116 , pp. 483-485
    • Richardson, D.R.1
  • 184
    • 77952491719 scopus 로고    scopus 로고
    • Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery
    • Roger E, Lagarce F, Garcion E, Benoit JP. (2010). Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery. Nanomedicine (Lond), 5, 287-306.
    • (2010) Nanomedicine (Lond) , vol.5 , pp. 287-306
    • Roger, E.1    Lagarce, F.2    Garcion, E.3    Benoit, J.P.4
  • 185
    • 70449625346 scopus 로고    scopus 로고
    • Safety and efcacy of inhaled human insulin (exubera) during discontinuation and readministration of therapy in adults with type 2 diabetes: A 3-year randomized controlled trial
    • Rosenstock J, Cefalu W T, Hollander PA, Klioze SS, Reis J, Duggan WT. (2009). Safety and efcacy of inhaled human insulin (exubera) during discontinuation and readministration of therapy in adults with type 2 diabetes: a 3-year randomized controlled trial. Diabetes Technol Ter, 11, 697-705.
    • (2009) Diabetes Technol ter , vol.11 , pp. 697-705
    • Rosenstock, J.1    Cefalu, W.T.2    Hollander, P.A.3    Klioze, S.S.4    Reis, J.5    Duggan, W.T.6
  • 187
    • 78049474668 scopus 로고    scopus 로고
    • Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin
    • Sajeesh S, Bouchemal K, Marsaud V, Vauthier C, Sharma CP. (2010a). Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin. J Control Release, 147, 377-384.
    • (2010) J Control Release , vol.147 , pp. 377-384
    • Sajeesh, S.1    Bouchemal, K.2    Marsaud, V.3    Vauthier, C.4    Sharma, C.P.5
  • 188
    • 75449113014 scopus 로고    scopus 로고
    • Surface-functionalized polymethacrylic acid based hydrogel microparticles for oral drug delivery
    • Sajeesh S, Bouchemal K, Sharma C P, Vauthier C. (2010b). Surface-functionalized polymethacrylic acid based hydrogel microparticles for oral drug delivery. Eur J Pharm Biopharm, 74, 209-218.
    • (2010) Eur J Pharm Biopharm , vol.74 , pp. 209-218
    • Sajeesh, S.1    Bouchemal, K.2    Sharma, C.P.3    Vauthier, C.4
  • 189
    • 77956631702 scopus 로고    scopus 로고
    • Tiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery
    • Sajeesh S, Vauthier C, Gueutin C, Ponchel G, Sharma CP. (2010c). Tiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery. Acta Biomater, 6, 3072-3080.
    • (2010) Acta Biomater , vol.6 , pp. 3072-3080
    • Sajeesh, S.1    Vauthier, C.2    Gueutin, C.3    Ponchel, G.4    Sharma, C.P.5
  • 190
    • 33750845387 scopus 로고    scopus 로고
    • In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery
    • Sakagami M. (2006). In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drug Deliv Rev, 58, 1030-1060.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1030-1060
    • Sakagami, M.1
  • 191
    • 33646492929 scopus 로고    scopus 로고
    • Tight junction modulation and its relationship to drug delivery
    • Salama NN, Eddington ND, Fasano A. (2006). Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev, 58, 15-28.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 15-28
    • Salama, N.N.1    Eddington, N.D.2    Fasano, A.3
  • 193
    • 34547402940 scopus 로고    scopus 로고
    • Nanoparticles based on N-trimethylchitosan: Evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models
    • Sandri G, Bonferoni MC, Rossi S, Ferrari F, Gibin S, Zambito Y, Di Colo G, Caramella C. (2007). Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models. Eur J Pharm Biopharm, 65, 68-77.
    • (2007) Eur J Pharm Biopharm , vol.65 , pp. 68-77
    • Sandri, G.1    Bonferoni, M.C.2    Rossi, S.3    Ferrari, F.4    Gibin, S.5    Zambito, Y.6    Di Colo, G.7    Caramella, C.8
  • 194
    • 0025825296 scopus 로고
    • Degradation of insulin by trypsin and alpha-chymotrypsin
    • Schilling RJ, Mitra AK. (1991). Degradation of insulin by trypsin and alpha-chymotrypsin. Pharm Res, 8, 721-727.
