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Volumn 47, Issue 10, 2008, Pages 655-667

Towards quantitative prediction of oral drug absorption

Author keywords

Absorption; Pharmacokinetic modelling

Indexed keywords

CIMETIDINE; DANAZOL; DIPYRIDAMOLE; EFAVIRENZ; EUDRAGIT; EXEMESTANE; GEFITINIB; GRISEOFULVIN; IVERMECTIN; KETOCONAZOLE; KETOPROFEN; MIDAZOLAM; NIFEDIPINE; NITRENDIPINE; PHENYTOIN; SPIRONOLACTONE;

EID: 51649104303     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200847100-00003     Document Type: Review
Times cited : (72)

References (96)
  • 1
    • 0033805179 scopus 로고    scopus 로고
    • In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs
    • Dressman JB, Reppas C. In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. Eur J Pharm Sci 2000; 11 Suppl. 2: S73-80
    • (2000) Eur J Pharm Sci , vol.11 , Issue.SUPPL. 2
    • Dressman, J.B.1    Reppas, C.2
  • 2
    • 0022618014 scopus 로고
    • Mixing-tank model for predicting dissolution rate control or oral absorption
    • Dressman JB, Fleisher D. Mixing-tank model for predicting dissolution rate control or oral absorption. J Pharm Sci 1986; 75 (2): 109-16
    • (1986) J Pharm Sci , vol.75 , Issue.2 , pp. 109-116
    • Dressman, J.B.1    Fleisher, D.2
  • 4
    • 0031913402 scopus 로고    scopus 로고
    • Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms
    • Dressman JB, Amidon GL, Reppas C, et al. Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms. Pharm Res 1998; 15 (1): 11-22
    • (1998) Pharm Res , vol.15 , Issue.1 , pp. 11-22
    • Dressman, J.B.1    Amidon, G.L.2    Reppas, C.3
  • 5
    • 44749087279 scopus 로고    scopus 로고
    • Dissolution media simulating conditions in the proximal human gastrointestinal tract: An update
    • Jantratid E, Janssen N, Reppas C, et al. Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update. Pharm Res 2008; 25 (7): 1663-76
    • (2008) Pharm Res , vol.25 , Issue.7 , pp. 1663-1676
    • Jantratid, E.1    Janssen, N.2    Reppas, C.3
  • 6
    • 21544447265 scopus 로고    scopus 로고
    • Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds
    • Vertzoni M, Dressman J, Butler J, et al. Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds. Eur J Pharm Biopharm 2005; 60 (3): 413-7
    • (2005) Eur J Pharm Biopharm , vol.60 , Issue.3 , pp. 413-417
    • Vertzoni, M.1    Dressman, J.2    Butler, J.3
  • 7
    • 0014318742 scopus 로고
    • Dissolution kinetics of drugs in human gastric juice: The role of surface tension
    • Finholt P, Solvang S. Dissolution kinetics of drugs in human gastric juice: the role of surface tension. J Pharm Sci 1968; 57 (8): 1322-6
    • (1968) J Pharm Sci , vol.57 , Issue.8 , pp. 1322-1326
    • Finholt, P.1    Solvang, S.2
  • 8
    • 0023097483 scopus 로고
    • Dissolution of 4 controlled-release theophylline formulations in milk
    • Macheras P, Koupparis M, Apostolleli E. Dissolution of 4 controlled-release theophylline formulations in milk. Int J Pharm 1987; 36: 73-9
    • (1987) Int J Pharm , vol.36 , pp. 73-79
    • Macheras, P.1    Koupparis, M.2    Apostolleli, E.3
  • 9
    • 0025012373 scopus 로고
    • A new in vitro model to detect interactions between controlled release dosage forms and food
    • Junginger HE, Verhoeven J, Peschier LJC. A new in vitro model to detect interactions between controlled release dosage forms and food. Acta Pharm Technol 1990; 36 (3): 155-60
    • (1990) Acta Pharm Technol , vol.36 , Issue.3 , pp. 155-160
    • Junginger, H.E.1    Verhoeven, J.2    Peschier, L.J.C.3
  • 12
    • 0030927353 scopus 로고    scopus 로고
    • Characterization of fluids from the stomach and proximal jejunum in men and women
    • Lindahl A, Ungell AL, Knutson L, et al. Characterization of fluids from the stomach and proximal jejunum in men and women. Pharm Res 1997; 14 (4): 497-502
    • (1997) Pharm Res , vol.14 , Issue.4 , pp. 497-502
    • Lindahl, A.1    Ungell, A.L.2    Knutson, L.3
  • 13
    • 32244434196 scopus 로고    scopus 로고
    • Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/ bioequivalence studies
