Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 77, Issue 1, 2011, Pages 11-19

  Zhang, Yueling ^a,b   Wei, Wei ^a,b   Lv, Piping ^a,b   Wang, Lianyan ^a   Ma, Guanghui ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Alginate chitosan microspheres; Insulin; Narrow size distribution; Oral administration; Protein or peptide; Sustained release

Indexed keywords

ALGINIC ACID; CHITOSAN; GLUCOSE; INSULIN; PEPSIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STABILITY; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; INTESTINE TRANSIT TIME; NONHUMAN; PARTICLE SIZE; PH; RAT; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ALGINATES; ANIMALS; BLOOD GLUCOSE; CHITOSAN; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG STABILITY; GASTRIC JUICE; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICROSPHERES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 78650710879     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.09.016     Document Type: Article

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