    • (1991) Pharm Res , vol.8 , pp. 721-727
    • Schilling, R.J.1    Mitra, A.K.2
  • 195
    • 0026663934 scopus 로고
    • Absorption enhancers in nasal insulin delivery and teir infuence on nasal ciliary functioning
    • Schipper NGM, Verhoef J, Romeijn SG, Merkus, FWHM. (1992). Absorption Enhancers in Nasal Insulin Delivery and Teir Infuence on Nasal Ciliary Functioning. J Controlled Release, 21:173-185.
    • (1992) J Controlled Release , vol.21 , pp. 173-185
    • Schipper, N.G.M.1    Verhoef, J.2    Romeijn, S.G.3    Merkus, F.W.H.M.4
  • 196
    • 0021023912 scopus 로고
    • Studies on the mechanism of bile salt-induced liposomal membrane damage
    • Schubert R, Jaroni H, Schoelmerich J, Schmidt KH. (1983). Studies on the mechanism of bile salt-induced liposomal membrane damage. Digestion, 28, 181-190.
    • (1983) Digestion , vol.28 , pp. 181-190
    • Schubert, R.1    Jaroni, H.2    Schoelmerich, J.3    Schmidt, K.H.4
  • 197
    • 2942546646 scopus 로고    scopus 로고
    • Potential applications of chitosan in veterinary medicine
    • Senel S, McClure SJ. (2004). Potential applications of chitosan in veterinary medicine. Adv Drug Deliv Rev, 56, 1467-1480.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1467-1480
    • Senel, S.1    McClure, S.J.2
  • 198
    • 0035888375 scopus 로고    scopus 로고
    • Bilosomes: The answer to oral vaccine delivery?
    • Senior K. (2001). Bilosomes: the answer to oral vaccine delivery? Drug Discov Today, 6, 1031-1032.
    • (2001) Drug Discov Today , vol.6 , pp. 1031-1032
    • Senior, K.1
  • 199
    • 0026674499 scopus 로고
    • Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: Correlation with facilitated drug transport
    • Shao Z, Mitra AK. (1992). Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport. Pharm Res, 9, 1184-1189.
    • (1992) Pharm Res , vol.9 , pp. 1184-1189
    • Shao, Z.1    Mitra, A.K.2
  • 200
    • 0038350680 scopus 로고    scopus 로고
    • Oral peptide and protein delivery: Unfulflled promises?
    • Shen WC. (2003). Oral peptide and protein delivery: unfulflled promises? Drug Discov Today, 8, 607-608.
    • (2003) Drug Discov Today , vol.8 , pp. 607-608
    • Shen, W.C.1
  • 201
    • 72449211710 scopus 로고    scopus 로고
    • M-cell targeted delivery of recombinant hepatitis B surface antigen using cholera toxin B subunit conjugated bilosomes
    • Shukla A, Katare OP, Singh B, Vyas SP. (2010). M-cell targeted delivery of recombinant hepatitis B surface antigen using cholera toxin B subunit conjugated bilosomes. Int J Pharm, 385, 47-52.
    • (2010) Int J Pharm , vol.385 , pp. 47-52
    • Shukla, A.1    Katare, O.P.2    Singh, B.3    Vyas, S.P.4
  • 202
    • 2942608191 scopus 로고    scopus 로고
    • Cholera toxin B subunit conjugated bile salt stabilized vesicles (bilosomes) for oral immunization
    • Singh P, Prabakaran D, Jain S, Mishra V, Jaganathan KS, Vyas SP. (2004). Cholera toxin B subunit conjugated bile salt stabilized vesicles (bilosomes) for oral immunization. Int J Pharm, 278, 379-390.
    • (2004) Int J Pharm , vol.278 , pp. 379-390
    • Singh, P.1    Prabakaran, D.2    Jain, S.3    Mishra, V.4    Jaganathan, K.S.5    Vyas, S.P.6
  • 203
    • 78649318567 scopus 로고    scopus 로고
    • Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies
    • Sintov AC, Levy HV, Botner S. (2010). Systemic delivery of insulin via the nasal route using a new microemulsion system: In vitro and in vivo studies. J Control Release, 148, 168-176.
