Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

Neuroscience

Volumn 127, Issue 2, 2004, Pages 481-496

  Thorne, R G ^a,b   Pronk, G J ^c   Padmanabhan, V ^b   Frey II, W H ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b HEALTHPARTNERS RESEARCH FOUNDATION   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Alzheimer's disease; area under the concentration time curve; AUC; blood brain barrier; cerebrospinal fluid; CSF; drug delivery; ERK; extracellular signal regulated protein kinase; horseradish peroxidase; HRP; IGF; neurotrophic factor; stroke

Indexed keywords

IODINE 125; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID ANALYSIS; CERVICAL LYMPH NODE; CONTROLLED STUDY; DRUG TRANSPORT; FRONTAL CORTEX; LYMPHATIC DRAINAGE; MALE; MICRODISSECTION; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RADIOASSAY; RAT; SIGNAL TRANSDUCTION; SPINAL CORD; TISSUE SECTION; TRIGEMINAL NUCLEUS;

ADMINISTRATION, INTRANASAL; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CEREBROSPINAL FLUID; DOSE-RESPONSE RELATIONSHIP, DRUG; INSULIN-LIKE GROWTH FACTOR I; IODINE RADIOISOTOPES; LYMPH NODES; MALE; OLFACTORY NERVE; OLFACTORY PATHWAYS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SIGNAL TRANSDUCTION; SPINAL CORD; TRIGEMINAL NERVE;

EID: 3242740239     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2004.05.029     Document Type: Article

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