Influence of molecular weight on oral absorption of water soluble chitosans

Journal of Controlled Release

Volumn 102, Issue 2, 2005, Pages 383-394

  Chae, Su Young ^a   Jang, Mi Kyeong ^a   Nah, Jae Woon ^a  

^a Sunchon National University   (South Korea)

Author keywords

Caco 2 cell; Chitosan; Molecular weight; Oral absorption; Permeability

Indexed keywords

BIOMEDICAL APPLICATIONS; CHITOSAN; WATER-SOLUBLE CHITOSANS (WSC);

ABSORPTION; BIOMEDICAL ENGINEERING; CELLS; CONCENTRATION (PROCESS); CYTOLOGY; MOLECULAR WEIGHT; PHARMACODYNAMICS;

POLYSACCHARIDES;

CHITOSAN;

ARTICLE; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CYTOTOXICITY; DRUG ABSORPTION; DRUG SOLUBILITY; FLUORESCENCE ANALYSIS; MOLECULAR WEIGHT; PRIORITY JOURNAL;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CELL SURVIVAL; CHEMISTRY, PHYSICAL; CHITOSAN; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; INTESTINAL ABSORPTION; MALE; MOLECULAR WEIGHT; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLIUM SALTS; THIAZOLES;

EID: 11844288271     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.10.012     Document Type: Article

References (34)

