메뉴 건너뛰기




Volumn 96, Issue 3, 2007, Pages 473-483

Nanoparticulate systems for nasal delivery of drugs: A real improvement over simple systems?

Author keywords

Chitosan; Drug delivery; Nanoparticles; Nasal; PLA PEG; Vaccine delivery

Indexed keywords

CHITOSAN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INSULIN; LECTIN; MACROGOL; NANOPARTICLE; PEPTIDE DERIVATIVE; POLYSTYRENE; PROTEIN DERIVATIVE; TETANUS TOXOID; VACCINE;

EID: 33947529032     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20718     Document Type: Review
Times cited : (213)

References (49)
  • 1
    • 0032484619 scopus 로고    scopus 로고
    • Large molecule and particulate uptake in the nasal cavity: The effect of size on nasal absorption
    • Donovan MD, Huang Y. 1998. Large molecule and particulate uptake in the nasal cavity: The effect of size on nasal absorption. Adv Drug Del Rev 29: 147-155
    • (1998) Adv Drug Del Rev , vol.29 , pp. 147-155
    • Donovan, M.D.1    Huang, Y.2
  • 2
    • 0035997333 scopus 로고    scopus 로고
    • Nasal delivery of insulin using novel chitosan based formulations: A comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles
    • Dyer AM, Hinchcliffe M, Watts P, Castile J, Jabbal-Gill I, Nankervis R, Smith A, Illum L. 2002. Nasal delivery of insulin using novel chitosan based formulations: A comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles. Pharm Res 19:998-1008.
    • (2002) Pharm Res , vol.19 , pp. 998-1008
    • Dyer, A.M.1    Hinchcliffe, M.2    Watts, P.3    Castile, J.4    Jabbal-Gill, I.5    Nankervis, R.6    Smith, A.7    Illum, L.8
  • 3
    • 0036733907 scopus 로고    scopus 로고
    • Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses
    • Cui Z, Mumper RJ. 2002. Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses. J Pharm Pharmacol 54:1195-1203.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 1195-1203
    • Cui, Z.1    Mumper, R.J.2
  • 8
    • 0035937593 scopus 로고    scopus 로고
    • Polysaccharide colloidal particles as delivery systems for macromolecules
    • Janes KA, Calvo P, Alonso MJ. 2001. Polysaccharide colloidal particles as delivery systems for macromolecules. Adv Drug Del Rev 47:83-97.
    • (2001) Adv Drug Del Rev , vol.47 , pp. 83-97
    • Janes, K.A.1    Calvo, P.2    Alonso, M.J.3
  • 10
    • 1842555353 scopus 로고    scopus 로고
    • Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery
    • Nagamoto T, Hattori Y, Takayama K, Maitani Y. 2004. Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery. Pharm Res 21:671-674.
    • (2004) Pharm Res , vol.21 , pp. 671-674
    • Nagamoto, T.1    Hattori, Y.2    Takayama, K.3    Maitani, Y.4
  • 11
    • 1042269557 scopus 로고    scopus 로고
    • Is nose-to-brain transport of drugs in man a reality ?
    • Illum L. 2004. Is nose-to-brain transport of drugs in man a reality ? J Pharm Pharmacol 56:3-17.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 3-17
    • Illum, L.1
  • 12
    • 0034733992 scopus 로고    scopus 로고
    • Modulation of tight junctional permeability
    • Madara JL. 2000. Modulation of tight junctional permeability. Adv Drug Del Rev 41:251-253.
    • (2000) Adv Drug Del Rev , vol.41 , pp. 251-253
    • Madara, J.L.1
  • 13
    • 0021843706 scopus 로고
    • Comparison of water influx and sieving coefficient in rat jejunal, rectal and nasal absorption of antipyrine
    • Hayashi M, Hirasawa T, Muraoka T, Shiga M, Awaza S. 1985. Comparison of water influx and sieving coefficient in rat jejunal, rectal and nasal absorption of antipyrine. Chem Pharm Bull 33: 2149-2152.
