Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride

Drug Delivery

Volumn 17, Issue 6, 2010, Pages 399-407

  Du Plessis, Lissinda H ^a   Kotzé, Awie F ^a   Junginger, Hans E ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b NARESUAN UNIVERSITY   (Thailand)

Author keywords

Absorption enhancer; Chitosan; N trimethyl chitosan chloride; Nasal route; Paracellular transport; Rectal route

Indexed keywords

CHITOSAN; CHITOSAN DERIVATIVE; GLUCOSE; HUMAN INSULIN; N TRIMETHYLCHITOSAN CHLORIDE; UNCLASSIFIED DRUG; DRUG CARRIER; GLUCOSE BLOOD LEVEL; INSULIN; N-TRIMETHYL CHITOSAN CHLORIDE; QUATERNARY AMMONIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INTESTINE EPITHELIUM; MALE; NONHUMAN; NOSE CONGESTION; NOSE MUCOSA; PH; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; TOXICITY TESTING; ABSORPTION; AMINATION; ANALYSIS; ANIMAL; CHEMISTRY; DRUG EFFECTS; INTESTINAL SECRETIONS; INTESTINE MUCOSA; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MUCUS; PATHOLOGY; RECTAL DRUG ADMINISTRATION; RECTUM; SECRETION (PROCESS); SOLUBILITY; SPRAGUE DAWLEY RAT;

ABSORPTION; ADMINISTRATION, INTRANASAL; ADMINISTRATION, RECTAL; AMINATION; ANIMALS; BLOOD GLUCOSE; CHITOSAN; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; INSULIN; INTESTINAL MUCOSA; INTESTINAL SECRETIONS; MALE; MUCUS; NASAL MUCOSA; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECTUM; SOLUBILITY;

EID: 77954247722     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717541003762888     Document Type: Article

References (45)