    • (2010) J Control Release , vol.148 , pp. 168-176
    • Sintov, A.C.1    Levy, H.V.2    Botner, S.3
  • 204
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • Smart JD. (2005). The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev, 57, 1556-1568.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1556-1568
    • Smart, J.D.1
  • 206
    • 76749103819 scopus 로고    scopus 로고
    • Enteric-coated capsules flled with freeze-dried chitosan/poly(gamma- glutamic acid) nanoparticles for oral insulin delivery
    • Sonaje K, Chen YJ, Chen HL, Wey SP, Juang JH, Nguyen HN, Hsu CW, Lin KJ, Sung HW. (2010a). Enteric-coated capsules flled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials, 31, 3384-3394.
    • (2010) Biomaterials , vol.31 , pp. 3384-3394
    • Sonaje, K.1    Chen, Y.J.2    Chen, H.L.3    Wey, S.P.4    Juang, J.H.5    Nguyen, H.N.6    Hsu, C.W.7    Lin, K.J.8    Sung, H.W.9
  • 207
    • 77954385916 scopus 로고    scopus 로고
    • Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-responsive nanoparticles vs. subcutaneous injection
    • Sonaje K, Lin KJ, Wey SP, Lin CK, Yeh TH, Nguyen HN, Hsu CW, Yen TC, Juang JH, Sung HW. (2010b). Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-responsive nanoparticles vs. subcutaneous injection. Biomaterials, 31, 6849-6858.
    • (2010) Biomaterials , vol.31 , pp. 6849-6858
    • Sonaje, K.1    Lin, K.J.2    Wey, S.P.3    Lin, C.K.4    Yeh, T.H.5    Nguyen, H.N.6    Hsu, C.W.7    Yen, T.C.8    Juang, J.H.9    Sung, H.W.10
  • 208
    • 60849130683 scopus 로고    scopus 로고
    • In vivo evaluation of safety and efcacy of self-assembled nanoparticles for oral insulin delivery
    • Sonaje K, Lin YH, Juang JH, Wey SP, Chen CT, Sung HW. (2009). In vivo evaluation of safety and efcacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials, 30, 2329-2339.
    • (2009) Biomaterials , vol.30 , pp. 2329-2339
    • Sonaje, K.1    Lin, Y.H.2    Juang, J.H.3    Wey, S.P.4    Chen, C.T.5    Sung, H.W.6
  • 209
    • 0037038305 scopus 로고    scopus 로고
    • Preparation and evaluation of proliposomes containing salmon calcitonin
    • Song KH, Chung SJ, Shim CK. (2002). Preparation and evaluation of proliposomes containing salmon calcitonin. J Control Release, 84, 27-37.
    • (2002) J Control Release , vol.84 , pp. 27-37
    • Song, K.H.1    Chung, S.J.2    Shim, C.K.3
  • 210
    • 23944494896 scopus 로고    scopus 로고
    • Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts
    • Song KH, Chung SJ, Shim CK. (2005). Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts. J Control Release, 106, 298-308.
    • (2005) J Control Release , vol.106 , pp. 298-308
    • Song, K.H.1    Chung, S.J.2    Shim, C.K.3
  • 211
    • 0028931103 scopus 로고
    • Evidence that tyrosine phosphorylation may increase tight junction permeability
    • Staddon JM, Herrenknecht K, Smales C, Rubin LL. (1995). Evidence that tyrosine phosphorylation may increase tight junction permeability. J Cell Sci, 108 (Pt 2), 609-619.
    • (1995) J Cell Sci , vol.108 , Issue.PART 2 , pp. 609-619
    • Staddon, J.M.1    Herrenknecht, K.2    Smales, C.3    Rubin, L.L.4
  • 212
    • 78650388990 scopus 로고    scopus 로고
    • Nasal delivery of recombinant human growth hormone: In vivo evaluation with Pheroid technology and N-trimethyl chitosan chloride
    • Steyn D, du Plessis L, Kotzé A. (2010). Nasal delivery of recombinant human growth hormone: in vivo evaluation with Pheroid technology and N-trimethyl chitosan chloride. J Pharm Pharm Sci, 13, 263-273.
