메뉴 건너뛰기




Volumn 5, Issue 2, 2010, Pages 287-306

Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery

Author keywords

Bioavailability; Biopharmaceutics; Gastrointestinal tract; Nanocarrier; Oral absorption; Oral administration

Indexed keywords

CEFOTAXIME; CEFUROXIME AXETIL; CHITOSAN; CLOZAPINE; CYCLOSPORIN A; DENDRIMER; DOXORUBICIN; FENOFIBRATE; GENISTEIN; INSULIN; LIGAND; LIPID NANOCAPSULE; LIPOSOME; MACROGOL; NANOCAPSULE; NANOCARRIER; NANOPARTICLE; NANOSPHERE; NITRENDIPINE; PACLITAXEL; POLYAMIDOAMINE; POLYGLACTIN; POLYMER; POLYSTYRENE; QUERCETIN; SALCATONIN; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCAMINE; VINPOCETINE;

EID: 77952491719     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.09.110     Document Type: Review
Times cited : (273)

References (198)
  • 1
    • 33745513833 scopus 로고    scopus 로고
    • Role of nanotechnology in targeted drug delivery and imaging: A concise review
    • Koo OM, Rubinstein I, Onyuksel H: Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomed. 1, 193-212 (2005).
    • (2005) Nanomed , vol.1 , pp. 193-212
    • Koo, O.M.1    Rubinstein, I.2    Onyuksel, H.3
  • 2
    • 24944496710 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration
    • Manjunathand K, Venkateswarlu V: Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J. Control Release 107, 215-228 (2005).
    • (2005) J. Control Release , vol.107 , pp. 215-228
    • Manjunathand, K.1    Venkateswarlu, V.2
  • 3
    • 58549089321 scopus 로고    scopus 로고
    • Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles
    • Li H, Zhao X, Ma Y, Zhai G, Li L, Lou H: Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J. Control Release 133, 238-244 (2009).
    • (2009) J. Control Release , vol.133 , pp. 238-244
    • Li, H.1    Zhao, X.2    Ma, Y.3    Zhai, G.4    Li, L.5    Lou, H.6
  • 4
    • 33947572663 scopus 로고    scopus 로고
    • Development and evaluation of nitrendipine loaded solid lipid nanoparticles: Infuence of wax and glyceride lipids on plasma pharmacokinetics
    • Kumar V V, Chandrasekar D, Ramakrishna S, Kishan V, Rao YM, Diwan PV: Development and evaluation of nitrendipine loaded solid lipid nanoparticles: infuence of wax and glyceride lipids on plasma pharmacokinetics. Int. J. Pharm. 335, 167-175 (2007).
    • (2007) Int. J. Pharm , vol.335 , pp. 167-175
    • Kumar, V.V.1    Chandrasekar, D.2    Ramakrishna, S.3    Kishan, V.4    Rao, Y.M.5    Diwan, P.V.6
  • 5
    • 33746626869 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability
    • Luo Y, Chen D, Ren L, Zhao X, Qin J: Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability. J. Control Release 114, 53-59 (2006).
    • (2006) J. Control Release , vol.114 , pp. 53-59
    • Luo, Y.1    Chen, D.2    Ren, L.3    Zhao, X.4    Qin, J.5
  • 6
    • 0022966767 scopus 로고
    • Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles
    • Maincent P, Le Verge R, Sado P, Couvreur P, Devissaguet JP: Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles. J. Pharm. Sci. 75, 955-958 (1986).
    • (1986) J. Pharm. Sci , vol.75 , pp. 955-958
    • Maincent, P.1    Le Verge, R.2    Sado, P.3    Couvreur, P.4    Devissaguet, J.P.5
  • 7
    • 0037027833 scopus 로고    scopus 로고
    • Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A
    • El-Shabouri MH: Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int. J. Pharm. 249, 101-108 (2002).
    • (2002) Int. J. Pharm , vol.249 , pp. 101-108
    • El-Shabouri, M.H.1
  • 8
    • 33745386420 scopus 로고    scopus 로고
    • Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules
    • Peltier S, Oger JM, Lagarce F, Couet W, Benoit JP: Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules. Pharm. Res. 23, 1243-1250 (2006).
    • (2006) Pharm. Res , vol.23 , pp. 1243-1250
    • Peltier, S.1    Oger, J.M.2    Lagarce, F.3    Couet, W.4    Benoit, J.P.5
  • 9
    • 33747884001 scopus 로고    scopus 로고
    • Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation
    • Cui F, Shi K, Zhang L, Tao A, Kawashima Y: Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J. Control Release 114, 242-250 (2006).
    • (2006) J. Control Release , vol.114 , pp. 242-250
    • Cui, F.1    Shi, K.2    Zhang, L.3    Tao, A.4    Kawashima, Y.5
  • 10
    • 60849130683 scopus 로고    scopus 로고
    • In vivo evaluation of safety and effcacy of self-assembled nanoparticles for oral insulin delivery
    • Sonaje K, Lin YH, Juang JH, Wey SP, Chen CT, Sung HW: In vivo evaluation of safety and effcacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 30, 2329-2339 (2009).
    • (2009) Biomaterials , vol.30 , pp. 2329-2339
    • Sonaje, K.1    Lin, Y.H.2    Juang, J.H.3    Wey, S.P.4    Chen, C.T.5    Sung, H.W.6
  • 11
    • 60049090585 scopus 로고    scopus 로고
    • Design of biodegradable nanoparticles for oral delivery of doxorubicin: In vivo pharmacokinetics and toxicity studies in rats
    • Kalaria DR, Sharma G, Beniwal V, Ravi Kumar MN: Design of biodegradable nanoparticles for oral delivery of doxorubicin: in vivo pharmacokinetics and toxicity studies in rats. Pharm. Res. 26, 492-501 (2009).
    • (2009) Pharm. Res , vol.26 , pp. 492-501
    • Kalaria, D.R.1    Sharma, G.2    Beniwal, V.3    Ravi Kumar, M.N.4
  • 12
    • 50149098764 scopus 로고    scopus 로고
    • Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability
    • Dhumal RS, Biradar SV, Yamamura S, Paradkar AR, York P: Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability. Eur. J. Pharm. Biopharm. 70, 109-115 (2008).
    • (2008) Eur. J. Pharm. Biopharm , vol.70 , pp. 109-115
    • Dhumal, R.S.1    Biradar, S.V.2    Yamamura, S.3    Paradkar, A.R.4    York, P.5
  • 13
    • 0037500855 scopus 로고    scopus 로고
    • Polyethylene glycol-coated liposomes for oral delivery of recombinant human epidermal growth factor
    • Li H, Song JH, Park JS, Han K: Polyethylene glycol-coated liposomes for oral delivery of recombinant human epidermal growth factor. Int. J. Pharm. 258, 11-19 (2003).
    • (2003) Int. J. Pharm , vol.258 , pp. 11-19
    • Li, H.1    Song, J.H.2    Park, J.S.3    Han, K.4
  • 14
    • 46649085083 scopus 로고    scopus 로고
    • Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration
    • Sun W, Zou W, Huang G, Li A, Zhang N: Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration. J. Drug Target. 16, 357-365 (2008).
    • (2008) J. Drug Target , vol.16 , pp. 357-365
    • Sun, W.1    Zou, W.2    Huang, G.3    Li, A.4    Zhang, N.5
  • 15
    • 33645277099 scopus 로고    scopus 로고
    • Enhanced oral bioavailability and intestinal lymphatic transport of a hydrophilic drug using liposomes
    • Ling SS, Magosso E, Khan NA, Yuen KH, Barker SA: Enhanced oral bioavailability and intestinal lymphatic transport of a hydrophilic drug using liposomes. Drug Dev. Ind. Pharm. 32, 335-345 (2006).
    • (2006) Drug Dev. Ind. Pharm , vol.32 , pp. 335-345
    • Ling, S.S.1    Magosso, E.2    Khan, N.A.3    Yuen, K.H.4    Barker, S.A.5
  • 16
    • 0034949616 scopus 로고    scopus 로고
    • Formulation and evaluation of a folic acid receptor-targeted oral vancomycin liposomal dosage form
    • Anderson KE, Eliot LA, Stevenson BR, Rogers JA: Formulation and evaluation of a folic acid receptor-targeted oral vancomycin liposomal dosage form. Pharm. Res. 18, 316-322 (2001).
    • (2001) Pharm. Res , vol.18 , pp. 316-322
    • Anderson, K.E.1    Eliot, L.A.2    Stevenson, B.R.3    Rogers, J.A.4
  • 17
    • 0037726624 scopus 로고    scopus 로고
    • Potentiality of double liposomes containing salmon calcitonin as an oral dosage form
    • DOI 10.1016/S0168-3659(03)00160-3
    • Yamabe K, Kato Y, Onishi H, Machida Y: Potentiality of double liposomes containing salmon calcitonin as an oral dosage form. J. Control Release 89, 429-436 (2003). (Pubitemid 36555902)
    • (2003) Journal of Controlled Release , vol.89 , Issue.3 , pp. 429-436
    • Yamabe, K.1    Kato, Y.2    Onishi, H.3    Machida, Y.4
  • 18
    • 34848855357 scopus 로고    scopus 로고
    • Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery
    • Kwon SH, Kim SY, Ha KW et al.: Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery. Arch Pharm. Res. 30, 1138-1143 (2007).
    • (2007) Arch Pharm. Res , vol.30 , pp. 1138-1143
    • Kwon, S.H.1    Kim, S.Y.2    Ha, K.W.3
  • 19
    • 19444375996 scopus 로고    scopus 로고
    • Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies
    • Sant V P, Smith D, Leroux JC: Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies. J. Control Release 104, 289-300 (2005).
    • (2005) J. Control Release , vol.104 , pp. 289-300
    • Sant, V.P.1    Smith, D.2    Leroux, J.C.3
  • 20
    • 49249137213 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system
    • Ke W, Zhao Y, Huang R, Jiang C, Pei Y: Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system. J. Pharm. Sci. 97, 2208-2216 (2008).