1. R. Hejazi, and M. Amiji Chitosan-based gastrointestinal delivery systems J. Control. Release 89 2003 151 165
2. J.W. Nah, and M.K. Jang Spectroscopic characterization and preparation of low molecular, water-soluble chitosan with free-amine group by novel method J. Polym. Sci., Part A, Polym. Chem. 40 2002 3796 3803
3. N.G.M. Schipper, K.M. Varum, and P. Artursson Chitosans as absorption enhancers for poorly absorbable drugs: 1. Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells Pharm. Res. 13 1996 1686 1692
4. N.G.M. Schipper, S. Olsson, J.A. Hoogstraate, A.G. deBoer, K.M. Varum, and P. Artursson Chitosans as absorption enhancers for poorly absorbable drugs: 2. Mechanism of absorption enhancement Pharm. Res. 14 1997 923 929
5. N.G.M. Schipper, K.M. Varum, P. Stenberg, G. Ocklind, H. Lennernas, and P. Artursson Chitosans as absorption enhancers of poorly absorbable drugs: 3. Influence of mucus on absorption enhancement Eur. J. Pharm. Sci. 8 1999 335 343
6. G. Ranaldi, I. Marigliano, I. Vespignani, G. Perozzi, and Y. Sambuy The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line J. Nutr. Biochem 13 2002 157 167
7. V. Dodane, M. Amin Khan, and J.R. Merwin Effect of chitosan on epithelial permeability and structure Int. J. Pharm. 182 1999 21 32
8. L. Illum Chitosan and its use as a pharmaceutical excipient Pharm. Res. 15 1998 1326 1331
9. A.F. Kotzé, B.J. de Leeuw, H.L. Lueben, A.G. de Boer, J.C. Verhoef, and H.E. Junginger Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayer Int. J. Pharm. 159 1997 243 253
10. S. Senel, M.J. Kremer, S. Kas, P.W. Wertz, A.A. Hincal, and C.A. Squier Enhancing effect of chitosan on peptide drug delivery across buccal mucosa Biomaterials 21 2000 2067 2071
11. M. Thanou, J.C. Verhoef, and H.E. Junginger Chitosan and its derivatives as intestinal absorption enhancers Adv. Drug Deliv. Rev. 50 2001 S91 S101
12. M. Thanou, J.C. Verhoef, and H.E. Junginger Oral drug absorption enhancement by chitosan and its derivatives Adv. Drug Deliv. Rev. 52 2001 117 126
13. A.M. Dyer, M. Hinchcliffe, P. Watts, J. Castile, I. Jabbal-Gill, R. Nankervis, A. Smith, and L. Illum Nasal delivery of insulin using novel chitosan based formulations: a comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles Pharm. Res. 19 2002 998 1008
14. K.A. Janes, P. Calvo, and M.J. Alonso Polysaccharide colloidal particles as delivery systems for macromolecules Adv. Drug Deliv. Rev. 47 2001 83 97
15. R. Fernandez-Urrusuno, P. Calvo, C. Remunan-Lopez, J.L. Vila-Jato, and M.J. Alonso Enhancement of nasal absorption of insulin using chitosan nanoparticles Pharm. Res. 16 1999 1576 1581
16. Y. Pan, Y. Li, H. Zhao, J. Zheng, H. Xu, G. Wei, J. Hao, and F. Cui Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo Int. J. Pharm. 249 2002 139 147
17. M. Andersson, and J.E. Lofroth Small particles of a heparin/chitosan complex prepared from a pharmaceutically acceptable microemulsion Int. J. Pharm. 257 2003 305 309
18. M. Thanou, M.T. Nihot, M. Jansen, J.C. Verhoef, and H.E. Junginger Nono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo J. Pharm. Sci. 90 2001 38 46
19. K.A. Janes, M.P. Fresneau, A. Marazuela, A. Fabra, and M.J. Alonso Chitosan nanoparticles as delivery systems for doxorubicin J. Control. Release 73 2001 255 267
20. A. Tokoro, N. Tatewaki, K. Suzuki, T. Mikami, S. Suzuki, and M. Suzuki Growth-inhibitory effect of hexa-N-acetylchitohexanose and chitohexanose against Meth-A solid tumor Chem. Pharm. Bull. 36 1988 784 790
21. H.O. Pae, W.G. Seo, N.Y. Kim, G.S. Oh, G.E. Kim, Y.H. Kim, H.J. Kwak, Y.G. Yun, C.D. Jun, and H.T. Chung Induction of granulocytic differentiation in acute promyeloocytic leukemia cells (HL-60) by water-soluble chitosan oligomer Leuk. Res. 25 2001 339 346
22. D.J. Ormrod, C.C. Holmes, and T.E. Miller Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis Atherosclerosis 138 1998 329 334
23. C.M. Gallaher, J. Munion, R. Hesslink Jr., J. Wise, and D.D. Gallaher Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats J. Nutr. 130 2000 2753 2759
24. C. Porporatto, I.D. Bianco, C.M. Riera, and S.G. Correa Chitosan induces different l-arginine metabolic pathways in resting and inflammatory macrophages Biochem. Biophys. Res. Commun. 304 2003 266 272
25. G. Peluso, O. Petillo, M. Tanieri, M. Santin, L. Ambrosic, D. Calabro, B. Avallone, and G. Balsamo Chitosan-mediated stimulation of macrophage function Biomaterials 15 1994 1215 1220
26. y mice Biol. Pharm. Bull. 25 2002 188 192
27. S. Hirano Chitin biotechnology applications Biotechnol. Annu. Rev. 2 1996 237 258
28. J.L. Kanul, M.R. Kasaai, V.T. Bui, and K.A.M. Creber Characterization of deacetylated chitosan and chitosan molecular weight review Can. J. Chem. 76 1998 1699 1706
29. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
30. H. Ichikawa, and N.A. Peppas Novel complexation hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers J. Biomed. Mater. Res. 67A 2003 609 617
31. M. Sugano, T. Fujikawa, Y. Hiratsuji, K. Nakashima, N. Fukuda, and Y. Hesegawa A novel use of chitosan as a hypocholesterolemic agent in rats Am. J. Clin. Nutr. 33 1980 787 793
32. W.T. Coakley, L.A. Hewison, and D. Tilley Interfacial instability and the agglutination of erythrocytes by polylysine Eur. Biophys. J. 13 1985 123 130
33. D.M.L. Morgan, V.L. Larvin, and J.D. Pearson Biochemical characterization of polycation-induced cytotoxicity to human vascular endothelial cells J. Cell. Sci. 94 1989 553 559
34. S. Choksakulnimitr, S. Masuda, H. Tokuda, Y. Takakura, and M. Hashida In vitro cytotoxicity of macromolecules in different cell culture systems J. Control. Release 34 1995 233 241