Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats

Journal of Pharmaceutical Sciences

Volumn 95, Issue 2, 2006, Pages 462-469

  Goto, Takahiro ^a   Morishita, Mariko ^a   Kavimandan, Nikhil J ^b   Takayama, Kozo ^a   Peppas, Nicholas A ^b  

^a HOSHI UNIVERSITY   (Japan)

^b The University of Texas at Austin   (United States)

Author keywords

Gastrointestinal transit; Hydrogels; Microparticles; Mucoadhesion; Particle size; Poly(ethylene glycol)

Indexed keywords

ETHYLENE GLYCOL; FLUORESCENT DYE; FREE RADICAL; POLYMER; POLYMETHACRYLIC ACID;

ADHESION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DUODENUM MUCOSA; GASTROINTESTINAL TRANSIT; HYDROGEL; INTESTINE PERFUSION; MALE; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; RAT;

EID: 32644440948     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20566     Document Type: Article

References (25)

1. Takeuchi H, Yamamoto H, Kawashima Y. 2001. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Deliv Revs 47:39-54.
2. Chowdary KP, Rao YS. 2004. Mucoadhesive microspheres for controlled drug delivery. Biol Pharm Bull 27:1717-1724.
3. Lehr CM. 1994. Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract. Crit Rev Ther Drug Carrier Syst 11:119-160.
4. Peppas NA. 2004. Devices based on intelligent biopolymers for oral protein delivery. Int J Pharm 277:11-17.
5. Dorkoosh FA, Stokkel MP, Blok D, Borchard G, Rafiee-Tehrani M, Verhoef JC, Junginger HE. 2004. Feasibility study on the retention of superporous hydrogel composite polymer in the intestinal tract of man using scintigraphy. J Control Release 99:199-206.
6. Lamprecht A, Saumet JL, Roux J, Benoit JP. 2004. Lipid nanocarriers as drug delivery system for ibuprofen in pain treatment. Int J Pharm 278:407-414.
7. Bernkop-Schnurch A, Kast CE, Richter MF. 2001. Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J Control Release 71:277-285.
8. Takeuchi H, Yamamoto H, Niwa T, Hino T, Kawashima Y. 1996. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm Res 13:896-901.
9. Bernkop-Schnurch A, Krajicek ME. 1998. Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: Synthesis and evaluation of different chitosan-EDTA conjugates. J Control Release 50:215-223.
10. Lowman AM, Peppas NA. 1997. Analysis of the complexation/decomplexation phenomena in graft copolymer networks. Macromolecules 30:4959-4965.
11. Lowman AM, Cowans BA, Peppas NA. 2000. Investigation of interpolymer complexation in swollen polyelectolyte networks using solid-state NMR spectroscopy. J Polym Sci Polym Phys 38:2823-2831.
12. Morishita M, Lowman AM, Takayama K, Nagai T, Peppas NA. 2002. Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers. J Control Release 81:25-32.
13. Lowman AM, Morishita M, Kajita M, Nagai T, Peppas NA. 1999. Oral delivery of insulin using pH-responsive complexation gels. J Pharm Sci 88:933-937.
14. Morishita M, Goto T, Peppas NA, Joseph JI, Torjman MC, Munsick C, Nakamura K, Yamagata T, Takayama K, Lowman AM. 2004. Mucosal insulin delivery systems based on complexation polymer hydrogels: Effect of particle size on insulin enteral absorption. J Control Release 97:115-124.
15. Morishita M, Goto T, Nakamura K, Lowman AM, Takayama K, Peppas NA. Novel oral insulin delivery systems based on complexation polymer hydrogels: Single and multiple administration studies in type 1 and 2 diabetic rats. J Control Release, in press.
16. Sahlin JJ, Peppas NA. 1997. Enhanced hydrogel adhesion by polymer interdiffusion: Use of linear poly(ethylene glycol) as an adhesion promoter. J Biomater Sci Polym Ed 8:421-436.
17. Huang Y, Leobandung W, Foss A, Peppas NA. 2000. Molecular aspects of muco- and bioadhesion: Tethered structures and site-specific surfaces. J Control Release 65:63-71.
18. Desai MP, Labhasetwar V, Amidon GL, Levy RJ. 1996. Gastrointestinal uptake of biodegradable microparticles: Effect of particle size. Pharm Res 13:1838-1845.
19. Lamprecht A, Schafer U, Lehr CM. 2001. Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res 18:788-793.
20. Akiyama Y, Nagahara N, Kashihara T, Hirai S, Toguchi H. 1995. In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative. Pharm Res 12:397-405.
21. Sakuma S, Sudo R, Suzuki N, Kikuchi H, Akashi M, Hayashi M. 1999. Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract. Int J Pharm 177:161-172.
22. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. 1981. A pharmacokinetic analysis program (multi) for microcomputer. J. Pharmacobiodyn 4:879-885.
23. Yamagata T, Morishita M, Kavimandan NJ, Nakamura K, Fukuoka Y, Takayama K, Peppas NA. Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids. J Control Release. Submitted.
24. Morishita M, Aoki Y, Sakagami M, Nagai T, Takayama K. 2004. In situ ileal absorption of insulin in rats: Effects of hyaluronidase pretreatment diminishing the mucous/glycocalyx layers. Pharm Res 21:309-316.
25. Aoki Y, Morishita M, Asai K, Akikusa B, Hosoda S, Takayama K. 2005. Region-Dependent Role of the Mucous/Glycocalyx Layers in Insulin Permeation Across Rat Small Intestinal Membrane. Pharm Res 22:1854-1862.