    • (2008) J. Pharm. Sci , vol.97 , pp. 2208-2216
    • Ke, W.1    Zhao, Y.2    Huang, R.3    Jiang, C.4    Pei, Y.5
  • 21
    • 0031939292 scopus 로고    scopus 로고
    • Utilizing bacterial mechanisms of epithelial cell entry: Invasin-induced oral uptake of latex nanoparticles
    • Hussain N, Florence AT: Utilizing bacterial mechanisms of epithelial cell entry: invasin-induced oral uptake of latex nanoparticles. Pharm. Res. 15, 153-156 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 153-156
    • Hussain, N.1    Florence, A.T.2
  • 22
    • 0025674686 scopus 로고
    • Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
    • Jani P, Halbert GW, Langridge J, Florence AT: Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42, 821-826 (1990).
    • (1990) J. Pharm. Pharmacol , vol.42 , pp. 821-826
    • Jani, P.1    Halbert, G.W.2    Langridge, J.3    Florence, A.T.4
  • 23
    • 4644335531 scopus 로고    scopus 로고
    • Polymeric micelles for oral drug delivery: Why and how
    • Francis MF, Cristea M, Winnik FM: Polymeric micelles for oral drug delivery: why and how. Pure Appl. Chem. 76, 1321-1335 (2004).
    • (2004) Pure Appl. Chem , vol.76 , pp. 1321-1335
    • Francis, M.F.1    Cristea, M.2    Winnik, F.M.3
  • 26
    • 0031913402 scopus 로고    scopus 로고
    • Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms
    • Dressman JB, Amidon GL, Reppas C, Shah VP: Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms. Pharm. Res. 15, 11-22 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 11-22
    • Dressman, J.B.1    Amidon, G.L.2    Reppas, C.3    Shah, V.P.4
  • 27
    • 0035292910 scopus 로고    scopus 로고
    • Infuence of physicochemical properties on dissolution of drugs in the gastrointestinal tract
    • Horterand D, Dressman JB: Infuence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv. Drug Deliv. Rev. 46, 75-87 (2001).
    • (2001) Adv. Drug Deliv. Rev , vol.46 , pp. 75-87
    • Horterand, D.1    Dressman, J.B.2
  • 28
    • 0032844618 scopus 로고    scopus 로고
    • Setting bioequivalence requirements for drug development based on preclinical data: Optimizing oral drug delivery systems
    • Lipkaand E, Amidon GL: Setting bioequivalence requirements for drug development based on preclinical data: optimizing oral drug delivery systems. J. Control Release 62, 41-49 (1999)
    • (1999) J. Control Release , vol.62 , pp. 41-49
    • Lipkaand, E.1    Amidon, G.L.2
  • 30
    • 0031750861 scopus 로고    scopus 로고
    • Evaluation of various dissolution media for predicting in vivo performance of class i and II drugs
    • Galia E, Nicolaides E, Horter D, Lobenberg R, Reppas C, Dressman JB: Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs. Pharm. Res. 15, 698-705 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 698-705
    • Galia, E.1    Nicolaides, E.2    Horter, D.3    Lobenberg, R.4    Reppas, C.5    Dressman, J.B.6
  • 31
    • 21544447265 scopus 로고    scopus 로고
    • Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds
    • Vertzoni M, Dressman J, Butler J, Hempenstall J, Reppas C: Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds. Eur. J. Pharm. Biopharm. 60, 413-417 (2005).
    • (2005) Eur. J. Pharm. Biopharm , vol.60 , pp. 413-417
    • Vertzoni, M.1    Dressman, J.2    Butler, J.3    Hempenstall, J.4    Reppas, C.5
  • 32
    • 32244434196 scopus 로고    scopus 로고
    • Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies
    • Kalantzi L, Goumas K, Kalioras V, Abrahamsson B, Dressman JB, Reppas C: Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies. Pharm. Res. 23, 165-176 (2006).
    • (2006) Pharm. Res , vol.23 , pp. 165-176
    • Kalantzi, L.1    Goumas, K.2    Kalioras, V.3    Abrahamsson, B.4    Dressman, J.B.5    Reppas, C.6
  • 33
    • 43249097007 scopus 로고    scopus 로고
    • Designing biorelevant dissolution tests for lipid formulations: Case example-lipid suspension of RZ-50
    • Jantratid E, Janssen N, Chokshi H, Tang K, Dressman JB: Designing biorelevant dissolution tests for lipid formulations: case example-lipid suspension of RZ-50. Eur. J. Pharm. Biopharm. 69, 776-785 (2008).
    • (2008) Eur. J. Pharm. Biopharm , vol.69 , pp. 776-785
    • Jantratid, E.1    Janssen, N.2    Chokshi, H.3    Tang, K.4    Dressman, J.B.5
  • 34
    • 44749087279 scopus 로고    scopus 로고
    • Dissolution media simulating conditions in the proximal human gastrointestinal tract: An update
    • Jantratid E, Janssen N, Reppas C, Dressman JB: Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update. Pharm. Res. 25, 1663-1676 (2008).
    • (2008) Pharm. Res , vol.25 , pp. 1663-1676
    • Jantratid, E.1    Janssen, N.2    Reppas, C.3    Dressman, J.B.4
  • 35
    • 1842576537 scopus 로고    scopus 로고
    • Dissolution media simulating the intralumenal composition of the small intestine: Physiological issues and practical aspects
    • Vertzoni M, Fotaki N, Kostewicz E et al.: Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects. J. Pharm. Pharmacol. 56, 453-462 (2004).
    • (2004) J. Pharm. Pharmacol , vol.56 , pp. 453-462
    • Vertzoni, M.1    Fotaki, N.2    Kostewicz, E.3
  • 36
    • 33745377516 scopus 로고    scopus 로고
    • Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents
    • Kalantzi L, Persson E, Polentarutti B et al.: Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents. Pharm. Res. 23, 1373-1381 (2006).
    • (2006) Pharm. Res , vol.23 , pp. 1373-1381
    • Kalantzi, L.1    Persson, E.2    Polentarutti, B.3
  • 38
    • 0034898463 scopus 로고    scopus 로고
    • A dynamic in vitro lipolysis model I. Controlling the rate of lipolysis by continuous addition of calcium
    • Zangenberg NH, Mullertz A, Kristensen HG, Hovgaard L: A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium. Eur. J. Pharm. Sci. 14, 115-122 (2001).
    • (2001) Eur. J. Pharm. Sci. , Issue.14 , pp. 115-122
    • Zangenberg, N.H.1    Mullertz, A.2    Kristensen, H.G.3    Hovgaard, L.4
  • 39
    • 0030598260 scopus 로고    scopus 로고
    • Biodegradation of solid lipid nanoparticles as a function of lipase incubation time
    • Müller RH, Rühl D, Runge SA: Biodegradation of solid lipid nanoparticles as a function of lipase incubation time. Int. J. Pharm. 144, 115-121 (1996).
    • (1996) Int. J. Pharm , vol.144 , pp. 115-121
    • Müller, R.H.1    Rühl, D.2    Runge, S.A.3
  • 40
    • 0345148806 scopus 로고    scopus 로고
    • Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures
    • Olbrichand C, Müller RH: Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures. Int. J. Pharm. 180, 31-39 (1999).
    • (1999) Int. J. Pharm , vol.180 , pp. 31-39
    • Olbrichand, C.1    Müller, R.H.2
  • 42
    • 0027185555 scopus 로고
    • Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract
    • Arien A, Goigoux C, Baquey C, Dupuy B: Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract. Life Sci. 53, 1279-1290 (1993).
    • (1993) Life Sci , vol.53 , pp. 1279-1290
    • Arien, A.1    Goigoux, C.2    Baquey, C.3    Dupuy, B.4
  • 43
    • 59649096972 scopus 로고    scopus 로고
    • Solubilisation of dipalmitoyl-phosphatidylcholine bilayers by sodium taurocholate: A model to study the stability of liposomes in the gastrointestinal tract and their mechanism of interaction with a model bile salt
    • Andrieux K, Forte L, Lesieur S, Paternostre M, Ollivon M, Grabielle-Madelmont C: Solubilisation of dipalmitoyl-phosphatidylcholine bilayers by sodium taurocholate: a model to study the stability of liposomes in the gastrointestinal tract and their mechanism of interaction with a model bile salt. Eur. J. Pharm. Biopharm. 71, 346-355 (2009).
    • (2009) Eur. J. Pharm. Biopharm , vol.71 , pp. 346-355
    • Andrieux, K.1    Forte, L.2    Lesieur, S.3    Paternostre, M.4    Ollivon, M.5    Grabielle-Madelmont, C.6
  • 45
    • 0033991088 scopus 로고    scopus 로고
    • Stability of SUV liposomes in the presence of cholate salts and pancreatic lipases: Effect of lipid composition
    • Kokkona M, Kallinteri P, Fatouros D, Antimisiaris SG: Stability of SUV liposomes in the presence of cholate salts and pancreatic lipases: effect of lipid composition. Eur. J. Pharm. Sci. 9, 245-252 (2000).
    • (2000) Eur. J. Pharm. Sci , vol.9 , pp. 245-252
    • Kokkona, M.1    Kallinteri, P.2    Fatouros, D.3    Antimisiaris, S.G.4
  • 46
    • 0029928231 scopus 로고    scopus 로고
    • Oral administration of recombinant human erythropoietin in liposomes in rats: Infuence of lipid composition and size of liposomes on bioavailability
    • Maitani Y, Hazama M, Tojo Y, Shimoda N, Nagai T: Oral administration of recombinant human erythropoietin in liposomes in rats: infuence of lipid composition and size of liposomes on bioavailability. J. Pharm. Sci. 85, 440-445 (1996).
    • (1996) J. Pharm. Sci , vol.85 , pp. 440-445
    • Maitani, Y.1    Hazama, M.2    Tojo, Y.3    Shimoda, N.4    Nagai, T.5
  • 47
    • 0019433074 scopus 로고
    • Uptake of free and liposome-entrapped horseradish peroxidase by rat intestinal sacs in vitro
    • Rowlandand RN, Woodley JF: Uptake of free and liposome-entrapped horseradish peroxidase by rat intestinal sacs in vitro. FEBS Lett. 123, 41-44 (1981).