    • Kalantzi L, Goumas K, Kalioras V, et al. Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/ bioequivalence studies. Pharm Res 2006; 23 (1): 165-76
    • (2006) Pharm Res , vol.23 , Issue.1 , pp. 165-176
    • Kalantzi, L.1    Goumas, K.2    Kalioras, V.3
  • 14
    • 0013932518 scopus 로고
    • Ionic constituents and osmolality of gastric and small-intestinal fluids after eating
    • Fordtran JS, Locklear TW. Ionic constituents and osmolality of gastric and small-intestinal fluids after eating. Am J Dig Dis 1966; 11 (7): 503-21
    • (1966) Am J Dig Dis , vol.11 , Issue.7 , pp. 503-521
    • Fordtran, J.S.1    Locklear, T.W.2
  • 15
    • 0029825085 scopus 로고    scopus 로고
    • Effects of food on drug absorption
    • Welling PG. Effects of food on drug absorption. Annu Rev Nutr 1996; 16: 383-415
    • (1996) Annu Rev Nutr , vol.16 , pp. 383-415
    • Welling, P.G.1
  • 16
    • 39149115065 scopus 로고    scopus 로고
    • Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption
    • Custodio JM, Wu C-Y, Benet LZ. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev 2008; 60: 717-33
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 717-733
    • Custodio, J.M.1    Wu, C.-Y.2    Benet, L.Z.3
  • 17
    • 33745416604 scopus 로고    scopus 로고
    • Oral absorption of poorly water-soluble drugs: Computer simulation of fraction absorbed in humans from a miniscale dissolution test
    • Takano R, Sugano K, Higashida A, et al. Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test. Pharm Res 2006; 23 (6): 1144-56
    • (2006) Pharm Res , vol.23 , Issue.6 , pp. 1144-1156
    • Takano, R.1    Sugano, K.2    Higashida, A.3
  • 18
    • 0034898463 scopus 로고    scopus 로고
    • A dynamic in vitro lipolysis model: I. Controlling the rate of lipolysis by continuous addition of calcium
    • Zangenberg NH, Müllertz A, Kristensen HG, et al. A dynamic in vitro lipolysis model: I. Controlling the rate of lipolysis by continuous addition of calcium. Eur J Pharm Sci 2001; 14 (2): 115-22
    • (2001) Eur J Pharm Sci , vol.14 , Issue.2 , pp. 115-122
    • Zangenberg, N.H.1    Müllertz, A.2    Kristensen, H.G.3
  • 19
    • 0034836387 scopus 로고    scopus 로고
    • A dynamic in vitro lipolysis model: II. Evaluation of the model
    • Zangenberg NH, Müllertz A, Kristensen HG, et al. A dynamic in vitro lipolysis model: II. Evaluation of the model. Eur J Pharm Sci 2001; 14 (3): 237-44
    • (2001) Eur J Pharm Sci , vol.14 , Issue.3 , pp. 237-244
    • Zangenberg, N.H.1    Müllertz, A.2    Kristensen, H.G.3
  • 20
    • 51649084118 scopus 로고    scopus 로고
    • Fatouros DG, Müllertz A. Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations. In: Hauss DJ, editor. Oral lipid-based formulations: enhancing the bioavailability of poorly water-soluble drugs. 1st ed. New York: Informa Healthcare USA, Inc., 2007: 257-72
    • Fatouros DG, Müllertz A. Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations. In: Hauss DJ, editor. Oral lipid-based formulations: enhancing the bioavailability of poorly water-soluble drugs. 1st ed. New York: Informa Healthcare USA, Inc., 2007: 257-72
  • 22
    • 33947493411 scopus 로고    scopus 로고
    • Biowaiver monographs for immediate release solid oral dosage forms: Isoniazid
    • Becker C, Dressman JB, Amidon GL, et al. Biowaiver monographs for immediate release solid oral dosage forms: isoniazid. J Pharm Sci 2007; 96 (3): 522-31
    • (2007) J Pharm Sci , vol.96 , Issue.3 , pp. 522-531
    • Becker, C.1    Dressman, J.B.2    Amidon, G.L.3
  • 23
    • 0032480901 scopus 로고    scopus 로고
    • Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters: A multivariate data analysis approach
    • Winiwarter S, Bonham NM, Ax F, et al. Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters: a multivariate data analysis approach. J Med Chem 1998; 41 (25): 4939-49
    • (1998) J Med Chem , vol.41 , Issue.25 , pp. 4939-4949
    • Winiwarter, S.1    Bonham, N.M.2    Ax, F.3
  • 24
    • 0031925268 scopus 로고    scopus 로고
    • Human intestinal permeability
    • Lennernäs H. Human intestinal permeability. J Pharm Sci 1998; 87 (4): 403-10
