Preparation of large porous deslorelin-PLGA microparticles with reduced residual solvent and cellular uptake using a supercritical carbon dioxide process

Pharmaceutical Research

Volumn 21, Issue 3, 2004, Pages 524-535

  Koushik, Kavitha ^a   Kompella, Uday B ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

A549 and Calu 3; Deslorelin; Macrophage uptake; Porous particles; Supercritical

Indexed keywords

CARBON DIOXIDE; DESLORELIN; ORGANIC SOLVENT; POLYGLACTIN; POLYMER; SOLVENT;

ANIMAL CELL; ARTICLE; BULK DENSITY; CELL LINE; CIRCULAR DICHROISM; CONFORMATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG RELEASE; EVAPORATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG ALVEOLUS MACROPHAGE; MASS SPECTROMETRY; MORPHOLOGY; NONHUMAN; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TEMPERATURE; ANIMAL; CHEMISTRY;

ANIMALS; CARBON DIOXIDE; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYMERS; POROSITY; SOLVENTS;

EID: 1542511344     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000019308.25479.a4     Document Type: Article

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