    • (1981) FEBS Lett , vol.123 , pp. 41-44
    • Rowlandand, R.N.1    Woodley, J.F.2
  • 48
    • 0019317828 scopus 로고
    • The stability of liposomes in vitro to pH, bile salts and pancreatic lipase
    • Rowlandand RN, Woodley JF: The stability of liposomes in vitro to pH, bile salts and pancreatic lipase. Biochim. Biophys. Acta 620, 400-409 (1980).
    • (1980) Biochim. Biophys. Acta , vol.620 , pp. 400-409
    • Rowlandand, R.N.1    Woodley, J.F.2
  • 49
    • 0033047397 scopus 로고    scopus 로고
    • Application of surface-coated liposomes for oral delivery of peptide: Effects of coating the liposome's surface on the GI transit of insulin
    • Iwanaga K, Ono S, Narioka K et al.: Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. J. Pharm. Sci. 88, 248-252 (1999).
    • (1999) J. Pharm. Sci , vol.88 , pp. 248-252
    • Iwanaga, K.1    Ono, S.2    Narioka, K.3
  • 50
    • 0242500998 scopus 로고    scopus 로고
    • Application of polyethyleneglycol (PEG)-modifed liposomes for oral vaccine: Effect of lipid dose on systemic and mucosal immunity
    • Minato S, Iwanaga K, Kakemi M, Yamashita S, Oku N: Application of polyethyleneglycol (PEG)-modifed liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity. J. Control Release 89, 189-197 (2003).
    • (2003) J. Control Release , vol.89 , pp. 189-197
    • Minato, S.1    Iwanaga, K.2    Kakemi, M.3    Yamashita, S.4    Oku, N.5
  • 51
    • 0030801601 scopus 로고    scopus 로고
    • Oral delivery of insulin by using surface coating liposomes: Improvement of stability of insulin in GI tract
    • Iwanaga K, Ono S, Narioka K et al.: Oral delivery of insulin by using surface coating liposomes: Improvement of stability of insulin in GI tract. Int. J. Pharm. 157, 73-80 (1997).
    • (1997) Int. J. Pharm , vol.157 , pp. 73-80
    • Iwanaga, K.1    Ono, S.2    Narioka, K.3
  • 52
    • 0035177375 scopus 로고    scopus 로고
    • Mucoadhesive chitosan-coated liposomes: Characteristics and stability
    • Filipovic-Grcic J, Skalko-Basnet N, Jalsenjak I: Mucoadhesive chitosan-coated liposomes: characteristics and stability. J. Microencapsul. 18, 3-12 (2001).
    • (2001) J. Microencapsul , vol.18 , pp. 3-12
    • Filipovic-Grcic, J.1    Skalko-Basnet, N.2    Jalsenjak, I.3
  • 53
    • 42549116239 scopus 로고    scopus 로고
    • Novel drug nanocarriers combining hydrophilic cyclodextrins and chitosan
    • Trapani A, Garcia-Fuentes M, Alonso MJ: Novel drug nanocarriers combining hydrophilic cyclodextrins and chitosan. Nanotechnology 19, 185101 (2008).
    • (2008) Nanotechnology , vol.19 , pp. 185101
    • Trapani, A.1    Garcia-Fuentes, M.2    Alonso, M.J.3
  • 54
    • 0037027876 scopus 로고    scopus 로고
    • Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo
    • Pan Y, Li YJ, Zhao HY et al.: Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm. 249, 139-147 (2002).
    • (2002) Int. J. Pharm , vol.249 , pp. 139-147
    • Pan, Y.1    Li, Y.J.2    Zhao, H.Y.3
  • 55
    • 36749067955 scopus 로고    scopus 로고
    • Design aspects of poly(alkylcyanoacrylate) nanoparticles for drug delivery
    • Vauthier C, Labarre D, Ponchel G: Design aspects of poly(alkylcyanoacrylate) nanoparticles for drug delivery. J. Drug Target. 15, 641-663 (2007).
    • (2007) J. Drug Target , vol.15 , pp. 641-663
    • Vauthier, C.1    Labarre, D.2    Ponchel, G.3
  • 56
    • 57349121969 scopus 로고    scopus 로고
    • Synthesis and characterization of PEGylated calcium phosphate nanoparticles for oral insulin delivery
    • Ramachandran R, Paul W, Sharma CP: Synthesis and characterization of PEGylated calcium phosphate nanoparticles for oral insulin delivery. J. Biomed. Mater. Res. Part B Appl. Biomater. 88, 41-48 (2009).
    • (2009) J. Biomed. Mater. Res. Part B Appl. Biomater , vol.88 , pp. 41-48
    • Ramachandran, R.1    Paul, W.2    Sharma, C.P.3
  • 57
    • 0030131048 scopus 로고    scopus 로고
    • Degradation of poly(D,L-lactic acid) nanoparticles coated with albumin in model digestive fuids (USP XXII)
    • Landry FB, Bazile DV, Spenlehauer G, Veillard M, Kreuter J: Degradation of poly(D,L-lactic acid) nanoparticles coated with albumin in model digestive fuids (USP XXII). Biomaterials 17, 715-723 (1996).
    • (1996) Biomaterials , vol.17 , pp. 715-723
    • Landry, F.B.1    Bazile, D.V.2    Spenlehauer, G.3    Veillard, M.4    Kreuter, J.5
  • 58
    • 0343962248 scopus 로고    scopus 로고
    • The role of PEG on the stability in digestive fuids and in vivo fate of PEG-PLA nanoparticles following oral administration
    • Tobío M, Sánchez A, Vila A et al.: The role of PEG on the stability in digestive fuids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf. B Biointerfaces 18, 315-323 (2000).
    • (2000) Colloids Surf. B Biointerfaces , vol.18 , pp. 315-323
    • Tobío, M.1    Sánchez, A.2    Vila, A.3
  • 60
    • 0037296404 scopus 로고    scopus 로고
    • Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules
    • García-Fuentes M, Torres D, Alonso MJ: Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules. Colloids Surf. B Biointerfaces 27, 159-168 (2003).
    • (2003) Colloids Surf. B Biointerfaces , vol.27 , pp. 159-168
    • García-Fuentes, M.1    Torres, D.2    Alonso, M.J.3
  • 61
    • 53649097113 scopus 로고    scopus 로고
    • Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells
    • Sahu A, Bora U, Kasoju N, Goswami P: Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomater. 4, 1752-1761 (2008).
    • (2008) Acta Biomater , vol.4 , pp. 1752-1761
    • Sahu, A.1    Bora, U.2    Kasoju, N.3    Goswami, P.4
  • 62
    • 56949101192 scopus 로고    scopus 로고
    • Hydrotropic polymer micelles containing acrylic acid moieties for oral delivery of paclitaxel
    • Kim S, Kim JY, Huh KM, Acharya G, Park K: Hydrotropic polymer micelles containing acrylic acid moieties for oral delivery of paclitaxel. J. Control Release 132(3), 222-229 2008.
    • (2008) J. Control Release , vol.132 , Issue.3 , pp. 222-229
    • Kim, S.1    Kim, J.Y.2    Huh, K.M.3    Acharya, G.4    Park, K.5
  • 63
    • 0036297426 scopus 로고    scopus 로고
    • A novel phase inversion-based process for the preparation of lipid nanocarriers
    • Heurtault B, Saulnier P, Pech B, Proust JE, Benoit JP: A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharm. Res. 19, 875-880 (2002).
    • (2002) Pharm. Res , vol.19 , pp. 875-880
    • Heurtault, B.1    Saulnier, P.2    Pech, B.3    Proust, J.E.4    Benoit, J.P.5
  • 64
    • 26944445100 scopus 로고    scopus 로고
    • Reorganization of lipid nanocapsules at air-water interface: Part 2. Properties of the formed surface flm
    • Minkov I, Ivanova T, Panaiotov I, Proust J, Saulnier P: Reorganization of lipid nanocapsules at air-water interface: part 2. Properties of the formed surface flm. Colloids Surf. B Biointerfacess 44, 197-203 (2005).
    • (2005) Colloids Surf. B Biointerfacess , vol.44 , pp. 197-203
    • Minkov, I.1    Ivanova, T.2    Panaiotov, I.3    Proust, J.4    Saulnier, P.5
  • 65
    • 33847127824 scopus 로고    scopus 로고
    • Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically
    • Eliyahu H, Joseph A, Schillemans JP, Azzam T, Domb AJ, Barenholz Y: Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically. Biomaterials 28, 2339-2349 (2007).
    • (2007) Biomaterials , vol.28 , pp. 2339-2349
    • Eliyahu, H.1    Joseph, A.2    Schillemans, J.P.3    Azzam, T.4    Domb, A.J.5    Barenholz, Y.6
  • 66
    • 0028840557 scopus 로고
    • Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption
    • Fagerholmand U, Lennernäs H: Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption. Eur. J. Pharm. Sci. 3, 247-253 (1995).
    • (1995) Eur. J. Pharm. Sci , vol.3 , pp. 247-253
    • Fagerholmand, U.1    Lennernäs, H.2
  • 67
    • 0031925268 scopus 로고    scopus 로고
    • Human intestinal permeability
    • Lennernas H: Human intestinal permeability. J. Pharm. Sci. 87, 403-410 (1998).
    • (1998) J. Pharm. Sci , vol.87 , pp. 403-410
    • Lennernas, H.1
  • 68
    • 0032403463 scopus 로고    scopus 로고
    • The effect of physical barriers and properties on the oral absorption of particulates
    • Norris DA, Puri N, Sinko PJ: The effect of physical barriers and properties on the oral absorption of particulates. Adv. Drug Deliv. Rev. 34, 135-154 (1998).