    • (1985) Chem Pharm Bull , vol.33 , pp. 2149-2152
    • Hayashi, M.1    Hirasawa, T.2    Muraoka, T.3    Shiga, M.4    Awaza, S.5
  • 14
    • 0034306505 scopus 로고    scopus 로고
    • Enhancing paracellular permeability by modulating epithelial tight junctions
    • Ward PD, Tippin TK, Thakker DR. 2000. Enhancing paracellular permeability by modulating epithelial tight junctions. PSIT 3:346-358.
    • (2000) PSIT , vol.3 , pp. 346-358
    • Ward, P.D.1    Tippin, T.K.2    Thakker, D.R.3
  • 15
    • 0033004247 scopus 로고    scopus 로고
    • Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins
    • Tsukamoto T, Nigam SK. 1999. Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Am J Physiol 276: F737-F750.
    • (1999) Am J Physiol , vol.276
    • Tsukamoto, T.1    Nigam, S.K.2
  • 16
    • 10644263255 scopus 로고    scopus 로고
    • Involvement of protein kinase C in chitosan glutamate-mediated tight junction disruption
    • Smith JM, Dornish M, Wood EJ. 2005. Involvement of protein kinase C in chitosan glutamate-mediated tight junction disruption. Biomaterials 26:3269-3276.
    • (2005) Biomaterials , vol.26 , pp. 3269-3276
    • Smith, J.M.1    Dornish, M.2    Wood, E.J.3
  • 18
    • 0036692366 scopus 로고    scopus 로고
    • Comparative uptake studies of bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
    • Behrens I, Vila Pena AI, Alonso MJ, Kissel T. 2002. Comparative uptake studies of bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport. Pharm Res 19:1185-1193.
    • (2002) Pharm Res , vol.19 , pp. 1185-1193
    • Behrens, I.1    Vila Pena, A.I.2    Alonso, M.J.3    Kissel, T.4
  • 19
    • 0029053808 scopus 로고
    • Factors affecting the oral uptake and translocation of polystyrene nanoparticles: Histological and analytical evidence
    • Florence AT, Hillery AM, Hussain N, Jani PU. 1995. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: Histological and analytical evidence. J Drug Target 3:65-70.
    • (1995) J Drug Target , vol.3 , pp. 65-70
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.3    Jani, P.U.4
  • 20
    • 0027461945 scopus 로고
    • Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(L-lactic acid) microspheres in rats, rabbits and gunea pigs
    • Almeida AJ, Alpar HO, Brown MRW. 1993. Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(L-lactic acid) microspheres in rats, rabbits and gunea pigs. J Pharm Pharmacol 45:198-203.
    • (1993) J Pharm Pharmacol , vol.45 , pp. 198-203
    • Almeida, A.J.1    Alpar, H.O.2    Brown, M.R.W.3
  • 21
    • 0000774776 scopus 로고    scopus 로고
    • Microspheres transport pathways in the rabbit nasal mucosa
    • Huang Y, Donovan MD. 1996. Microspheres transport pathways in the rabbit nasal mucosa. Int J Pharm Adv 1:298-309.
    • (1996) Int J Pharm Adv , vol.1 , pp. 298-309
    • Huang, Y.1    Donovan, M.D.2
  • 22
    • 0034891405 scopus 로고    scopus 로고
    • Transport of nanoparticles across the rat nasal mucosa
    • Brooking J, Davis SS, Illum L. 2001. Transport of nanoparticles across the rat nasal mucosa. J Drug Target 9:267-279.
    • (2001) J Drug Target , vol.9 , pp. 267-279
    • Brooking, J.1    Davis, S.S.2    Illum, L.3
  • 23
    • 0031918253 scopus 로고    scopus 로고
    • Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
    • Tobia M, Gref R, Sanchez A, Langer R, Alonso MJ. 1998. Stealth PLA-PEG nanoparticles as protein carriers for nasal administration. Pharm Res 15: 270-275.
