Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery

Journal of Controlled Release

Volumn 137, Issue 2, 2009, Pages 104-109

  Chono, Sumio ^a   Fukuchi, Rie ^a   Seki, Toshinobu ^a   Morimoto, Kazuhiro ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Dipalmitoyl phosphatidylcholine; Insulin; Liposomes; Lung surfactant components; Pulmonary delivery

Indexed keywords

CELL DAMAGE; CELL MONOLAYERS; DIMYRISTOYL; DIPALMITOYL PHOSPHATIDYLCHOLINE; ENHANCING EFFECT; EPITHELIAL CELLS; IN-VITRO; INSULIN DELIVERY; LUNG SURFACTANT COMPONENTS; LUNG TISSUE; PHOSPHATIDYLCHOLINE; PLASMA GLUCOSE LEVEL; PROTEIN DRUGS; PULMONARY DELIVERY; TRANSEPITHELIAL ELECTRICAL RESISTANCES;

AMINES; BIOLOGICAL ORGANS; GLUCOSE; INSULIN; MONOLAYERS; PHOSPHOLIPIDS; PLASMA DIAGNOSTICS; RATS; SURFACE ACTIVE AGENTS;

LIPOSOMES;

DILAUROYLPHOSPHATIDYLCHOLINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIOLEOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DISTEAROYLPHOSPHATIDYLCHOLINE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GLUCOSE; INSULIN; LACTATE DEHYDROGENASE; LIPOSOME;

AEROSOL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; ELECTRIC RESISTANCE; EPITHELIUM CELL; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MEMBRANE PERMEABILITY; MONOLAYER CULTURE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT MUCOSA;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ANIMALS; BRONCHI; CELL LINE; CELL MEMBRANE PERMEABILITY; DEXTRANS; EPITHELIAL CELLS; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; INSULIN; L-LACTATE DEHYDROGENASE; LIPOSOMES; MACROPHAGES; MALE; PARTICLE SIZE; PULMONARY ALVEOLI; RATS; RATS, WISTAR;

EID: 67349152120     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.03.019     Document Type: Article

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