    • (1998) Adv. Drug Deliv. Rev , vol.34 , pp. 135-154
    • Norris, D.A.1    Puri, N.2    Sinko, P.J.3
  • 69
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • Lai SK, Wang YY, Hanes J: Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv. Drug Deliv. Rev. 61, 158-171 (2009).
    • (2009) Adv. Drug Deliv. Rev , vol.61 , pp. 158-171
    • Lai, S.K.1    Wang, Y.Y.2    Hanes, J.3
  • 70
    • 0036692366 scopus 로고    scopus 로고
    • Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
    • Behrens I, Pena AI, Alonso MJ, Kissel T: Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm. Res. 19, 1185-1193 (2002).
    • (2002) Pharm. Res , vol.19 , pp. 1185-1193
    • Behrens, I.1    Pena, A.I.2    Alonso, M.J.3    Kissel, T.4
  • 71
    • 32244438967 scopus 로고    scopus 로고
    • Design of estradiol loaded PLGA nanoparticulate formulations: A potential oral delivery system for hormone therapy
    • Hariharan S, Bhardwaj V, Bala I, Sitterberg J, Bakowsky U, Ravi Kumar M: Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy. Pharm. Res. 23, 184-195 (2006).
    • (2006) Pharm. Res , vol.23 , pp. 184-195
    • Hariharan, S.1    Bhardwaj, V.2    Bala, I.3    Sitterberg, J.4    Bakowsky, U.5    Ravi Kumar, M.6
  • 72
    • 33846799473 scopus 로고    scopus 로고
    • Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles
    • DOI 10.1016/j.biomaterials.2007.01.005, PII S0142961207000117
    • Bravo-Osuna I, Vauthier C, Farabollini A, Palmieri GF, Ponchel G: Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles. Biomaterials 28, 2233-2243 (2007). (Pubitemid 46216448)
    • (2007) Biomaterials , vol.28 , Issue.13 , pp. 2233-2243
    • Bravo-Osuna, I.1    Vauthier, C.2    Farabollini, A.3    Palmieri, G.F.4    Ponchel, G.5
  • 75
    • 59349092521 scopus 로고    scopus 로고
    • Localization and quantifcation of biodegradable particles in an intestinal cell model: The infuence of particle size
    • Gaumet M, Gurny R, Delie F: Localization and quantifcation of biodegradable particles in an intestinal cell model: the infuence of particle size. Eur. J. Pharm. Sci. 36, 465-473 (2009).
    • (2009) Eur. J. Pharm. Sci , vol.36 , pp. 465-473
    • Gaumet, M.1    Gurny, R.2    Delie, F.3
  • 76
    • 40649101051 scopus 로고    scopus 로고
    • Chromium nanoparticle exhibits higher absorption effciency than chromium picolinate and chromium chloride in Caco-2 cell monolayers
    • Zha LY, Xu ZR, Wang MQ, Gu LY: Chromium nanoparticle exhibits higher absorption effciency than chromium picolinate and chromium chloride in Caco-2 cell monolayers. J. Anim. Physiol. Anim. Nutr. (Berl.) 92, 131-140 (2008).
    • (2008) J. Anim. Physiol. Anim. Nutr. (Berl.) , vol.92 , pp. 131-140
    • Zha, L.Y.1    Xu, Z.R.2    Wang, M.Q.3    Gu, L.Y.4
  • 77
    • 0344946091 scopus 로고    scopus 로고
    • Uptake of chitosan and associated insulin in Caco-2 cell monolayers: A comparison between chitosan molecules and chitosan nanoparticles
    • Maand Z, Lim LY: Uptake of chitosan and associated insulin in Caco-2 cell monolayers: a comparison between chitosan molecules and chitosan nanoparticles. Pharm. Res. 20, 1812-1819 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 1812-1819
    • Maand, Z.1    Lim, L.Y.2
  • 78
    • 45749109076 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs using nanoparticles self-assembled by poly(g-glutamic acid) and a chitosan derivative functionalized by trimethylation
    • Mi FL, Wu YY, Lin YH et al.: Oral delivery of peptide drugs using nanoparticles self-assembled by poly(g-glutamic acid) and a chitosan derivative functionalized by trimethylation. Bioconjug. Chem. 19, 1248-1255 (2008).
    • (2008) Bioconjug. Chem , vol.19 , pp. 1248-1255
    • Mi, F.L.1    Wu, Y.Y.2    Lin, Y.H.3
  • 79
    • 33846410236 scopus 로고    scopus 로고
    • Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery
    • Lin YH, Mi FL, Chen CT et al.: Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules 8, 146-152 (2007).
    • (2007) Biomacromolecules , vol.8 , pp. 146-152
    • Lin, Y.H.1    Mi, F.L.2    Chen, C.T.3
  • 81
    • 56649089693 scopus 로고    scopus 로고
    • Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs
    • Lin YH, Sonaje K, Lin KM et al.: Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J. Control Release 132, 141-149 (2008).
    • (2008) J. Control Release , vol.132 , pp. 141-149
    • Lin, Y.H.1    Sonaje, K.2    Lin, K.M.3
  • 82
    • 0842310894 scopus 로고    scopus 로고
    • Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin
    • Sang Yooand H, Gwan Park T: Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin. J. Pharm. Sci. 93, 488-495 (2004).
    • (2004) J. Pharm. Sci , vol.93 , pp. 488-495
    • Sang Yooand, H.1    Gwan Park, T.2
  • 83
    • 44949228208 scopus 로고    scopus 로고
    • Fluorescent bionanoprobes to characterize cytoadhesion and cytoinvasion
    • Fillafer C, Friedl DS, Wirth M, Gabor F: Fluorescent bionanoprobes to characterize cytoadhesion and cytoinvasion. Small 4, 627-633 (2008).
    • (2008) Small , vol.4 , pp. 627-633
    • Fillafer, C.1    Friedl, D.S.2    Wirth, M.3    Gabor, F.4
  • 84
    • 6344256207 scopus 로고    scopus 로고
    • Binding and uptake of wheat germ agglutinin-grafted PLGA-nanospheres by Caco-2 monolayers
    • Weissenboeck A, Bogner E, Wirth M, Gabor F: Binding and uptake of wheat germ agglutinin-grafted PLGA-nanospheres by Caco-2 monolayers. Pharm. Res. 21, 1917-1923 (2004).
    • (2004) Pharm. Res , vol.21 , pp. 1917-1923
    • Weissenboeck, A.1    Bogner, E.2    Wirth, M.3    Gabor, F.4
  • 85
    • 0242584996 scopus 로고    scopus 로고
    • Wheat germ agglutinin binds to the epidermal growth factor receptor of artifcial Caco-2 membranes as detected by silver nanoparticle enhanced fuorescence
    • Lochner N, Pittner F, Wirth M, Gabor F: Wheat germ agglutinin binds to the epidermal growth factor receptor of artifcial Caco-2 membranes as detected by silver nanoparticle enhanced fuorescence. Pharm. Res. 20, 833-839 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 833-839
    • Lochner, N.1    Pittner, F.2    Wirth, M.3    Gabor, F.4
  • 86
    • 54449083850 scopus 로고    scopus 로고
    • Quantum dots for tracking cellular transport of lectin-functionalized nanoparticles
    • Gao X, Wang T, Wu B et al.: Quantum dots for tracking cellular transport of lectin-functionalized nanoparticles. Biochem. Biophys. Res. Commun. 377, 35-40 (2008).
    • (2008) Biochem. Biophys. Res. Commun , vol.377 , pp. 35-40
    • Gao, X.1    Wang, T.2    Wu, B.3
  • 87
    • 33749663431 scopus 로고    scopus 로고
    • Self-assembled nanoparticles of poly(lactide)-vitamin e TPGS copolymers for oral chemotherapy
    • Zhangand Z, Feng SS: Self-assembled nanoparticles of poly(lactide)- vitamin E TPGS copolymers for oral chemotherapy. Int. J. Pharm. 324, 191-198 (2006).
    • (2006) Int. J. Pharm , vol.324 , pp. 191-198
    • Zhangand, Z.1    Feng, S.S.2
  • 89
    • 37349041646 scopus 로고    scopus 로고
    • In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery
    • Chen F, Zhang ZR, Yuan F, Qin X, Wang M, Huang Y: In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery. Int. J. Pharm. 349, 226-233 (2008).
    • (2008) Int. J. Pharm , vol.349 , pp. 226-233
    • Chen, F.1    Zhang, Z.R.2    Yuan, F.3    Qin, X.4    Wang, M.5    Huang, Y.6
  • 90
    • 33744552970 scopus 로고    scopus 로고
    • Polyelectrolyte nanoparticles with high drug loading enhance the oral uptake of hydrophobic compounds
    • Cheng WP, Gray AI, Tetley L, Hang Tle M, Schatzlein AG, Uchegbu IF: Polyelectrolyte nanoparticles with high drug loading enhance the oral uptake of hydrophobic compounds. Biomacromolecules 7, 1509-1520 (2006).
    • (2006) Biomacromolecules , vol.7 , pp. 1509-1520
    • Cheng, W.P.1    Gray, A.I.2    Tetley, L.3    Hang Tle, M.4    Schatzlein, A.G.5    Uchegbu, I.F.6
  • 91
    • 70350617685 scopus 로고    scopus 로고
    • Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis
    • Roger E, Lagarce F, Garcion E, Benoit JP: Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis. J. Control Release 140(2), 174-181 (2009).
    • (2009) J. Control Release , vol.140 , Issue.2 , pp. 174-181
    • Roger, E.1    Lagarce, F.2    Garcion, E.3    Benoit, J.P.4
  • 92
    • 0030922812 scopus 로고    scopus 로고
    • Binding, uptake, and transport of hypericin by Caco-2 cell monolayers
    • Sattler S, Schaefer U, Schneider W, Hoelzl J, Lehr CM: Binding, uptake, and transport of hypericin by Caco-2 cell monolayers. J. Pharm. Sci. 86, 1120-1126 (1997).