    • (1998) J Pharm Sci , vol.87 , Issue.4 , pp. 403-410
    • Lennernäs, H.1
  • 25
    • 0035866672 scopus 로고    scopus 로고
    • High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes
    • Wohnsland F, Faller B. High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. J Med Chem 2001; 44 (6): 923-30
    • (2001) J Med Chem , vol.44 , Issue.6 , pp. 923-930
    • Wohnsland, F.1    Faller, B.2
  • 26
    • 0032568397 scopus 로고    scopus 로고
    • Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes
    • Kansy M, Senner F, Gubernator K. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. J Med Chem 1998; 41 (7): 1007-10
    • (1998) J Med Chem , vol.41 , Issue.7 , pp. 1007-1010
    • Kansy, M.1    Senner, F.2    Gubernator, K.3
  • 27
    • 0034979192 scopus 로고    scopus 로고
    • High throughput prediction of oral absorption: Improvement of the composition of the lipid solution used in parallel artificial membrane permeation assay
    • Sugano K, Hamada H, Machida M, et al. High throughput prediction of oral absorption: improvement of the composition of the lipid solution used in parallel artificial membrane permeation assay. J Biomol Screen 2001; 6 (3): 189-96
    • (2001) J Biomol Screen , vol.6 , Issue.3 , pp. 189-196
    • Sugano, K.1    Hamada, H.2    Machida, M.3
  • 28
    • 0036238280 scopus 로고    scopus 로고
    • A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential
    • Zhu C, Jiang L, Chen TM, et al. A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential. Eur J Med Chem 2002; 37 (5): 399-407
    • (2002) Eur J Med Chem , vol.37 , Issue.5 , pp. 399-407
    • Zhu, C.1    Jiang, L.2    Chen, T.M.3
  • 29
    • 33644895842 scopus 로고    scopus 로고
    • The rise of PAMPA. Expert Opin Drug Metab
    • Avdeef A. The rise of PAMPA. Expert Opin Drug Metab Toxicol 2005; 1 (2): 325-42
    • (2005) Toxicol , vol.1 , Issue.2 , pp. 325-342
    • Avdeef, A.1
  • 30
    • 36849083571 scopus 로고    scopus 로고
    • PAMPA-critical factors for better predictions of absorption
    • Avdeef A, Bendels S, Di L, et al. PAMPA-critical factors for better predictions of absorption. J Pharm Sci 2007; 96 (11): 2893-909
    • (2007) J Pharm Sci , vol.96 , Issue.11 , pp. 2893-2909
    • Avdeef, A.1    Bendels, S.2    Di, L.3
  • 31
    • 0024593744 scopus 로고
    • Characterization of the human colon carcino-ma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the human colon carcino-ma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989; 96 (3): 736-49
    • (1989) Gastroenterology , vol.96 , Issue.3 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 32
    • 0035286778 scopus 로고    scopus 로고
    • Caco-2 monolayers in experimental and theoretical predictions of drug transport
    • Artursson P, Palm K, Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 2001; 46 (1-3): 27-43
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 27-43
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 33
    • 0346216088 scopus 로고    scopus 로고
    • Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis
    • Alsenz J, Haenel E. Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis. Pharm Res 2003; 20 (12): 1961-9
    • (2003) Pharm Res , vol.20 , Issue.12 , pp. 1961-1969
    • Alsenz, J.1    Haenel, E.2
  • 34
    • 1842557505 scopus 로고    scopus 로고
    • Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers
    • Ingels F, Beck B, Oth M, et al. Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers. Int J Pharm 2004; 274 (1-2): 221-32
    • (2004) Int J Pharm , vol.274 , Issue.1-2 , pp. 221-232
    • Ingels, F.1    Beck, B.2    Oth, M.3
  • 35
    • 0029020035 scopus 로고
    • Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: Relationship to absorption in humans
    • Stewart BH, Chan OH, Lu RH, et al. Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans. Pharm Res 1995; 12 (5): 693-9
    • (1995) Pharm Res , vol.12 , Issue.5 , pp. 693-699
    • Stewart, B.H.1    Chan, O.H.2    Lu, R.H.3
  • 36
    • 0029939330 scopus 로고    scopus 로고
    • In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system
