Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 58, Issue 2, 2004, Pages 225-235

  Van Der Merwe, S M ^a,b   Verhoef, J C ^b   Verheijden, J H M ^c   Kotze A F ^a   Junginger, H E ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Absorption enhancer; Chitosan; Mucoadhesive; N trimethyl chitosan chloride; Peptide drugs; Tight junctions; Transepithelial electrical resistance

Indexed keywords

CHITOSAN DERIVATIVE; CYTOSKELETON PROTEIN; F ACTIN; MACROGOL 4000; MANNITOL; METHYL GROUP; N TRIMETHYL CHITOSAN CHLORIDE; OCTREOTIDE; PEPTIDE; POLYMER; UNCLASSIFIED DRUG; WATER;

CELL STRAIN CACO 2; CONFOCAL LASER MICROSCOPY; CYTOTOXICITY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; EPITHELIUM CELL; EVALUATION; HUMAN; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; METHYLATION; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; REVIEW; TIGHT JUNCTION;

ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG CARRIERS; HUMANS; PEPTIDES; TIME FACTORS;

EID: 3843146208     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.03.023     Document Type: Review

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