    • (1997) J. Pharm. Sci , vol.86 , pp. 1120-1126
    • Sattler, S.1    Schaefer, U.2    Schneider, W.3    Hoelzl, J.4    Lehr, C.M.5
  • 93
    • 36148935211 scopus 로고    scopus 로고
    • Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier
    • Mathot F, des Rieux A, Arien A, Schneider YJ, Brewster M, Preat V: Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier. J. Control Release 124, 134-143 (2007).
    • (2007) J. Control Release , vol.124 , pp. 134-143
    • Mathot, F.1    Des Rieux, A.2    Arien, A.3    Schneider, Y.J.4    Brewster, M.5    Preat, V.6
  • 94
    • 33846861762 scopus 로고    scopus 로고
    • Investigation of pluronic and PEG-PE micelles as carriers of meso-tetraphenyl porphine for oral administration
    • Sezgin Z, Yuksel N, Baykara T: Investigation of pluronic and PEG-PE micelles as carriers of meso-tetraphenyl porphine for oral administration. Int. J. Pharm. 332, 161-167 (2007).
    • (2007) Int. J. Pharm , vol.332 , pp. 161-167
    • Sezgin, Z.1    Yuksel, N.2    Baykara, T.3
  • 95
    • 0031665981 scopus 로고    scopus 로고
    • Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells
    • Batrakova EV, Han HY, Miller DW, Kabanov AV: Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells. Pharm. Res. 15, 1525-1532 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 1525-1532
    • Batrakova, E.V.1    Han, H.Y.2    Miller, D.W.3    Kabanov, A.V.4
  • 96
    • 0142042448 scopus 로고    scopus 로고
    • Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity
    • Jevprasesphant R, Penny J, Attwood D, McKeown NB, D'Emanuele A: Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity. Pharm. Res. 20, 1543-1550 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 1543-1550
    • Jevprasesphant, R.1    Penny, J.2    Attwood, D.3    McKeown, N.B.4    D'Emanuele, A.5
  • 97
    • 0141867744 scopus 로고    scopus 로고
    • Transport mechanism(s) of poly (amidoamine) dendrimers across Caco-2 cell monolayers
    • El-Sayed M, Rhodes CA, Ginski M, Ghandehari H: Transport mechanism(s) of poly (amidoamine) dendrimers across Caco-2 cell monolayers. Int. J. Pharm. 265, 151-157 (2003).
    • (2003) Int. J. Pharm , vol.265 , pp. 151-157
    • El-Sayed, M.1    Rhodes, C.A.2    Ginski, M.3    Ghandehari, H.4
  • 99
    • 42549146106 scopus 로고    scopus 로고
    • Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells
    • Kitchens KM, Kolhatkar RB, Swaan PW, Ghandehari H: Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells. Mol. Pharm. 5, 364-369 (2008)
    • (2008) Mol. Pharm , vol.5 , pp. 364-369
    • Kitchens, K.M.1    Kolhatkar, R.B.2    Swaan, P.W.3    Ghandehari, H.4
  • 101
    • 0025954040 scopus 로고
    • Mechanisms of peptide and protein absorption: (1) Paracellular intestinal transport: Modulation of absorption
    • Nellans HN: (B) Mechanisms of peptide and protein absorption: (1) Paracellular intestinal transport: modulation of absorption. Adv. Drug Deliv. Rev. 7, 339-364 (1991).
    • (1991) Adv. Drug Deliv. Rev. , vol.7 , pp. 339-364
    • Nellans, H.N.1
  • 102
    • 0017363309 scopus 로고
    • Persorption of particles: Physiology and pharmacology
    • Volkheimer G: Persorption of particles: physiology and pharmacology. Adv. Pharmacol. Chemother. 14, 163-187 (1977).
    • (1977) Adv. Pharmacol. Chemother , vol.14 , pp. 163-187
    • Volkheimer, G.1
  • 103
    • 0034601281 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake?
    • Jung T, Kamm W, Breitenbach A, Kaiserling E, Xiao JX, Kissel T: Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm. 50, 147-160 (2000).
    • (2000) Eur. J. Pharm. Biopharm , vol.50 , pp. 147-160
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3    Kaiserling, E.4    Xiao, J.X.5    Kissel, T.6
  • 104
    • 0034306505 scopus 로고    scopus 로고
    • Enhancing paracellular permeability by modulating epithelial tight junctions
    • Ward PD, Tippin TK, Thakker DR: Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm. Sci. Technol. Today 3, 346-358 (2000).
    • (2000) Pharm. Sci. Technol. Today , vol.3 , pp. 346-358
    • Ward, P.D.1    Tippin, T.K.2    Thakker, D.R.3
  • 105
    • 16244418685 scopus 로고    scopus 로고
    • Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium
    • Salamat-Millerand N, Johnston TP: Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium. Int. J. Pharm. 294, 201-216 (2005).
    • (2005) Int. J. Pharm , vol.294 , pp. 201-216
    • Salamat-Millerand, N.1    Johnston, T.P.2
  • 106
    • 50249129610 scopus 로고    scopus 로고
    • Permeation enhancer effect of chitosan and chitosan derivatives: Comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells
    • Sadeghi AM, Dorkoosh FA, Avadi MR et al.: Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells. Eur. J. Pharm. Biopharm. 70, 270-278 (2008).
    • (2008) Eur. J. Pharm. Biopharm , vol.70 , pp. 270-278
    • Sadeghi, A.M.1    Dorkoosh, F.A.2    Avadi, M.R.3
  • 107
    • 0031413702 scopus 로고    scopus 로고
    • Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
    • Arturssonand P, Borchardt RT: Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharm. Res. 14, 1655-1658 (1997).
    • (1997) Pharm. Res , vol.14 , pp. 1655-1658
    • Arturssonand, P.1    Borchardt, R.T.2
  • 111
    • 34249914746 scopus 로고    scopus 로고
    • Passive diffusion of polymeric surfactants across lipid bilayers
    • Mathot F, Schanck A, Van Bambeke F et al.: Passive diffusion of polymeric surfactants across lipid bilayers. J. Control Release 120, 79-87 (2007).
    • (2007) J. Control Release , vol.120 , pp. 79-87
    • Mathot, F.1    Schanck, A.2    Van Bambeke, F.3
  • 112
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • Winand KY, Feng SS: Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 26, 2713-2722 (2005).
    • (2005) Biomaterials , vol.26 , pp. 2713-2722
    • Winand, K.Y.1    Feng, S.S.2
  • 113
    • 0029841664 scopus 로고    scopus 로고
    • M cells in Peyer's patches of the intestine
    • Gebert A, Rothkotter HJ, Pabst R: M cells in Peyer's patches of the intestine. Int. Rev. Cytol. 167, 91-159 (1996).
    • (1996) Int. Rev. Cytol , vol.167 , pp. 91-159
    • Gebert, A.1    Rothkotter, H.J.2    Pabst, R.3
  • 114
    • 0032403490 scopus 로고    scopus 로고
    • Physiological considerations in the design of particulate dosage forms for oral vaccine delivery
    • Yeh P, Ellens H, Smith PL: Physiological considerations in the design of particulate dosage forms for oral vaccine delivery. Adv. Drug Deliv. Rev. 34, 123-133 (1998).
    • (1998) Adv. Drug Deliv. Rev , vol.34 , pp. 123-133
    • Yeh, P.1    Ellens, H.2    Smith, P.L.3
  • 115
    • 21744458087 scopus 로고    scopus 로고
    • Nanoparticle uptake by the oral route: Fulflling its potential?
    • Florence AT: Nanoparticle uptake by the oral route: fulflling its potential? Drug Discov. Today: Technologies. 2, 75-81 (2005).
    • (2005) Drug Discov. Today: Technologies , vol.2 , pp. 75-81
    • Florence, A.T.1
  • 116
    • 33751253462 scopus 로고    scopus 로고
    • Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
    • des Rieux A, Fievez V, Garinot M, Schneider YJ, Preat V: Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J. Control Release 116, 1-27 (2006).
    • (2006) J. Control Release , vol.116 , pp. 1-27
    • Des Rieux, A.1    Fievez, V.2    Garinot, M.3    Schneider, Y.J.4    Preat, V.5
  • 117
    • 39049124118 scopus 로고    scopus 로고
    • Nanoparticle strategies for the oral delivery of insulin
    • Damge C, Reis CP, Maincent P: Nanoparticle strategies for the oral delivery of insulin. Expert Opin. Drug. Deliv. 5, 45-68 (2008).
    • (2008) Expert Opin. Drug. Deliv , vol.5 , pp. 45-68
    • Damge, C.1    Reis, C.P.2    Maincent, P.3
  • 118
    • 15544362279 scopus 로고    scopus 로고
    • Polymeric particulates to improve oral bioavailability of peptide drugs
    • Delieand F, Blanco-Prieto MJ: Polymeric particulates to improve oral bioavailability of peptide drugs. Molecules 10, 65-80 (2005).
    • (2005) Molecules , vol.10 , pp. 65-80
    • Delieand, F.1    Blanco-Prieto, M.J.2
  • 119
    • 25144503019 scopus 로고    scopus 로고
    • Keynote review: Intestinal Peyer's patch M cells and oral vaccine targeting
    • Brayden DJ, Jepson MA, Baird AW: Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting. Drug Discov. Today 10, 1145-1157 (2005).
    • (2005) Drug Discov. Today , vol.10 , pp. 1145-1157
    • Brayden, D.J.1    Jepson, M.A.2    Baird, A.W.3
  • 120
    • 0034822710 scopus 로고    scopus 로고
    • Oral vaccination in man using antigens in particles: Current status
    • Brayden DJ: Oral vaccination in man using antigens in particles: current status. Eur. J. Pharm. Sci. 14, 183-189 (2001).
    • (2001) Eur. J. Pharm. Sci , vol.14 , pp. 183-189
    • Brayden, D.J.1
  • 121
    • 9244247602 scopus 로고    scopus 로고
    • Exploiting receptor biology for oral vaccination with biodegradable particulates
    • Fosterand N, Hirst BH: Exploiting receptor biology for oral vaccination with biodegradable particulates. Adv. Drug Deliv. Rev. 57, 431-450 (2005).
