The effect of chronic nasal application of chitosan solutions on cilia beat frequency in guinea pigs

International Journal of Pharmaceutics

Volumn 153, Issue 2, 1997, Pages 137-146

  Aspden, Trudi ^a   Illum, Lisbeth ^a,b   Skaugrud, Øyvind ^c  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Albert Einstein Centre   (United Kingdom)

^c Pronova Biomedical   (Norway)

Author keywords

Chitosan; Cilia beat frequency; Guinea pigs; Nasal administration; Nasal toxicity

Indexed keywords

CHITOSAN; COCAINE; TAURODIHYDROFUSIDATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CILIARY MOTILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; FEMALE; GUINEA PIG; INTRANASAL DRUG ADMINISTRATION; MALE; MOLECULAR WEIGHT; NONHUMAN; NOSE INJURY; PRIORITY JOURNAL;

EID: 0030791920     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)04914-4     Document Type: Article

References (16)

1. Artursson, P., Lindmark, T., Davis, S.S. Illum, L., 1994. Effect of Chitosan on the permeability of monolayers of intestinal epithelial cells (CaCo-2). Pharm. Res. 11, 1358-1361.
2. Aspden, T.F., Mason, J.D.T., Jones, N., Lowe J., Skaugrud, Ø. Illum, L., 1997. Chitosan as a nasal delivery system: The effect of chitosan on in vitro and in vivo mucociliary transport rates. J. Pharm. Sci. 86, 509-513.
3. Batts, A.H.C., Marriott, G.P. Martin, C.F. Wood, Bond S.W., 1990. The effect of some preservatives used in nasal preparations on the mucus and ciliary components of mucociliary clearance. J. Pharm. Pharmacol. 42, 145-151.
4. Braat J.P.M., Ainge, G., Bowles, J.A.K., Richards, D.H.D. Van Riessen, W.J., Visser, Rijntjes E., 1995. The lack of effect of benzalkonium chloride on the cilia of the nasal mucosa in patients with perennial allergic rhinitis: a combined functional, light, scanning and transmission electron microscopy study. Clin. Exptl. Allergy 25, 957-965.
5. Daugherty, A.L., Liggitt, H.D., McCabe, J.G., Moore, J.A., Patton, J.S., 1988. Absorption of recombinant methionyl-human growth hormone (Met-hGH) from rat nasal mucosa. Int. J. Pharm., pp. 197-206.
6. Duchateau, G.S.M.J.E., Zuidema, J., Merkus, F.W.H.M., 1986. Bile salts and intranasal drug absorption. Int. J. Pharm. 31, 193-199.
7. Ennis, R.D.L., Borden, Lee, W.A., 1990. The effects of permeation enhancers on the surface morphology of the rat nasal mucosa: a scanning electron microscopy study. Pharm. Res. 7, 468-475.
8. Eshel, D., Grossman, Y., Priel, Z., 1985. 'Spectral characterisation of CBF; variations of frequency with time. Am. J. Physiol. 249, C160-C165.
9. Fabriant, N.D., 1941. Significance of the pH of nasal secretions in situ. Arch. Otolaryngol. 34, 150-163.
10. Forbes, A.R., Horrigan, R.W., 1977. Mucociliary flow in the trachea during anaesthesia with euflurane, ether, nitrous oxide and morphine. Anaesthesiology 46, 319-321.
11. Forbes, A.R., Gamsu, G., 1979. Depression of lung mucociliary clearance by thipental and halothane. Anaesth. Anal. 58, 387-389.
12. Hermens, W.A.J.J., Hooymans, P.M., Verhoef, J.C., Merkus, F.W.H.M., 1990. Effects of absorption enhancers on human tissue ciliary movement in vitro. Pharm. Res. 7, 63-67.
13. Herzon, F.S., 1983. Nasal ciliary structural pathology. Laryngoscope 93, 63-67.
14. Hirai, S., Yashiki T., Mima, H., 1981. Mechanisms for the enhancement of the nasal absorption of insulin by surfactants. Int. J. Pharm. 9, 173-184.
15. Hirai, S., Ikenaga, T., Matswzawa, T., 1978. Nasal absorption of insulin in dogs. Diabetes 27, 296-299.
16. Illum, L., Farraj, N.F., Davis. S.S., 1994. Chitosan as a novel delivery system for peptide drugs. Pharm. Res. 11, 147-156.