    • (2010) J Pharm Pharm Sci , vol.13 , pp. 263-273
    • Steyn, D.1    Du Plessis, L.2    Kotzé, A.3
  • 214
    • 84861817552 scopus 로고    scopus 로고
    • Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin
    • Sun S, Liang N, Kawashima Y, Xia D, Cui F. (2011). Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin. Int J Nanomedicine, 6, 3049-3056.
    • (2011) Int J Nanomedicine , vol.6 , pp. 3049-3056
    • Sun, S.1    Liang, N.2    Kawashima, Y.3    Xia, D.4    Cui, F.5
  • 215
    • 0034074385 scopus 로고    scopus 로고
    • Histopathological study of the efects of a single intratracheal instillation of surface active agents on lung in rats
    • Suzuki M, Machida M, Adachi K, Otabe K, Sugimoto T, Hayashi M, Awazu S. (2000). Histopathological study of the efects of a single intratracheal instillation of surface active agents on lung in rats. J Toxicol Sci, 25, 49-55.
    • (2000) J Toxicol Sci , vol.25 , pp. 49-55
    • Suzuki, M.1    MacHida, M.2    Adachi, K.3    Otabe, K.4    Sugimoto, T.5    Hayashi, M.6    Awazu, S.7
  • 216
  • 217
    • 0037449495 scopus 로고    scopus 로고
    • Mucoadhesive properties of carbopol or chitosan-coated liposomes and their efectiveness in the oral administration of calcitonin to rats
    • Takeuchi H, Matsui Y, Yamamoto H, Kawashima Y. (2003). Mucoadhesive properties of carbopol or chitosan-coated liposomes and their efectiveness in the oral administration of calcitonin to rats. J Control Release, 86, 235-242.
    • (2003) J Control Release , vol.86 , pp. 235-242
    • Takeuchi, H.1    Matsui, Y.2    Yamamoto, H.3    Kawashima, Y.4
  • 218
    • 17644384876 scopus 로고    scopus 로고
    • Efects of hydrophilic cyclodextrins on aggregation of recombinant human growth hormone
    • Tavornvipas S, Tajiri S, Hirayama F, Arima H, Uekama K. (2004). Efects of hydrophilic cyclodextrins on aggregation of recombinant human growth hormone. Pharm Res, 21, 2369-2376.
    • (2004) Pharm Res , vol.21 , pp. 2369-2376
    • Tavornvipas, S.1    Tajiri, S.2    Hirayama, F.3    Arima, H.4    Uekama, K.5
  • 219
    • 33846550081 scopus 로고    scopus 로고
    • N-sulfonato-N,O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules
    • Tanou M, Henderson S, Kydonieus A, Elson C. (2007). N-sulfonato-N,O- carboxymethylchitosan: a novel polymeric absorption enhancer for the oral delivery of macromolecules. J Control Release, 117, 171-178.
    • (2007) J Control Release , vol.117 , pp. 171-178
    • Tanou, M.1    Henderson, S.2    Kydonieus, A.3    Elson, C.4
  • 220
    • 0035478758 scopus 로고    scopus 로고
    • Chitosan and its derivatives as intestinal absorption enhancers
    • Tanou M, Verhoef JC, Junginger HE. (2001a). Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Deliv Rev, 50 Suppl 1, S91-101.
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.SUPPL. 1
    • Tanou, M.1    Verhoef, J.C.2    Junginger, H.E.3
  • 221
    • 0035813752 scopus 로고    scopus 로고
    • Oral drug absorption enhancement by chitosan and its derivatives
    • Tanou M, Verhoef JC, Junginger HE. (2001b). Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev, 52, 117-126.
    • (2001) Adv Drug Deliv Rev , vol.52 , pp. 117-126
    • Tanou, M.1    Verhoef, J.C.2    Junginger, H.E.3
  • 222
    • 0033960143 scopus 로고    scopus 로고
    • Efect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayers
    • Tanou MM, Kotzé AF, Scharringhausen T, Luessen HL, de Boer AG, Verhoef JC, Junginger HE. (2000). Efect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayers. J Control Release, 64, 15-25.