    • (2005) Adv. Drug Deliv. Rev , vol.57 , pp. 431-450
    • Fosterand, N.1    Hirst, B.H.2
  • 123
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro-and nanoparticulates: Neither exceptional nor unusual
    • Florence AT: The oral absorption of micro-and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 14, 259-266 (1997).
    • (1997) Pharm. Res , vol.14 , pp. 259-266
    • Florence, A.T.1
  • 124
    • 47349113115 scopus 로고    scopus 로고
    • M cell-targeted delivery of vaccines and therapeutics
    • Kuoleeand R, Chen W: M cell-targeted delivery of vaccines and therapeutics. Expert Opin. Drug. Deliv. 5, 693-702 (2008).
    • (2008) Expert Opin. Drug. Deliv , vol.5 , pp. 693-702
    • Kuoleeand, R.1    Chen, W.2
  • 125
    • 34250332586 scopus 로고    scopus 로고
    • Implication of nanoparticles/microparticles in mucosal vaccine delivery
    • Vyasand SP, Gupta PN: Implication of nanoparticles/microparticles in mucosal vaccine delivery. Expert Rev. Vaccines 6, 401-418 (2007).
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 401-418
    • Vyasand, S.P.1    Gupta, P.N.2
  • 126
    • 1142309545 scopus 로고    scopus 로고
    • M cell targeting by lectins: A strategy for mucosal vaccination and drug delivery
    • Jepson MA, Clark MA, Hirst BH: M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery. Adv. Drug Deliv. Rev. 56, 511-525 (2004).
    • (2004) Adv. Drug Deliv. Rev , vol.56 , pp. 511-525
    • Jepson, M.A.1    Clark, M.A.2    Hirst, B.H.3
  • 127
  • 128
    • 0029411993 scopus 로고
    • The importance of gastrointestinal uptake of particles in the design of oral delivery systems
    • Lavelle EC, Sharif S, Thomas NW, Holland J, Davis SS: The importance of gastrointestinal uptake of particles in the design of oral delivery systems. Adv. Drug Deliv. Rev. 18, 5-22 (1995).
    • (1995) Adv. Drug Deliv. Rev , vol.18 , pp. 5-22
    • Lavelle, E.C.1    Sharif, S.2    Thomas, N.W.3    Holland, J.4    Davis, S.S.5
  • 129
    • 36749076604 scopus 로고    scopus 로고
    • M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B
    • Gupta PN, Khatri K, Goyal AK, Mishra N, Vyas SP: M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B. J. Drug Target. 15, 701-713 (2007).
    • (2007) J. Drug Target , vol.15 , pp. 701-713
    • Gupta, P.N.1    Khatri, K.2    Goyal, A.K.3    Mishra, N.4    Vyas, S.P.5
  • 130
    • 34447306055 scopus 로고    scopus 로고
    • PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination
    • Garinot M, Fievez V, Pourcelle V et al.: PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination. J. Control Release 120, 195-204 (2007).
    • (2007) J. Control Release , vol.120 , pp. 195-204
    • Garinot, M.1    Fievez, V.2    Pourcelle, V.3
  • 131
    • 33751171961 scopus 로고    scopus 로고
    • Identifcation of cell adhesion molecules in the human follicle-associated epithelium that improve nanoparticle uptake into the Peyer's patches
    • Gullberg E, Keita AV, Salim SY et al.: Identifcation of cell adhesion molecules in the human follicle-associated epithelium that improve nanoparticle uptake into the Peyer's patches. J. Pharmacol. Exp. Ther. 319, 632-639 (2006).
    • (2006) J. Pharmacol. Exp. Ther , vol.319 , pp. 632-639
    • Gullberg, E.1    Keita, A.V.2    Salim, S.Y.3
  • 132
    • 0034731393 scopus 로고    scopus 로고
    • Expression of specifc markers and particle transport in a new human intestinal M-cell model
    • Gullberg E, Leonard M, Karlsson J et al.: Expression of specifc markers and particle transport in a new human intestinal M-cell model. Biochem. Biophys. Res. Commun. 279, 808-813 (2000).
    • (2000) Biochem. Biophys. Res. Commun , vol.279 , pp. 808-813
    • Gullberg, E.1    Leonard, M.2    Karlsson, J.3
  • 133
    • 0035851035 scopus 로고    scopus 로고
    • Targeting polymerised liposome vaccine carriers to intestinal M cells
    • Clark MA, Blair H, Liang L, Brey RN, Brayden D, Hirst BH: Targeting polymerised liposome vaccine carriers to intestinal M cells. Vaccine 20, 208-217 (2001).
    • (2001) Vaccine , vol.20 , pp. 208-217
    • Clark, M.A.1    Blair, H.2    Liang, L.3    Brey, R.N.4    Brayden, D.5    Hirst, B.H.6
  • 134
    • 0037523228 scopus 로고    scopus 로고
    • Visualization of insulin-loaded nanocapsules: In vitro and in vivo studies after oral administration to rats
    • Pinto-Alphandary H, Aboubakar M, Jaillard D, Couvreur P, Vauthier C: Visualization of insulin-loaded nanocapsules: in vitro and in vivo studies after oral administration to rats. Pharm. Res. 20, 1071-1084 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 1071-1084
    • Pinto-Alphandary, H.1    Aboubakar, M.2    Jaillard, D.3    Couvreur, P.4    Vauthier, C.5
  • 135
    • 0033802503 scopus 로고    scopus 로고
    • Ileal uptake of polyalkylcyanoacrylate nanocapsules in the rat
    • Damge C, Aprahamian M, Humbert W, Pinget M: Ileal uptake of polyalkylcyanoacrylate nanocapsules in the rat. J. Pharm. Pharmacol. 52, 1049-1056 (2000).
    • (2000) J. Pharm. Pharmacol , vol.52 , pp. 1049-1056
    • Damge, C.1    Aprahamian, M.2    Humbert, W.3    Pinget, M.4
  • 136
    • 0025018162 scopus 로고
    • Intestinal translocation of particulates-implications for drug and antigen delivery
    • O'Hagan ST: Intestinal translocation of particulates-implications for drug and antigen delivery. Adv. Drug Deliv. Rev. 5, 265-285 (1990).
    • (1990) Adv. Drug Deliv. Rev , vol.5 , pp. 265-285
    • O'Hagan, S.T.1
  • 137
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • Connerand DS, Schmid SL: Regulated portals of entry into the cell. Nature 422, 37-44 (2003).
    • (2003) Nature , vol.422 , pp. 37-44
    • Connerand, D.S.1    Schmid, S.L.2
  • 138
    • 22144449986 scopus 로고    scopus 로고
    • The role of enterocytes in the intestinal barrier function and antigen uptake
    • Snoeck V, Goddeeris B, Cox E: The role of enterocytes in the intestinal barrier function and antigen uptake. Microbes Infect. 7, 997-1004 (2005).
    • (2005) Microbes Infect , vol.7 , pp. 997-1004
    • Snoeck, V.1    Goddeeris, B.2    Cox, E.3
  • 139
    • 0033981633 scopus 로고    scopus 로고
    • Rab GTPases coordinate endocytosis
    • Somsel RJ, Wandinger-Ness A: Rab GTPases coordinate endocytosis. J. Cell Sci. 113(Pt 2) 183-192 (2000).
    • (2000) J. Cell Sci , vol.113 , Issue.PART 2 , pp. 183-192
    • Somsel, R.J.1    Wandinger-Ness, A.2
  • 140
    • 0036017680 scopus 로고    scopus 로고
    • Clathrin-dependent or not: Is it still the question?
    • Johannesand L, Lamaze C: Clathrin-dependent or not: is it still the question? Traffc 3, 443-451 (2002).
    • (2002) Traffc , vol.3 , pp. 443-451
    • Johannesand, L.1    Lamaze, C.2
  • 141
    • 54949156390 scopus 로고    scopus 로고
    • Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis
    • Ragnarsson EG, Schoultz I, Gullberg E et al.: Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis. Lab. Invest. 88, 1215-1226 (2008).
    • (2008) Lab. Invest , vol.88 , pp. 1215-1226
    • Ragnarsson, E.G.1    Schoultz, I.2    Gullberg, E.3
  • 142
    • 34447524004 scopus 로고    scopus 로고
    • Clathrin-coated pits: Vive la difference?
    • Benmerahand A, Lamaze C: Clathrin-coated pits: vive la difference? Traffc 8, 970-982 (2007).
    • (2007) Traffc , vol.8 , pp. 970-982
    • Benmerahand, A.1    Lamaze, C.2
  • 143
    • 4444224966 scopus 로고    scopus 로고
    • Endocytosis by random initiation and stabilization of clathrin-coated pits
    • Ehrlich M, Boll W, Van Oijen A et al.: Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell 118, 591-605 (2004).
    • (2004) Cell , vol.118 , pp. 591-605
    • Ehrlich, M.1    Boll, W.2    Van Oijen, A.3
  • 144
    • 28744441403 scopus 로고    scopus 로고
    • Transepithelial and endothelial transport of poly (amidoamine) dendrimers
    • Kitchens KM, El-Sayed ME, Ghandehari H: Transepithelial and endothelial transport of poly (amidoamine) dendrimers. Adv. Drug Deliv. Rev. 57, 2163-2176 (2005).
    • (2005) Adv. Drug Deliv. Rev , vol.57 , pp. 2163-2176
    • Kitchens, K.M.1    El-Sayed, M.E.2    Ghandehari, H.3
  • 145
    • 0345706824 scopus 로고    scopus 로고
    • Caveosomes and endocytosis of lipid rafts
    • Nichols B: Caveosomes and endocytosis of lipid rafts. J. Cell Sci. 116, 4707-4714 (2003).
    • (2003) J. Cell Sci , vol.116 , pp. 4707-4714
    • Nichols, B.1
  • 146
    • 34548150618 scopus 로고    scopus 로고
    • Regulation of raft-dependent endocytosis
    • Lajoieand P, Nabi IR: Regulation of raft-dependent endocytosis. J. Cell. Mol. Med. 11, 644-653 (2007).