1. Amidi M. Mastrobattista E. Jiskoot W. Hennik W.E. (2010). Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev. 62:59-82.
2. Amidi, M., Romeijn, S.G., Borchard, G., Junginger, H.E., Hennik., W.E., Jiskoot, W. (2006). Preparation and characterisation of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J Contr Rel. 111:107-116
3. Artursson, P., Lindmark, T., Davis, S.S., Illum, L., (1994). Efect of chi-tosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res. 11:1358-1361
4. Aspden, T.J., Adler, J., Davis, S.S., Skaugrud, Ø., Illum, L. (1995). Chitosan as a nasal delivery system: evaluation of the efect of chitosan on mucociliary clearance rate in the frog palate model. Int J Pharm. 122:69-78.
5. Aspden, T.J., Illum, L., Skaugrud, Ø. (1996). Chitosan as a nasal delivery system: evaluation of insulin absorption enhancement and efect on nasal membrane integrity using rat models. Eur J Pharm Sci. 4:23-31.
6. Aspden, T.J., Mason, J.D., Jones, N.S., Lowe, J., Skaugrud, O., Illum, L. (1997). Chitosan as a nasal delivery system: the efect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers. J Pharm Sci. 86:509-513
7. Avadi, M.R., Jalali, A., Sadeghi, A.M.M., Shamimi, K., Bayati, K.H., Nahid, E., Dehpour, A.R., Rafee-Tehrani, M. (2005). Diethyl methyl chitosan as an intestinal paracellular enhancer: ex vivo and in vivo studies. Int J Pharm. 293:83-89
8. Borchard, G., Leußen, H.L., de Boer, A.G., Verhoef, J.C., Lehr, C., Junginger, H.E. (1996). Te potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Efects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J Contr Rel. 39:131-138
9. Domard, A., Rinaudo, M., Terrassin, C. (1986). New method for the quaternization of chitosan. Int J Biol Macromol. 8:105-107
10. du Plessis, L.H., Lubbe, J., Strauss, T., Kotzé, A.F. (2010). Enhancement of nasal and intestinal calcitonin delivery by the novel Pheroid fatty acid based delivery system, and by N-trimethyl chitosan chloride. Int J Pharm. 385:181-186
11. Felt, O., Buri, P., Gurny, R. (1998). Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm. 24:979-993
12. Gao, X., Wu, B., Zhang, Q., Chen, J., Zhu, J., Zhang, W., Rong, Z., Chen, H., Jiang, X. (2007). Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration. J Contr Rel. 121:156-167
13. Gao, Y., He, L., Katsumi, H., Sakane, T., Fujita, T., Yamamoto, A. (2008). Improvement of intestinal absorption of insulin and water-soluble macromolecular compounds by chitosan oligomers in rats. Int J Pharm. 359:70-78
14. Hafejee, N., Du Plessis, J., Muller, D.G., Schultz, C., Kotzé, A.F., Goosen, C. (2001). Intranasal toxicity of selected absorption enhancers. Pharmazie. 56:882-888
15. Illum, L. (1998). Chitosan and its use as a pharmaceutical excipient. Pharm Res. 15:1326-1331
16. Illum, L., Farraj, N.F., Davis, S.S. (1994). Chitosan as a novel nasal delivery system for peptide drugs. Pharm Res. 11:1186-1189
17. Khafagy, E., Morishita, M., Onuki, Y., Takayama, K. (2007). Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev. 59:1521-1546
18. Kotzé, A.F., de Leeuw, B.J., Leußen, H.L., de Boer, A.G., Verhoef, J.C., Junginger, H.E. (1997a). Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers. Int J Pharm. 159:243-253
19. Kotzé, A.F., Leußen, H.L., de Boer, A.G., Verhoef, J.C., Junginger, H.E. (1999a). Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments. Eur J Pharm Sci. 7:145-151
20. Kotzé, A.F., Luessen, H.L., de Leeuw, B.J., de Boer, A.G., Verhoef, J.C., Junginger, H.E. (1998). Comparison of the efect of diferent chi-tosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Contr Rel. 51:35-46.
21. Kotzé, A.F., Luessen, H.L., de Leeuw, B.J., de Boer, B.G., Verhoef, J.C., Junginger, H.E. (1997b). N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: in vitro evaluation in intestinal epithelial cells (Caco-2). Pharm Res. 14:1197-1202
22. Kotzé, A.F., Tanou, M.M., Leußen, H.L., de Boer, A.G.D., Verhoef, J.C., Junginger, H.E. (1999b). Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2). J Pharm Sci. 88:253-257.
23. Lehr, C., Bouwstra, J.A., Spies, F., Onderwater, J., van het Noordeinde, J., Vermeij-Keers, C., van Munsteren, C.J., Junginger, H.E. (1992). Visualization studies of the mucoadhesive interface. J Contr Rel. 18:249-260
24. Luessen, H.L., de Leeuw, B.J., Langemeyer, M.W., de Boer, A.B., Verhoef, J.C., Junginger, H.E. (1996). Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm Res. 13:1668-1672
25. Leußen, H.L., Rentel, C., Kotzé, A.F., Lehr, C., de Boer, A.G., Verhoef, J.C., Junginger, H.E. (1997). Mucoadhesive polymers in peroral peptide drug delivery. I V. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J Contr Rel. 45:15-23.
26. Mackay, M., Phillips, J., Hastewell, J. (1997). Peptide drug delivery: colonic and rectal absorption. Adv Drug Deliv Rev. 28:253-273
27. Madara, J.L., Moore, R., Carlson, S. (1987). Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction. Am J Physiol. 253:C854-61.
28. Mi, F.-L., Wu, Y.-Y., Lin, Y.-H., Sonaje, K., Ho, Y.-C., Chen, C.-T., Juang, J.-H., Sung, H.-W. (2008). Oral delivery of peptide drugs using nanoparticles self-assembled by poly(γ-glutamic acid) and a chitosan derivative functionalized by trimethylation. Bioconjugate Chem. 19:1248-1255
29. Muranishi, S. (1990). Absorption enhancers. Crit Rev Ter Drug Carrier Syst. 7:1-33.
30. Sadeghi, A.M.M., Dorkoosh, F.A., Avadi, M.R., Weinhold, M., Bayat, A., Delie, F., Gurny, R., Larijani, B., Rafee-Tehrani, M., Junginger, H.E. (2008). Permeation enhancer efect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells. Eur J Pharm Biopharm. 70:270-278
31. Schipper, N.G., Olsson, S., Hoogstraate, J.A., deBoer, A.G., Varum, K.M., Artursson, P. (1997). Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res. 14:923-929
32. Schipper, N.G., Varum, K.M., Artursson, P. (1996). Chitosans as absorption enhancers for poorly absorbable drugs. 1: Infuence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm Res. 13:1686-1692
33. Siegel, S.M., Daly, O. (1966). Regulation of betacyanin efux from beet root by poly-L-lysine, Ca-ion and other substances. Plant Physiol. 41:1429-1434
34. Sieval, A.B., Tanou, M., Kotzé, A.F., Verhoef, J.C., Brussee, J., Junginger, H.E. (1998). Preparation and NMR characterization of highly substituted N-trimethyl chitosan chloride. Carbohydrate Polym. 36:157-165
35. Smith, P.L., Wall, D.A., Gochoco, C.H., Wilson, G. (1992). (D) Routes of delivery: case studies: (5) Oral absorption of peptides and proteins. Adv Drug Deliv Rev. 8:253-290
36. Sonaje, K., Lin, Y.-H., Juang, J.-H., Wey, S.-W., Chen, C.-T., Sung, H.-W. (2009). In vivo evaluation of safety and efcacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials. 30:2329-2339
37. Tanou, M., Verhoef, J.C., Junginger, H.E. (2001). Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev. 52:117-126
38. Tanou, M.M., Kotzé, A.F., Scharringhausen, T., Lueßen, H.L., de Boer, A.G., Verhoef, J.C., Junginger, H.E. (2000). Efect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers. J Contr Rel. 64:15-25.
39. Tomita, M., Hayashi, M., Awazu, S. (1996). Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cells. J Pharm Sci. 85:608-611
40. Verheul, R.J., Amidi, M., van der Wal, S., van Riet, E., Jiskoot, W., Hennik, W.E. (2008). Synthesis, characterisation and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan. Biomaterials. 29:3642-3649
41. Wang, L.-Y., Gu, Y.-H., Su, Z.-G., Ma, G.H. (2006). Preparation and improvement of release behaviour of chitosan micropsheres containing insulin. Int J Pharm. 311:187-195
42. Wei, W., Ma, G.-H., Wang, L.-Y., Wu, J., Su, Z.-G. (2010). Hollow quaternized chitosan micropsheres increase the therapeutic efect of orally administered insulin. Acta Biomaerilia. 6: 205-209
43. Yin, L., Ding, J., He, C., Cui, L., Tang, C., Yin, C. (2009). Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials. 20:5691-5700
44. Yu, S., Zhao, Y., Wu, F., Zhang, X., Lu, W., Zhang, H., Zhang, Q. (2004). Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies. Int J Pharm. 281:11-23.
45. Zhang, X., Zhang, H., Wu, Z., Wang, Z., Niu, H., Li, C. (2008). Nasal absorption enhancement of insulin using PEG-grafted chitosan nanoparticles. Eur J Pharm Biopharm. 68: 526-534