    • (2000) J Control Release , vol.64 , pp. 15-25
    • Tanou, M.M.1    Kotzé, A.F.2    Scharringhausen, T.3    Luessen, H.L.4    De Boer, A.G.5    Verhoef, J.C.6    Junginger, H.E.7
  • 223
    • 34250840641 scopus 로고    scopus 로고
    • Mucoadhesive properties of various pectins on gastrointestinal mucosa: An in vitro evaluation using texture analyzer
    • Tirawong N, Nunthanid J, Puttipipatkhachorn S, Sriamornsak P. (2007). Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer. Eur J Pharm Biopharm, 67, 132-140.
    • (2007) Eur J Pharm Biopharm , vol.67 , pp. 132-140
    • Tirawong, N.1    Nunthanid, J.2    Puttipipatkhachorn, S.3    Sriamornsak, P.4
  • 224
    • 38349112036 scopus 로고    scopus 로고
    • Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes
    • Tirawong N, Tongborisute J, Takeuchi H, Sriamornsak P. (2008). Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes. J Control Release, 125, 236-245.
    • (2008) J Control Release , vol.125 , pp. 236-245
    • Tirawong, N.1    Tongborisute, J.2    Takeuchi, H.3    Sriamornsak, P.4
  • 225
    • 67349139863 scopus 로고    scopus 로고
    • The complexation between novel comb shaped amphiphilic polyallylamine and insulin: Towards oral insulin delivery
    • Tompson CJ, Tetley L, Uchegbu IF, Cheng WP. (2009). The complexation between novel comb shaped amphiphilic polyallylamine and insulin: towards oral insulin delivery. Int J Pharm, 376, 46-55.
    • (2009) Int J Pharm , vol.376 , pp. 46-55
    • Tompson, C.J.1    Tetley, L.2    Uchegbu, I.F.3    Cheng, W.P.4
  • 226
    • 40949134628 scopus 로고    scopus 로고
    • Delivery of interferon-beta to the monkey nervous system following intranasal administration
    • Torne RG, Hanson LR, Ross TM, Tung D, Frey WH 2nd. (2008). Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience, 152, 785-797.
    • (2008) Neuroscience , vol.152 , pp. 785-797
    • Torne, R.G.1    Hanson, L.R.2    Ross, T.M.3    Tung, D.4    Frey II, W.H.5
  • 227
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Torne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. (2004). Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience, 127, 481-496.
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Torne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey II, W.H.4
  • 228
    • 43049085459 scopus 로고    scopus 로고
    • Preparation and properties of inhalable nanocomposite particles: Efects of the size, weight ratio of the primary nanoparticles in nanocomposite particles and temperature at a spray-dryer inlet upon properties of nanocomposite particles
    • Tomoda K, Ohkoshi T, Nakajima T, Makino K. (2008). Preparation and properties of inhalable nanocomposite particles: efects of the size, weight ratio of the primary nanoparticles in nanocomposite particles and temperature at a spray-dryer inlet upon properties of nanocomposite particles. Colloids Surf B Biointerfaces, 64, 70-76.
    • (2008) Colloids Surf B Biointerfaces , vol.64 , pp. 70-76
    • Tomoda, K.1    Ohkoshi, T.2    Nakajima, T.3    Makino, K.4
  • 230
    • 52449102429 scopus 로고    scopus 로고
    • Complexation hydrogels for oral insulin delivery: Efects of polymer dosing on in vivo efcacy
    • Tuesca A, Nakamura K, Morishita M, Joseph J, Peppas N, Lowman A. (2008). Complexation hydrogels for oral insulin delivery: efects of polymer dosing on in vivo efcacy. J Pharm Sci, 97, 2607-2618.
    • (2008) J Pharm Sci , vol.97 , pp. 2607-2618
    • Tuesca, A.1    Nakamura, K.2    Morishita, M.3    Joseph, J.4    Peppas, N.5    Lowman, A.6
  • 231
    • 61649125992 scopus 로고    scopus 로고
    • Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: In vivo deposition and hypoglycaemic activity after delivery to rat lungs
    • Ungaro F, d'Emmanuele di Villa Bianca R, Giovino C, Miro A, Sorrentino R, Quaglia F, La Rotonda MI. (2009). Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: in vivo deposition and hypoglycaemic activity after delivery to rat lungs. J Control Release, 135, 25-34.