    • Chong S, Dando SA, Soucek KM, et al. In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system. Pharm Res 1996; 13 (1): 120-3
    • (1996) Pharm Res , vol.13 , Issue.1 , pp. 120-123
    • Chong, S.1    Dando, S.A.2    Soucek, K.M.3
  • 37
    • 0030023536 scopus 로고    scopus 로고
    • Comparison between active and passive transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
    • Lennernäs H, Palm K, Fagerholm U, et al. Comparison between active and passive transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo. Int J Pharm 1996; 127: 103-7
    • (1996) Int J Pharm , vol.127 , pp. 103-107
    • Lennernäs, H.1    Palm, K.2    Fagerholm, U.3
  • 38
    • 0030990079 scopus 로고    scopus 로고
    • In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: Fact or myth
    • Yee S. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth. Pharm Res 1997; 14 (6): 763-6
    • (1997) Pharm Res , vol.14 , Issue.6 , pp. 763-766
    • Yee, S.1
  • 39
    • 0030030387 scopus 로고    scopus 로고
    • Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption
    • Collett A, Sims E, Walker D, et al. Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption. Pharm Res 1996; 13 (2): 216-21
    • (1996) Pharm Res , vol.13 , Issue.2 , pp. 216-221
    • Collett, A.1    Sims, E.2    Walker, D.3
  • 40
    • 0031786518 scopus 로고    scopus 로고
    • Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats
    • Chiou WL, Barve A. Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats. Pharm Res 1998; 15 (11): 1792-5
    • (1998) Pharm Res , vol.15 , Issue.11 , pp. 1792-1795
    • Chiou, W.L.1    Barve, A.2
  • 41
    • 0036296060 scopus 로고    scopus 로고
    • Comparison of oral absorption and bioavailablity of drugs between monkey and human
    • Chiou WL, Buehler PW. Comparison of oral absorption and bioavailablity of drugs between monkey and human. Pharm Res 2002; 19 (6): 868-74
    • (2002) Pharm Res , vol.19 , Issue.6 , pp. 868-874
    • Chiou, W.L.1    Buehler, P.W.2
  • 42
    • 34250004062 scopus 로고    scopus 로고
    • Development and validation of a physiology-based model for the prediction of oral absorption in monkeys
    • Willmann S, Edginton AN, Dressman JB. Development and validation of a physiology-based model for the prediction of oral absorption in monkeys. Pharm Res 2007; 24 (7): 1275-82
    • (2007) Pharm Res , vol.24 , Issue.7 , pp. 1275-1282
    • Willmann, S.1    Edginton, A.N.2    Dressman, J.B.3
  • 43
    • 0032945581 scopus 로고    scopus 로고
    • Paracellular glucose transport plays a minor role in the unanesthetized dog
    • Lane JS, Whang EE, Rigberg DA, et al. Paracellular glucose transport plays a minor role in the unanesthetized dog. Am J Physiol 1999; 276 (3 Pt 1): G789-94
    • (1999) Am J Physiol , vol.276 , Issue.3 PART 1
    • Lane, J.S.1    Whang, E.E.2    Rigberg, D.A.3
  • 44
    • 0031958251 scopus 로고    scopus 로고
    • Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides
    • He YL, Murby S, Warhurst G, et al. Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides. J Pharm Sci 1998; 87 (5): 626-33
    • (1998) J Pharm Sci , vol.87 , Issue.5 , pp. 626-633
    • He, Y.L.1    Murby, S.2    Warhurst, G.3
  • 45
    • 0026536551 scopus 로고
    • Characterization of human cytochrome P450 enzymes
    • Guengerich FP. Characterization of human cytochrome P450 enzymes. FASEB J 1992; 6 (2): 745-8
    • (1992) FASEB J , vol.6 , Issue.2 , pp. 745-748
    • Guengerich, F.P.1
  • 49
    • 0027174992 scopus 로고
    • Cyclosporin clinical pharmacokinetics
    • Fahr A. Cyclosporin clinical pharmacokinetics. Clin Pharmacokinet 1993; 24 (6): 472-95
    • (1993) Clin Pharmacokinet , vol.24 , Issue.6 , pp. 472-495
    • Fahr, A.1
  • 50
    • 0021327073 scopus 로고
    • Clinical pharmacokinetics of ranitidine
    • Roberts CJ. Clinical pharmacokinetics of ranitidine. Clin Pharmacokinet 1984; 9 (3): 211-21
    • (1984) Clin Pharmacokinet , vol.9 , Issue.3 , pp. 211-221
    • Roberts, C.J.1
  • 51
    • 0022445306 scopus 로고
    • First-order elimination kinetics following baclofen overdose
