Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 2, 2000, Pages 594-600

  Xia, C Q ^a   Wang, J ^a   Shen, W C ^a  

^a PSC 404B ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; N ETHYLMALEIMIDE; PROTEINASE INHIBITOR; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONJUGATE; CONTROLLED STUDY; DISULFIDE BOND; DOSE RESPONSE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG STABILITY; FEMALE; HYPOGLYCEMIA; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TRANSCYTOSIS;

ADMINISTRATION, ORAL; ANIMAL; BLOOD GLUCOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; DRUG STABILITY; FEMALE; HUMAN; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; LIVER; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; TRANSFERRIN;

EID: 0033771566     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Pulmonary delivery of therapeutic peptides and proteins
2. Report of the expert committee on the diagnosis and classification of diabetes mellitus
3. The use of cultured epithelial and endothelial cells for drug transport and metabolism studies
4. Resistance of metal complexes of conalbumin and transferrin to proteolysis and thermal denaturation
5. The presence of insulin-degrading enzyme in human ileal and colonic mucosal cells
6. Insulin-degrading enzyme in a human colon adenocarcinoma cell line (Caco-2)
7. Transferrin receptors in the human gastrointestinal tract
8. The first clinical use of insulin
9. Potential developments in systemic delivery of insulin
10. Proteins of iron storage and transport
11. Lilly lecture 1987: The triumvirate: B-cell, muscle, liver. A collusion responsible for NIDDM
12. Splanchnic and renal metabolism of insulin in human subjects: A dose-response study
13. Improving insulin therapy: Achievements and challenges
14. Application of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physiological barriers posed by the intestinal epithelium
15. Physiological significance of altered insulin metabolism in the conscious rat during lactation
16. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
17. Mucosal penetration enhancers for facilitation of peptide and protein drug absorption
18. Hepatic glucose production is regulated both by direct hepatic effects of insulin in humans
19. Alteration in the organ distribution of iron by truncated transferrin: Implications for iron chelation therapy
20. Soluble fatty acid acylated insulins bind albumin and showed protracted action in pigs
21. Delivery of systemic regular insulin via ocular route in dogs
22. Internal insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100
23. Acylation of human insulin with palmitic acid extends the time of action of haman insulin in diabetic dogs
24. Influence of polyethylene glycol insulin on lipid tissues of experimental animals
25. Human blood-brain barrier transferrin receptor
26. Development of intestinal cell culture models for drug transport and metabolism studies
27. Insulin drug delivery systems: Rectal gels
28. Receptor-mediated endocytosis of insulin by culture endothelial cells
29. A new approach to the oral administration of insulin and other peptide drugs
30. Transepithelial delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells
31. Different effects of anionic, cationic, nonionic and physiologic surfactants on the dissociation, achymotryptic degradation, and eternal absorption of insulin hexamers
32. Enhancement of polypeptide and protein absorption by macromolecular carrier via endocytosis and transcytosis
33. Lessons from studies of insulin pharmacokinetics
34. Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages
35. Instability of bovine insulin in poly(lactide-co-glycolide) (PLGS) microspheres
36. Oral delivery of insulin-transferrin conjugate in streptozotocin-treated CF/1 mice
37. Biodistribution and plasma survival in mice of anti-melanoma monoclonal antibody cross-linked to OKT3
38. Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats