Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers

Journal of Controlled Release

Volumn 64, Issue 1-3, 2000, Pages 15-25

  Thanou, M M ^a   Kotze A F ^a,b   Scharringhausen, T ^a   Luessen H L ^c   De Boer, A G ^a   Verhoef, J C ^a   Junginger, H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NORTH WEST UNIVERSITY   (South Africa)

^c OctoPlus NV   (Netherlands)

Author keywords

Absorption enhancers; Caco 2 monolayers; Degree of substitution; Tight junctions; Trimethyl chitosan chloride

Indexed keywords

CARBON 14; CHITOSAN; CHITOSAN DERIVATIVE; FUNCTIONAL GROUP; MANNITOL; PENETRATION ENHANCING AGENT; SEACURE 210; UNCLASSIFIED DRUG;

ABSORPTION; CELL STRAIN CACO 2; CELL VIABILITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG TRANSPORT; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; HYDROPHILICITY; INTESTINE EPITHELIUM; MONOLAYER CULTURE; PERMEABILITY; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SOLUBILITY; SYNTHESIS; TIGHT JUNCTION;

BIOCOMPATIBLE MATERIALS; CACO-2 CELLS; CELL SURVIVAL; CHITIN; CHITOSAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; EPIDERMIS; HUMANS; INTESTINES; MANNITOL; PERMEABILITY; SOLUBILITY; TIGHT JUNCTIONS; TIME FACTORS;

EID: 0033960143     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00131-5     Document Type: Conference Paper

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