    • (1998) Pharm Res , vol.15 , pp. 270-275
    • Tobia, M.1    Gref, R.2    Sanchez, A.3    Langer, R.4    Alonso, M.J.5
  • 24
  • 25
    • 0033300109 scopus 로고    scopus 로고
    • Development of a freeze dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration
    • Fernandez-Urrusuno R, Romani D, Calvo P, Vila-Jato JL, Alonso MJ. 1999. Development of a freeze dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration. S.T.P Pharma Sci 9:429-436.
    • (1999) S.T.P Pharma Sci , vol.9 , pp. 429-436
    • Fernandez-Urrusuno, R.1    Romani, D.2    Calvo, P.3    Vila-Jato, J.L.4    Alonso, M.J.5
  • 26
    • 29244468833 scopus 로고    scopus 로고
    • Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells
    • Mao S, Germershaus O, Fischer D, Linn T, Schnepf R, Kissel T. 2005. Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells. Pharm Res 22: 2058-2068.
    • (2005) Pharm Res , vol.22 , pp. 2058-2068
    • Mao, S.1    Germershaus, O.2    Fischer, D.3    Linn, T.4    Schnepf, R.5    Kissel, T.6
  • 27
    • 27144446642 scopus 로고    scopus 로고
    • Insulin containing nanocomplexes formed by self-assembly from biodegradable amine-modified poly(vinyl alcohol)-graft-poly(L-lactide): Bioavailability and nasal tolerability in rats
    • Simon M, Wittmar M, Kissel T, Linn T. 2005. Insulin containing nanocomplexes formed by self-assembly from biodegradable amine-modified poly(vinyl alcohol)-graft-poly(L-lactide): Bioavailability and nasal tolerability in rats. Pharm Res 22:1879-1886.
    • (2005) Pharm Res , vol.22 , pp. 1879-1886
    • Simon, M.1    Wittmar, M.2    Kissel, T.3    Linn, T.4
  • 28
    • 0031815431 scopus 로고    scopus 로고
    • Kravtzoff R, Fisher A, de Miguel I, Perkins A, Major M, Betbeder D, anf Etienne A. 1998. Nasal residence time evaluation of cationic biovectorTM in human volunteers. Proc Int Symp Control Rel Bioact Mater 25:818-819
    • Kravtzoff R, Fisher A, de Miguel I, Perkins A, Major M, Betbeder D, anf Etienne A. 1998. Nasal residence time evaluation of cationic biovectorTM in human volunteers. Proc Int Symp Control Rel Bioact Mater 25:818-819
  • 30
    • 33645013856 scopus 로고    scopus 로고
    • Lectin-conjugated PEG-PLA nanoparticles: Preparation and brain delivery after intranasal administration
    • Gao X, Tao W, Lu W, Zhang Q, Zhang Y, Jiang X, Fu S. 2006. Lectin-conjugated PEG-PLA nanoparticles: Preparation and brain delivery after intranasal administration. Biomaterials 27:3482-3490.
    • (2006) Biomaterials , vol.27 , pp. 3482-3490
    • Gao, X.1    Tao, W.2    Lu, W.3    Zhang, Q.4    Zhang, Y.5    Jiang, X.6    Fu, S.7
  • 31
    • 0034950338 scopus 로고    scopus 로고
    • Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): Evaluation of antibody response after oral and nasal application in mice
    • Jung T, Kamm W, Breitenbach A, Hungerer K-L, Hundt E, Kissel T. 2001. Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): Evaluation of antibody response after oral and nasal application in mice. Pharm Res 18:352-360.
