Protein inhalation powders: Spray drying vs spray freeze drying

Pharmaceutical Research

Volumn 16, Issue 2, 1999, Pages 249-254

  Maa, Yuh Fun ^a   Nguyen, Phuong Anh ^a   Sweeney, Theresa ^a   Shire, Steven J ^a   Hsu, Chung ^a  

^a GENENTECH INC   (United States)

Author keywords

Aerodynamic particle size; Cascade impaction; Dispersibility; Fine particle fraction; Liquid impingement; Spray drying; Spray freeze drying

Indexed keywords

CARBOHYDRATE; DEOXYRIBONUCLEASE; DORNASE ALFA; EXCIPIENT; IMMUNOGLOBULIN E ANTIBODY; PROTEIN;

AEROSOL; ARTICLE; CRYSTALLIZATION; DRUG FORMULATION; DRY POWDER; FREEZE DRYING; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; X RAY POWDER DIFFRACTION;

EID: 0033043629     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018828425184     Document Type: Article

References (10)

1. 1. E. G. Rippie. Powders. In: E. W. Martin (ed), Remington's Pharmaceutical Sciences, 17th ed., pp. 1585-1602 (1985).
2. 2. S.-D. Yeo, G.-B. Lim, P. G. Debenedetti, and H. Bernstein. Formation of microparticulate protein powders using a supercritical fluid antisolvent. Biotechn. Bioeng. 41:341-346 (1993).
3. 3. M. A. Winters, B. L. Knutson, P. G. Debenedetti, H. G. Sparks, T. M. Przybycien, C. L. Stevenson, and S. J. Prestrelski. Precipitation of proteins in supercritical carbon dioxide. J. Pharm. Sci. 85:586-594 (1996).
4. 4. W. R. Gombotz and L. R. Brown. Process for producing small particles of biologically active molecules," International Patent Application PCT/US90/02421 (1990).
5. 5. A. J. Hickey, N. M. Concessio, M. M. Van Oot, and R. M. Platz, Factors influencing the dispersion of dry powders as aerosols. Pharm. Tech. 18:58-82 (1994).
6. 6. Y.-F. Maa, H. R. Costantino, P.-A. Nguyen, and C. C. Hsu. The effect of operating and formulation variables on the morphology of spray-dried protein particles. Pharm. Dev. Tech. 2:213-223 (1997).
7. 7. D. A. Edwards, J. Hanes, G. Caponetti, J. Hrkach, A. Ben-Jebria, M. L. Eskew, J. Mintzes, D. Deaver, N. Lotan, and R. Langer. Large porous particles for pulmonary drug delivery. Science 276:1868-1871 (1997).
8. 8. Y.-F. Maa, P.-A. Nguyen, K. Sit, and C. C. Hsu. Spray-drying performance of bench-top spray dryer for protein aerosol powder preparation. Biotechn. Bioeng. in press.
9. 9. Y. F. Maa, P. A. Nguyen, J. D. Andya, N. Dasovich, T. D. Sweeney, S. J. Shire, and C. C. Hsu. Effect of spray drying and subsequent processing conditions on residual moisture content and physical/ biochemical stability of protein inhalation powders. Pharm. Res. 15:768-775 (1998).
10. 10. Y. F. Maa, P. A. Nguyen, and C. Hsu. Spray drying of air-liquid interface sensitive recombinant human growth hormone. J. Pharm. Sci. 87:152-159 (1998).