    • (2009) J Control Release , vol.135 , pp. 25-34
    • Ungaro, F.1    D'Emmanuele Di Villa Bianca, R.2    Giovino, C.3    Miro, A.4    Sorrentino, R.5    Quaglia, F.6    La Rotonda, M.I.7
  • 232
    • 33745863492 scopus 로고    scopus 로고
    • Cyclodextrins in the production of large porous particles: Development of dry powders for the sustained release of insulin to the lungs
    • Ungaro F, De Rosa G, Miro A, Quaglia F, La Rotonda MI. (2006). Cyclodextrins in the production of large porous particles: development of dry powders for the sustained release of insulin to the lungs. Eur J Pharm Sci, 28, 423-432.
    • (2006) Eur J Pharm Sci , vol.28 , pp. 423-432
    • Ungaro, F.1    De Rosa, G.2    Miro, A.3    Quaglia, F.4    La Rotonda, M.I.5
  • 234
    • 23844540692 scopus 로고    scopus 로고
    • Spray freeze drying to produce a stable Delta(9)-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation
    • van Drooge DJ, Hinrichs WL, Dickhof BH, Elli MN, Visser MR, Zijlstra GS, Frijlink HW. (2005). Spray freeze drying to produce a stable Delta(9)-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation. Eur J Pharm Sci, 26, 231-240.
    • (2005) Eur J Pharm Sci , vol.26 , pp. 231-240
    • Van Drooge, D.J.1    Hinrichs, W.L.2    Dickhof, B.H.3    Elli, M.N.4    Visser, M.R.5    Zijlstra, G.S.6    Frijlink, H.W.7
  • 235
    • 26944452043 scopus 로고    scopus 로고
    • PEGylation, successful approach to drug delivery
    • Veronese FM, Pasut G. (2005). PEGylation, successful approach to drug delivery. Drug Discov Today, 10, 1451-1458.
    • (2005) Drug Discov Today , vol.10 , pp. 1451-1458
    • Veronese, F.M.1    Pasut, G.2
  • 236
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • Vivès E, Brodin P, Lebleu B. (1997). A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem, 272, 16010-16017.
    • (1997) J Biol Chem , vol.272 , pp. 16010-16017
    • Vivès, E.1    Brodin, P.2    Lebleu, B.3
  • 237
    • 54949153043 scopus 로고    scopus 로고
    • Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting
    • Wang X, Chi N, Tang X. (2008). Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting. Eur J Pharm Biopharm, 70, 735-740.
    • (2008) Eur J Pharm Biopharm , vol.70 , pp. 735-740
    • Wang, X.1    Chi, N.2    Tang, X.3
  • 239
    • 61349145559 scopus 로고    scopus 로고
    • Chitosan-aprotinin coated liposomes for oral peptide delivery: Development, characterisation and in vivo evaluation
    • Werle M, Takeuchi H. (2009). Chitosan-aprotinin coated liposomes for oral peptide delivery: Development, characterisation and in vivo evaluation. Int J Pharm, 370, 26-32.
    • (2009) Int J Pharm , vol.370 , pp. 26-32
    • Werle, M.1    Takeuchi, H.2
  • 240
    • 0024267743 scopus 로고
    • Nasal drug delivery-an invitro characterization of trans-epithelial electrical-properties and fluxes in the presence or absence of enhancers
    • Wheatley MA, Dent J, Wheeldon EB, Smith PL. (1988). Nasal Drug Delivery-an Invitro Characterization of Trans-Epithelial Electrical-Properties and Fluxes in the Presence or Absence of Enhancers. J Controlled Release, 8, 167-177.
    • (1988) J Controlled Release , vol.8 , pp. 167-177
    • Wheatley, M.A.1    Dent, J.2    Wheeldon, E.B.3    Smith, P.L.4
  • 241
    • 0043127376 scopus 로고    scopus 로고
    • Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers
    • Widera A, Kim KJ, Crandall ED, Shen WC. (2003). Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers. Pharm Res, 20, 1231-1238.