    • (2001) Pharm Res , vol.18 , pp. 352-360
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3    Hungerer, K.-L.4    Hundt, E.5    Kissel, T.6
  • 32
    • 0037150490 scopus 로고    scopus 로고
    • Intranasal immunization with recombinant antigens associated with new cationic particles induces strong mucosal as well as systemic antibody and CTL responses
    • Debin A, Kravtzoff R, Vaz Santiago J, Cazales L, Sperandino S, Melber K, Janowics Z, Betbeder D, Moynier M. 2002. Intranasal immunization with recombinant antigens associated with new cationic particles induces strong mucosal as well as systemic antibody and CTL responses. Vaccine 20: 2752-2763.
    • (2002) Vaccine , vol.20 , pp. 2752-2763
    • Debin, A.1    Kravtzoff, R.2    Vaz Santiago, J.3    Cazales, L.4    Sperandino, S.5    Melber, K.6    Janowics, Z.7    Betbeder, D.8    Moynier, M.9
  • 33
    • 0030779190 scopus 로고    scopus 로고
    • Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines
    • Calvo P, Remunan-Lopez C, Vila Jato JL, Alonso MJ. 1997. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res 14:1431-1436.
    • (1997) Pharm Res , vol.14 , pp. 1431-1436
    • Calvo, P.1    Remunan-Lopez, C.2    Vila Jato, J.L.3    Alonso, M.J.4
  • 34
    • 0031550212 scopus 로고    scopus 로고
    • Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
    • Calvo P, Remunan-Lopez C, Vila Jato JL, Alonso MJ. 1997. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J Appl Poly Sci 63:125-132.
    • (1997) J Appl Poly Sci , vol.63 , pp. 125-132
    • Calvo, P.1    Remunan-Lopez, C.2    Vila Jato, J.L.3    Alonso, M.J.4
  • 36
    • 0029938692 scopus 로고    scopus 로고
    • The effect of absorbed poloxamer 188 and 407 surfactants on the intestinal uptake of 60 nm polystyrene particles after oral administration in the rats
    • Hillery AM, Florence AT. 1996. The effect of absorbed poloxamer 188 and 407 surfactants on the intestinal uptake of 60 nm polystyrene particles after oral administration in the rats. Int J Pharm 132:123-130.
    • (1996) Int J Pharm , vol.132 , pp. 123-130
    • Hillery, A.M.1    Florence, A.T.2
  • 37
    • 33644809831 scopus 로고    scopus 로고
    • Differences in the adsorption behaviour of poly(ethylene oxide) copolymers onto model colloidal drug carrier assessed by isothermal titration microcalorimetry
    • Stolnik S, Heal CR, Garnett MG, Illum L, Davis SS. 2005. Differences in the adsorption behaviour of poly(ethylene oxide) copolymers onto model colloidal drug carrier assessed by isothermal titration microcalorimetry J Drug Target 13:449-458.
    • (2005) J Drug Target , vol.13 , pp. 449-458
    • Stolnik, S.1    Heal, C.R.2    Garnett, M.G.3    Illum, L.4    Davis, S.S.5
  • 38
    • 3242717735 scopus 로고    scopus 로고
    • Transport of PLA-PEG particles across the nasal mucosa: Effect of particle size and PEG coating density
    • Vila A, Gill H, McCallion O, Alonson MJ. 2004. Transport of PLA-PEG particles across the nasal mucosa: Effect of particle size and PEG coating density. J Control Rel 98:231-244.
    • (2004) J Control Rel , vol.98 , pp. 231-244
    • Vila, A.1    Gill, H.2    McCallion, O.3    Alonson, M.J.4
  • 39
    • 0343962248 scopus 로고    scopus 로고
    • The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration
    • Tobio M, Sanchez A, Vila A, Soriano I, Evora C, Vila-Jato JL, Alonso MJ. 2000. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf B Biointerfaces 18:315-323.