    • Gerkin R, Curry SC, Vance MV, et al. First-order elimination kinetics following baclofen overdose. Ann Emerg Med 1986; 15 (7): 843-6
    • (1986) Ann Emerg Med , vol.15 , Issue.7 , pp. 843-846
    • Gerkin, R.1    Curry, S.C.2    Vance, M.V.3
  • 52
    • 0037338655 scopus 로고    scopus 로고
    • Gentamicin pharmacokinetics during slow daily home hemodialysis
    • Manley HJ, Bailie GR, McClaran ML, et al. Gentamicin pharmacokinetics during slow daily home hemodialysis. Kidney Int 2003; 63 (3): 1072-8
    • (2003) Kidney Int , vol.63 , Issue.3 , pp. 1072-1078
    • Manley, H.J.1    Bailie, G.R.2    McClaran, M.L.3
  • 53
    • 0017693612 scopus 로고
    • Pharmacokinetics of hydrochlorothiazide in man
    • Beermann B, Groschinsky-Grind M. Pharmacokinetics of hydrochlorothiazide in man. Eur J Clin Pharmacol 1977; 12 (4): 297-303
    • (1977) Eur J Clin Pharmacol , vol.12 , Issue.4 , pp. 297-303
    • Beermann, B.1    Groschinsky-Grind, M.2
  • 54
    • 0026685806 scopus 로고
    • Improved oral bioavailability of propranolol in healthy human volunteers using a liver bypass drug delivery system containing oleic acid
    • Barnwell SG, Laudanski T, Story MJ, et al. Improved oral bioavailability of propranolol in healthy human volunteers using a liver bypass drug delivery system containing oleic acid. Int J Pharm 1992; 88: 423-32
    • (1992) Int J Pharm , vol.88 , pp. 423-432
    • Barnwell, S.G.1    Laudanski, T.2    Story, M.J.3
  • 55
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270 (1): 414-23
    • (1994) J Pharmacol Exp Ther , vol.270 , Issue.1 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3
  • 56
    • 33645809139 scopus 로고    scopus 로고
    • The human intestinal cytochrome P450 'pie'
    • Paine MF, Hart HL, Ludington SS, et al. The human intestinal cytochrome P450 'pie'. Drug Metab Dispos 2006; 34 (5): 880-6
    • (2006) Drug Metab Dispos , vol.34 , Issue.5 , pp. 880-886
    • Paine, M.F.1    Hart, H.L.2    Ludington, S.S.3
  • 57
    • 0023588109 scopus 로고
    • Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
    • Watkins PB, Wrighton SA, Schuetz EG, et al. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 1987; 80 (4): 1029-36
    • (1987) J Clin Invest , vol.80 , Issue.4 , pp. 1029-1036
    • Watkins, P.B.1    Wrighton, S.A.2    Schuetz, E.G.3
  • 58
    • 0031445547 scopus 로고    scopus 로고
    • Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
    • Paine MF, Khalighi M, Fisher JM, et al. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J Pharmacol Exp Ther 1997; 283 (3): 1552-62
    • (1997) J Pharmacol Exp Ther , vol.283 , Issue.3 , pp. 1552-1562
    • Paine, M.F.1    Khalighi, M.2    Fisher, J.M.3
  • 59
    • 4744373595 scopus 로고    scopus 로고
    • Cytochrome P450 3A expression and activity in the human small intestine
    • Yang J, Tucker GT, Rostami-Hodjegan A. Cytochrome P450 3A expression and activity in the human small intestine. Clin Pharmacol Ther 2004; 76 (4): 391
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.4 , pp. 391
    • Yang, J.1    Tucker, G.T.2    Rostami-Hodjegan, A.3
  • 60
    • 0025719746 scopus 로고
    • First-pass metabolism of cyclosporin by the gut
    • Kolars JC, Awni WM, Merion RM, et al. First-pass metabolism of cyclosporin by the gut. Lancet 1991; 338 (8781): 1488-90
    • (1991) Lancet , vol.338 , Issue.8781 , pp. 1488-1490
    • Kolars, J.C.1    Awni, W.M.2    Merion, R.M.3
  • 61
    • 0029738490 scopus 로고    scopus 로고
    • First-pass metabolism of midazolam by the human intestine
    • Paine MF, Shen DD, Kunze KL, et al. First-pass metabolism of midazolam by the human intestine. Clin Pharmacol Ther 1996; 60 (1): 14-24
    • (1996) Clin Pharmacol Ther , vol.60 , Issue.1 , pp. 14-24
    • Paine, M.F.1    Shen, D.D.2    Kunze, K.L.3
  • 62
    • 0034827018 scopus 로고    scopus 로고
    • Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique
    • von Richter O, Greiner B, Fromm MF, et al. Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique. Clin Pharmacol Ther 2001; 70 (3): 217-27
    • (2001) Clin Pharmacol Ther , vol.70 , Issue.3 , pp. 217-227
    • von Richter, O.1    Greiner, B.2    Fromm, M.F.3
  • 63
