Improvement of intestinal absorption of water-soluble macromolecules by various polyamines: Intestinal mucosal toxicity and absorption-enhancing mechanism of spermine

International Journal of Pharmaceutics

Volumn 354, Issue 1-2, 2008, Pages 126-134

  Gao, Yang ^a   He, Lin ^a,b   Katsumi, Hidemasa ^a   Sakane, Toshiyasu ^a   Fujita, Takuya ^c   Yamamoto, Akira ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

Absorption enhancer; Intestinal absorption; Macromolecule; Membrane toxicity; Polyamine; Spermine

Indexed keywords

EDETIC ACID; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; LACTATE DEHYDROGENASE; POLYAMINE DERIVATIVE; PUTRESCINE; SPERMIDINE; SPERMINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ADSORPTION; ELECTRIC RESISTANCE; GASTROINTESTINAL TOXICITY; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; JEJUNUM MUCOSA; MACROMOLECULE; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DEXTRANS; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; FLUORESCEIN-5-ISOTHIOCYANATE; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; JEJUNUM; L-LACTATE DEHYDROGENASE; MALE; MOLECULAR WEIGHT; POLYAMINES; PUTRESCINE; RATS; RATS, WISTAR; SPERMIDINE; SPERMINE;

EID: 40849086344     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.11.061     Document Type: Article

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