Enteric-coated capsules filled with freeze-dried chitosan/poly(γ-glutamic acid) nanoparticles for oral insulin delivery

Biomaterials

Volumn 31, Issue 12, 2010, Pages 3384-3394

  Sonaje, Kiran ^a   Chen, Yi Jia ^a   Chen, Hsin Lung ^a   Wey, Shiaw Pyng ^b   Juang, Jyuhn Huarng ^b   Nguyen, Ho Ngoc ^a   Hsu, Chia Wei ^a   Lin, Kun Ju ^b,c   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Diabetes; pH sensitivity; Pharmacodynamic and pharmacokinetic profiles; SPECT CT tomography; X ray imaging

Indexed keywords

DIABETES; PH-SENSITIVITY; PHARMACOKINETIC PROFILES; SPECT/CT; SPECT/CT TOMOGRAPHY; XRAY IMAGING;

BIOCHEMISTRY; DISSOLUTION; GLUCOSE; NANOPARTICLES; PHARMACOKINETICS; PHOTODEGRADATION; TOMOGRAPHY; X RAY ANALYSIS;

INSULIN;

CHITOSAN; EUDRAGIT; GLUCOSE; INSULIN; NANOPARTICLE; POLYGLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG CAPSULE; DRUG DISTRIBUTION; ELECTRIC RESISTANCE; ENTERIC COATED TABLET; FREEZE DRYING; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MALE; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMALL INTESTINE ABSORPTION; TOXICITY TESTING; TRANSMISSION ELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; DIABETES MELLITUS, EXPERIMENTAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FREEZE DRYING; INSULIN; MALE; NANOPARTICLES; RATS; RATS, WISTAR; SCATTERING, RADIATION; SOLUBILITY;

RATTUS;

EID: 76749103819     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.01.042     Document Type: Article

References (37)