    • 0031856787 scopus 로고    scopus 로고
    • Characterization of CYP2C19 and CYP2C9 from human liver: Respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations
    • Lasker JM, Wester MR, Aramsombatdee E, et al. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch Biochem Biophys 1998; 353 (1): 16-28
    • (1998) Arch Biochem Biophys , vol.353 , Issue.1 , pp. 16-28
    • Lasker, J.M.1    Wester, M.R.2    Aramsombatdee, E.3
  • 64
    • 33747599176 scopus 로고    scopus 로고
    • Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: Impact on prediction of first-pass metabolism
    • Galetin A, Houston JB. Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism. J Pharmacol Exp Ther 2006; 318 (3): 1220-9
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.3 , pp. 1220-1229
    • Galetin, A.1    Houston, J.B.2
  • 65
    • 0033022765 scopus 로고    scopus 로고
    • Characterization of human small intestinal cytochromes P-450
    • Zhang QY, Dunbar D, Ostrowska A, et al. Characterization of human small intestinal cytochromes P-450. Drug Metab Dispos 1999; 27 (7): 804-9
    • (1999) Drug Metab Dispos , vol.27 , Issue.7 , pp. 804-809
    • Zhang, Q.Y.1    Dunbar, D.2    Ostrowska, A.3
  • 66
    • 0024604149 scopus 로고
    • Cytochromes P-450 in the intestinal mucosa of man
    • Peters WH, Kremers PG. Cytochromes P-450 in the intestinal mucosa of man. Biochem Pharmacol 1989; 38 (9): 1535-8
    • (1989) Biochem Pharmacol , vol.38 , Issue.9 , pp. 1535-1538
    • Peters, W.H.1    Kremers, P.G.2
  • 67
    • 0033009998 scopus 로고    scopus 로고
    • Is the role of the small intestine in first-pass metabolism overemphasized?
    • Lin JH, Chiba M, Baillie TA. Is the role of the small intestine in first-pass metabolism overemphasized? Pharmacol Rev 1999; 51 (2): 135-58
    • (1999) Pharmacol Rev , vol.51 , Issue.2 , pp. 135-158
    • Lin, J.H.1    Chiba, M.2    Baillie, T.A.3
  • 68
    • 0032956839 scopus 로고    scopus 로고
    • Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: Comparison of Ki values and impact of CYP3A5 expression
    • Gibbs MA, Thummel KE, Shen DD, et al. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab Dispos 1999; 27 (2): 180-7
    • (1999) Drug Metab Dispos , vol.27 , Issue.2 , pp. 180-187
    • Gibbs, M.A.1    Thummel, K.E.2    Shen, D.D.3
  • 69
    • 0029972195 scopus 로고    scopus 로고
    • The nifedipine-rifampin interaction: Evidence for induction of gut wall metabolism
    • Holtbecker N, Fromm MF, Kroemer HK, et al. The nifedipine-rifampin interaction: evidence for induction of gut wall metabolism. Drug Metab Dispos 1996; 24 (10): 1121-3
    • (1996) Drug Metab Dispos , vol.24 , Issue.10 , pp. 1121-1123
    • Holtbecker, N.1    Fromm, M.F.2    Kroemer, H.K.3
  • 70
    • 35348939199 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics-gut-wall metabolism
    • Fagerholm U. Prediction of human pharmacokinetics-gut-wall metabolism. J Pharm Pharmacol 2007; 59 (10): 1335-43
    • (2007) J Pharm Pharmacol , vol.59 , Issue.10 , pp. 1335-1343
    • Fagerholm, U.1
  • 71
    • 35348895572 scopus 로고    scopus 로고
    • Prediction of intestinal first-pass drug metabolism
    • Yang J, Jamei M, Yeo KR, et al. Prediction of intestinal first-pass drug metabolism. Curr Drug Metab 2007; 8 (7): 676-84
    • (2007) Curr Drug Metab , vol.8 , Issue.7 , pp. 676-684
    • Yang, J.1    Jamei, M.2    Yeo, K.R.3
  • 72
    • 30744469769 scopus 로고    scopus 로고
    • From in vivo to in vitro/in silico ADME: Progress and challenges
    • Van de Waterbeemd H. From in vivo to in vitro/in silico ADME: progress and challenges. Expert Opin Drug Metab Toxicol 2005; 1 (1): 1-4
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , Issue.1 , pp. 1-4
    • Van de Waterbeemd, H.1
  • 73
    • 33748338819 scopus 로고    scopus 로고
    • From physicochemistry to absorption and distribution: Predictive mechanistic modelling and computational tools
    • Willmann S, Lippert J, Schmitt W. From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools. Expert Opin Drug Metab Toxicol 2005; 1 (1): 159-68