    • (2000) Colloids Surf B Biointerfaces , vol.18 , pp. 315-323
    • Tobio, M.1    Sanchez, A.2    Vila, A.3    Soriano, I.4    Evora, C.5    Vila-Jato, J.L.6    Alonso, M.J.7
  • 40
    • 0028071051 scopus 로고
    • Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
    • Artursson P, Lindmark T, Davis SS, Illum L. 1994. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res 11:1358-1361.
    • (1994) Pharm Res , vol.11 , pp. 1358-1361
    • Artursson, P.1    Lindmark, T.2    Davis, S.S.3    Illum, L.4
  • 42
    • 33344467489 scopus 로고    scopus 로고
    • Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system
    • Amidi M, Romeijn SG, Borchard G, Junginger HE, Hennink WE, Jiskoot W. 2006. Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J Control Rel 111:107-116.
    • (2006) J Control Rel , vol.111 , pp. 107-116
    • Amidi, M.1    Romeijn, S.G.2    Borchard, G.3    Junginger, H.E.4    Hennink, W.E.5    Jiskoot, W.6
  • 43
    • 0035860620 scopus 로고    scopus 로고
    • Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration
    • Eyles JE, Bramwell VW, Williamson ED, Alpar HO. 2001. Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration. Vaccine 19:4732-4742.
    • (2001) Vaccine , vol.19 , pp. 4732-4742
    • Eyles, J.E.1    Bramwell, V.W.2    Williamson, E.D.3    Alpar, H.O.4
  • 45
    • 0032928872 scopus 로고    scopus 로고
    • Identification of particular epithelial areas and cells that transport polypeptide-coated nanoparticles in the nasal respiratory mucosa of the rabbit
    • Ghirardelli R, Bonasoro F, Porta C, Cremaschi D. 1999. Identification of particular epithelial areas and cells that transport polypeptide-coated nanoparticles in the nasal respiratory mucosa of the rabbit. Biochim Biophys Acta 1416:39-47.
    • (1999) Biochim Biophys Acta , vol.1416 , pp. 39-47
    • Ghirardelli, R.1    Bonasoro, F.2    Porta, C.3    Cremaschi, D.4
  • 46
    • 85030524106 scopus 로고    scopus 로고
    • Nanoscience and nanotechnologies: Opportunities and uncertainties
    • The Royal Society, Chapter 5, health, environmental and safety aspects
    • The Royal Society. 2004. Nanoscience and nanotechnologies: Opportunities and uncertainties. Chapter 5. Possible adverse health, environmental and safety aspects. www.royalsoc.ac.uk.
    • (2004) Possible adverse
  • 47
    • 33748201186 scopus 로고    scopus 로고
    • Response of well-differentiated nasal epithelial cells exposed to particles: Role of the epithelial in airway inflammation
    • April 26 Epub ahead of print
    • Auger F, Gendron MC, Chamot C, Marano F, Dazy AC. 2006. Response of well-differentiated nasal epithelial cells exposed to particles: Role of the epithelial in airway inflammation. Toxicol Appl Pharmacol April 26 (Epub ahead of print).
    • (2006) Toxicol Appl Pharmacol
    • Auger, F.1    Gendron, M.C.2    Chamot, C.3    Marano, F.4    Dazy, A.C.5
  • 48
    • 0025233551 scopus 로고
    • Model of disposition of drugs administered into the human nasal cavity
    • Gonda I, Gipps E. 1990. Model of disposition of drugs administered into the human nasal cavity. Pharm Res 7:69-75.
    • (1990) Pharm Res , vol.7 , pp. 69-75
    • Gonda, I.1    Gipps, E.2
  • 49
    • 0032484664 scopus 로고    scopus 로고
    • Mathematical modeling of deposition and disposition of drugs administered via the nose
    • Gonda I. 1998. Mathematical modeling of deposition and disposition of drugs administered via the nose. Adv Drug Del Rev 29:179-184.
    • (1998) Adv Drug Del Rev , vol.29 , pp. 179-184
    • Gonda, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.