1. Carino G.P., and Mathiowitz E. Oral insulin delivery. Adv Drug Deliv Rev 35 2-3 (1999) 249-257
2. Zambanini A., Newson R.B., Maisey M., and Feher M.D. Injection related anxiety in insulin-treated diabetes. Diabetes Res Clin Pract 46 3 (1999) 239-246
3. Owens D.R., Zinman B., and Bolli G. Alternative routes of insulin delivery. Diabet Med 20 11 (2003) 886-898
4. Khafagy E.S., Morishita M., Onuki Y., and Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev 59 15 (2007) 1521-1546
5. Lin Y.H., Sonaje K., Lin K.M., Juang J.H., Mi F.L., Yang H.W., et al. Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J Control Release 132 2 (2008) 141-149
6. Sonaje K., Lin Y.H., Juang J.H., Wey S.P., Chen C.T., and Sung H.W. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 30 12 (2009) 2329-2339
7. Thanou M., Verhoef J.C., and Junginger H.E. Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev 52 2 (2001) 117-126
8. Chen M.C., Wong H.S., Lin K.J., Chen H.L., Wey S.P., Sonaje K., et al. The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials 30 34 (2009) 6629-6637
9. Lin K.J., Liao C.H., Hsiao I.T., Yen T.C., Chen T.C., Jan Y.Y., et al. Improved hepatocyte function of future liver remnant of cirrhotic rats after portal vein ligation: a bonus other than volume shifting. Surgery 145 2 (2009) 202-211
10. Sameti M., Bohr G., Ravi Kumar M.N.V., Kneuer C., Bakowsky U., Nacken M., et al. Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery. Int J Pharm 266 1-2 (2003) 51-60
11. Pan Y., Li Y., Zhao H., Zheng J., Xu H., Wei G., et al. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 249 1-2 (2002) 139-147
12. Lin Y.H., Mi F.L., Chen C.T., Chang W.C., Peng S.F., Liang H.F., et al. Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules 8 1 (2007) 146-152
13. Lin Y.H., Chen C.T., Liang H.F., Kulkarni A.R., Lee P.W., Chen C.H., et al. Novel nanoparticles for oral insulin delivery via the paracellular pathway. Nanotechnology 18 10 (2007) 105102
14. Chi Q., Wang T., and Huang K. Effect of insulin nitration by peroxynitrite on its biological activity. Biochem Biophys Res Commun 330 3 (2005) 791-796
15. Anlezark G.M., Vaughan T., Fashola-Stone E., Paul Michael N., Murdoch H., Sims M.A., et al. Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954. Microbiology 148 1 (2002) 297-306
16. He X., Sugawara M., Takekuma Y., and Miyazaki K. Absorption of ester prodrugs in Caco-2 and rat intestine models. Antimicrob Agents Chemother 48 7 (2004) 2604-2609
17. Yun Z., Takagi M., and Yoshida T. Repeated addition of insulin for dynamic control of apoptosis in serum-free culture of Chinese hamster ovary cells. J Biosci Bioeng 96 1 (2003) 59-64
18. Dodane V., Amin Khan M., and Merwin J.R. Effect of chitosan on epithelial permeability and structure. Int J Pharm 182 1 (1999) 21-32
19. Marvola T., Marvola J., Kanerva H., Ahonen A., Lindevall K., and Marvola M. Neutron activation based gamma scintigraphic evaluation of enteric-coated capsules for local treatment in colon. Int J Pharm 349 1-2 (2008) 24-29
20. Ma Z., and Lim L.-Y. Uptake of chitosan and associated insulin in Caco-2 cell monolayers: a comparison between chitosan molecules and chitosan nanoparticles. Pharm Res 20 11 (2003) 1812-1819
21. Chung H., Kim J., Um J.Y., Kwon I.C., and Jeong S.Y. Self-assembled "nanocubicle" as a carrier for peroral insulin delivery. Diabetologia 45 3 (2002) 448-451
22. Damge C., Maincent P., and Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release 117 2 (2007) 163-170
23. O'Connor S.D., and Summers R.M. Revisiting oral barium sulfate contrast agents. Acad Radiol 14 1 (2007) 72-80
24. Teply B.A., Tong R., Jeong S.Y., Luther G., Sherifi I., Yim C.H., et al. The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials 29 9 (2008) 1216-1223
25. Koide S.S. Chitin-chitosan: properties, benefits and risks. Nutr Res 18 (1998) 1091-1101
26. Abdelwahed W., Degobert G., Stainmesse S., and Fessi H. Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev 58 15 (2006) 1688-1713
27. Abdelwahed W., Degobert G., and Fessi H. A pilot study of freeze drying of poly(epsilon-caprolactone) nanocapsules stabilized by poly(vinyl alcohol): formulation and process optimization. Int J Pharm 309 1-2 (2006) 178-188
28. Liuquan C., Deanna S., Joanna S., David O., Kathleen L.G., Xiaolin T., et al. Mechanism of protein stabilization by sugars during freeze-drying and storage: native structure preservation, specific interaction, and/or immobilization in a glassy matrix?. J Pharm Sci 94 7 (2005) 1427-1444
29. Roe R.J. Methods of X-ray and neutron scattering in polymer science (2000), Oxford University Press, New York [Chapter 5]
30. Costantino H.R., Langer R., and Klibanov A.M. Moisture-induced aggregation of lyophilized insulin. Pharm Res 11 1 (1994) 21-29
31. Hidalgo I., Raub T., and Borchardt R. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96 3 (1989) 736-749
32. Ward P.D., Tippin T.K., and Thakker D.R. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Tech Today 3 10 (2000) 346-358
33. Ranaldi G., Marigliano I., Vespignani I., Perozzi G., and Sambuy Y. The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line. J Nutr Biochem 13 3 (2002) 157-167
34. Smith J.M., Dornish M., and Wood E.J. Involvement of protein kinase C in chitosan glutamate-mediated tight junction disruption. Biomaterials 26 16 (2005) 3269-3276
35. Ammar H.O., and Khalil R.M. Preparation and evaluation of sustained-release solid dispersions of drugs with Eudragit polymers. Drug Dev Ind Pharm 23 11 (1997) 1043-1054
36. ® S100 combinations. J Control Release 58 2 (1999) 215-222
37. Evans D.F., Pye G., Bramley R., Clark A.G., Dyson T.J., and Hardcastle J.D. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 29 8 (1988) 1035-1041