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , Issue.1 , pp. 159-168
    • Willmann, S.1    Lippert, J.2    Schmitt, W.3
  • 74
    • 3242778534 scopus 로고    scopus 로고
    • A physiological model for the estimation of the fraction dose absorbed in humans
    • Willmann S, Schmitt W, Keldenich J, et al. A physiological model for the estimation of the fraction dose absorbed in humans. J Med Chem 2004; 47 (16): 4022-31
    • (2004) J Med Chem , vol.47 , Issue.16 , pp. 4022-4031
    • Willmann, S.1    Schmitt, W.2    Keldenich, J.3
  • 75
    • 0031026707 scopus 로고    scopus 로고
    • Simulation models to predict oral drug absorption from in vitro data
    • Grass GM. Simulation models to predict oral drug absorption from in vitro data. Adv Drug Deliv Rev 1997; 23: 199-219
    • (1997) Adv Drug Deliv Rev , vol.23 , pp. 199-219
    • Grass, G.M.1
  • 76
    • 0036606241 scopus 로고    scopus 로고
    • Predicting ADME properties in silico: Methods and models
    • Butina D, Segall MD, Frankcombe K. Predicting ADME properties in silico: methods and models. Drug Discov Today 2002; 7 Suppl. 11: S83-8
    • (2002) Drug Discov Today , vol.7 , Issue.SUPPL. 11
    • Butina, D.1    Segall, M.D.2    Frankcombe, K.3
  • 77
    • 0037204540 scopus 로고    scopus 로고
    • Physiologically-based pharmacokinetic simulation modelling
    • Grass GM, Sinko PJ. Physiologically-based pharmacokinetic simulation modelling. Adv Drug Deliv Rev 2002; 54 (3): 433-51
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.3 , pp. 433-451
    • Grass, G.M.1    Sinko, P.J.2
  • 78
    • 0033999569 scopus 로고    scopus 로고
    • Norris DA, Leesman GD, Sinko PJ, et al. Development of predictive pharmacokinetic simulation models for drug discovery. J Control Release 2000; 65 1-2, 55-62
    • Norris DA, Leesman GD, Sinko PJ, et al. Development of predictive pharmacokinetic simulation models for drug discovery. J Control Release 2000; 65 (1-2): 55-62
  • 79
    • 15244345072 scopus 로고    scopus 로고
    • Prediction of oral drug absorption in humans by theoretical passive absorption model
    • Obata K, Sugano K, Saitoh R, et al. Prediction of oral drug absorption in humans by theoretical passive absorption model. Int J Pharm 2005; 293 (1-2): 183-92
    • (2005) Int J Pharm , vol.293 , Issue.1-2 , pp. 183-192
    • Obata, K.1    Sugano, K.2    Saitoh, R.3
  • 80
    • 13244293389 scopus 로고    scopus 로고
    • Simulation models for drug disposition and drug interactions
    • Dickens M, van de Waterbeemd H. Simulation models for drug disposition and drug interactions. Drug Discov Today Biosilico 2004; 2 (1): 38-45
    • (2004) Drug Discov Today Biosilico , vol.2 , Issue.1 , pp. 38-45
    • Dickens, M.1    van de Waterbeemd, H.2
  • 81
    • 34249905607 scopus 로고    scopus 로고
    • Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs
    • Willmann S, Hohn K, Edginton A, et al. Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs. J Pharmacokinet Pharmacodyn 2007; 34 (3): 401-31
    • (2007) J Pharmacokinet Pharmacodyn , vol.34 , Issue.3 , pp. 401-431
    • Willmann, S.1    Hohn, K.2    Edginton, A.3
  • 82
    • 0035478779 scopus 로고    scopus 로고
    • Predicting the impact of physiological and biochemical processes on oral drug bioavailability
    • Agoram B, Woltosz WS, Bolger MB. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Adv Drug Deliv Rev 2001; 50 Suppl. 1: S41-67
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.SUPPL. 1
    • Agoram, B.1    Woltosz, W.S.2    Bolger, M.B.3
  • 83
    • 0032531309 scopus 로고    scopus 로고
    • Characterization of small intestinal transit time distribution in humans
    • Yu LX, Amidon GL. Characterization of small intestinal transit time distribution in humans. Int J Pharm 1998; 171: 157-63
    • (1998) Int J Pharm , vol.171 , pp. 157-163
    • Yu, L.X.1    Amidon, G.L.2
  • 84
    • 0032888376 scopus 로고    scopus 로고
    • A compartmental absorption and transit model for estimating oral drug absorption
    • Yu LX, Amidon GL. A compartmental absorption and transit model for estimating oral drug absorption. Int J Pharm 1999; 186 (2): 119-25