    • (2003) Pharm Res , vol.20 , pp. 1231-1238
    • Widera, A.1    Kim, K.J.2    Crandall, E.D.3    Shen, W.C.4
  • 242
    • 47049095564 scopus 로고    scopus 로고
    • Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation
    • Woitiski CB, Carvalho RA, Ribeiro AJ, Neufeld RJ, Veiga F. (2008). Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation. BioDrugs, 22, 223-237.
    • (2008) BioDrugs , vol.22 , pp. 223-237
    • Woitiski, C.B.1    Carvalho, R.A.2    Ribeiro, A.J.3    Neufeld, R.J.4    Veiga, F.5
  • 243
    • 79957529691 scopus 로고    scopus 로고
    • Facilitated nanoscale delivery of insulin across intestinal membrane models
    • Woitiski CB, Sarmento B, Carvalho RA, Neufeld RJ, Veiga F. (2011). Facilitated nanoscale delivery of insulin across intestinal membrane models. Int J Pharm, 412, 123-131.
    • (2011) Int J Pharm , vol.412 , pp. 123-131
    • Woitiski, C.B.1    Sarmento, B.2    Carvalho, R.A.3    Neufeld, R.J.4    Veiga, F.5
  • 244
    • 43149116521 scopus 로고    scopus 로고
    • Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery
    • Wood KM, Stone GM, Peppas NA. (2008). Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery. Biomacromolecules, 9, 1293-1298.
    • (2008) Biomacromolecules , vol.9 , pp. 1293-1298
    • Wood, K.M.1    Stone, G.M.2    Peppas, N.A.3
  • 245
    • 70449717366 scopus 로고    scopus 로고
    • The efect of complexation hydrogels on insulin transport in intestinal epithelial cell models
    • Wood KM, Stone GM, Peppas NA. (2010). The efect of complexation hydrogels on insulin transport in intestinal epithelial cell models. Acta Biomater, 6, 48-56.
    • (2010) Acta Biomater , vol.6 , pp. 48-56
    • Wood, K.M.1    Stone, G.M.2    Peppas, N.A.3
  • 246
    • 0035068551 scopus 로고    scopus 로고
    • Bioadhesion: New possibilities for drug administration?
    • Woodley J. (2001). Bioadhesion: new possibilities for drug administration? Clin Pharmacokinet, 40, 77-84.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 77-84
    • Woodley, J.1
  • 247
    • 0028657017 scopus 로고
    • Enzymatic barriers for GI peptide and protein delivery
    • Woodley J F. (1994). Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ter Drug Carrier Syst, 11, 61-95.
    • (1994) Crit Rev ter Drug Carrier Syst , vol.11 , pp. 61-95
    • Woodley, J.F.1
  • 249
    • 0033771566 scopus 로고    scopus 로고
    • Hypoglycemic efect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats
    • Xia CQ, Wang J, Shen WC. (2000). Hypoglycemic efect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats. J Pharmacol Exp Ter, 295, 594-600.
    • (2000) J Pharmacol Exp ter , vol.295 , pp. 594-600
    • Xia, C.Q.1    Wang, J.2    Shen, W.C.3
  • 251
    • 0027988721 scopus 로고
    • Efects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats
    • Yamamoto A, Taniguchi T, Rikyuu K, Tsuji T, Fujita T, Murakami M, Muranishi S. (1994). Efects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm Res, 11, 1496-1500.
    • (1994) Pharm Res , vol.11 , pp. 1496-1500
    • Yamamoto, A.1    Taniguchi, T.2    Rikyuu, K.3    Tsuji, T.4    Fujita, T.5    Murakami, M.6    Muranishi, S.7
  • 252
    • 84862777284 scopus 로고    scopus 로고
    • Preparation, characterization and in vivo evaluation of pH-sensitive oral insulin-loaded poly(lactic-co-glycolicacid) nanoparticles
    • Yang J, Sun H, Song C. (2012). Preparation, characterization and in vivo evaluation of pH-sensitive oral insulin-loaded poly(lactic-co-glycolicacid) nanoparticles. Diabetes Obes Metab, 14, 358-364.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 358-364
    • Yang, J.1    Sun, H.2    Song, C.3
  • 253
    • 20444403247 scopus 로고    scopus 로고
    • Pulmonary delivery of low molecular weight heparins
    • Yang T, Mustafa F, Bai S, Ahsan F. (2004). Pulmonary delivery of low molecular weight heparins. Pharm Res, 21, 2009-2016.