    • (2007) J. Cell. Mol. Med , vol.11 , pp. 644-653
    • Lajoieand, P.1    Nabi, I.R.2
  • 147
    • 0031706594 scopus 로고    scopus 로고
    • Caveolin is present in intestinal cells: Role in cholesterol traffcking?
    • Field FJ, Born E, Murthy S, Mathur SN: Caveolin is present in intestinal cells: role in cholesterol traffcking? J. Lipid Res. 39, 1938-1950 (1998).
    • (1998) J. Lipid Res , vol.39 , pp. 1938-1950
    • Field, F.J.1    Born, E.2    Murthy, S.3    Mathur, S.N.4
  • 148
    • 0019994630 scopus 로고
    • Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins
    • Montesano R, Roth J, Robert A, Orci L: Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature 296, 651-653 (1982).
    • (1982) Nature , vol.296 , pp. 651-653
    • Montesano, R.1    Roth, J.2    Robert, A.3    Orci, L.4
  • 149
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simonsand K, Ikonen E: Functional rafts in cell membranes. Nature 387, 569-572 (1997).
    • (1997) Nature , vol.387 , pp. 569-572
    • Simonsand, K.1    Ikonen, E.2
  • 150
    • 0035017308 scopus 로고    scopus 로고
    • Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
    • Pelkmans L, Kartenbeck J, Helenius A: Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nat. Cell Biol. 3, 473-483 (2001).
    • (2001) Nat. Cell Biol , vol.3 , pp. 473-483
    • Pelkmans, L.1    Kartenbeck, J.2    Helenius, A.3
  • 151
    • 34548231783 scopus 로고    scopus 로고
    • "Alternative" endocytic mechanisms exploited by pathogens: New avenues for therapeutic delivery?
    • Medina-Kauwe LK: "Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? Adv. Drug Deliv. Rev. 59, 798-809 (2007).
    • (2007) Adv. Drug Deliv. Rev , vol.59 , pp. 798-809
    • Medina-Kauwe, L.K.1
  • 152
    • 0027997787 scopus 로고
    • Filipin-sensitive caveolae-mediated transport in endothelium: Reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules
    • Schnitzer JE, Oh P, Pinney E, Allard J: Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J. Cell Biol. 127, 1217-1232 (1994).
    • (1994) J. Cell Biol , vol.127 , pp. 1217-1232
    • Schnitzer, J.E.1    Oh, P.2    Pinney, E.3    Allard, J.4
  • 153
    • 39149108776 scopus 로고    scopus 로고
    • Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
    • Trevaskis NL, Charman WN, Porter CJ: Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Adv. Drug Deliv. Rev. 60, 702-716 (2008).
    • (2008) Adv. Drug Deliv. Rev , vol.60 , pp. 702-716
    • Trevaskis, N.L.1    Charman, W.N.2    Porter, C.J.3
  • 154
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • Panyamand J, Labhasetwar V: Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55, 329-347 (2003).
    • (2003) Adv. Drug Deliv. Rev , vol.55 , pp. 329-347
    • Panyamand, J.1    Labhasetwar, V.2
  • 155
    • 0036324712 scopus 로고    scopus 로고
    • Rapid endolysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: Implications for drug and gene delivery
    • Panyam J, Zhou WZ, Prabha S, Sahoo SK, Labhasetwar V: Rapid endolysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery. Faseb J. 16, 1217-1226 (2002).
    • (2002) Faseb J , vol.16 , pp. 1217-1226
    • Panyam, J.1    Zhou, W.Z.2    Prabha, S.3    Sahoo, S.K.4    Labhasetwar, V.5
  • 156
    • 0037331856 scopus 로고    scopus 로고
    • Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells
    • Panyamand J, Labhasetwar V: Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm. Res. 20, 212-220 (2003).
    • (2003) Pharm. Res , vol.20 , pp. 212-220
    • Panyamand, J.1    Labhasetwar, V.2
  • 157
    • 33748785439 scopus 로고    scopus 로고
    • N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: Endocytosis, exocytosis and drug release
    • Park JS, Han TH, Lee KY et al.: N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release. J. Control Release 115, 37-45 (2006).
    • (2006) J. Control Release , vol.115 , pp. 37-45
    • Park, J.S.1    Han, T.H.2    Lee, K.Y.3
  • 158
    • 46549090126 scopus 로고    scopus 로고
    • Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
    • Morille M, Passirani C, Vonarbourg A, Clavreul A, Benoit JP: Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 29, 3477-3496 (2008).
    • (2008) Biomaterials , vol.29 , pp. 3477-3496
    • Morille, M.1    Passirani, C.2    Vonarbourg, A.3    Clavreul, A.4    Benoit, J.P.5
  • 159
    • 0026545612 scopus 로고
    • Potocytosis: Sequestration and transport of small molecules by caveolae
    • Anderson RG, Kamen BA, Rothberg KG, Lacey SW: Potocytosis: sequestration and transport of small molecules by caveolae. Science 255, 410-411 (1992).
    • (1992) Science , vol.255 , pp. 410-411
    • Anderson, R.G.1    Kamen, B.A.2    Rothberg, K.G.3    Lacey, S.W.4
  • 160
    • 0031777867 scopus 로고    scopus 로고
    • Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways
    • Swaan PW: Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways. Pharm. Res. 15, 826-834 (1998).
    • (1998) Pharm. Res , vol.15 , pp. 826-834
    • Swaan, P.W.1
  • 161
    • 34548049483 scopus 로고    scopus 로고
    • Nanosizing-oral formulation development and biopharmaceutical evaluation
    • Kesisoglou F, Panmai S, Wu Y: Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv. Drug Deliv. Rev. 59, 631-644 (2007).
    • (2007) Adv. Drug Deliv. Rev , vol.59 , pp. 631-644
    • Kesisoglou, F.1    Panmai, S.2    Wu, Y.3
  • 162
    • 33750089277 scopus 로고    scopus 로고
    • Preparation and in vitro/in vivo evaluation of nano-sized crystals for dissolution rate enhancement of ucb-35440-35443, a highly dosed poorly water-soluble weak base
    • Hecq J, Deleers M, Fanara D et al.: Preparation and in vitro/in vivo evaluation of nano-sized crystals for dissolution rate enhancement of ucb-35440-35443, a highly dosed poorly water-soluble weak base. Eur. J. Pharm. Biopharm. 64, 360-368 (2006).
    • (2006) Eur. J. Pharm. Biopharm , vol.64 , pp. 360-368
    • Hecq, J.1    Deleers, M.2    Fanara, D.3
  • 163
    • 0036689390 scopus 로고    scopus 로고
    • Effect of nanonization on absorption of 301029: Ex vivo and in vivo pharmacokinetic correlations determined by liquid chromatography/mass spectrometry
    • Jia L, Wong H, Cerna C, Weitman SD: Effect of nanonization on absorption of 301029: ex vivo and in vivo pharmacokinetic correlations determined by liquid chromatography/mass spectrometry. Pharm. Res. 19, 1091-1096 (2002).
    • (2002) Pharm. Res , vol.19 , pp. 1091-1096
    • Jia, L.1    Wong, H.2    Cerna, C.3    Weitman, S.D.4
  • 164
    • 22144477899 scopus 로고    scopus 로고
    • Mechanics of receptor-mediated endocytosis
    • Gao H, Shi W, Freund LB: Mechanics of receptor-mediated endocytosis. Proc. Natl Acad. Sci. USA 102, 9469-9474 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 9469-9474
    • Gao, H.1    Shi, W.2    Freund, L.B.3
  • 165
    • 67349179610 scopus 로고    scopus 로고
    • Nanoparticle-based targeted drug delivery
    • Singhand R, Lillard JW Jr: Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol. 86, 215-223 (2009).
    • (2009) Exp. Mol. Pathol , vol.86 , pp. 215-223
    • Singhand, R.1    Lillard Jr, J.W.2
  • 166
    • 33646397592 scopus 로고    scopus 로고
    • Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    • Chithrani BD, Ghazani AA, Chan WC: Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 6, 662-668 (2006).
    • (2006) Nano Lett , vol.6 , pp. 662-668
    • Chithrani, B.D.1    Ghazani, A.A.2    Chan, W.C.3
  • 167
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai MP, Labhasetwar V, Amidon GL, Levy RJ: Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13, 1838-1845 (1996).
    • (1996) Pharm. Res , vol.13 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 168
    • 1642575957 scopus 로고    scopus 로고
    • Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis
    • Rejman J, Oberle V, Zuhorn IS, Hoekstra D: Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis. Biochem. J. 377, 159-169 (2004).
    • (2004) Biochem. J , vol.377 , pp. 159-169
    • Rejman, J.1    Oberle, V.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 169
    • 0034291676 scopus 로고    scopus 로고
    • Functional polymer microspheres
    • Kawaguchi H: Functional polymer microspheres. Prog. Polym. Sci.25, 1171-1210 (2000).
    • (2000) Prog. Polym. Sci. , vol.25 , pp. 1171-1210
    • Kawaguchi, H.1
  • 171
    • 23744473464 scopus 로고    scopus 로고
    • Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization
    • Krauel K, Davies NM, Hook S, Rades T: Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization. J. Control Release 106, 76-87 (2005).
    • (2005) J. Control Release , vol.106 , pp. 76-87
    • Krauel, K.1    Davies, N.M.2    Hook, S.3    Rades, T.4
  • 173
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • Wissing SA, Kayser O, Muller RH: Solid lipid nanoparticles for parenteral drug delivery. Adv. Drug Deliv. Rev. 56, 1257-1272 (2004).
    • (2004) Adv. Drug Deliv. Rev , vol.56 , pp. 1257-1272
    • Wissing, S.A.1    Kayser, O.2    Muller, R.H.3
  • 174
    • 0037237718 scopus 로고    scopus 로고
    • The infuence of lipid nanocapsule composition on their size distribution
    • Heurtault B, Saulnier P, Pech B et al.: The infuence of lipid nanocapsule composition on their size distribution. Eur. J. Pharm. Sci. 18, 55-61 (2003).