    • (1999) Int J Pharm , vol.186 , Issue.2 , pp. 119-125
    • Yu, L.X.1    Amidon, G.L.2
  • 85
    • 34748925493 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics using physiologically based modeling: A retrospective analysis of 26 clinically tested drugs
    • De Buck SS, Sinha VK, Fenu LA, et al. Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs. Drug Metab Dispos 2007; 35 (10): 1766-80
    • (2007) Drug Metab Dispos , vol.35 , Issue.10 , pp. 1766-1780
    • De Buck, S.S.1    Sinha, V.K.2    Fenu, L.A.3
  • 86
    • 0036803219 scopus 로고    scopus 로고
    • Prediction of intestinal absorption: Comparative assessment of GastroPlus and Idea
    • Parrott N, Lave T. Prediction of intestinal absorption: comparative assessment of GastroPlus and Idea. Eur J Pharm Sci 2002; 17 (1-2): 51-61
    • (2002) Eur J Pharm Sci , vol.17 , Issue.1-2 , pp. 51-61
    • Parrott, N.1    Lave, T.2
  • 87
    • 28444451169 scopus 로고    scopus 로고
    • A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study
    • Kuentz M, Nick S, Parrott N, et al. A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study. Eur J Pharm Sci 2006; 27 (1): 91-9
    • (2006) Eur J Pharm Sci , vol.27 , Issue.1 , pp. 91-99
    • Kuentz, M.1    Nick, S.2    Parrott, N.3
  • 88
    • 33845467297 scopus 로고    scopus 로고
    • Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling
    • Jones HM, Parrott N, Ohlenbusch G, et al. Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling. Clin Pharmacokinet 2006; 45 (12): 1213-26
    • (2006) Clin Pharmacokinet , vol.45 , Issue.12 , pp. 1213-1226
    • Jones, H.M.1    Parrott, N.2    Ohlenbusch, G.3
  • 89
    • 21744457064 scopus 로고    scopus 로고
    • Physiology-based pharmacokinetic modeling: Ready to be used
    • Schmitt W, Willmann S. Physiology-based pharmacokinetic modeling: ready to be used. Drug Discov Today Technologies 2005; 2 (1): 125-32
    • (2005) Drug Discov Today Technologies , vol.2 , Issue.1 , pp. 125-132
    • Schmitt, W.1    Willmann, S.2
  • 90
    • 13244280971 scopus 로고    scopus 로고
    • PK-Sim® : A physiologically based pharmacokinetic 'whole-body' model
    • Willmann S, Lippert J, Sevestre M, et al. PK-Sim® : a physiologically based pharmacokinetic 'whole-body' model. Biosilico 2003; 1 (4): 121-4
    • (2003) Biosilico , vol.1 , Issue.4 , pp. 121-124
    • Willmann, S.1    Lippert, J.2    Sevestre, M.3
  • 92
    • 33645503065 scopus 로고    scopus 로고
    • Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: Cimetidine
    • Jantratid E, Prakongpan S, Amidon GL, et al. Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: cimetidine. Clin Pharmacokinet 2006; 45 (4): 385-99
    • (2006) Clin Pharmacokinet , vol.45 , Issue.4 , pp. 385-399
    • Jantratid, E.1    Prakongpan, S.2    Amidon, G.L.3
  • 93
    • 51649099110 scopus 로고    scopus 로고
    • Physiology-based models to simulate gut wall metabolism of nifedipine
    • October 10-13; Erlangen
    • Blank K, Becker C, Lippert J, et al. Physiology-based models to simulate gut wall metabolism of nifedipine. DPhG Jahrestagung; 2007 October 10-13; Erlangen
    • (2007) DPhG Jahrestagung
    • Blank, K.1    Becker, C.2    Lippert, J.3
  • 95
    • 0029897299 scopus 로고    scopus 로고
    • Investigation of nifedipine absorption in different regions of the human gastrointestinal (GI) tract after simultaneous administration of 13C- and 12C-nifedipine
    • Bode H, Brendel E, Ahr G, et al. Investigation of nifedipine absorption in different regions of the human gastrointestinal (GI) tract after simultaneous administration of 13C- and 12C-nifedipine. Eur J Clin Pharmacol 1996; 50 (3): 195-201
    • (1996) Eur J Clin Pharmacol , vol.50 , Issue.3 , pp. 195-201
    • Bode, H.1    Brendel, E.2    Ahr, G.3
  • 96
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • Guengerich FP, Martin MV, Beaune PH, et al. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J Biol Chem 1986; 261 (11): 5051-60
    • (1986) J Biol Chem , vol.261 , Issue.11 , pp. 5051-5060
    • Guengerich, F.P.1    Martin, M.V.2    Beaune, P.H.3


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