In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan

Biomaterials

Volumn 27, Issue 23, 2006, Pages 4250-4255

  Föger, Florian ^a   Schmitz, Thierry ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Oral drug delivery; P glycoprotein; P gp inhibition; Rhodamine 123; Thiolated chitosan

Indexed keywords

KETONES; MECHANICAL PERMEABILITY; PLASMAS; POLYMERS; PROTEINS;

CHITOSAN; DELIVERY SYSTEM; DRUG ABSORPTION; RHODAMINE;

SUBSTRATES;

AMIDINE; BUFFER; CHITOSAN; CHITOSAN 4 THIOBUTYLAMIDINE; CHITOSAN DERIVATIVE; GLUTATHIONE; GLYCOPROTEIN P; RHODAMINE 123; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; IN VITRO STUDY; INTESTINE MUCOSA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TABLET;

ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; DRUG DELIVERY SYSTEMS; FLUORESCENT DYES; MALE; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; SULFHYDRYL COMPOUNDS;

ANIMALIA;

EID: 33646159752     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2006.03.033     Document Type: Article

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