    • (2003) Eur. J. Pharm. Sci , vol.18 , pp. 55-61
    • Heurtault, B.1    Saulnier, P.2    Pech, B.3
  • 175
    • 0035167372 scopus 로고    scopus 로고
    • Liposomes (a review)-part one: Manufacturing issues
    • Suggy SC, Murari R, Imran A: Liposomes (a review)-part one: manufacturing issues. Biopharm. 14, 10 (2001).
    • (2001) Biopharm , vol.14 , pp. 10
    • Suggy, S.C.1    Murari, R.2    Imran, A.3
  • 176
    • 68949218775 scopus 로고    scopus 로고
    • The gastrointestinal stability of lipid nanocapsules
    • Roger E, Lagarce F, Benoit JP: The gastrointestinal stability of lipid nanocapsules. Int. J. Pharm. 379, 260-265 (2009).
    • (2009) Int. J. Pharm , vol.379 , pp. 260-265
    • Roger, E.1    Lagarce, F.2    Benoit, J.P.3
  • 177
    • 0029896657 scopus 로고    scopus 로고
    • Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time
    • Uster PS, Allen TM, Daniel BE, Mendez CJ, Newman MS, Zhu GZ: Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time. FEBS Lett. 386, 243-246 (1996).
    • (1996) FEBS Lett , vol.386 , pp. 243-246
    • Uster, P.S.1    Allen, T.M.2    Daniel, B.E.3    Mendez, C.J.4    Newman, M.S.5    Zhu, G.Z.6
  • 178
    • 0035937591 scopus 로고    scopus 로고
    • Design of nanoparticles composed of graft copolymers for oral peptide delivery
    • Sakuma S, Hayashi M, Akashi M: Design of nanoparticles composed of graft copolymers for oral peptide delivery. Adv. Drug Deliv. Rev. 47, 21-37 (2001).
    • (2001) Adv. Drug Deliv. Rev , vol.47 , pp. 21-37
    • Sakuma, S.1    Hayashi, M.2    Akashi, M.3
  • 179
    • 17444372009 scopus 로고    scopus 로고
    • Mucoadhesives in the gastrointestinal tract: Revisiting the literature for novel applications
    • Dodou D, Breedveld P, Wieringa PA: Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications. Eur. J. Pharm. Biopharm. 60, 1-16 (2005).
    • (2005) Eur. J. Pharm. Biopharm , vol.60 , pp. 1-16
    • Dodou, D.1    Breedveld, P.2    Wieringa, P.A.3
  • 180
    • 0035937594 scopus 로고    scopus 로고
    • Mucoadhesive nanoparticulate systems for peptide drug delivery
    • DOI 10.1016/S0169-409X(00)00120-4, PII S0169409X00001204
    • Takeuchi H, Yamamoto H, Kawashima Y: Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv. Drug Deliv. Rev. 47, 39-54 (2001). (Pubitemid 32209231)
    • (2001) Advanced Drug Delivery Reviews , vol.47 , Issue.1 , pp. 39-54
    • Takeuchi, H.1    Yamamoto, H.2    Kawashima, Y.3
  • 181
    • 34548863653 scopus 로고    scopus 로고
    • Lectin-conjugated PLGA nanoparticles loaded with thymopentin: Ex vivo bioadhesion and in vivo biodistribution
    • Yin Y, Chen D, Qiao M, Wei X, Hu H: Lectin-conjugated PLGA nanoparticles loaded with thymopentin: ex vivo bioadhesion and in vivo biodistribution. J. Control Release 123, 27-38 (2007).
    • (2007) J. Control Release , vol.123 , pp. 27-38
    • Yin, Y.1    Chen, D.2    Qiao, M.3    Wei, X.4    Hu, H.5
  • 182
    • 0032402214 scopus 로고    scopus 로고
    • O'Hagan: The preparation and characterization of polymeric antigen delivery systems for oral administration
    • Singhand MD, O'Hagan: The preparation and characterization of polymeric antigen delivery systems for oral administration. Adv. Drug Deliv. Rev. 34, 285-304 (1998).
    • (1998) Adv. Drug Deliv. Rev , vol.34 , pp. 285-304
    • Singhand, M.D.1
  • 185
    • 37349044610 scopus 로고    scopus 로고
    • A novel IRQ ligand-modifed nano-carrier targeted to a unique pathway of caveolar endocytic pathway
    • Mudhakir D, Akita H, Tan E, Harashima H: A novel IRQ ligand-modifed nano-carrier targeted to a unique pathway of caveolar endocytic pathway. J. Control Release 125, 164-173 (2008).
    • (2008) J. Control Release , vol.125 , pp. 164-173
    • Mudhakir, D.1    Akita, H.2    Tan, E.3    Harashima, H.4
  • 186
    • 34548267667 scopus 로고    scopus 로고
    • Endocytic mechanisms for targeted drug delivery
    • Barefordand LM, Swaan PW: Endocytic mechanisms for targeted drug delivery. Adv. Drug Deliv. Rev. 59, 748-758 (2007).
    • (2007) Adv. Drug Deliv. Rev , vol.59 , pp. 748-758
    • Barefordand, L.M.1    Swaan, P.W.2
  • 187
    • 34547302844 scopus 로고    scopus 로고
    • Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    • Chithraniand BD, Chan WC: Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett. 7, 1542-1550 (2007).
    • (2007) Nano Lett , vol.7 , pp. 1542-1550
    • Chithraniand, B.D.1    Chan, W.C.2
  • 188
    • 28844463125 scopus 로고    scopus 로고
    • Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation-and clathrin-dependent endocytosis
    • Muro S, Schuchman EH, Muzykantov VR: Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation-and clathrin-dependent endocytosis. Mol. Ther. 13, 135-141 (2006).
    • (2006) Mol. Ther , vol.13 , pp. 135-141
    • Muro, S.1    Schuchman, E.H.2    Muzykantov, V.R.3
  • 189
    • 0032403467 scopus 로고    scopus 로고
    • Specifc and non-specifc bioadhesive particulate systems for oral delivery to the gastrointestinal tract
    • Poncheland G, Irache J: Specifc and non-specifc bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv. Drug Deliv. Rev. 34, 191-219 (1998).
    • (1998) Adv. Drug Deliv. Rev , vol.34 , pp. 191-219
    • Poncheland, G.1    Irache, J.2
  • 190
    • 0022427984 scopus 로고
    • Tomato lectin resists digestion in the mammalian alimentary canal and binds to intestinal villi without deleterious effects
    • Kilpatrick DC, Pusztai A, Grant G, Graham C, Ewen SW: Tomato lectin resists digestion in the mammalian alimentary canal and binds to intestinal villi without deleterious effects. FEBS Lett. 185, 299-305 (1985).
    • (1985) FEBS Lett , vol.185 , pp. 299-305
    • Kilpatrick, D.C.1    Pusztai, A.2    Grant, G.3    Graham, C.4    Ewen, S.W.5
  • 191
    • 0030952669 scopus 로고    scopus 로고
    • Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat
    • Hussain N, Jani PU, Florence AT: Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat. Pharm. Res. 14, 613-618 (1997).
    • (1997) Pharm. Res , vol.14 , pp. 613-618
    • Hussain, N.1    Jani, P.U.2    Florence, A.T.3
  • 192
    • 0029092672 scopus 로고
    • Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate
    • Florence AT, Hillery AM, Hussain N, Jani PU: Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate. J. Control Release 36, 39-46 (1995).
    • (1995) J. Control Release , vol.36 , pp. 39-46
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.3    Jani, P.U.4
  • 193
    • 67349092492 scopus 로고    scopus 로고
    • Effcient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells
    • Gabrielsonand NP, Pack DW: Effcient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells. J. Control Release 136(1), 54-61 (2009).
    • (2009) J. Control Release , vol.136 , Issue.1 , pp. 54-61
    • Gabrielsonand, N.P.1    Pack, D.W.2
  • 194
    • 0032586956 scopus 로고    scopus 로고
    • 12-mediated transport of nanoparticles across Caco-2 cells
    • DOI 10.1016/S0378-5173(98)00394-9, PII S0378517398003949
    • Russell-Jones GJ, Arthur L, Walker H: Vitamin B12-mediated transport of nanoparticles across Caco-2 cells. Int. J. Pharm. 179, 247-255 (1999). (Pubitemid 29131434)
    • (1999) International Journal of Pharmaceutics , vol.179 , Issue.2 , pp. 247-255
    • Russell-Jones, G.J.1    Arthur, L.2    Walker, H.3
  • 195
    • 36549037212 scopus 로고    scopus 로고
    • The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles
    • Samstein RM, Perica K, Balderrama F, Look M, Fahmy TM: The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles. Biomaterials 29, 703-708 (2008).
    • (2008) Biomaterials , vol.29 , pp. 703-708
    • Samstein, R.M.1    Perica, K.2    Balderrama, F.3    Look, M.4    Fahmy, T.M.5
  • 196
    • 0028850112 scopus 로고
    • Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice
    • Leroux JC, Cozens R, Roesel JL et al.: Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice. J. Pharm. Sci. 84, 1387-1391 (1995).
    • (1995) J. Pharm. Sci , vol.84 , pp. 1387-1391
    • Leroux, J.C.1    Cozens, R.2    Roesel, J.L.3
  • 197
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classifcation: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon GL, Lennernas H, Shah V P, Crison JR: A theoretical basis for a biopharmaceutic drug classifcation: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12, 413-420 (1995).
    • (1995) Pharm. Res , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 198
    • 0037817352 scopus 로고    scopus 로고
    • Transcytosis: Crossing cellular barriers
    • Tumaand PL, Hubbard AL: Transcytosis: crossing cellular barriers. Physiol. Rev. 83, 871-932 (2003).
    • (2003) Physiol. Rev , vol.83 , pp. 871-932
    • Tumaand, P.L.1    Hubbard, A.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.