    • (2004) Pharm Res , vol.21 , pp. 2009-2016
    • Yang, T.1    Mustafa, F.2    Bai, S.3    Ahsan, F.4
  • 254
  • 256
    • 68549122512 scopus 로고    scopus 로고
    • Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
    • Yin L, Ding J, He C, Cui L, Tang C, Yin C. (2009). Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials, 30, 5691-5700.
    • (2009) Biomaterials , vol.30 , pp. 5691-5700
    • Yin, L.1    Ding, J.2    He, C.3    Cui, L.4    Tang, C.5    Yin, C.6
  • 257
    • 33845207048 scopus 로고    scopus 로고
    • Evaluation of therapeutic potentials of site-specifc PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability
    • Youn YS, Chae SY, Lee S, Jeon JE, Shin HG, Lee KC. (2007). Evaluation of therapeutic potentials of site-specifc PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability. Biochem Pharmacol, 73, 84-93.
    • (2007) Biochem Pharmacol , vol.73 , pp. 84-93
    • Youn, Y.S.1    Chae, S.Y.2    Lee, S.3    Jeon, J.E.4    Shin, H.G.5    Lee, K.C.6
  • 258
    • 79957692320 scopus 로고    scopus 로고
    • Formation, characterization, and fate of inhaled drug nanoparticles
    • Zhang J, Wu L, Chan HK, Watanabe W. (2011a). Formation, characterization, and fate of inhaled drug nanoparticles. Adv Drug Deliv Rev, 63, 441-455.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 441-455
    • Zhang, J.1    Wu, L.2    Chan, H.K.3    Watanabe, W.4
  • 259
    • 16244422972 scopus 로고    scopus 로고
    • Investigation of lectin-modifed insulin liposomes as carriers for oral administration
    • Zhang N, Ping QN, Huang GH, Xu W F. (2005a). Investigation of lectin-modifed insulin liposomes as carriers for oral administration. Int J Pharm, 294, 247-259.
    • (2005) Int J Pharm , vol.294 , pp. 247-259
    • Zhang, N.1    Ping, Q.N.2    Huang, G.H.3    Xu, W.F.4
  • 260
    • 39849104613 scopus 로고    scopus 로고
    • Nasal absorption enhancement of insulin using PEG-grafted chitosan nanoparticles
    • Zhang X, Zhang H, Wu Z, Wang Z, Niu H, Li C. (2008). Nasal absorption enhancement of insulin using PEG-grafted chitosan nanoparticles. Eur J Pharm Biopharm, 68, 526-534.
    • (2008) Eur J Pharm Biopharm , vol.68 , pp. 526-534
    • Zhang, X.1    Zhang, H.2    Wu, Z.3    Wang, Z.4    Niu, H.5    Li, C.6
  • 261
    • 78650710879 scopus 로고    scopus 로고
    • Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin
    • Zhang Y, Wei W, Lv P, Wang L, Ma G. (2011b). Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin. Eur J Pharm Biopharm, 77, 11-19.
    • (2011) Eur J Pharm Biopharm , vol.77 , pp. 11-19
    • Zhang, Y.1    Wei, W.2    Lv, P.3    Wang, L.4    Ma, G.5
  • 262
    • 27744602761 scopus 로고    scopus 로고
    • Permeation-enhancing efects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo
    • Zhang YJ, Ma CH, Lu WL, Zhang X, Wang XL, Sun JN, Zhang Q. (2005b). Permeation-enhancing efects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo. Acta Pharmacol Sin, 26, 1402-1408.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1402-1408
    • Zhang, Y.J.1    Ma, C.H.2    Lu, W.L.3    Zhang, X.4    Wang, X.L.5    Sun, J.N.6    Zhang, Q.7


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