Mucosal insulin delivery systems based on complexation polymer hydrogels: Effect of particle size on insulin enteral absorption

Journal of Controlled Release

Volumn 97, Issue 1, 2004, Pages 115-124

  Morishita, Mariko ^a   Goto, Takahiro ^a   Peppas, Nicholas A ^b   Joseph, Jeffery I ^c   Torjman, Marc C ^c   Munsick, Carey ^c   Nakamura, Koji ^d   Yamagata, Tetsuo ^a   Takayama, Kozo ^a   Lowman, Anthony M ^d  

^a HOSHI UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d Drexel University   (United States)

Author keywords

Complexation polymers; Insulin delivery; Microparticles; Mucoadhesion

Indexed keywords

ABSORPTION; CELLS; COMPLEXATION; GLUCOSE; HYDROGELS; POLYMERS;

HYPOGLYCEMIC EFFECTS; INSULIN LOADED POLYMERS; ORAL ADMINISTRATION;

INSULIN;

INSULIN; LACTATE DEHYDROGENASE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG SAFETY; DRUG SPECIFICITY; HYDROGEL; HYPOGLYCEMIA; HYPOTHESIS; ILEUM; INSULIN RELEASE; INTESTINE ABSORPTION; INTESTINE MUCOSA; JEJUNUM; MALE; MEMBRANE ELECTROPHYSIOLOGY; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION;

ANIMALS; DRUG DELIVERY SYSTEMS; HYDROGELS; INSULIN; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; PARTICLE SIZE; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1842857988     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.03.008     Document Type: Article

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